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  1. Article ; Online: Preparation, Optimization and In vitro Evaluation of Doxorubicin-loaded into Hyaluronic Acid Coated Niosomes Against Breast Cancer.

    Faddah, Haya / Nsairat, Hamdi / Shalan, Naeem M / El-Tanani, Mohamed / Alqudah, Dana A / Alshaer, Walhan

    Chemistry & biodiversity

    2024  Volume 21, Issue 2, Page(s) e202301470

    Abstract: Doxorubicin (DOX) is widely used against solid tumors. Niosomes are self-assembled nanocarriers of non-ionic surfactants. DOX loaded into cationic niosomes (DOX-Nio) was prepared via thin film hydration method. DOX-Nio was then decorated with a ... ...

    Abstract Doxorubicin (DOX) is widely used against solid tumors. Niosomes are self-assembled nanocarriers of non-ionic surfactants. DOX loaded into cationic niosomes (DOX-Nio) was prepared via thin film hydration method. DOX-Nio was then decorated with a hyaluronic acid (DOX-HA-Nio) via electrostatic interaction. DOX-Nio and DOX-HA-Nio displayed a particle size of 120.0±1.02 and 182.9±2.3 nm, and charge of + 35.5±0.15 and -15.6±0.25 mV, respectively, with PDI < 0.3. DOX-HA-Nio showed a good stability regarding size and charge over 4 weeks at 4 °C and maintain their integrity after lyophilization. HPLC results showed a 94.1±4.2 % encapsulation efficiency of DOX with good entrapment and slow, prolonged DOX release even after 48 hrs. Cell viability assay showed an IC
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Liposomes ; Hyaluronic Acid ; Doxorubicin/pharmacology ; MCF-7 Cells
    Chemical Substances Liposomes ; Hyaluronic Acid (9004-61-9) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting.

    Twal, Shrouq / Jaber, Nisrein / Al-Remawi, Mayyas / Hamad, Islam / Al-Akayleh, Faisal / Alshaer, Walhan

    RSC advances

    2024  Volume 14, Issue 5, Page(s) 3070–3084

    Abstract: A dual stimuli-responsive nanocarrier was developed from smart biocompatible chitosan and soluplus graft copolymers. The copolymerization was investigated by differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), and Fourier ... ...

    Abstract A dual stimuli-responsive nanocarrier was developed from smart biocompatible chitosan and soluplus graft copolymers. The copolymerization was investigated by differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), and Fourier transform infrared (FTIR). The optimized chitosan-soluplus nanoparticles (CS-SP NPs) were further used for the encapsulation of a poorly water-soluble anticancer drug. Tamoxifen citrate (TC) was used as the model drug and it was loaded in CS-SP NPs. TC CS-SP NPs were characterized in terms of particle size, zeta potential, polydispersity, morphology, encapsulation efficiency, and physical stability. The nanoparticles showed homogenous spherical features with a size around 94 nm, a slightly positive zeta potential, and an encapsulation efficiency around 96.66%. Dynamic light scattering (DLS),
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08074a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning.

    Jaradat, Nour Jamal / Alshaer, Walhan / Hatmal, Mamon / Taha, Mutasem Omar

    RSC advances

    2023  Volume 13, Issue 7, Page(s) 4623–4640

    Abstract: STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we used multiple docked poses ... ...

    Abstract STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we used multiple docked poses of STAT3 inhibitors to augment training data for machine learning QSAR modeling. Ligand-Receptor Contact Fingerprints and scoring values were implemented as descriptor variables. Escalating docking-scoring consensus levels were scanned against orthogonal machine learners, and the best learners (Random Forests and XGBoost) were coupled with genetic algorithm and Shapley additive explanations (SHAP) to identify critical descriptors that determine anti-STAT3 bioactivity to be translated into pharmacophore model(s). Two successful pharmacophores were deduced and subsequently used for
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra07007c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aptasensors: employing molecular probes for precise medical diagnostics and drug monitoring.

    Lafi, Zainab / Gharaibeh, Lobna / Nsairat, Hamdi / Asha, Nisreen / Alshaer, Walhan

    Bioanalysis

    2023  Volume 15, Issue 23, Page(s) 1439–1460

    Abstract: Accurate detection and monitoring of therapeutic drug levels are vital for effective patient care and treatment management. Aptamers, composed of single-stranded DNA or RNA molecules, are integral components of biosensors designed for both qualitative ... ...

    Abstract Accurate detection and monitoring of therapeutic drug levels are vital for effective patient care and treatment management. Aptamers, composed of single-stranded DNA or RNA molecules, are integral components of biosensors designed for both qualitative and quantitative detection of biological samples. Aptasensors play crucial roles in target identification, validation, detection of drug-target interactions and screening potential of drug candidates. This review focuses on the pivotal role of aptasensors in early disease detection, particularly in identifying biomarkers associated with various diseases such as cancer, infectious diseases and cardiovascular disorders. Aptasensors have demonstrated exceptional potential in enhancing disease diagnostics and monitoring therapeutic drug levels. Aptamer-based biosensors represent a transformative technology in the field of healthcare, enabling precise diagnostics, drug monitoring and disease detection.
    MeSH term(s) Humans ; Molecular Probes ; Drug Monitoring ; Aptamers, Nucleotide ; Biomarkers ; Neoplasms ; Biosensing Techniques
    Chemical Substances Molecular Probes ; Aptamers, Nucleotide ; Biomarkers
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2023-0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of nanotechnology on the oral delivery of phyto-bioactive compounds

    Nsairat, Hamdi / Lafi, Zainab / Al-Sulaibi, Mazen / Gharaibeh, Lobna / Alshaer, Walhan

    Food Chemistry. 2023 Oct., v. 424 p.136438-

    2023  

    Abstract: Nanotechnology is an advanced field that has remarkable nutraceutical and food applications. Phyto-bioactive compounds (PBCs) play critical roles in promoting health and disease treatment. However, PBCs generally encounter several limitations that delay ... ...

    Abstract Nanotechnology is an advanced field that has remarkable nutraceutical and food applications. Phyto-bioactive compounds (PBCs) play critical roles in promoting health and disease treatment. However, PBCs generally encounter several limitations that delay their widespread application. For example, most PBCs have low aqueous solubility, poor biostability, poor bioavailability, and a lack of target specificity. Moreover, the high concentrations of effective PBC doses also limit their application. As a result, encapsulating PBCs into an appropriate nanocarrier may increase their solubility and biostability and protect them from premature degradation. Moreover, nanoencapsulation could improve absorption and prolong circulation with a high opportunity for targeted delivery that may decrease unwanted toxicity. This review addresses the main parameters, variables, and barriers that control and affect oral PBC delivery. Moreover, this review discusses the potential role of biocompatible and biodegradable nanocarriers in improving the water solubility, chemical stability, bioavailability, and specificity/selectivity of PBCs.
    Keywords absorption ; bioavailability ; biodegradability ; dietary supplements ; food chemistry ; nanocapsules ; nanocarriers ; toxicity ; water solubility ; BBB ; EGCG ; GIF ; GIT ; GM ; MRPs ; NDs ; NLCs ; P-gp ; PBCs ; PCL ; PLA ; PLGA ; RIOM ; RVT ; SLNs ; SJC ; TJC ; Phyto-bioactive compounds ; Nutraceutical ; Nanoencapsulation ; Biostability ; Oral delivery
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.136438
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  6. Article ; Online: Anticancer Cardenolides from the aerial parts of

    Sweidan, Nuha / Esawi, Ezaldeen / Ismail, Mohammad / Alshaer, Walhan

    Zeitschrift fur Naturforschung. C, Journal of biosciences

    2021  Volume 76, Issue 5-6, Page(s) 243–250

    Abstract: Column chromatography (CC) analysis of methanol and butanol extracts of the aerial parts ... ...

    Abstract Column chromatography (CC) analysis of methanol and butanol extracts of the aerial parts of
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apocynaceae/chemistry ; Apocynaceae/metabolism ; Cardenolides/chemistry ; Cardenolides/isolation & purification ; Cardenolides/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Plant Components, Aerial/chemistry ; Plant Components, Aerial/metabolism ; Plant Extracts/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Cardenolides ; Plant Extracts ; calotropin (3XK21U1BZS)
    Language English
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124636-7
    ISSN 1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
    ISSN (online) 1865-7125
    ISSN 0341-0382 ; 0341-0471 ; 0939-5075
    DOI 10.1515/znc-2020-0281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 962: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Preparation of novel shell-ionotropically crosslinked micelles based on hexadecylamine and tripolyphosphate for cancer drug delivery.

    Alkhafaji, Enas / Dmour, Isra / Al-Essa, Mohamed K / Alshaer, Walhan / Aljaberi, Ahmad / Khalil, Enam A / Taha, Mutasem O

    Pharmaceutical development and technology

    2024  , Page(s) 1–17

    Abstract: Aims: Micellar systems have the advantage of being easily prepared, cheap, and readily loadable with bioactive molecular cargo. However, their fundamental pitfall is poor stability, particularly under dilution conditions. We propose to use simple ... ...

    Abstract Aims: Micellar systems have the advantage of being easily prepared, cheap, and readily loadable with bioactive molecular cargo. However, their fundamental pitfall is poor stability, particularly under dilution conditions. We propose to use simple quaternary ammonium surfactants, namely, hexadecylamine (HDA) and hexadecylpyridinium (HDAP), together with tripolyphosphate (TPP) anion, to generate ionotropically stabilized micelles capable of drug delivery into cancer cells.
    Methods: optimized mixed HDA/HDAP micelles were prepared and stabilized with TPP. Curcumin was used as a loaded model drug. The prepared nanoparticles were characterized by dynamic light scattering, infrared spectroscopy, transmission electron microscopy, and differential scanning calorimetry. Moreover, their cellular uptake was assessed using flow cytometry and confocal fluorescence microscopy.
    Results: The prepared nanoparticles were found to be stable under dilution and at high temperatures and to have a size range from 139 nm to 580 nm, depending on pH (4.6-7.4), dilution (up to 100 times), and temperature (25 - 80 °C). They were effective at delivering their load into cancer cells. Additionally, flow cytometry indicated the resulting stabilized micellar nanoparticles to be non-cytotoxic.
    Conclusions: The described novel stabilized micelles are simple to prepare and viable for cancer delivery.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1331774-x
    ISSN 1097-9867 ; 1083-7450
    ISSN (online) 1097-9867
    ISSN 1083-7450
    DOI 10.1080/10837450.2024.2332457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5043: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Editorial: Anti-cancer drug delivery: lipid-based nanoparticles.

    Alkilany, Alaaldin M / Elhissi, Abdelbary / Alshaer, Walhan / Kunwar, Amit / Giri, Jyotsnendu

    Frontiers in oncology

    2023  Volume 13, Page(s) 1248272

    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1248272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development and validation of reversed-phase-HPLC method for simultaneous quantification of fulvestrant and disulfiram in liposomes.

    Nsairat, Hamdi / Alshaer, Walhan / Lafi, Zainab / Ahmad, Somaya / Al-Sanabrah, Alaa / El-Tanani, Mohamed

    Bioanalysis

    2023  Volume 15, Issue 23, Page(s) 1393–1405

    Abstract: This study aims to develop and validate an HPLC technique for the determination of fulvestrant and disulfiram in liposomes. Encapsulation of both drugs into liposomes may improve their anticancer potential. Validation was performed following the ... ...

    Abstract This study aims to develop and validate an HPLC technique for the determination of fulvestrant and disulfiram in liposomes. Encapsulation of both drugs into liposomes may improve their anticancer potential. Validation was performed following the International Conference on Harmonization guidelines for specificity, linearity, limit of detection, limit of quantification, precision, accuracy and robustness. Method specificity displayed no interference and linearity over 25-200 and 12.5-100 μg/ml for fulvestrant and disulfiram, respectively. Precision and accuracy exhibited a low relative standard deviation (<1.70%) and appropriate recovery. The validated method could be designated as a proper method for the simultaneous determination of fulvestrant and disulfiram in liposomes. The liposomes displayed 148.5 ± 5.1 nm size. The encapsulation efficiencies were 73.52 and 50.50% for fulvestrant and disulfiram, respectively.
    MeSH term(s) Limit of Detection ; Fulvestrant ; Disulfiram ; Liposomes ; Chromatography, High Pressure Liquid/methods
    Chemical Substances Fulvestrant (22X328QOC4) ; Disulfiram (TR3MLJ1UAI) ; Liposomes
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2023-0137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of nanotechnology on the oral delivery of phyto-bioactive compounds.

    Nsairat, Hamdi / Lafi, Zainab / Al-Sulaibi, Mazen / Gharaibeh, Lobna / Alshaer, Walhan

    Food chemistry

    2023  Volume 424, Page(s) 136438

    Abstract: Nanotechnology is an advanced field that has remarkable nutraceutical and food applications. Phyto-bioactive compounds (PBCs) play critical roles in promoting health and disease treatment. However, PBCs generally encounter several limitations that delay ... ...

    Abstract Nanotechnology is an advanced field that has remarkable nutraceutical and food applications. Phyto-bioactive compounds (PBCs) play critical roles in promoting health and disease treatment. However, PBCs generally encounter several limitations that delay their widespread application. For example, most PBCs have low aqueous solubility, poor biostability, poor bioavailability, and a lack of target specificity. Moreover, the high concentrations of effective PBC doses also limit their application. As a result, encapsulating PBCs into an appropriate nanocarrier may increase their solubility and biostability and protect them from premature degradation. Moreover, nanoencapsulation could improve absorption and prolong circulation with a high opportunity for targeted delivery that may decrease unwanted toxicity. This review addresses the main parameters, variables, and barriers that control and affect oral PBC delivery. Moreover, this review discusses the potential role of biocompatible and biodegradable nanocarriers in improving the water solubility, chemical stability, bioavailability, and specificity/selectivity of PBCs.
    MeSH term(s) Nanotechnology ; Dietary Supplements ; Solubility ; Biological Availability ; Nanoparticles/chemistry ; Drug Delivery Systems
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.136438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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