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  1. Article ; Online: Interleukin-6 in Rheumatoid Arthritis.

    Pandolfi, Franco / Franza, Laura / Carusi, Valentina / Altamura, Simona / Andriollo, Gloria / Nucera, Eleonora

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development ... ...

    Abstract The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
    MeSH term(s) Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Disease Progression ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/metabolism ; Molecular Targeted Therapy ; Signal Transduction/drug effects
    Chemical Substances Antibodies, Monoclonal ; IL6 protein, human ; Interleukin-6
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Key Role of DAMP in Inflammation, Cancer, and Tissue Repair.

    Pandolfi, Franco / Altamura, Simona / Frosali, Simona / Conti, Pio

    Clinical therapeutics

    2016  Volume 38, Issue 5, Page(s) 1017–1028

    Abstract: Purpose: This review aimed to take stock of the current status of research on damage-associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP molecules in inflammation, cancer, and tissue repair. The high-mobility group box ( ... ...

    Abstract Purpose: This review aimed to take stock of the current status of research on damage-associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP molecules in inflammation, cancer, and tissue repair. The high-mobility group box (HMGB)-1 and adenosine triphosphate proteins are well-known DAMP molecules and have been primarily associated with inflammation. However, as we shall see, recent data have linked these molecules to tissue repair. HMGB1 is associated with cancer-related inflammation. It activates nuclear factor kB, which is involved in cancer regulation via its receptor for advanced glycation end-products (RAGE), Toll-like receptors 2 and 4. Proinflammatory activity and tissue repair may lead to pharmacologic intervention, by blocking DAMP RAGE and Toll like receptor 2 and 4 role in inflammation and by increasing their concentration in tissue repair, respectively.
    Methods: We conducted a MEDLINE search for articles pertaining to the various issues related to DAMP, and we discuss the most relevant articles especially (ie, not only those published in journals with a higher impact factor).
    Findings: A cluster of remarkable articles on DAMP have appeared in the literature in recent years. Regarding inflammation, several strategies have been proposed to target HMGB1, from antibodies to recombinant box A, which interacts with RAGE, competing with the full molecule. In tissue repair, it was reported that the overexpression of HMGB1 or the administration of exogenous HMGB1 significantly increased the number of vessels and promoted recovery in skin-wound, ischemic injury.
    Implications: Due to the bivalent nature of DAMP, it is often difficult to explain the relative role of DAMP in inflammation versus its role in tissue repair. However, this point is crucial as DAMP-related treatments move into clinical practice.
    MeSH term(s) Alarmins ; Animals ; Humans ; Inflammation ; Mice ; Neoplasms ; Wound Healing
    Chemical Substances Alarmins
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2016.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Interleukin-6 in Rheumatoid Arthritis

    Pandolfi, Franco / Franza, Laura / Carusi, Valentina / Altamura, Simona / Andriollo, Gloria / Nucera, Eleonora

    Abstract: The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development ... ...

    Abstract The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #670369
    Database COVID19

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  4. Article ; Online: Interleukin-6 in Rheumatoid Arthritis

    Pandolfi, Franco (orcid:0000-0001-8799-8173) / Franza, Laura / Carusi, Valentina / Altamura, Simona / Andriollo, Gloria / Nucera, Eleonora (orcid:0000-0002-0565-7680)

    2020  

    Abstract: The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development ... ...

    Abstract The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
    Keywords IL-6 ; Settore MED/09 - MEDICINA INTERNA ; covid19
    Language English
    Publisher MDPI
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Integrins: Integrating the Biology and Therapy of Cell-cell Interactions.

    Pandolfi, Franco / Franza, Laura / Altamura, Simona / Mandolini, Claudia / Cianci, Rossella / Ansari, Aftab / Kurnick, James T

    Clinical therapeutics

    2017  Volume 39, Issue 12, Page(s) 2420–2436

    Abstract: Purpose: Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse ... ...

    Abstract Purpose: Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings. The purpose of this review was to address this gap in our knowledge with the hypothesis that there is, in fact, a common pathway by which integrins may function.
    Methods: This article provides an in-depth perspective on the discovery, development, and design of therapeutics that modulate cellular function by targeting integrin:ligand interactions by reviewing the literature on this subject; the review included the most recent results of clinical and subclinical studies. A MEDLINE search was conducted for articles pertaining to the various issues related to integrins, and the most relevant articles are discussed (ie, not only those published in journals with a higher impact factor).
    Findings: It seems that the ligation of the integrins with their cognate ligands plays a major role in translating membrane dialogue into biological function. In addition, they also seem to play a major regulatory role that can enhance or inhibit biological function depending on the context within which such receptor:ligand interactions occur and the organ and tissues at which interactions occurs and is manipulated. Those studies that used statistical analyses have been included where appropriate.
    Implications: Our findings show that anti-integrin treatment has the potential to become a valid coadjuvant in the treatment of several diseases including cancer, inflammatory diseases, HIv infection and cardiovascular diseases.
    MeSH term(s) Animals ; Antibodies, Monoclonal/therapeutic use ; Cell Communication ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Integrins/antagonists & inhibitors ; Integrins/immunology ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Psoriasis/drug therapy ; Psoriasis/immunology ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Acquired Immunodeficiency Syndrome/immunology ; Thrombosis/drug therapy ; Thrombosis/immunology
    Chemical Substances Antibodies, Monoclonal ; Integrins
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2017.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection.

    Perrella, Alessandro / Vitiello, Laura / Atripaldi, Luigi / Sbreglia, Costanza / Grattacaso, Stella / Bellopede, Pasquale / Patarino, Tommaso / Morelli, Giuseppe / Altamura, Simona / Racioppi, Luigi / Perrella, Oreste

    Journal of gastroenterology and hepatology

    2008  Volume 23, Issue 7 Pt 2, Page(s) e105–10

    Abstract: Background and aim: Hepatitis A virus (HAV) causes a transient illness leaving permanent protection against reinfection. Few data are available on the regulatory mechanisms involved in the CD4+ T helper activation. We aimed to investigate the frequency ... ...

    Abstract Background and aim: Hepatitis A virus (HAV) causes a transient illness leaving permanent protection against reinfection. Few data are available on the regulatory mechanisms involved in the CD4+ T helper activation. We aimed to investigate the frequency and function of CD3+/CD4+/CD25+ T cells with regulatory function (Tregs) during acute HAV infection.
    Methods: We enrolled 35 consecutive patients and 15 healthy donors, enumerated Tregs by flow cytometry assay and evaluated, after immunomagnetical sorting with magnetic beads, their ability to inhibit the proliferation of CD4+/CD25- T lymphocytes at different ratios (1:1, 1:10, 1:20).
    Results: All patients had the usual course of infection. Our immunological analysis showed Tregs frequency in these patients (6.5% [range, 5-8.8%]; 36 [range, 10-87] cells) did not have any statistical difference compared with healthy donors (6% [range, 5-8%]; 48 (range, 23-71) cells), while their ability to suppress CD4+/CD25- was drastically reduced at different ratios (Mann-Whitney U-test; ratio 1:1, 93% vs 72%, z = -3.34, P < 0.0001; ratio 1:10, 86% vs 51%, z = -4.04, P < 0.001; ratio 1:20, 56% vs 30%, z = -3.43, P < 0.0001). After the seroconversion, CD4+/CD25+ frequency and function in HAV-infected patients did not differ from healthy individuals.
    Conclusion: CD4+/CD25+ T cells seem to be impaired in their function during the HAV acute infection. This evidence might help to determine an optimal T helper cell immune network that is a predisposing factor for a self-limiting disease.
    MeSH term(s) Adult ; CD3 Complex/analysis ; CD4 Antigens/analysis ; Case-Control Studies ; Cells, Cultured ; Female ; Hepatitis A/immunology ; Hepatitis A Virus, Human/immunology ; Humans ; Interleukin-2 Receptor alpha Subunit/analysis ; Lymphocyte Activation ; Male ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/virology
    Chemical Substances CD3 Complex ; CD4 Antigens ; Interleukin-2 Receptor alpha Subunit
    Language English
    Publishing date 2008-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/j.1440-1746.2007.05008.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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