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  1. Article ; Online: Neumotórax bilateral espontáneo como forma de presentación de histiocitosis de células de Langerhans.

    Martínez García, Jesús Javier / Rios Osuna, Mirna Guadalupe / Altamirano Álvarez, Eduardo

    Archivos argentinos de pediatria

    2014  Volume 112, Issue 3, Page(s) e113–6

    Abstract: Pulmonary Langerhans cell histiocytosis is an interstitial lung disease that results from the accumulation of specific histiocytic cells in the lung. Spontaneous pneumothorax is a recognized feature of pulmonary Langerhans cell histiocytosis and results ... ...

    Title translation Bilateral spontaneous pneumothorax as a setting of Langerhans cell histiocytosis.
    Abstract Pulmonary Langerhans cell histiocytosis is an interstitial lung disease that results from the accumulation of specific histiocytic cells in the lung. Spontaneous pneumothorax is a recognized feature of pulmonary Langerhans cell histiocytosis and results from destruction of lung parenchyma with associated cystic changes. We report on a 2-year-old boy with recurrent bilateral spontaneous pneumothorax; a computed tomography scan showed marked interstitial changes, fibrosis, cystic spaces and bilateral bullae. The diagnosis was confirmed by the histology and the immunohistochemistry examination of the pulmonary biopsy with CD1 and S100 positive antibodies. The child was treated with prednisone and etoposide, and had a good clinical response and favorable changes in the second thoracic CT scan.
    MeSH term(s) Child, Preschool ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/diagnosis ; Humans ; Male ; Pneumothorax/etiology ; Pneumothorax/pathology
    Language Spanish
    Publishing date 2014-06
    Publishing country Argentina
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.1590/S0325-00752014000300018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Evaluation of factors leading to poor outcomes for pediatric acute lymphoblastic leukemia in Mexico: a multi-institutional report of 2,116 patients.

    Moreira, Daniel C / González-Ramella, Oscar / Echavarría Valenzuela, Maite / Carrillo, Angela K / Faughnan, Lane / Job, Godwin / Chen, Yichen / Villegas, Cesar / Ellis Irigoyen, Andrea / Barra Urbays, Rosario / Ramírez Martinez, Maribel / Altamirano Alvarez, Eduardo / León Espitia, José Antonio / López Facundo, Norma Araceli / Colunga Pedraza, Julia Esther / Reyes Gutierrez, Flor de María / Aguilar Román, Ana Berenice / Tamez Gómez, Edna Liliana / Portillo Zavala, Claudia Selene /
    Negroe Ocampo, Natalia Del Carmen / Pulido Sanchez, Sandra Guadalupe / Cortés Alva, Deyanira / Casillas Toral, Paola / Salas Villa, Karime / Mendoza Sánchez, Patricia Judith / Pérez Alvarado, Carlos / Tamayo Pedraza, Gabriela / González Zamorano, Margarita / Ávila Alba, José Manuel Ricardo / Becerril Becerril, Jocelyn / Ramírez Durán, Hernán / Sandoval Cabrera, Antonio / Pineda Gordillo, Adolfo / de la Rosa Alonso, Dora Iveth / Mejía Marín, Leonardo Javier / Benítez Can, Leslie de Los Ángeles / Gutiérrez Martinez, Itzel / Jiménez Osorio, Mariana Isabel / Echeandia, Naomi / Casillas, Erika / Guerrero-Gomez, Karla / Devidas, Meenakshi / Friedrich, Paola

    Frontiers in oncology

    2023  Volume 13, Page(s) 1255555

    Abstract: Background and aims: Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- and middle-income countries are lower due to deficiencies in multilevel factors, including access to timely diagnosis, risk-stratified therapy, and comprehensive ... ...

    Abstract Background and aims: Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- and middle-income countries are lower due to deficiencies in multilevel factors, including access to timely diagnosis, risk-stratified therapy, and comprehensive supportive care. This retrospective study aimed to analyze outcomes for pediatric ALL at 16 centers in Mexico.
    Methods: Patients <18 years of age with newly diagnosed B- and T-cell ALL treated between January 2011 and December 2019 were included. Clinical and biological characteristics and their association with outcomes were examined.
    Results: Overall, 2,116 patients with a median age of 6.3 years were included. B-cell immunophenotype was identified in 1,889 (89.3%) patients. The median white blood cells at diagnosis were 11.2.5 × 10
    Conclusion: Outcomes in this multi-institutional cohort describe poor outcomes, influenced by incomplete and inconsistent risk stratification, early toxic death, high on-treatment mortality, and high CNS relapse rate. Adopting comprehensive risk-stratification strategies, evidence-informed de-intensification for favorable-risk patients and optimized supportive care could improve outcomes.
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1255555
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  3. Article ; Online: Incidence of childhood cancer among Mexican children registered under a public medical insurance program.

    Rivera-Luna, Roberto / Correa-González, Cecilia / Altamirano-Alvarez, Eduardo / Sánchez-Zubieta, Fernando / Cárdenas-Cardós, Rocio / Escamilla-Asian, Gabriela / Olaya-Vargas, Alberto / Bautista-Marquez, Aurora / Aguilar-Romo, Manuel

    International journal of cancer

    2013  Volume 132, Issue 7, Page(s) 1646–1650

    Abstract: Prior to 2005, 51% of children in Mexico diagnosed with cancer received no standardized optimal multidisciplinary medical care. A government-subsidized national cancer treatment program was therefore created for these patients and a National Cooperative ... ...

    Abstract Prior to 2005, 51% of children in Mexico diagnosed with cancer received no standardized optimal multidisciplinary medical care. A government-subsidized national cancer treatment program was therefore created for these patients and a National Cooperative Childhood Cancer Treatment Group was consequently formed for these patients. Pediatric patients with a proven diagnosis of leukemia, lymphoma or solid tumor and who were registered in the Popular Medical Insurance (PMI) program from January 2007 to December 2010, are described in this report. These patients had been enrolled and registered in one of the 49 nationwide certified medical institutions in Mexico. The national incidence and frequency data for childhood cancers were analyzed for the whole program. At the end of a 4-year study, the analysis revealed that 8,936 children from across Mexico had been diagnosed with cancer. The incidence rate for the PMI patients was 150.3/million/year (2010) for children of 0-18 years. The highest age incidence rate was 51.9 between 0 and 4 years and boys were the predominant group for all types of cancer. The leukemia incidence was 75.3/million/year (2010), and an average frequency of 50.75% throughout the 4 years. The overall mortality rate was measured at 5.4/100,000/year (2010). This study demonstrates a high frequency and incidence of childhood cancer and a beneficial impact of the PMI program over the quality of life in these children.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Insurance, Health ; Male ; Mexican Americans/statistics & numerical data ; Mexico/epidemiology ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/mortality ; Prognosis ; Program Development ; Public Health ; Registries ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2013-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.27771
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 478: Show issues Location:
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    Zs.MO 576: Show issues

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  4. Article ; Online: Descriptive Epidemiology in Mexican children with cancer under an open national public health insurance program.

    Rivera-Luna, Roberto / Shalkow-Klincovstein, Jaime / Velasco-Hidalgo, Liliana / Cárdenas-Cardós, Rocio / Zapata-Tarrés, Marta / Olaya-Vargas, Alberto / Aguilar-Ortiz, Marco R / Altamirano-Alvarez, Eduardo / Correa-Gonzalez, Cecilia / Sánchez-Zubieta, Fernando / Pantoja-Guillen, Francisco

    BMC cancer

    2014  Volume 14, Page(s) 790

    Abstract: Background: All the children registered at the National Council for the Prevention and Treatment of Childhood Cancer were analyzed. The rationale for this Federal Government Council is to financially support the treatment of all children registered into ...

    Abstract Background: All the children registered at the National Council for the Prevention and Treatment of Childhood Cancer were analyzed. The rationale for this Federal Government Council is to financially support the treatment of all children registered into this system. All patients are within a network of 55 public certified hospitals nationwide.
    Methods: In the current study, data from 2007 to 2012 are presented for all patients (0-18 years) with a pathological diagnosis of leukemia, lymphoma and solid tumors. The parameters analyzed were prevalence, incidence, mortality, and abandonment rate.
    Results: A diagnosis of cancer was documented in 14,178 children. The incidence was of 156.9/million/year (2012). The median age was 4.9. The most common childhood cancer is leukemia, which occurs in 49.8% of patients (2007-2012); and has an incidence rate of 78.1/million/year (2012). The national mortality rate was 5.3/100,000 in 2012, however in the group between 15 to 18 years it reaches a level of 8.6.
    Conclusions: The study demonstrates that there is a high incidence of childhood cancer in Mexico. In particular, the results reveal an elevated incidence and prevalence of leukemia especially from 0 to 4 years. Only 4.7% of these patients abandoned treatment. The clinical outcome for all of the children studied improved since the establishment of this national program.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Insurance, Health ; Male ; Mexico/epidemiology ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/mortality ; Prevalence ; Public Health Surveillance ; Registries
    Language English
    Publishing date 2014-10-29
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/1471-2407-14-790
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  5. Article: Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP).

    Rivera-Luna, Roberto / López, Enrique / Rivera-Marquez, Hugo / Rivera-Ortegón, Francisco / Altamirano-Alvarez, Eduardo / Mercado, Gabriela / Covarrubias, Gilberto / Rueda-Franco, Fernando / Marhx-Bracho, Alfonso / Gutiérrez, Pedro

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2002  Volume 18, Issue 1-2, Page(s) 38–42

    Abstract: Background: The prognosis of medulloblastoma in children under 3 years of age is poor.: Methods: A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free ... ...

    Abstract Background: The prognosis of medulloblastoma in children under 3 years of age is poor.
    Methods: A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.
    Results: A total of 534 children were diagnosed with medulloblastoma during the study period, 49 (9.1%) of whom were under 3 years of age and were evaluated. Their ages ranged from 5 to 35 months with a mean of 18.5 months. In 39 (79.6%) of these patients the tumors were staged as T3M0 or under, while 10 (20.4%) had metastasis at diagnosis. The OS was 38% and PFS 37% in the whole series, while PFS was 32% in those with metastasis and 40% in those without ( P=0.78). For those who received radiotherapy the PFS was 62%, and in those not treated with radiotherapy PFS was nil ( P=0.0001). When the children were divided into those who received surgical treatment plus chemotherapy and those who received surgery plus radiotherapy plus chemotherapy, the PFS was nil and 66%, respectively ( P=0.00001).
    Conclusion: Because of the high morbidity of radiotherapy in children under 3 years old, surgery continues to be the basis of improved prognosis, followed by chemotherapy.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/radiotherapy ; Cerebellar Neoplasms/surgery ; Child, Preschool ; Combined Modality Therapy ; Cranial Fossa, Posterior ; Female ; Humans ; Infant ; Male ; Medulloblastoma/drug therapy ; Medulloblastoma/radiotherapy ; Medulloblastoma/surgery ; Neurosurgical Procedures ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2002-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0256-7040 ; 0302-2803
    ISSN (online) 1433-0350
    ISSN 0256-7040 ; 0302-2803
    DOI 10.1007/s00381-001-0527-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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