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Article ; Online: Knowledge, Attitude, and Practice (KAP) toward the Novel Coronavirus (COVID-19) Pandemic in a Saudi Population-Based Survey.

Alqahtani, Abdulrahman H / Alqahtani, Saleh A / Alhodaib, Abdullah S / Al-Wathinani, Ahmed M / Daoulah, Amin / Alhamid, Sameer / Al-Otaibi, Salah N / Abufayyah, Mohammed / Wazzan, Ahmad M / Alshahrani, Saif S / Almaleh, Yahya S / Mobrad, Abdulmajeed M

International journal of environmental research and public health

2021 Volume 18, Issue 10

Abstract: Background: The Coronavirus Disease 2019 (COVID-19) outbreak has affected all regions and countries with varying impacts based on infection rates and the associated fatalities. This study aimed to assess knowledge, attitude, and practices (KAP) toward ... ...

Abstract	Background: The Coronavirus Disease 2019 (COVID-19) outbreak has affected all regions and countries with varying impacts based on infection rates and the associated fatalities. This study aimed to assess knowledge, attitude, and practices (KAP) toward the COVID-19 pandemic among Saudi Arabians. Methods: The study utilized a cross-sectional research design. Web-based questionnaires' link was sent via emails and social media and sample was 5483 respondents. Purposive sampling ensured only those participants that met the inclusion criteria. Validity and reliability were checked. Results: Most respondents, 67.9%, were aged between 18 and 35 years and highest level of education university. The findings based on the study objectives indicated a high level of knowledge about COVID-19, which indicated early detection can improve treatment by 4701 (85.7%), the disease can be treated at home 84.6%, the disease can be prevented and avoided when precautions are taken 96.8%. Moreover, 37.2% of the respondents still used herbal products to prevent and treat the disease, and 72.1% indicating immediate visit the physician when there are symptoms. Conclusion: Promoting public knowledge about COVID-19 by the Ministry of Health is paramount in defeating this disease. Providing more education and awareness for public to comply with WHO's recommendation is recommended.
MeSH term(s)	Adolescent ; Adult ; COVID-19 ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Humans ; Pandemics ; Reproducibility of Results ; SARS-CoV-2 ; Saudi Arabia/epidemiology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2021-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18105286
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Article ; Online: Spontaneous Coronary Artery Dissection in the Gulf: G-SCAD Registry.

Angiology

2020 Volume 72, Issue 1, Page(s) 32–43

Abstract: Data on spontaneous coronary artery dissection (SCAD) is based on European and North American registries. We assessed the prevalence, epidemiology, and outcomes of patients presenting with SCAD in Arab Gulf countries. Patients (n = 83) were diagnosed ... ...

Abstract	Data on spontaneous coronary artery dissection (SCAD) is based on European and North American registries. We assessed the prevalence, epidemiology, and outcomes of patients presenting with SCAD in Arab Gulf countries. Patients (n = 83) were diagnosed with SCAD based on angiographic and intravascular imaging whenever available. Thirty centers in 4 Arab Gulf countries (Kingdom of Saudi Arabia, United Arab Emirates, Kuwait, and Bahrain) were involved from January 2011 to December 2017. In-hospital (myocardial infarction [MI], percutaneous coronary intervention, ventricular tachycardia/fibrillation, cardiogenic shock, death, implantable cardioverter-defibrillator placement, dissection extension) and follow-up (MI, de novo SCAD, death, spontaneous superior mesenteric artery dissection) cardiac events were recorded. Median age was 44 (37-55) years, 42 (51%) were females and 28.5% were pregnancy-associated (21.4% were multiparous). Of the patients, 47% presented with non-ST-elevation acute coronary syndrome, 49% with acute ST-elevation myocardial infarction, 12% had left main involvement, 43% left anterior descending, 21.7% right coronary, 9.6% left circumflex, and 9.6% multivessel; 52% of the SCAD were type 1, 42% type 2, 3.6% type 3, and 2.4% multitype; 40% managed medically, 53% underwent percutaneous coronary intervention, 7% underwent coronary artery bypass grafting. Females were more likely than males to experience overall (in-hospital and follow-up) adverse cardiovascular events (
MeSH term(s)	Adult ; Coronary Angiography ; Coronary Artery Bypass/statistics & numerical data ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/epidemiology ; Coronary Vessel Anomalies/therapy ; Dual Anti-Platelet Therapy ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Middle East/epidemiology ; Non-ST Elevated Myocardial Infarction/epidemiology ; Percutaneous Coronary Intervention/statistics & numerical data ; Pregnancy ; Pregnancy Complications, Cardiovascular/epidemiology ; Pregnancy Complications, Cardiovascular/therapy ; Prevalence ; Registries ; Retrospective Studies ; ST Elevation Myocardial Infarction/epidemiology ; Tomography, Optical Coherence ; Vascular Diseases/congenital ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/epidemiology ; Vascular Diseases/therapy
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319720946974
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Article ; Online: Impact of left ventricular ejection fraction on outcomes after left main revascularization: g-LM Registry.

Daoulah, Amin / Naser, Maryam Jameel / Hersi, Ahmad S / Alshehri, Mohammed / Garni, Turki Al / Abuelatta, Reda / Yousif, Nooraldaem / Almahmeed, Wael / Alasmari, Abdulaziz / Aljohar, Alwaleed / Alzahrani, Badr / Abumelha, Bader K / Ghani, Mohamed Ajaz / Amin, Haitham / Hashmani, Shahrukh / Hiremath, Niranjan / Kazim, Hameedullah M / Refaat, Wael / Selim, Ehab /

Jamjoom, Ahmed / El-Sayed, Osama / Al-Faifi, Salem M / Feteih, Maun N / Dahdouh, Ziad / Aithal, Jairam / Ibrahim, Ahmed M / Elganady, Abdelmaksoud / Qutub, Mohammed A / Alama, Mohamed N / Abohasan, Abdulwali / Hassan, Taher / Balghith, Mohammed / Hussien, Adnan Fathey / Abdulhabeeb, Ibrahim A M / Ahmad, Osama / Ramadan, Mohamed / Alqahtani, Abdulrahman H / Alshahrani, Saif S / Qenawi, Wael / Shawky, Ahmed / Ghonim, Ahmed A / Elmahrouk, Ahmed / Alhamid, Sameer / Maghrabi, Mohamed / Haddara, Mamdouh M / Iskandar, Mina / Shawky, Abeer M / Hurley, William T / Elmahrouk, Youssef / Ahmed, Waleed A / Lotfi, Amir

Journal of cardiovascular medicine (Hagerstown, Md.)

2022 Volume 24, Issue 1, Page(s) 23–35

Abstract: Aims: The impact of left ventricular dysfunction on clinical outcomes following revascularization is not well established in patients with unprotected left main coronary artery disease (ULMCA). In this study, we evaluated the impact of left ventricular ... ...

Abstract	Aims: The impact of left ventricular dysfunction on clinical outcomes following revascularization is not well established in patients with unprotected left main coronary artery disease (ULMCA). In this study, we evaluated the impact of left ventricular ejection fraction (LVEF) on clinical outcomes of patients with ULMCA requiring revascularization with percutaneous coronary intervention (PCI) compared with coronary artery bypass graft (CABG). Methods: The details of the design, methods, end points, and relevant definitions are outlined in the Gulf Left Main Registry: a retrospective, observational study conducted between January 2015 and December 2019 across 14 centres in 3 Gulf countries. In this study, the data on patients with ULMCA who underwent revascularization through PCI or CABG were stratified by LVEF into three main subgroups; low (l-LVEF <40%), mid-range (m-LVEF 40-49%), and preserved (p-LVEF ≥50%). Primary outcomes were hospital major adverse cardiovascular and cerebrovascular events (MACCE) and mortality and follow-up MACCE and mortality. Results: A total of 2137 patients were included; 1221 underwent PCI and 916 had CABG. During hospitalization, MACCE was significantly higher in patients with l-LVEF [(10.10%), P = 0.005] and m-LVEF [(10.80%), P = 0.009], whereas total mortality was higher in patients with m-LVEF [(7.40%), P = 0.009] and p-LVEF [(7.10%), P = 0.045] who underwent CABG. There was no mortality difference between groups in patients with l-LVEF. At a median follow-up of 15 months, there was no difference in MACCE and total mortality between patients who underwent CABG or PCI with p-LVEF and m-LVEF. Conclusion: CABG was associated with higher in-hospital events. Hospital mortality in patients with l-LVEF was comparable between CABG and PCI. At 15 months' follow-up, PCI could have an advantage in decreasing MACCE in patients with l-LVEF.
MeSH term(s)	Humans ; Stroke Volume ; Percutaneous Coronary Intervention/adverse effects ; Retrospective Studies ; Ventricular Function, Left ; Treatment Outcome ; Drug-Eluting Stents ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Registries
Language	English
Publishing date	2022-10-11
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001383
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Article ; Online: Outcomes of myocardial revascularization in diabetic patients with left main coronary artery disease: A multicenter observational study from three gulf countries.

Daoulah, Amin / Elfarnawany, Amr / Al Garni, Turki / Hersi, Ahmad S / Alshehri, Mohammed / Almahmeed, Wael / Yousif, Nooraldaem / Abuelatta, Reda / Alasmari, Abdulaziz / Elsheikh-Mohamed, Nezar Essam / Alzahrani, Badr / Ghani, Mohamed Ajaz / Amin, Haitham / Hashmani, Shahrukh / Hiremath, Niranjan / Alshali, Khalid Z / Elmahrouk, Youssef / Kazim, Hameedullah M / Refaat, Wael /

Selim, Ehab / Jamjoom, Ahmed / Feteih, Maun N / El-Sayed, Osama / Al-Faifi, Salem M / Dahdouh, Ziad / Aithal, Jairam / Ibrahim, Ahmed M / Elganady, Abdelmaksoud / Qutub, Mohammed A / Alama, Mohamed N / Abohasan, Abdulwali / Hassan, Taher / Balghith, Mohammed / Hussien, Adnan Fathey / Abdulhabeeb, Ibrahim A M / Ahmad, Osama / Ramadan, Mohamed / Alqahtani, Abdulrahman H / Abumelha, Bader K / Qenawi, Wael / Shawky, Ahmed / Ghonim, Ahmed A / Elmahrouk, Ahmed / Alhamid, Sameer / Maghrabi, Mohamed / Haddara, Mamdouh M / Aljohar, Alwaleed / Hurley, William T / Alshahrani, Saif S / Lotfi, Amir

Cardiovascular revascularization medicine : including molecular interventions

2022

Abstract: Background: Real-world data for managing patients with diabetes and left main coronary artery (LMCA) disease are scarce. We compared percutaneous coronary intervention (PCI) outcomes versus coronary artery bypass grafting (CABG) in diabetes and LMCA ... ...

Abstract	Background: Real-world data for managing patients with diabetes and left main coronary artery (LMCA) disease are scarce. We compared percutaneous coronary intervention (PCI) outcomes versus coronary artery bypass grafting (CABG) in diabetes and LMCA disease patients. Methods: We retrospectively studied patients with LMCA presented to 14 centers from 2015 to 2019. The study included 2138 patients with unprotected LMCA disease; 1468 (68.7 %) had diabetes. Patients were grouped into; diabetes with PCI (n = 804) or CABG (n = 664) and non-diabetes with PCI (n = 418) or CABG (n = 252). Results: In diabetes, cardiac (34 (5.1 %) vs. 22 (2.7 %); P = 0.016), non-cardiac (13 (2 %) vs. 6 (0.7 %); P = 0.027) and total hospital mortality (47 (7.1 %) vs. 28 (3.5 %); P = 0.0019), myocardial infarction (45 (6.8 %) vs. 11 (1.4 %); P = 0.001), cerebrovascular events (25 (3.8 %) vs. 12 (1.5 %); P = 0.005) and minor bleeding (65 (9.8 %) vs. 50 (6.2 %); P = 0.006) were significantly higher in CABG patients compared to PCI; respectively. The median follow-up time was 20 (10-37) months. In diabetes, total mortality was higher in CABG (P = 0.001) while congestive heart failure was higher in PCI (P = 0.001). There were no differences in major adverse cerebrovascular events and target lesion revascularization between PCI and CABG. Predictors of mortality in diabetes were high anatomical SYNTAX, peripheral arterial disease, chronic kidney disease, and cardiogenic shock. Conclusions: In this multicenter retrospective study, we found no significant difference in clinical outcomes during the short-term follow-up between PCI with second-generation DES and CABG except for lower total mortality and a higher rate of congestive heart failure in PCI group of patients. Randomized trials to characterize patients who could benefit from each treatment option are needed.
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2022.08.002
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Article ; Online: Expanding the clinical and genetic heterogeneity of hereditary disorders of connective tissue.

Alazami, Anas M / Al-Qattan, Sarah M / Faqeih, Eissa / Alhashem, Amal / Alshammari, Muneera / Alzahrani, Fatema / Al-Dosari, Mohammed S / Patel, Nisha / Alsagheir, Afaf / Binabbas, Bassam / Alzaidan, Hamad / Alsiddiky, Abdulmonem / Alharbi, Nasser / Alfadhel, Majid / Kentab, Amal / Daza, Riza M / Kircher, Martin / Shendure, Jay / Hashem, Mais /

Alshahrani, Saif / Rahbeeni, Zuhair / Khalifa, Ola / Shaheen, Ranad / Alkuraya, Fowzan S

Human genetics

2016 Volume 135, Issue 5, Page(s) 525–540

Abstract: Ehlers-Danlos syndrome (EDS) describes a group of clinical entities in which the connective tissue, primarily that of the skin, joint and vessels, is abnormal, although the resulting clinical manifestations can vary widely between the different ... ...

Abstract	Ehlers-Danlos syndrome (EDS) describes a group of clinical entities in which the connective tissue, primarily that of the skin, joint and vessels, is abnormal, although the resulting clinical manifestations can vary widely between the different historical subtypes. Many cases of hereditary disorders of connective tissue that do not seem to fit these historical subtypes exist. The aim of this study is to describe a large series of patients with inherited connective tissue disorders evaluated by our clinical genetics service and for whom a likely causal variant was identified. In addition to clinical phenotyping, patients underwent various genetic tests including molecular karyotyping, candidate gene analysis, autozygome analysis, and whole-exome and whole-genome sequencing as appropriate. We describe a cohort of 69 individuals representing 40 families, all referred because of suspicion of an inherited connective tissue disorder by their primary physician. Molecular lesions included variants in the previously published disease genes B3GALT6, GORAB, ZNF469, B3GAT3, ALDH18A1, FKBP14, PYCR1, CHST14 and SPARC with interesting variations on the published clinical phenotypes. We also describe the first recessive EDS-like condition to be caused by a recessive COL1A1 variant. In addition, exome capture in a familial case identified a homozygous truncating variant in a novel and compelling candidate gene, AEBP1. Finally, we also describe a distinct novel clinical syndrome of cutis laxa and marked facial features and propose ATP6V1E1 and ATP6V0D2 (two subunits of vacuolar ATPase) as likely candidate genes based on whole-genome and whole-exome sequencing of the two families with this new clinical entity. Our study expands the clinical spectrum of hereditary disorders of connective tissue and adds three novel candidate genes including two that are associated with a highly distinct syndrome.
MeSH term(s)	Amino Acid Sequence ; Cohort Studies ; Connective Tissue Diseases/genetics ; Connective Tissue Diseases/pathology ; Exome/genetics ; Female ; Genetic Heterogeneity ; Genetic Markers/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Molecular Sequence Data ; Pedigree ; Phenotype ; Sequence Homology, Amino Acid ; Skin Abnormalities/genetics
Chemical Substances	Genetic Markers
Language	English
Publishing date	2016-03-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223009-4
ISSN	1432-1203 ; 0340-6717
ISSN (online)	1432-1203
ISSN	0340-6717
DOI	10.1007/s00439-016-1660-z
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Article ; Online: STEMI and COVID-19 Pandemic in Saudi Arabia.

Daoulah, Amin / Hersi, Ahmad S / Al-Faifi, Salem M / Alasmari, Abdulaziz / Aljohar, Alwaleed / Balghith, Mohammed / Alshehri, Mohammed / Youssef, Ali A / ElSayed, Osama / Alama, Mohamed Nabil / Refaat, Wael A / Alzahrani, Badr / Dahdouh, Ziad / Khan, Abdul Salim / Ghani, Mohamed A / Soofi, Muhammad Adil / Alasnag, Mirvat / Kazim, Hameedullah M / Elganady, Abdelmaksoud /

Hassan, Taher / Ibrahim, Ahmed Mahmoud / Amellal, Zainab / Alsmadi, Faisal / Ghazi, Abdulrahman M / Alshehri, Abdulaziz M / Alhulayfi, Mohammed S / Ghonim, Ahmed A / Algazzar, Alaa S / Al Garni, Turki A / AlHarbi, Waleed / Jouda, Ahmed A / Al-Shaibi, Khaled / Albasiri, Saleh / Abuelatta, Reda / Tawfik, Wael / Magdy, Mohamed / Alasmari, Sami Rashed / Selim, Ehab / Elramly, Mohamed / Abufayyah, Mohammed A / Alshahrani, Saif S / Alqahtani, Abdulrahman H / Ahmed, Fatima Ali / Ahmed, Waleed A / Lotfi, Amir

Current problems in cardiology

2020 Volume 46, Issue 3, Page(s) 100656

Abstract: The COVID-19 pandemic had significant impact on health care worldwide which has led to a reduction in all elective admissions and management of patients through virtual care. The purpose of this study is to assess changes in STEMI volumes, door to ... ...

Abstract	The COVID-19 pandemic had significant impact on health care worldwide which has led to a reduction in all elective admissions and management of patients through virtual care. The purpose of this study is to assess changes in STEMI volumes, door to reperfusion, and the time from the onset of symptoms until reperfusion therapy, and in-hospital events between the pre-COVID-19 (PC) and after COVID-19 (AC) period. All acute ST-segment elevation myocardial infarction (STEMI) cases were retrospectively identified from 16 centers in the Kingdom of Saudi Arabia during the COVID-19 period from January 01 to April 30, 2020. These cases were compared to a pre-COVID period from January 01 to April 30, 2018 and 2019. One thousand seven hundred and eighty-five patients with a mean age 56.3 (SD ± 12.4) years, 88.3% were male. During COVID-19 Pandemic the total STEMI volumes was reduced (28%, n = 500), STEMI volumes for those treated with reperfusion therapy was reduced too (27.6%, n= 450). Door to balloon time < 90 minutes was achieved in (73.1%, no = 307) during 2020. Timing from the onset of symptoms to the balloon of more than 12 hours was higher during 2020 comparing to pre-COVID 19 years (17.2% vs <3%, respectively). There were no differences between the AC and PC period with respect to in-hospital events and the length of hospital stay. There was a reduction in the STEMI volumes during 2020. Our data reflected the standard of care for STEMI patients continued during the COVID-19 pandemic while demonstrating patients delayed presenting to the hospital.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; Disease Transmission, Infectious/prevention & control ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Outcome and Process Assessment, Health Care ; Patient Acceptance of Health Care/psychology ; Patient Acceptance of Health Care/statistics & numerical data ; Percutaneous Coronary Intervention/methods ; Percutaneous Coronary Intervention/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/therapy ; Saudi Arabia/epidemiology ; Severity of Illness Index ; Standard of Care/organization & administration ; Time-to-Treatment/statistics & numerical data
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2020.100656
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Article ; Online: Percutaneous Coronary Intervention Vs Coronary Artery Bypass Surgery for Unprotected Left Main Coronary Disease: G-LM Registry.

Daoulah, Amin / Alasmari, Abdulaziz / Hersi, Ahmad S / Alshehri, Mohammed / Garni, Turki Al / Abuelatta, Reda / Amin, Haitham / Almahmeed, Wael / Aljohar, Alwaleed / Abumelha, Bader K / Alzahrani, Badr / Ghani, Mohamed Ajaz / Yousif, Nooraldaem / Hashmani, Shahrukh / Al-Faifi, Salem M / Kazim, Hameedullah M / Refaat, Wael / Dahdouh, Ziad / Khaliel, Feras /

Aithal, Jairam / Elmahrouk, Ahmed / Ibrahim, Ahmed M / Elganady, Abdelmaksoud / Qutub, Mohammed A / Alama, Mohamed N / Abohasan, Abdulwali / Hassan, Taher / Balghith, Mohammed / Alqahtani, Abdulrahman M / Abdelaziz, Ahmed F / Altnji, Issam / Hussien, Adnan Fathey / Abdulhabeeb, Ibrahim A M / Ahmad, Osama / Haddara, Mamdouh M / Alqahtani, Abdulrahman H / Alshahrani, Saif S / Qenawi, Wael / Izzeldin, Mohamed H / El-Sayed, Osama / Jamjoom, Ahmed / Moghairi, Abdulrahman Al / Amri, Hussein Al / Ibrahim, Waleed Moubark / Alarbash, Mohsen M / Hussain, Tajammul / Shamsi, Fahad / Selim, Ehab / Ramadan, Mohamed / Al-Sergani, Hani / Mohamed, Tahir / Khalifa, Abdulwahab Al / Hiremath, Niranjan / Ibrahim, Amira Ali Taha / Abdallah, Hassane / Elprince, Amr / Diab, Ahmed / Seoud, Diaa Eldin A / Alghamdi, Ahmed A / Alebrahim, Khaled E / Basudan, Duna / Nasser, Faisal Omar M Al / Ali, Ibrahim Ahmed Abuagila / Shawky, Abeer M / Ghonim, Ahmed / Khushail, Abdullah Al / Feteih, Maun N / Abualnaja, Seraj / Alhaddadi, Bandar / Alhamid, Sameer / Ahmed, Waleed A / Jafary, Zainab M / Ahnia, Samir / Gasem, Jala / Alaydarous, Shahad / Khatab, Tamer / Mohamed, Ataaelrahman / Maghrabi, Mohamed / Samadi, Faisal Al / Kannout, Tareef H / Mahrous, Najeeb / Almaleh, Yahya / Riyami, Adil B Al / Yousef, Altayyeb / Ahmed, Mohammed Ali / Ahmed, Ruqayyah Ali / Tawfik, Wael / Almegreb, Nasser / Faden, Mazen S / Haq, Ejazul / AlOtaibi, Salah N / Eldesoky, Akram / Clarkson, Francis A / Lotfi, Amir

Current problems in cardiology

2021 Volume 47, Issue 10, Page(s) 101002

Abstract: Coronary artery bypass surgery (CABG) has been the standard of care for revascularization for patients with obstructive unprotected left main coronary disease (ULMCA). There have been multiple randomized and registry data demonstrating the technical and ... ...

Abstract	Coronary artery bypass surgery (CABG) has been the standard of care for revascularization for patients with obstructive unprotected left main coronary disease (ULMCA). There have been multiple randomized and registry data demonstrating the technical and clinical efficacy of PCI in certain patients with ULMCA. The purpose of this study is to evaluate clinical outcomes of ULMCA PCI as compared to CABG in patients requiring revascularization in three Gulf countries. All ULMCA cases treated by PCI with DES versus CABG were retrospectively identified from 14 centers in 3 Arab Gulf countries (KSA, UAE, and Bahrain) from January 2015 to December 2019. In total, 2138 patients were included: 1222 were treated with PCI versus 916 with CABG. Patients undergoing PCI were older, and had higher comorbidities and mean European System for Cardiac Operative Risk Evaluation (EuroSCORE). Aborted cardiac arrest and cardiogenic shock were reported more in the PCI group at hospital presentation. In addition, lower ejection fractions were reported in the PCI group. In hospital mortality and major adverse cardiovascular and cerebrovascular events (MACCE) occurred more in patients undergoing CABG than PCI. At median follow-up of 15 months (interquartile range, 30), no difference was observed in freedom from revascularization, MACCE, or total mortality between those treated with PCI and CABG. While findings are similar to Western data registries, continued follow-up will be needed to ascertain whether this pattern continues into latter years.
MeSH term(s)	Coronary Artery Bypass ; Coronary Artery Disease ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention ; Registries ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2021-09-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2021.101002
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Article: STEMI and COVID-19 Pandemic in Saudi Arabia

Curr Probl Cardiol

Abstract	The COVID-19 pandemic had significant impact on health care worldwide which has led to a reduction in all elective admissions and management of patients through virtual care. The purpose of this study is to assess changes in STEMI volumes, door to reperfusion, and the time from the onset of symptoms until reperfusion therapy, and in-hospital events between the pre-COVID-19 (PC) and after COVID-19 (AC) period. All acute ST-segment elevation myocardial infarction (STEMI) cases were retrospectively identified from 16 centers in the Kingdom of Saudi Arabia during the COVID-19 period from January 01 to April 30, 2020. These cases were compared to a pre-COVID period from January 01 to April 30, 2018 and 2019. One thousand seven hundred and eighty-five patients with a mean age 56.3 (SD ± 12.4) years, 88.3% were male. During COVID-19 Pandemic the total STEMI volumes was reduced (28%, nâ¯=â¯500), STEMI volumes for those treated with reperfusion therapy was reduced too (27.6%, n= 450). Door to balloon time < 90 minutes was achieved in (73.1%, noâ¯=â¯307) during 2020. Timing from the onset of symptoms to the balloon of more than 12 hours was higher during 2020 comparing to pre-COVID 19 years (17.2% vs <3%, respectively). There were no differences between the AC and PC period with respect to in-hospital events and the length of hospital stay. There was a reduction in the STEMI volumes during 2020. Our data reflected the standard of care for STEMI patients continued during the COVID-19 pandemic while demonstrating patients delayed presenting to the hospital.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #663316
Database	COVID19

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Article ; Online: STEMI and COVID-19 Pandemic in Saudi Arabia

Daoulah, Amin / Hersi, Ahmad S. / Al-Faifi, Salem M. / Alasmari, Abdulaziz / Aljohar, Alwaleed / Balghith, Mohammed / Alshehri, Mohammed / Youssef, Ali A. / ElSayed, Osama / Alama, Mohamed Nabil / Refaat, Wael A. / Alzahrani, Badr / Dahdouh, Ziad / Khan, Abdul Salim / Ghani, Mohamed A. / Soofi, Muhammad Adil / Alasnag, Mirvat / Kazim, Hameedullah M. / Elganady, Abdelmaksoud /

Hassan, Taher / Ibrahim, Ahmed Mahmoud / Amellal, Zainab / Alsmadi, Faisal / Ghazi, Abdulrahman M. / Alshehri, Abdulaziz M. / Alhulayfi, Mohammed S. / Ghonim, Ahmed A. / Algazzar, Alaa S. / AL Garni, Turki A. / AlHarbi, Waleed / Jouda, Ahmed A. / Al-Shaibi, Khaled / Albasiri, Saleh / Abuelatta, Reda / Tawfik, Wael / Magdy, Mohamed / Alasmari, Sami Rashed / Selim, Ehab / Elramly, Mohamed / Abufayyah, Mohammed A. / Alshahrani, Saif S. / Alqahtani, Abdulrahman H. / Ahmed, Fatima Ali / Ahmed, Waleed A. / Lotfi, Amir

Current Problems in Cardiology

2020 , Page(s) 100656

Keywords	Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	441230-8
ISSN	0146-2806
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2020.100656
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.

Monies, Dorota / Abouelhoda, Mohamed / AlSayed, Moeenaldeen / Alhassnan, Zuhair / Alotaibi, Maha / Kayyali, Husam / Al-Owain, Mohammed / Shah, Ayaz / Rahbeeni, Zuhair / Al-Muhaizea, Mohammad A / Alzaidan, Hamad I / Cupler, Edward / Bohlega, Saeed / Faqeih, Eissa / Faden, Maha / Alyounes, Banan / Jaroudi, Dyala / Goljan, Ewa / Elbardisy, Hadeel /

Akilan, Asma / Albar, Renad / Aldhalaan, Hesham / Gulab, Shamshad / Chedrawi, Aziza / Al Saud, Bandar K / Kurdi, Wesam / Makhseed, Nawal / Alqasim, Tahani / El Khashab, Heba Y / Al-Mousa, Hamoud / Alhashem, Amal / Kanaan, Imaduddin / Algoufi, Talal / Alsaleem, Khalid / Basha, Talal A / Al-Murshedi, Fathiya / Khan, Sameena / Al-Kindy, Adila / Alnemer, Maha / Al-Hajjar, Sami / Alyamani, Suad / Aldhekri, Hasan / Al-Mehaidib, Ali / Arnaout, Rand / Dabbagh, Omar / Shagrani, Mohammad / Broering, Dieter / Tulbah, Maha / Alqassmi, Amal / Almugbel, Maisoon / AlQuaiz, Mohammed / Alsaman, Abdulaziz / Al-Thihli, Khalid / Sulaiman, Raashda A / Al-Dekhail, Wajeeh / Alsaegh, Abeer / Bashiri, Fahad A / Qari, Alya / Alhomadi, Suzan / Alkuraya, Hisham / Alsebayel, Mohammed / Hamad, Muddathir H / Szonyi, Laszlo / Abaalkhail, Faisal / Al-Mayouf, Sulaiman M / Almojalli, Hamad / Alqadi, Khalid S / Elsiesy, Hussien / Shuaib, Taghreed M / Seidahmed, Mohammed Zain / Abosoudah, Ibraheem / Akleh, Hana / AlGhonaium, Abdulaziz / Alkharfy, Turki M / Al Mutairi, Fuad / Eyaid, Wafa / Alshanbary, Abdullah / Sheikh, Farrukh R / Alsohaibani, Fahad I / Alsonbul, Abdullah / Al Tala, Saeed / Balkhy, Soher / Bassiouni, Randa / Alenizi, Ahmed S / Hussein, Maged H / Hassan, Saeed / Khalil, Mohamed / Tabarki, Brahim / Alshahwan, Saad / Oshi, Amira / Sabr, Yasser / Alsaadoun, Saad / Salih, Mustafa A / Mohamed, Sarar / Sultana, Habiba / Tamim, Abdullah / El-Haj, Moayad / Alshahrani, Saif / Bubshait, Dalal K / Alfadhel, Majid / Faquih, Tariq / El-Kalioby, Mohamed / Subhani, Shazia / Shah, Zeeshan / Moghrabi, Nabil / Meyer, Brian F / Alkuraya, Fowzan S

Human genetics

2017 Volume 136, Issue 8, Page(s) 921–939

Abstract: In this study, we report the experience of the only reference clinical next-generation sequencing lab in Saudi Arabia with the first 1000 families who span a wide-range of suspected Mendelian phenotypes. A total of 1019 tests were performed in the period ...

Abstract	In this study, we report the experience of the only reference clinical next-generation sequencing lab in Saudi Arabia with the first 1000 families who span a wide-range of suspected Mendelian phenotypes. A total of 1019 tests were performed in the period of March 2016-December 2016 comprising 972 solo (index only), 14 duo (parents or affected siblings only), and 33 trio (index and parents). Multigene panels accounted for 672 tests, while whole exome sequencing (WES) represented the remaining 347 tests. Pathogenic or likely pathogenic variants that explain the clinical indications were identified in 34% (27% in panels and 43% in exomes), spanning 279 genes and including 165 novel variants. While recessive mutations dominated the landscape of solved cases (71% of mutations, and 97% of which are homozygous), a substantial minority (27%) were solved on the basis of dominant mutations. The highly consanguineous nature of the study population also facilitated homozygosity for many private mutations (only 32.5% of the recessive mutations are founder), as well as the first instances of recessive inheritance of previously assumed strictly dominant disorders (involving ITPR1, VAMP1, MCTP2, and TBP). Surprisingly, however, dual molecular diagnosis was only observed in 1.5% of cases. Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CABP1, CCDC186, CCP110, CLSTN2, CNTN3, CNTN5, CTNNA2, CWC22, DMAP1, DMKN, DMXL1, DSCAM, DVL2, ECI1, EP400, EPB41L5, FBXL22, GAP43, GEMIN7, GIT1, GRIK4, GRSF1, GTRP1, HID1, IFNL1, KCNC4, LRRC52, MAP7D3, MCTP2, MED26, MPP7, MRPS35, MTDH, MTMR9, NECAP2, NPAT, NRAP, PAX7, PCNX, PLCH2, PLEKHF1, PTPN12, QKI, RILPL2, RIMKLA, RIMS2, RNF213, ROBO1, SEC16A, SIAH1, SIRT2, SLAIN2, SLC22A20, SMDT1, SRRT, SSTR1, ST20, SYT9, TSPAN6, UBR4, VAMP4, VPS36, WDR59, WDYHV1, and WHSC1) not previously linked to human phenotypes and these are presented to accelerate post-publication matchmaking. Two of these genes were independently mutated in more than one family with similar phenotypes, which substantiates their link to human disease (AKAP6 in intellectual disability and UBR4 in early dementia). If the novel candidate disease genes in this cohort are independently confirmed, the yield of WES will have increased to 83%, which suggests that most "negative" clinical exome tests are unsolved due to interpretation rather than technical limitations.
MeSH term(s)	Consanguinity ; Exome ; Female ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/epidemiology ; Genetic Testing ; Genome, Human ; High-Throughput Nucleotide Sequencing ; Homozygote ; Humans ; Male ; Molecular Sequence Annotation ; Morbidity ; Mutation ; Phenotype ; Reproducibility of Results ; Saudi Arabia/epidemiology ; Sequence Analysis, DNA
Language	English
Publishing date	2017-06-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	223009-4
ISSN	1432-1203 ; 0340-6717
ISSN (online)	1432-1203
ISSN	0340-6717
DOI	10.1007/s00439-017-1821-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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