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Article ; Online: Targeting BCL11A through gene therapy in sickle cell disease: Will one size fit all or most?

Alsultan, Abdulrahman

2024 Volume 71, Issue 6, Page(s) e30934

Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30934
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Article: Antithrombin Deficiency Is Associated with a Novel Homozygous Detrimental Mutation in

Alqarni, Sana / Alqarni, Baraah / Alsultan, Abdulrahman

Case reports in medicine

2023 Volume 2023, Page(s) 8872346

Abstract: Antithrombin (AT) deficiency is a blood disorder associated with an increased tendency to form thrombosis. Hereditary AT deficiency is frequently caused by mutations ... ...

Abstract	Antithrombin (AT) deficiency is a blood disorder associated with an increased tendency to form thrombosis. Hereditary AT deficiency is frequently caused by mutations in
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2023/8872346
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Article ; Online: Risedronate and Methotrexate Are High-Affinity Inhibitors of New Delhi Metallo-β-Lactamase-1 (NDM-1): A Drug Repurposing Approach.

Muteeb, Ghazala / Alsultan, Abdulrahman / Farhan, Mohd / Aatif, Mohammad

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 4

Abstract: Bacteria expressing New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze β-lactam antibiotics (penicillins, cephalosporins, and carbapenems) and, thus, mediate multidrug resistance. The worldwide dissemination of NDM-1 poses a serious threat to public ... ...

Abstract	Bacteria expressing New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze β-lactam antibiotics (penicillins, cephalosporins, and carbapenems) and, thus, mediate multidrug resistance. The worldwide dissemination of NDM-1 poses a serious threat to public health, imposing a huge economic burden in the development of new antibiotics. Thus, there is an urgent need for the identification of novel NDM-1 inhibitors from a pool of already-known drug molecules. Here, we screened a library of FDA-approved drugs to identify novel non-β-lactam ring-containing inhibitors of NDM-1 by applying computational as well as in vitro experimental approaches. Different steps of high-throughput virtual screening, molecular docking, molecular dynamics simulation, and enzyme kinetics were performed to identify risedronate and methotrexate as the inhibitors with the most potential. The molecular mechanics/generalized Born surface area (MM/GBSA) and molecular dynamics (MD) simulations showed that both of the compounds (risedronate and methotrexate) formed a stable complex with NDM-1. Furthermore, analyses of the binding pose revealed that risedronate formed two hydrogen bonds and three electrostatic interactions with the catalytic residues of NDM-1. Similarly, methotrexate formed four hydrogen bonds and one electrostatic interaction with NDM-1's active site residues. The docking scores of risedronate and methotrexate for NDM-1 were -10.543 kcal mol
MeSH term(s)	Algorithms ; Dose-Response Relationship, Drug ; Drug Discovery ; Drug Repositioning ; Ligands ; Methotrexate/chemistry ; Methotrexate/pharmacology ; Microbial Sensitivity Tests ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; ROC Curve ; Risedronic Acid/chemistry ; Risedronic Acid/pharmacology ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamases/chemistry ; beta-Lactamases/metabolism
Chemical Substances	Ligands ; beta-Lactamase Inhibitors ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase NDM-1 (EC 3.5.2.6) ; Risedronic Acid (KM2Z91756Z) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27041283
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Article ; Online: Orbital extramedullary leukemia relapse in a pediatric patient post-CART cell therapy-Case report.

Essa, Mohammed F / Alsultan, Abdulrahman

Pediatric transplantation

2020 Volume 25, Issue 5, Page(s) e13852

Abstract: CART therapy is an approved therapy in advanced ALL. The mechanism of relapse post-CART therapy is under vigorous research. We report a 9-year-old boy who received CD19-CART therapy after BM ALL relapse post-HSCT. He presented with unilateral eye ... ...

Abstract	CART therapy is an approved therapy in advanced ALL. The mechanism of relapse post-CART therapy is under vigorous research. We report a 9-year-old boy who received CD19-CART therapy after BM ALL relapse post-HSCT. He presented with unilateral eye swelling which was initially managed as orbital cellulitis. Later on, it was proven to be an isolated ALL orbital relapse without peripheral blood B-cell detection or BM involvement. Despite radiotherapy, he subsequently developed refractory CD19 positive ALL BM relapse. This case highlights the possibility of unusual relapse sites after CART-therapy and that regular peripheral B-cell monitoring is not enough to assure remission status. Better monitoring tools are needed to detect early disease relapse. Further understanding of the pathophysiology of isolated extramedullary relapse post-CART therapy is warranted to improve the management of such challenging presentations.
MeSH term(s)	Antigens, CD19 ; Cell- and Tissue-Based Therapy/methods ; Child ; Humans ; Male ; Orbital Diseases/diagnosis ; Orbital Diseases/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Recurrence
Chemical Substances	Antigens, CD19
Language	English
Publishing date	2020-09-30
Publishing country	Denmark
Document type	Case Reports
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.13852
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Zs.A 4947: Show issues

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Article ; Online: Regional Prevalence of Hemoglobin C Across Saudi Arabia: An Epidemiological Survey.

Aljabry, Mansour / Sulimani, Suha / Alotaibi, Ghazi / Aljabri, Hassan / Alomary, Shaker / Adam, Izzeldin / Aljabri, Omar / Alzahrani, Mansour Khater / Alsultan, Abdulrahman

Journal of epidemiology and global health

2024

Abstract: Introduction: HbC is a common structural hemoglobinopathy especially in West Africa. Prevalence and regional distribution of HbC in Saudi Arabia are widely undocumented. Patients with homozygous HbC disease may have mild hemolytic anemia whereas ... ...

Abstract	Introduction: HbC is a common structural hemoglobinopathy especially in West Africa. Prevalence and regional distribution of HbC in Saudi Arabia are widely undocumented. Patients with homozygous HbC disease may have mild hemolytic anemia whereas combination with hemoglobin S (HbS) leads to a clinically severe phenotype. Aim: The current epidemiological study, considered the largest from Saudi Arabia, aimed to evaluate the regional prevalence of the HbC variant among the couples participating in the premarital screening program from 2011 to 2018. Methods: Data from the PMSGC program were obtained for premarital screening and genetic counseling. The collected data were then entered into the SEHA platform, a centralized electronic repository for the 13 designated regions in Saudi Arabia. Hemoglobin electrophoresis samples are analyzed using either HPLC, capillary electrophoresis, or a combination of both methods to confirm the presence of abnormal hemoglobin bands. Results: This study included 1,871,184 individuals from 2011 to 2018. Of those, 49.8% were males and 50.2% were females. 112,618 (6.0%) had an abnormal test. Total number of Hb C cases were 778 (0.04%). HbC trait (HbAC) was detected in 764 participants while homozygous HbC (HbCC) and combined heterozygous (HbSC) were found in 9 and 5 cases, respectively. The regions near the Red Sea have higher rates than the central and eastern regions. Conclusion: HbC is a rare variant in Saudi Arabia with varying regional frequencies. HbC variant is more common in Mecca and Madina regions. The geographic area of HbC distribution differs from the areas with high prevalence of HbS, which explains why HbSC disease cases are overwhelmingly rare.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2645324-1
ISSN	2210-6014 ; 2210-6014
ISSN (online)	2210-6014
ISSN	2210-6014
DOI	10.1007/s44197-024-00193-w
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Article ; Online: Comparing between HLA-matched sibling donor allogenic HSCT and non-sibling matched related donor allogenic HSCT outcome in pediatric patients; single center retrospective study.

Essa, Mohammed F / Alghazwani, Sarah / Abujoub, Rodaina / Memon, Shahbaz / Alkaiyat, Mohammed / Ardah, Husam / Alsultan, Abdulrahman

Pediatric transplantation

2024 Volume 28, Issue 1, Page(s) e14692

Abstract: Background: Extended family donor search other than siblings may yield an HLA matched donor in communities with high rate of consanguinity. The outcome of patients who are transplanted from non-sibling matched related donors (NS-MRD) including ... ...

Abstract	Background: Extended family donor search other than siblings may yield an HLA matched donor in communities with high rate of consanguinity. The outcome of patients who are transplanted from non-sibling matched related donors (NS-MRD) including engraftment and graft versus host disease (GVHD) are scarce in comparison with matched sibling donor (MSD). Methods: We retrospectively reviewed the outcome of all our pediatric hematopoietic stem cell transplantation (HSCT) patients who had non-sibling matched related donor and controlled them with matched sibling donor HSCT (based on age, indication of HSCT, conditioning regimen, GVHD prophylaxis, serotherapy, stem cell source and cytomegalovirus status). Results: A total of 76 patients were reviewed during study period. Thirty patients (39.5%) in NS-MRD arm and 46 patients in MSD (60.5%) were identified after matching in age, disease, and conditioning regimens. All patients had similar approach including stem cell source and GVHD prophylaxis (CNI + 2nd agent). Out of the NS-MRD group, 18 patients (59%) had one of their parents as a donor and the rest as second degree relatives. Both groups were equally distributed and were homogeneous. Both groups had no statistically significant difference in outcome including engraftment, GVHD and Chimerism tests results. GVHD was seen in (13%) NS-MRD patients compared to (11%) in MSD patients. All patients remain alive with median follow up of 1249 days (431-3525). Conclusions: This study showed no significant difference in allogenic HSCT outcomes between matched sibling donors and non-sibling matched related donors and support using the same management approach in terms of conditioning therapy, GVHD prophylaxis, and serotherapy only if indicated.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Transplantation, Homologous/methods ; Tissue Donors ; Siblings ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects
Language	English
Publishing date	2024-02-05
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14692
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Leaves of

Muteeb, Ghazala / Aatif, Mohammad / Farhan, Mohd / Alsultan, Abdulrahman / Alshoaibi, Adil / Alam, Mir Waqas

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: ... Moringa ... ...

Abstract	Moringa oleifera
MeSH term(s)	beta Carotene ; Moringa oleifera/genetics ; Arabidopsis/genetics ; Phylogeny ; Brassica napus/genetics ; Brassica rapa/genetics ; Plants, Medicinal/genetics ; Gene Expression Profiling ; Plant Extracts ; Plant Leaves
Chemical Substances	beta Carotene (01YAE03M7J) ; Plant Extracts
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041578
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Article: Case report: Durable response to ruxolitinib in a child with

Bin Khathlan, Yasir / Almutairi, Sajdi / Albadr, Fahad B / Alangari, Abdullah A / Alsultan, Abdulrahman

Frontiers in pediatrics

2023 Volume 11, Page(s) 1178919

Abstract: Background: JAK inhibitors are useful in treating interferonopathies, presumably because they downregulate the JAK/STAT signaling. There are limited studies about the safety and effectiveness of using JAK inhibitors in children with : Case ... ...

Abstract	Background: JAK inhibitors are useful in treating interferonopathies, presumably because they downregulate the JAK/STAT signaling. There are limited studies about the safety and effectiveness of using JAK inhibitors in children with Case presentation: We report an 8-year-old female who presented at five years of age with features suggestive of hemophagocytic lymphohistiocytosis (HLH)-like disorder. The infectious disease workup was negative. Neurological assessment was normal. A brain CT scan was performed because of headache. It showed a faint subcortical calcification at right frontal lobe and almost symmetrical calcification within the basal ganglia. Brain MRI showed bilateral symmetrical globus pallidus, high T1 signal intensities, and a few scattered nonspecific FLAIR hyperintensities in subcortical and deep white matter. IVIG as an immune modulating agent was administered initially which led to the resolution of fever, improvement of blood count parameters, inflammatory markers, and normalization of liver enzymes. The child remained afebrile with no significant events for several months, then had disease flare up. The patient was started on pulse methylprednisolone 30 mg/kg for three days, then continued on 2 mg/kg. Whole exome sequencing revealed a novel heterozygous missense Conclusion: This case highlights the potential role of ruxolitinib in the treatment of
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1178919
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Article ; Online: The effect of intensity of conditioning regimen on the outcome of HSCT in children with sickle cell disease.

Alsultan, Abdulrahman / Abujoub, Rodina / Elbashir, Enas / Essa, Mohammed F

Clinical transplantation

2022 , Page(s) e14787

Abstract: Background: Allogeneic hematopoietic stem cell transplantation (HSCT) provides a cure for patients with sickle cell disease (SCD). This study describes the effect of conditioning regimen intensity on HSCT outcomes among children younger than 14 years ... ...

Abstract	Background: Allogeneic hematopoietic stem cell transplantation (HSCT) provides a cure for patients with sickle cell disease (SCD). This study describes the effect of conditioning regimen intensity on HSCT outcomes among children younger than 14 years with SCD. Methods: Transplants from HLA-matched related donors (MRD) and unrelated donors (MUD) using either myeloablative conditioning (MAC) regimens or reduced intensity conditioning (RIC) regimens were considered. Event-free survival (EFS) was the primary endpoint. Secondary endpoints included overall survival (OS) and occurrence of GVHD. Results: 48 SCD patients underwent HSCT, 45 (93.8%) patients had MRD, 1 (2.1%) had 9/10 related donor, and 2 (4.1%) had MUD. The median age at transplant was 8.6 years (range, 3.1-13.8). Conditioning regimens were myeloablative (MAC) in 41 (85.4%) patients and of reduced intensity in 7 (14.6%) patients. EFS at 2 years was 100% among MAC group compared to 29% in the RIC group (p < .001). The median follow-up was 43.4 months (range 26.8-134). All events in the RIC group were secondary graft failure. However, OS was 100% in both groups at 2 years. Acute GVHD II-IV was diagnosed in 2 (4.1%) patients. Chronic GVHD occurred in 2 (4.1%) patients. GVHD did not occur in patients who underwent MUD HSCT. Conclusions: MAC in children with SCD is well tolerated and associated with an excellent outcome for HLA-matched HSCT in SCD. There was a high rate of secondary graft failure with the use of RIC. Future studies are needed to optimize RIC regimens in HSCT of children with SCD.
Language	English
Publishing date	2022-08-05
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14787
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Article: Potential phytoconstituents of Ficus religiosa L. and Ficus benghalensis L. with special reference to the treatment of blood disorders

Kumar, Sunil / Arif, Muhammad / Shafi, Sheeba / Al-Jaber, Nadia / Alsultan, Abdulrahman A.

Medicinal Plants. 2022 June, v. 14, no. 2

2022

Abstract: Ficus plants are woody trees found all over the world. It has a long history in indigenous medical systems such as Ayurveda, Siddha, Unani, and Homoeopathy. The barks, leaves, and fruits of these trees are documented in use for several health ailments. ... ...

Abstract	Ficus plants are woody trees found all over the world. It has a long history in indigenous medical systems such as Ayurveda, Siddha, Unani, and Homoeopathy. The barks, leaves, and fruits of these trees are documented in use for several health ailments. Several phytochemicals of pharmaceutical values have been identified in these plants. Blood disorders including haemorrhage, hemophilia, different kinds of blood cancers, leukorrhea, and anemia are the major health issues, especially in women. Different parts of Ficus religiosa and F. benghalensis, are common components in Ayurvedic and traditional formulas for the treatment of several blood disorders. The limited literature on the pharmacological action of Ficus religiosa and F. bengalensisin in the treatment of blood diseases has been documented, hence, in the present review, a comprehensive overview of phytoconstituents and the role of both the species of Ficus against blood diseases are discussed.
Keywords	Ayurvedic medicine ; Ficus benghalensis ; Ficus religiosa ; anemia ; blood ; chemical constituents of plants ; hemophilia ; hemorrhage ; phytochemicals
Language	English
Dates of publication	2022-06
Size	p. 221-232.
Publishing place	Society for Conservation and Resource Development of Medicinal Plants
Document type	Article
ZDB-ID	2881592-0
ISSN	0975-6892 ; 0975-4261
ISSN (online)	0975-6892
ISSN	0975-4261
DOI	10.5958/0975-6892.2022.00025.9
Database	NAL-Catalogue (AGRICOLA)

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