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Article ; Online: LncOb rs10487505 variant is associated with leptin levels in pediatric non-alcoholic fatty liver disease.

Manco, Melania / Crudele, Annalisa / Mosca, Antonella / Caccamo, Romina / Braghini, Maria Rita / De Vito, Rita / Alterio, Arianna / Pizzolante, Fabrizio / De Peppo, Francesco / Alisi, Anna

Pediatric research

2022

Abstract: Background: Low and high leptin levels are associated with non-alcoholic fatty liver disease (NAFLD). The LncOb rs10487505 variant has been associated with body mass index (BMI), and the C allele was reported as leptin-lowering. We evaluated the ... ...

Abstract	Background: Low and high leptin levels are associated with non-alcoholic fatty liver disease (NAFLD). The LncOb rs10487505 variant has been associated with body mass index (BMI), and the C allele was reported as leptin-lowering. We evaluated the association of rs10487505 with leptin levels, liver histology, and surgery-induced weight loss in youths with NAFLD. Methods: One-hundred five obese youths with NAFLD, of whom 19 undergoing laparoscopic sleeve gastrectomy (LSG), were analyzed for rs10487505 and leptin circulating levels. Results: The G allele frequency was lower in youths with NAFLD than in controls (p = 0.049). No difference was found in anthropometrics, biochemistry and histology between G allele carriers and CC homozygotes, except for leptin levels (p = 0.016). Leptin correlated with body weight, BMI, BMI-z score, waist circumference, insulin resistance/sensitivity, and triglycerides (p ≤ 0.01). A multivariable regression model including body weight and homeostasis model assessment of insulin resistance was a good predictor of plasma leptin (R Conclusions: LncOb rs10487505 variant was associated with pediatric NAFLD and high leptin levels, and with weight and leptin reduction after LSG in youths. Impact: The interplay of environment, genetics and epigenetics is crucial inflating the risk of non-alcoholic fatty liver disease (NAFLD). Several long non-coding RNA (LncRNAs) are found associated with NAFLD pathogenesis. Here, we evaluated the impact of the genetic variant rs10487505 in LncOb which is involved in the regulation of leptin gene expression. The LncOb rs10487505 is associated with increased levels of leptin, but not with liver histology, in youths with NAFLD. The LncOb rs10487505 was also associated with the significant decrease of leptin and body weight after bariatric surgery.
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-022-02032-9
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article ; Online: Non-alcoholic fatty liver and metabolic syndrome in children: a vicious circle.

Alterio, Arianna / Alisi, Anna / Liccardo, Daniela / Nobili, Valerio

Hormone research in paediatrics

2014 Volume 82, Issue 5, Page(s) 283–289

Abstract: During the last decade, paediatricians have observed a dramatic increase of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in children. Furthermore, several lines of evidence have reported that a large part of children with NAFLD ... ...

Abstract	During the last decade, paediatricians have observed a dramatic increase of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in children. Furthermore, several lines of evidence have reported that a large part of children with NAFLD presents one or more traits of MS making plausible that, in the coming years, these subjects may present a rapid course of disease towards more severe cirrhosis and cardiovascular disease. Genetic susceptibility and the pressure of intrauterine environment and lifestyle are all crucial to activate molecular machinery that leads to development of NAFLD and MS in childhood. In this scenario, central obesity and consequent adipose tissue inflammation are critical to promote both MS-associated metabolic dysfunctions and NAFLD-related hepatic damage. An excessive dietary intake may in fact cause a specific lipid partitioning and induce metabolic stressors, which in turn promote insulin resistance and the release of several circulating factors. These molecules, on the one hand, trigger steatosis and the inflammatory response that characterize liver damage in NAFLD, and on the other hand contribute to the onset of other features of MS. This review provides an overview of current genetic, pathogenetic and clinical evidence of the vicious circle created by NAFLD and MS in children.
MeSH term(s)	Adolescent ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Child ; Child, Preschool ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/genetics ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology
Language	English
Publishing date	2014
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2537278-6
ISSN	1663-2826 ; 1663-2818
ISSN (online)	1663-2826
ISSN	1663-2818
DOI	10.1159/000365192
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Article ; Online: Elevated Hemoglobin Level Is Associated With Advanced Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease.

Giorgio, Valentina / Mosca, Antonella / Alterio, Arianna / Alisi, Anna / Grieco, Antonio / Nobili, Valerio / Miele, Luca

Journal of pediatric gastroenterology and nutrition

2017 Volume 65, Issue 2, Page(s) 150–155

Abstract: Objectives: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the ... ...

Abstract	Objectives: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the association between hematological parameters, and the severity of disease in children with biopsy-proven NAFLD. Methods: A total of 117 children (85 boys, mean age 12 years) with ultrasound evidence of NAFLD undergoing liver biopsy for diagnosis of nonalcoholic steatohepatitis (NASH), were prospectively enrolled between January 2011 and May 2013 in the setting of a tertiary care center. Children were screened for routine hematological and metabolic parameters, and causes of liver steatosis other than nonalcoholic were excluded, before liver biopsy was performed. Results: A total of 41 NAFLD (boys 29, mean age 11.2 years) and 76 NASH (boys 56, mean age 12.8 years) children were studied. Alanine transaminase levels were significantly higher in NASH group compared with NAFLD group (P = 0.05), and homeostatic model assessment of insulin resistance and triglycerides levels (P = 0.03 and 0.02, respectively). Regarding hematological components: red cell count, Hb, hematocrit, and RDW values were all significantly higher in NASH group compared with NAFLD group (P < 0.05 for each parameter). Conclusions: Children with NASH were more likely to have high levels of RDW compared to those with steatosis only. Moreover, NASH was associated with higher red cell count, Hb, and hematocrit. If confirmed in future follow-up studies, hematological parameters may be introduced in algorithms for NASH risk prediction.
MeSH term(s)	Biomarkers/blood ; Child ; Erythrocyte Count ; Erythrocyte Indices ; Female ; Hematocrit ; Hemoglobins/metabolism ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/pathology ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Biomarkers ; Hemoglobins
Language	English
Publishing date	2017-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000001614
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Zs.A 1728: Show issues

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Article ; Online: Elevated Hemoglobin Level is Associated With Advanced Fibrosis in Pediatric Non Alcoholic Fatty Liver Disease.

Giorgio, Valentina / Mosca, Antonella / Alterio, Arianna / Alisi, Anna / Grieco, Antonio / Nobili, Valerio / Miele, Luca

Journal of pediatric gastroenterology and nutrition

2017

Abstract: Objectives: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the ... ...

Abstract	Objectives: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the association between hematological parameters, and the severity of disease in children with biopsy proven NAFLD. Methods: 117 children (85 males, mean age 12 years) with ultrasound (US) evidence of NAFLD undergoing liver biopsy for diagnosis of non alcoholic steatohepatitis (NASH), were prospectively enrolled between January 2011 and May 2013 in the setting of a tertiary care centre. Children were screened for routine hematological and metabolic parameters, and causes of liver steatosis other than non-alcoholic were excluded, before liver biopsy was performed. Results: 41 NAFLD (males 29, mean age 11,2 years) and 76 NASH (males 56, mean age 12,8) children were studied. ALT levels were significantly higher in NASH group vs NAFLD group (p = 0,05), as well as HOMA-IR and triglycerides levels (p = 0,03 and 0,02 respectively). Regarding hematological components: red cell count, hemoglobin, hematocrit and RDW values were all significantly higher in NASH group vs NAFLD group (p < 0,05 for each parameter). Conclusion: Children with NASH were more likely to have high levels of RDW compared to those with steatosis only. Moreover, NASH was associated with higher red cell count, hemoglobin and hematocrit. If confirmed in future follow-up studies, hematological parameters might be introduced in algorithms for NASH risk prediction.
Language	English
Publishing date	2017-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000001614
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Zs.A 1728: Show issues

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Article ; Online: Good adherence to the Mediterranean diet reduces the risk for NASH and diabetes in pediatric patients with obesity: The results of an Italian Study.

Della Corte, Claudia / Mosca, Antonella / Vania, Andrea / Alterio, Arianna / Iasevoli, Salvatore / Nobili, Valerio

Nutrition (Burbank, Los Angeles County, Calif.)

2017 Volume 39-40, Page(s) 8–14

Abstract: Objective: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver ... ...

Abstract	Objective: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to analyze the association between adherence to the MD and NAFLD, with laboratory and histologic evaluation, in a group of children and adolescents with obesity. Methods: We enrolled 243 patients with obesity referred to our department from March 2014 to November 2015. In all patients, we performed abdominal ultrasound and laboratory assays. In selected cases (100 patients) liver biopsy was performed. Level of adherence to the MD was evaluated by a clinical questionnaire, the Mediterranean Diet Quality Index for children and adolescents (KIDMED). Results: The prevalence of low KIDMED score was significantly higher in patients with nonalcoholic steatohepatitis compared with other groups; poor adherence to the MD correlated with liver damage, the NAFLD activity score >5, and grade 2 fibrosis. Moreover, in patients with poor adherence to the MD, higher values of C-reactive protein, fasting insulin, homeostatic model assessment of insulin resistance, and homeostatic model assessment of β cell function were observed. Conclusion: The MD could be a safe and inexpensive therapeutic option for children with obesity and NAFLD.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2017.02.008
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Zs.A 2290: Show issues

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Article ; Online: Pediatric liver diseases: current challenges and future perspectives.

Della Corte, Claudia / Mosca, Antonella / Vania, Andrea / Alterio, Arianna / Alisi, Anna / Nobili, Valerio

Expert review of gastroenterology & hepatology

2016 Volume 10, Issue 2, Page(s) 255–265

Abstract: Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma. The prevalence of ... ...

Abstract	Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma. The prevalence of liver diseases in children is unknown. In the USA, every year, 15,000 children are hospitalized for liver diseases, but these disorders continue to be under-recognized or diagnosed late. The main reason is due to the frequent absence of symptoms in the vast majority of liver diseases, especially in the early stages. In the last few decades several advances have been made in understanding the pathogenesis of liver diseases, permitting the discovery of new therapeutic targets to treat liver diseases, thus improving the natural history of these disorders. In this article we discuss the most recent advances in the understanding of the pathogenesis, diagnosis and treatment of the most frequent pediatric liver diseases.
MeSH term(s)	Adolescent ; Age of Onset ; Child ; Child, Preschool ; Chronic Disease ; Disease Progression ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/epidemiology ; Liver Diseases/therapy ; Pediatrics ; Prevalence ; Prognosis ; Risk Factors
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1586/17474124.2016.1129274
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Zs.A 6978: Show issues

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Article ; Online: Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD.

Mosca, Antonella / Crudele, Annalisa / Smeriglio, Antonella / Braghini, Maria Rita / Panera, Nadia / Comparcola, Donatella / Alterio, Arianna / Sartorelli, Maria Rita / Tozzi, Giulia / Raponi, Massimiliano / Trombetta, Domenico / Alisi, Anna

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2020 Volume 53, Issue 9, Page(s) 1154–1158

Abstract: Background: The rise in paediatric non-alcoholic fatty liver disease (NAFLD) is particularly alarming. We recently reported that Hydroxytyrosol (HXT) and Vitamin E (VitE) may improve oxidative stress, insulin resistance, and steatosis in children with ... ...

Abstract	Background: The rise in paediatric non-alcoholic fatty liver disease (NAFLD) is particularly alarming. We recently reported that Hydroxytyrosol (HXT) and Vitamin E (VitE) may improve oxidative stress, insulin resistance, and steatosis in children with biopsy-proven NAFLD. Aim: Here, we investigated if HXT+VitE may reduce systemic inflammation in the above-mentioned patients. Methods: This study analysed the plasma levels of IL (interleukin)-6, IL-1β, IL-10, tumour necrosis factor (TNF)-α, 4‑hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'deoxyguanosine (8-OHdG) in children enrolled in the HXT+VitE trial (ClinicalTrials.gov, NCT02842567). Results: Changes in markers of systemic inflammation were found in both placebo (Pla) and HXT+VitE. In particular, after four months, the levels of IL-1β and TNF-α were reduced in both groups, while IL-6 decreased, and IL-10 increased significantly only in the group treated with HXT+VitE. Children treated with HXT+VitE showed a significant decrease of 4-HNE and 8-OHdG that correlated with the improvement of triglyceride levels. Noticeably, only the 8-OHdG decrease correlated with steatosis amelioration and with the increase of IL-10 levels. Conclusion: The treatment with HXT and VitE reduced the NAFLD-related systemic inflammation in children, mainly by an increase of IL-10 circulating levels that occurred in response to DNA damage recovery, ultimately improving steatosis and hypertriglyceridemia.
MeSH term(s)	Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Biomarkers/blood ; Child ; Drug Combinations ; Female ; Humans ; Interleukin-10/blood ; Male ; Non-alcoholic Fatty Liver Disease/drug therapy ; Oxidative Stress/drug effects ; Phenylethyl Alcohol/administration & dosage ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/pharmacology ; Vitamin E/administration & dosage ; Vitamin E/metabolism ; Vitamin E/pharmacology
Chemical Substances	Antioxidants ; Biomarkers ; Drug Combinations ; IL10 protein, human ; 3,4-dihydroxyphenylethanol (10597-60-1) ; Interleukin-10 (130068-27-8) ; Vitamin E (1406-18-4) ; Phenylethyl Alcohol (ML9LGA7468)
Language	English
Publishing date	2020-10-13
Publishing country	Netherlands
Document type	Journal Article ; Observational Study ; Randomized Controlled Trial
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2020.09.021
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Zs.A 1134: Show issues

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Article ; Online: Changes in Total Homocysteine and Glutathione Levels After Laparoscopic Sleeve Gastrectomy in Children with Metabolic-Associated Fatty Liver Disease.

Pastore, Anna / Panera, Nadia / Mosca, Antonella / Caccamo, Romina / Camanni, Daniela / Crudele, Annalisa / De Stefanis, Cristiano / Alterio, Arianna / Di Giovamberardino, Gianna / De Vito, Rita / Francalanci, Paola / Battaglia, Sonia / Muda, Andrea Onetti / De Peppo, Francesco / Alisi, Anna

Obesity surgery

2021 Volume 32, Issue 1, Page(s) 82–89

Abstract: Purpose: Paediatric obesity is a well-known risk factor for metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the levels of total homocysteine (tHcy) and total ...

Abstract	Purpose: Paediatric obesity is a well-known risk factor for metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the levels of total homocysteine (tHcy) and total glutathione (tGSH) plasma levels in children with MAFLD. Material and methods: Twenty-four children with severe obesity who underwent LSG were included in the study. The metabolic parameters, systemic inflammatory markers, one-carbon metabolism products, ultrasound and histological improvement were evaluated at baseline (T0M) and after 12 months from LSG (T12M). Results: The patients exhibited a significant amelioration of several metabolic parameters at T12M. A significant reduction of steatosis was observed at ultrasound (from 72.7% of moderate-severe grade to 0% severe steatosis), accompanied by a statistically significant improvement of ballooning, portal and lobular inflammation and fibrosis. A statistically significant decrease of tumour necrosis factor circulating levels was also observed (T0M median = 290.3, IQR = 281.0-317.0 pg/mL; T12M median = 260.4, IQR = 240.0-279.0 pg/mL; p < 0.0001). After 12 months from LSG, a significant increase of mean plasma levels of tHcy(T0M mean = 15.7 ± 4.1 μmol/L; T12M mean = 21.1 ± 9.3 μmol/L; p = 0.0146) was also observed. The increase of tHcy showed no causal link with the improvement of MAFLD-related inflammatory, metabolic and histological pattern. Conclusion: LSG in children with obesity induces an improvement of MAFLD-related metabolic derangement and liver damage, but also a mild hyperhomocysteinemia that should be avoided to prevent cardiovascular risk.
MeSH term(s)	Child ; Gastrectomy/adverse effects ; Glutathione ; Homocysteine ; Humans ; Laparoscopy/adverse effects ; Non-alcoholic Fatty Liver Disease/complications ; Obesity, Morbid/surgery ; Pediatric Obesity/complications ; Pediatric Obesity/surgery ; Treatment Outcome
Chemical Substances	Homocysteine (0LVT1QZ0BA) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-021-05701-6
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Zs.A 3381: Show issues

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Article: Non-Alcoholic Fatty Liver and Metabolic Syndrome in Children: A Vicious Circle

Alterio, Arianna / Alisi, Anna / Liccardo, Daniela / Nobili, Valerio

Hormone Research in Paediatrics

2014 Volume 82, Issue 5, Page(s) 283–289

Institution	Hepato-Metabolic Disease Unit and Liver Research Unit, ‘Bambino Gesù' Children's Hospital, IRCCS, Rome, Italy
Abstract	During the last decade, paediatricians have observed a dramatic increase of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in children. Furthermore, several lines of evidence have reported that a large part of children with NAFLD presents one or more traits of MS making plausible that, in the coming years, these subjects may present a rapid course of disease towards more severe cirrhosis and cardiovascular disease. Genetic susceptibility and the pressure of intrauterine environment and lifestyle are all crucial to activate molecular machinery that leads to development of NAFLD and MS in childhood. In this scenario, central obesity and consequent adipose tissue inflammation are critical to promote both MS-associated metabolic dysfunctions and NAFLD-related hepatic damage. An excessive dietary intake may in fact cause a specific lipid partitioning and induce metabolic stressors, which in turn promote insulin resistance and the release of several circulating factors. These molecules, on the one hand, trigger steatosis and the inflammatory response that characterize liver damage in NAFLD, and on the other hand contribute to the onset of other features of MS. This review provides an overview of current genetic, pathogenetic and clinical evidence of the vicious circle created by NAFLD and MS in children.
Keywords	Non-alcoholic fatty liver disease ; Metabolic syndrome ; Obesity ; Insulin resistance ; Children
Language	English
Publishing date	2014-10-15
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Mini Review
ZDB-ID	2537278-6
ISSN	1663-2826 ; 1663-2818
ISSN (online)	1663-2826
ISSN	1663-2818
DOI	10.1159/000365192
Database	Karger publisher's database

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Article ; Online: The Contribution of the Adipose Tissue-Liver Axis in Pediatric Patients with Nonalcoholic Fatty Liver Disease after Laparoscopic Sleeve Gastrectomy.

Franchitto, Antonio / Carpino, Guido / Alisi, Anna / De Peppo, Francesco / Overi, Diletta / De Stefanis, Cristiano / Romito, Ilaria / De Vito, Rita / Caccamo, Romina / Sonia, Battaglia / Alessandra, Salvatori / Mosca, Antonella / Alterio, Arianna / Onori, Paolo / Gaudio, Eugenio / Nobili, Valerio

The Journal of pediatrics

2019 Volume 216, Page(s) 117–127.e2

Abstract: Objective: To evaluate the histopathologic modifications in liver and visceral adipose tissue (VAT), and to correlate these changes with clinical measures, adipokine production, and proinflammatory cytokines in a population of adolescents with obesity ... ...

Abstract	Objective: To evaluate the histopathologic modifications in liver and visceral adipose tissue (VAT), and to correlate these changes with clinical measures, adipokine production, and proinflammatory cytokines in a population of adolescents with obesity with nonalcoholic fatty liver disease (NAFLD) who underwent laparoscopic sleeve gastrectomy (LSG). Study design: Twenty adolescents with obesity who underwent LSG and with biopsy-proven NAFLD were included. Patients underwent clinical evaluation and blood tests at baseline and 1 year after the surgical procedure. Liver and VAT specimens were processed for routine histology, immunohistochemistry, and immunofluorescence. Results: In adolescents with obesity and NAFLD, hepatic histologic alterations were uncorrelated with VAT inflammation. LSG induced in both liver and VAT tissue histopathology amelioration and macrophage profile modification that were correlated with body mass index and improvement in insulin resistance. The adipokine profile in liver and VAT was associated with weight loss and histologic improvement after LSG. Serum proinflammatory cytokines were correlated with liver and VAT histopathology and IL-1β and IL-6 levels were independently predicted by liver necroinflammatory grade. Conclusions: This study suggests a unique adipose tissue/fatty liver crosstalk in pediatric patients. LSG induces a similar pattern of histologic improvement in the liver and in VAT. Besides VAT, our results strengthen the role of the liver in adipocytokine production and its contribution to systemic inflammation in pediatric patients with NAFLD.
MeSH term(s)	Adipokines/biosynthesis ; Adolescent ; Correlation of Data ; Female ; Gastrectomy/methods ; Humans ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/pathology ; Laparoscopy ; Liver/metabolism ; Liver/pathology ; Macrophages ; Male ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/pathology ; Pediatric Obesity/complications ; Pediatric Obesity/surgery ; Prospective Studies
Chemical Substances	Adipokines
Language	English
Publishing date	2019-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2019.07.037
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