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  1. AU="Altayban, Abdullah"
  2. AU="Ford, Allison"
  3. AU="Lally, Jag"
  4. AU=Karkhanis Jamuna
  5. AU=Hoffmann Michael
  6. AU="McCormick, Paul C"
  7. AU="Niu, Xinhui"
  8. AU=Guzeloglu-Kayisli Ozlem
  9. AU="Tuck, Christopher"
  10. AU=Janssens Nico AU=Janssens Nico
  11. AU="Roberto Giacomelli"
  12. AU="Zarenezhad, Elham"
  13. AU="Oyefule, Omobolanle"
  14. AU="Baskey, Swarnamayee"
  15. AU="J. Kotzka"
  16. AU=Richardson Paul D
  17. AU="Forbes, Stuart"
  18. AU="Padilla, Michele"
  19. AU="Wenaweser, Peter"
  20. AU=Jahnlova Denisa
  21. AU="Nicole Fasel"
  22. AU="Carâp, Alexandru Constantin"
  23. AU="Gruber-Wackernagel, Alexandra"
  24. AU="Ye, Sining"
  25. AU="Bekele, B Nebiyou"
  26. AU="Bolognesi, Martino"
  27. AU="Delabesse, Eric"

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  1. Artikel: A pilot study on the pharmacokinetics of a single intramuscular injection of cefquinome in Arabian camel calves.

    Altayban, Abdullah / Kandeel, Mahmoud / Kitade, Yukio / Al-Nazawi, Mohammed

    Acta veterinaria Hungarica

    2020  Band 68, Heft 1, Seite(n) 59–64

    Abstract: This study was conducted to evaluate the pharmacokinetics of cefquinome in camel calves after a single intramuscular injection in a dose of 2 mg/kg body weight (kg b. w.). Cefquinome concentrations were measured by ultra-high performance liquid ... ...

    Abstract This study was conducted to evaluate the pharmacokinetics of cefquinome in camel calves after a single intramuscular injection in a dose of 2 mg/kg body weight (kg b. w.). Cefquinome concentrations were measured by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS). A non-compartmental pharmacokinetic model was used to fit the time-concentration curve and estimate the pharmacokinetic parameters. The peak serum concentration (Cmax) was 28.4 μg/mL at the time of maximum concentration (Tmax) of 25 min. The elimination half-life (t1/2) was 17.4 h. The area under the concentration-time curve (AUC0-∞) was 103.7 μg/ml-1h and the mean residence time (MRT0-∞) was 21.3 h. In comparison with other animal species, the pharmacokinetics of cefquinome in Arabian camel calves showed faster absorption from the site of injection and slower elimination. Since cefquinome, as other beta-lactams, is a time-dependent antimicrobial agent, a single dose of 2 mg/kg b. w. might be sufficient against the most sensitive organisms in camel calves owing to its prolonged elimination phase. However, dose readjustment is required for cases needing concentrations above 2 µg/mL for 12 h or above 1 µg/mL for 24 h.
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Camelus/metabolism ; Cephalosporins/administration & dosage ; Cephalosporins/pharmacokinetics ; Injections, Intramuscular/veterinary ; Male ; Pilot Projects
    Chemische Substanzen Anti-Bacterial Agents ; Cephalosporins ; cefquinome (Z74S078CWP)
    Sprache Englisch
    Erscheinungsdatum 2020-05-08
    Erscheinungsland Hungary
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605742-1
    ISSN 1588-2705 ; 0236-6290 ; 0365-8198
    ISSN (online) 1588-2705
    ISSN 0236-6290 ; 0365-8198
    DOI 10.1556/004.2020.00008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Cefotaxime pharmacokinetics in Arabian camel (Camelus dromedarius) calves after single intravenous injection

    Altayban, Abdullah / Kandeel, Mahmoud / Tahoun, Amin / Al-Nazawi, Mohammed

    Tropical animal health and production. 2020 Mar., v. 52, no. 2

    2020  

    Abstract: Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the pharmacokinetics of cefotaxime were determined in dromedary camel calves by single intravenous injection ... ...

    Abstract Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the pharmacokinetics of cefotaxime were determined in dromedary camel calves by single intravenous injection of 10 mg/kg b.w. Cefotaxime levels were estimated by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Cefotaxime pharmacokinetics in camel calves obeyed three-compartment kinetics model. There was a central compartment and two peripheral, one shallow and one deep compartment. The shallow compartment equilibrates very rapidly with distribution half-life (t1/2α) of 0.6 min, while the deep compartment has large distribution half-life (t1/2β) of 42 min indicating slower uptake of cefotaxime. The elimination rate constant (γ = 0.04 h−1) and elimination half-life (t1/2 γ) = 15.46 h indicating slow elimination. In comparison with other animals, cefotaxime pharmacokinetics in camel calves showed potential wide distribution in multi-compartment, lower elimination constant, lower clearance and higher volume of distribution at steady state. This indicates substantial differences in cefotaxime pharmacokinetics in camel calves with a very characteristic ultra-rapid distribution into three-compartment and slow elimination.
    Schlagwörter Camelus dromedarius ; Gram-negative bacteria ; calves ; camels ; cefotaxime ; half life ; intravenous injection ; pharmacokinetics ; tandem mass spectrometry ; ultra-performance liquid chromatography
    Sprache Englisch
    Erscheinungsverlauf 2020-03
    Umfang p. 887-891.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-019-02080-0
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Cefotaxime pharmacokinetics in Arabian camel (Camelus dromedarius) calves after single intravenous injection.

    Altayban, Abdullah / Kandeel, Mahmoud / Tahoun, Amin / Al-Nazawi, Mohammed

    Tropical animal health and production

    2019  Band 52, Heft 2, Seite(n) 887–891

    Abstract: Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the pharmacokinetics of cefotaxime were determined in dromedary camel calves by single intravenous injection ... ...

    Abstract Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the pharmacokinetics of cefotaxime were determined in dromedary camel calves by single intravenous injection of 10 mg/kg b.w. Cefotaxime levels were estimated by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Cefotaxime pharmacokinetics in camel calves obeyed three-compartment kinetics model. There was a central compartment and two peripheral, one shallow and one deep compartment. The shallow compartment equilibrates very rapidly with distribution half-life (t
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/pharmacokinetics ; Camelus/growth & development ; Camelus/metabolism ; Cefotaxime/pharmacokinetics ; Half-Life ; Injections, Intravenous/veterinary ; Kinetics
    Chemische Substanzen Anti-Bacterial Agents ; Cefotaxime (N2GI8B1GK7)
    Sprache Englisch
    Erscheinungsdatum 2019-11-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-019-02080-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2159: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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