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  1. Article: A simple thermal-detoxified method for castor bean (Ricinus communis L.) cake, and its potential nutraceutical properties

    Herrera, Mayra Denise / Jiménez-Ocampo, Rafael / Rosales-Serna, Rigoberto / Rodríguez-González, Jorge Alberto / Santos-De la Cruz, Juan Luis / Cruz-Bravo, Raquel Karina / Alvarado-Aguilar, Pablo / Gamboa-Gómez, Claudia Ivette / Guerrero-Romero, Fernando

    Industrial crops and products. 2021 Dec. 15, v. 174

    2021  

    Abstract: In order to search viable alternatives for detoxifying the castor bean toxic waste, and harnessing for diverse applications, the objective of this study was evaluate the thermal-detoxified method and determinate the castor bean cake nutraceutical ... ...

    Abstract In order to search viable alternatives for detoxifying the castor bean toxic waste, and harnessing for diverse applications, the objective of this study was evaluate the thermal-detoxified method and determinate the castor bean cake nutraceutical potential properties. Autoclaving (15 psi, 15 min, 121 ° C) process in presence of humidity (30 %) was performed as detoxified method. Presence of ricin was evaluated using ELISA and the castor bean cake lethal dose (LD₅₀) determinate by acute toxicity assay in male Wistar rats. Additionally, the castor bean cake chemical and phytochemical characterization was evaluated and its nutraceutical potential determinate throughout antioxidant and hypoglycemic effects. The results showed that after the thermal-detoxified treatment, ricin concentration decreased over 99 %, and the castor bean cake LD₅₀ was greater than 5000 mg/kg of body weight. After detoxified process, protein content increases 17.5 % and lipids decreases 10 %. In addition, a greater content of insoluble fraction (13 %) and 2.6-fold times more of resistant starch, as compared to un-detoxified cake, was observed. Furthermore, in comparison with untreated cake, thermal process led to an upsurge of gallic acid (3.5-fold times) and 4-O- caffeoylquinic acid (8.8-fold times). About nutraceutical potential properties, a lower antioxidant capacity and a hypoglycemic effect, in comparison with the control, were observed. The thermal-detoxified method eliminates ricin of castor bean cake, providing to be a potential source of proteins, lipids, fiber, and bioactive compounds as well as exhibiting antioxidant and hypoglycemic effects.
    Keywords Ricinus communis ; acute toxicity ; antioxidant activity ; antioxidants ; autoclaving ; body weight ; cakes ; castor bean cake ; castor beans ; chlorogenic acid ; dietary supplements ; gallic acid ; glycemic effect ; humidity ; males ; phytochemicals ; protein content ; resistant starch ; ricin ; wastes
    Language English
    Dates of publication 2021-1215
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2021.114151
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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  2. Article ; Online: Inhibitory effect of Mexican oregano (Lippia graveolens Kunth) extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo.

    Gamboa-Gómez, Claudia I / Denise-Herrera, Mayra / Simental-Mendía, Luis E / Zamilpa-Alvarez, Alejandro / González-Cortazar, Manasés / Martínez-Aguilar, Gerardo / Alvarado-Aguilar, Pablo / Morales-Castro, Elisa P / Ávila-Soto, José A / Amador-Herrera, Juan A / Guerrero-Romero, Fernando

    Journal of ethnopharmacology

    2022  Volume 297, Page(s) 115527

    Abstract: Ethnopharmacological relevance: Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed.: Aim of the study: Assess the effect of Mexican oregano (Lippia ... ...

    Abstract Ethnopharmacological relevance: Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed.
    Aim of the study: Assess the effect of Mexican oregano (Lippia graveolens Kunth) on carbohydrates and lipids absorption in vivo. The antioxidant activity also was investigated.
    Materials and methods: Enzymatic inhibitory action of lipase, α-amylase, and α-glucosidase was evaluated in vitro. Oral lipid (OLTT) and starch tolerance tests (OSTT) were conducted with L. graveolens acetone (O-A) and ethanol (O-E) extracts (at 102 mg/kg body weight equivalent to a 1 g human doses) in male Wistar rats. The antioxidant activity was evaluated through inhibition of lipid peroxidation and scavenging radical.
    Results: Both extracts exhibited higher inhibitory median concentration (IC
    Conclusions: Both extracts reduce lipid absorption; whereas O-E decreases carbohydrate absorption in vivo. Both extracts inhibit lipid peroxidation and scavenging free radicals in vitro.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Carbohydrates ; Humans ; Lipase ; Lipids ; Lippia/chemistry ; Male ; Origanum/chemistry ; Plant Extracts/chemistry ; Rats ; Rats, Wistar ; Starch ; alpha-Amylases ; alpha-Glucosidases
    Chemical Substances Antioxidants ; Carbohydrates ; Lipids ; Plant Extracts ; Starch (9005-25-8) ; Lipase (EC 3.1.1.3) ; alpha-Amylases (EC 3.2.1.1) ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2022-07-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Inhibitory effect of Mexican oregano (Lippia graveolens Kunth) extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo

    Gamboa-Gómez, Claudia I. / Denise-Herrera, Mayra / Simental-Mendía, Luis E. / Zamilpa-Alvarez, Alejandro / González-Cortazar, Manasés / Martínez-Aguilar, Gerardo / Alvarado-Aguilar, Pablo / Morales-Castro, Elisa P. / Ávila-Soto, José A. / Amador-Herrera, Juan A. / Guerrero-Romero, Fernando

    Journal of ethnopharmacology. 2022 Oct. 28, v. 297

    2022  

    Abstract: Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed. Assess the effect of Mexican oregano (Lippia graveolens Kunth) on carbohydrates and lipids absorption in ...

    Abstract Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed. Assess the effect of Mexican oregano (Lippia graveolens Kunth) on carbohydrates and lipids absorption in vivo. The antioxidant activity also was investigated. Enzymatic inhibitory action of lipase, α-amylase, and α-glucosidase was evaluated in vitro. Oral lipid (OLTT) and starch tolerance tests (OSTT) were conducted with L. graveolens acetone (O-A) and ethanol (O-E) extracts (at 102 mg/kg body weight equivalent to a 1 g human doses) in male Wistar rats. The antioxidant activity was evaluated through inhibition of lipid peroxidation and scavenging radical. Both extracts exhibited higher inhibitory median concentration (IC₅₀) of lipase activity (1.9 μg/μL for O-E and 1.8 μg/μL for O-A) than the positive control (Orlistat) (0.07 μg/μL). The IC₅₀ of α-amylase was higher (41.8 μg/μL for O-E and 25.2 μg/μL for O-A) than the Acarbose (2.5 μg/μL); while α-glucosidase results showed not statistically differences between groups (∼1.7 μg/μL). The OLTT results showed that both extracts significantly reduced serum triglycerides (∼147 mg/dL for O-E and ∼155 mg/dL for O-A) as compared with negative control group (only lipid load). In the OSTT, glucose levels showed a significant decrease (∼31 mg/dL for O-E and ∼17 mg/dL for O-A) than the negative control group (only starch load). About in vitro antioxidant evaluation, not statistically differences between extracts and positive control (Trolox) were observed for scavenged free radicals (∼2.0 μg/μL); whereas O-A inhibited lipid peroxidation similar to the Trolox (∼0.8 μg/μL IC₅₀). The main chemical composition of both extracts was coumaric acid, luteolin, rutinoside, naringenin, and carvacrol. Both extracts reduce lipid absorption; whereas O-E decreases carbohydrate absorption in vivo. Both extracts inhibit lipid peroxidation and scavenging free radicals in vitro.
    Keywords Lippia graveolens ; absorption ; acarbose ; acetone ; alpha-amylase ; antioxidant activity ; blood serum ; body weight ; carboxylic ester hydrolases ; carvacrol ; chemical composition ; coumaric acids ; ethanol ; glucose ; humans ; lipid peroxidation ; luteolin ; males ; naringenin ; rutin ; starch ; traditional medicine
    Language English
    Dates of publication 2022-1028
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115527
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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