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  1. AU="Aluicio-Sarduy, Eduardo"
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  1. Article ; Online: Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [

    Lin, Wilson / Fonseca Cabrera, German Oscar / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Mixdorf, Jason C / Li, Zibo / Wu, Zhanhong / Engle, Jonathan W

    Bioconjugate chemistry

    2024  Volume 35, Issue 3, Page(s) 412–418

    Abstract: Cobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier ... ...

    Abstract Cobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier added
    MeSH term(s) Humans ; Animals ; Mice ; Tissue Distribution ; Cyclotrons ; Heterografts ; Copper Radioisotopes/pharmacokinetics ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacokinetics ; Neoplasms ; Cell Line, Tumor ; Cobalt Radioisotopes
    Chemical Substances Cobalt-55 ; Copper Radioisotopes ; Radiopharmaceuticals ; Cobalt Radioisotopes
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Radiolabeling and

    Martin, Kirsten E / Mattocks, Joseph A / Śmiłowicz, Dariusz / Aluicio-Sarduy, Eduardo / Whetter, Jennifer N / Engle, Jonathan W / Cotruvo, Joseph A / Boros, Eszter

    RSC chemical biology

    2023  Volume 4, Issue 8, Page(s) 613

    Abstract: This corrects the article DOI: 10.1039/D3CB00020F.]. ...

    Abstract [This corrects the article DOI: 10.1039/D3CB00020F.].
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Published Erratum
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d3cb90017g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiolabeling and

    Martin, Kirsten E / Mattocks, Joseph A / Śmiłowicz, Dariusz / Aluicio-Sarduy, Eduardo / Whetter, Jennifer N / Engle, Jonathan W / Cotruvo, Joseph A / Boros, Eszter

    RSC chemical biology

    2023  Volume 4, Issue 6, Page(s) 414–421

    Abstract: Short-lived, radioactive lanthanides comprise an emerging class of radioisotopes attractive for biomedical imaging and therapy applications. To deliver such isotopes to target tissues, they must be appended to entities that target antigens overexpressed ... ...

    Abstract Short-lived, radioactive lanthanides comprise an emerging class of radioisotopes attractive for biomedical imaging and therapy applications. To deliver such isotopes to target tissues, they must be appended to entities that target antigens overexpressed on the target cell's surface. However, the thermally sensitive nature of biomolecule-derived targeting vectors requires the incorporation of these isotopes without the use of denaturing temperatures or extreme pH conditions; chelating systems that can capture large radioisotopes under mild conditions are therefore highly desirable. Herein, we demonstrate the successful radiolabeling of the lanthanide-binding protein, lanmodulin (LanM), with medicinally relevant radioisotopes:
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d3cb00020f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Copper-Mediated Radiobromination of (Hetero)Aryl Boronic Pinacol Esters.

    Mixdorf, Jason C / Hoffman, Sabrina L V / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Engle, Jonathan W / Ellison, Paul A

    The Journal of organic chemistry

    2023  Volume 88, Issue 4, Page(s) 2089–2094

    Abstract: A copper-mediated radiobromination of (hetero)aryl boronic pinacol esters is described. Cyclotron-produced [ ...

    Abstract A copper-mediated radiobromination of (hetero)aryl boronic pinacol esters is described. Cyclotron-produced [
    MeSH term(s) Copper ; Esters ; Boron ; Glycols
    Chemical Substances Copper (789U1901C5) ; pinacol ; Esters ; Boron (N9E3X5056Q) ; Glycols
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography.

    Lin, Wilson / Aluicio-Sarduy, Eduardo / Barrett, Kendall E / Barnhart, Todd E / Mixdorf, Jason C / DeLuca, Molly C / Engle, Jonathan W

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 200, Page(s) 110980

    Abstract: Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron- ... ...

    Abstract Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron-produced
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.110980
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  6. Article: Amplification of Cerenkov luminescence using semiconducting polymers for cancer theranostics.

    Rosenkrans, Zachary T / Hsu, Jessica C / Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Engle, Jonathan W / Cai, Weibo

    Advanced functional materials

    2023  Volume 33, Issue 33

    Abstract: The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy ... ...

    Abstract The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides. SPNs can be doped with photosensitizers and have nearly 100% energy transfer efficiency by multiple energy transfer mechanisms. Herein, we investigated an optimized photosensitizer doped SPN as a nanosystem to harness and amplify CL for cancer theranostics. We found that semiconducting polymers significantly amplified CL energy transfer efficiency. Bimodal PET and optical imaging studies showed high tumor uptake and retention of the optimized SPNs when administered intravenously or intratumorally. Lastly, we found that photosensitizer doped SPNs have excellent potential as a cancer theranostics nanosystem in an in vivo tumor therapy study. Our study shows that SPNs are ideally suited to harness and amplify CL for cancer theranostics, which may provide a significant advancement for CRIT that are unabated by tissue penetration limits.
    Language English
    Publishing date 2023-05-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039420-2
    ISSN 1616-3028 ; 1616-301X
    ISSN (online) 1616-3028
    ISSN 1616-301X
    DOI 10.1002/adfm.202302777
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  7. Article: PET Imaging of the Neurotensin Targeting Peptide NOTA-NT-20.3 Using Cobalt-55, Copper-64 and Gallium-68.

    Houson, Hailey A / Tekin, Volkan / Lin, Wilson / Aluicio-Sarduy, Eduardo / Engle, Jonathan W / Lapi, Suzanne E

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: Introduction: Neurotensin receptor 1 (NTSR1) is an emerging target for imaging and therapy of many types of cancer. Nuclear imaging of NTSR1 allows for noninvasive assessment of the receptor levels of NTSR1 on the primary tumor, as well as potential ... ...

    Abstract Introduction: Neurotensin receptor 1 (NTSR1) is an emerging target for imaging and therapy of many types of cancer. Nuclear imaging of NTSR1 allows for noninvasive assessment of the receptor levels of NTSR1 on the primary tumor, as well as potential metastases. This work focuses on a the neurotensin peptide analogue NT-20.3 conjugated to the chelator NOTA for radiolabeling for use in noninvasive positron emission tomography (PET). NOTA-NT-20.3 was radiolabeled with gallium-68, copper-64, and cobalt-55 to determine the effect that modification of the radiometal has on imaging and potential therapeutic properties of NOTA-NT-20.3. Methods: In vitro assays investigating cell uptake and subcellular localization of the radiolabeled peptides were performed using human colorectal adenocarcinoma HT29 cells. In vivo PET/CT imaging was used to determine the distribution and clearance of the peptide in mice bearing NTSR1 expressing HT29 tumors. Results: Cell uptake studies showed that the highest uptake was obtained with [55Co] Co-NOTA-NT-20.3 (18.70 ± 1.30%ID/mg), followed by [64Cu] Cu-NOTA-NT-20.3 (15.46 ± 0.91%ID/mg), and lastly [68Ga] Ga-NOTA-NT-20.3 (10.94 ± 0.46%ID/mg) (p < 0.001). Subcellular distribution was similar across the three constructs, with the membranous fraction containing the highest amount of radioactivity. In vivo PET/CT imaging of the three constructs revealed similar distribution and tumor uptake at the 1 h imaging timepoint. Tumor uptake was receptor-specific and blockable by co-injection of non-radiolabeled NOTA-NT-20.3. SUV ratios of tumor to heart at the 24 h imaging timepoint show that [55Co] Co-NOTA-NT-20.3 (20.28 ± 3.04) outperformed [64Cu] Cu-NOTA-NT-20.3 (6.52 ± 1.97). In conclusion, our studies show that enhanced cell uptake and increasing tumor to blood ratios over time displayed the superiority of [55Co] Co-NOTA-NT-20.3 over [68Ga] Ga-NOTA-NT-20.3 and [64Cu] Cu-NOTA-NT-20.3 for the targeting of NTSR1.
    Language English
    Publishing date 2022-12-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122724
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  8. Article ; Online: Development of an Engineered Single-Domain Antibody for Targeting MET in Non-Small Cell Lung Cancer.

    Luo, Natalie Y / Minne, Rachel L / Gallant, Joseph P / Gunaratne, Gihan S / West, Jayden L / Javeri, Saahil / Robertson, Austin J / Lake, Eric W / Engle, Jonathan W / Mixdorf, Jason C / Aluicio-Sarduy, Eduardo / Nickel, Kwang P / Hernandez, Reinier / Kimple, Randall J / Baschnagel, Andrew M / LeBeau, Aaron M

    Bioconjugate chemistry

    2024  Volume 35, Issue 3, Page(s) 389–399

    Abstract: The Mesenchymal Epithelial Transition (MET) receptor tyrosine kinase is upregulated or mutated in 5% of non-small-cell lung cancer (NSCLC) patients and overexpressed in multiple other cancers. We sought to develop a novel single-domain camelid antibody ... ...

    Abstract The Mesenchymal Epithelial Transition (MET) receptor tyrosine kinase is upregulated or mutated in 5% of non-small-cell lung cancer (NSCLC) patients and overexpressed in multiple other cancers. We sought to develop a novel single-domain camelid antibody with high affinity for MET that could be used to deliver conjugated payloads to MET expressing cancers. From a naïve camelid variable-heavy-heavy (VHH) domain phage display library, we identified a VHH clone termed 1E7 that displayed high affinity for human MET and was cross-reactive with MET across multiple species. When expressed as a bivalent human Fc fusion protein, 1E7-Fc was found to selectively bind to EBC-1 (MET amplified) and UW-Lung 21 (MET exon 14 mutated) cell lines by flow cytometry and immunofluorescence imaging. Next, we investigated the ability of [
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Single-Domain Antibodies ; Lung Neoplasms/pathology ; Positron-Emission Tomography/methods ; Positron Emission Tomography Computed Tomography ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Cell Line, Tumor
    Chemical Substances Single-Domain Antibodies ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00019
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  9. Article ; Online: "Off-Label Use" of the Siderophore Enterobactin Enables Targeted Imaging of Cancer with Radioactive Ti

    Koller, Angus J / Glaser, Owen / DeLuca, Molly C / Motz, Rachel N / Amason, Edith K / Carbo-Bague, Imma / Mixdorf, Jason C / Guzei, Ilia A / Aluicio-Sarduy, Eduardo / Śmiłowicz, Dariusz / Barnhart, Todd E / Ramogida, Caterina F / Nolan, Elizabeth M / Engle, Jonathan W / Boros, Eszter

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 18, Page(s) e202319578

    Abstract: The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting ... ...

    Abstract The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting radionuclide
    MeSH term(s) Humans ; Male ; Animals ; Mice ; Siderophores/chemistry ; Enterobactin/metabolism ; Titanium/chemistry ; Off-Label Use ; Prostatic Neoplasms/metabolism ; Radioisotopes
    Chemical Substances Siderophores ; Enterobactin (28384-96-5) ; Titanium (D1JT611TNE) ; Radioisotopes
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202319578
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  10. Article ; Online: Cyclotron-Produced

    Aluicio-Sarduy, Eduardo / Barnhart, Todd E / Weichert, Jamey / Hernandez, Reinier / Engle, Jonathan W

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 62, Issue 7, Page(s) 1012–1015

    Abstract: The aim of this work was to ... ...

    Abstract The aim of this work was to explore
    MeSH term(s) Cell Line, Tumor ; Cyclotrons ; Humans ; Positron Emission Tomography Computed Tomography ; Tissue Distribution
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.255794
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    Zs.MO 328: Show issues

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