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Article: Pharmacogenetics of HIV therapy: State of the art in Latin American countries.

Velozo, Camila de Almeida / Lamarão, Flávia Rachel Moreira / Alvarado-Arnez, Lucia Elena / Cardoso, Cynthia Chester

2022 Volume 45, Issue 3 Suppl 1, Page(s) e20220120

Abstract: The use of combined antiretroviral therapy (cART) has resulted in a remarkable reduction in morbidity and mortality of people living with HIV worldwide. Nevertheless, interindividual variations in drug response often impose a challenge to cART ... ...

Abstract	The use of combined antiretroviral therapy (cART) has resulted in a remarkable reduction in morbidity and mortality of people living with HIV worldwide. Nevertheless, interindividual variations in drug response often impose a challenge to cART effectiveness. Although personalized therapeutic regimens may help overcome incidence of adverse reactions and therapeutic failure attributed to host factors, pharmacogenetic studies are often restricted to a few populations. Latin American countries accounted for 2.1 million people living with HIV and 1.4 million undergoing cART in 2020-21. The present review describes the state of art of HIV pharmacogenetics in this region and highlights that such analyses remain to be given the required relevance. A broad analysis of pharmacogenetic markers in Latin America could not only provide a better understanding of genetic structure of these populations, but might also be crucial to develop more informative dosing algorithms, applicable to non-European populations.
Language	English
Publishing date	2022-09-30
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1445712-x
ISSN	1678-4685 ; 1415-4757
ISSN (online)	1678-4685
ISSN	1415-4757
DOI	10.1590/1678-4685-GMB-2022-0120
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Article ; Online: Correction: Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.

Leturiondo, André Luiz / Noronha, Ariani Batista / Mendonça, Carla Yael Ribeiro / Ferreira, Cynthia de Oliveira / Alvarado-Arnez, Lucia Elena / Manta, Fernanda Saloum de Neves / Bezerra, Ohanna Cavalcanti de Lima / Carvalho, Elizeu Fagundes de / Moraes, Milton Ozório / Rodrigues, Fabíola da Costa / Talhari, Carolina

PLoS neglected tropical diseases

2023 Volume 17, Issue 3, Page(s) e0011228

Abstract: This corrects the article DOI: 10.1371/journal.pntd.0008247.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pntd.0008247.].
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011228
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Article ; Online: Research on

Rodriguez-Morales, Alfonso J / Bonilla-Aldana, D Katterine / Escalera-Antezana, Juan Pablo / Alvarado-Arnez, Lucia Elena

F1000Research

2018 Volume 7, Page(s) 1987

Abstract: Given the emergence and reemergence of tick-borne diseases, here we assessed the publishing patterns of research focused ... ...

Abstract	Given the emergence and reemergence of tick-borne diseases, here we assessed the publishing patterns of research focused on
MeSH term(s)	Animals ; Babesia/isolation & purification ; Babesiosis/parasitology ; Babesiosis/transmission ; Bibliometrics ; Biomedical Research ; Host-Parasite Interactions ; Humans ; Tick Infestations/parasitology ; Tick-Borne Diseases/epidemiology ; Ticks/parasitology
Language	English
Publishing date	2018-12-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.17581.2
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Article ; Online: Fatal Zika virus disease in adults: A critical reappraisal of an under-recognized clinical entity.

Rodríguez-Morales, Alfonso J / Ramírez-Vallejo, Eduardo / Alvarado-Arnez, Lucia Elena / Paniz-Mondolfi, Alberto / Zambrano, Lysien I / Ko, Albert I

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2019 Volume 83, Page(s) 160–162

Language	English
Publishing date	2019-03-09
Publishing country	Canada
Document type	Editorial
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2019.03.002
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Article ; Online: Sexual transmission of arboviruses: More to explore?

Cardona-Ospina, Jaime Andrés / Alvarado-Arnez, Lucia Elena / Escalera-Antezana, Juan Pablo / Bandeira, Antonio C / Musso, Didier / Rodríguez-Morales, Alfonso J

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2018 Volume 76, Page(s) 126–127

Language	English
Publishing date	2018-09-07
Publishing country	Canada
Document type	Letter
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2018.08.022
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Article ; Online: Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.

PLoS neglected tropical diseases

2020 Volume 14, Issue 5, Page(s) e0008247

Abstract: Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these ...

Abstract	Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through independent replication studies in different ethnicities. The population from Amazon state (northern Brazil) is admixed and it contains the highest proportion of Native American genetic ancestry in Brazil. We conducted a case-control study for leprosy in which we tested fourteen previously associated SNPs in key immune response regulating genes: TLR1 (rs4833095), NOD2 (rs751271, rs8057341), TNF (rs1800629), IL10 (rs1800871), CCDC122/LACC1 (rs4942254), PACRG/PRKN (rs9356058, rs1040079), IFNG (rs2430561), IL6 (rs2069845), LRRK2 (rs7298930, rs3761863), IL23R (rs76418789) and TYK2 (rs55882956). Genotyping was carried out by allelic discrimination in 967 controls and 412 leprosy patients. Association with susceptibility was assessed by logistic regression analyses adjusted for the following covariates: gender, age and ancestry. Genetic ancestry was similar in case and control groups. Statistically significant results were only found for IFNG and NOD2. The rs8057341 polymorphism within NOD2 was identified as significant for the AA genotype (OR = 0.56; 95% CI, 0.37-0.84; P = 0.005) and borderline for the A allele (OR = 0.76; 95% CI, 0.58-1.00; P = 0.053) and carrier (OR = 0.76; 95% CI, 0.58-1.00; P = 0.051). The rs2430561 SNP in IFNG was associated with disease susceptibility for the AT genotype (OR = 1.40; 95% CI, 1.06-1.85; P = 0.018) and carrier (OR = 1.44; 95% CI, 1.10-1.88; P = 0.008). We confirmed that NOD2 and IFNG are major players in immunity against M.leprae in the Amazon ethnic admixed population.
MeSH term(s)	Adult ; Aged ; Brazil ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genotyping Techniques ; Humans ; Interferon-gamma/genetics ; Leprosy/genetics ; Male ; Middle Aged ; Nod2 Signaling Adaptor Protein/genetics ; Polymorphism, Single Nucleotide ; Young Adult
Chemical Substances	IFNG protein, human ; NOD2 protein, human ; Nod2 Signaling Adaptor Protein ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0008247
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Article: Risk factors for mortality in patients with Coronavirus Disease 2019 (COVID-19) in Bolivia: An analysis of the first 107 confirmed cases.

Escalera-Antezana, Juan Pablo / Lizon-Ferrufino, Nicolas Freddy / Maldonado-Alanoca, Americo / Alarcon-De-la-Vega, Gricel / Alvarado-Arnez, Lucia Elena / Balderrama-Saavedra, Maria Alejandra / Bonilla-Aldana, D Katterine / Rodriguez-Morales, Alfonso J

Le infezioni in medicina

2020 Volume 28, Issue 2, Page(s) 238–242

Abstract: The present study is aimed to assess the risk factors for mortality in the first 107 rRT-PCR confirmed cases of SARS-CoV-2 infections in Bolivia. For this observational, retrospective and cross-sectional study, the epidemiological data records were ... ...

Abstract	The present study is aimed to assess the risk factors for mortality in the first 107 rRT-PCR confirmed cases of SARS-CoV-2 infections in Bolivia. For this observational, retrospective and cross-sectional study, the epidemiological data records were collected from the Hospitals and the Ministry of Health of Bolivia, obtaining the clinical and epidemiological data of the COVID-19 cases that were laboratory-diagnosed during March 2-29, 2020. Samples were tested by rRT-PCR to SARS-CoV-2 at the Laboratory of the National Center of Tropical Diseases (CENETROP), following the protocol Charite, Berlin, Germany. The odds ratio (OR) with respective 95% confidence interval (95%CI) for mortality as dependent variable was calculated. When we comparatively analyzed survivors and non-survivors in this first group of 107 cases in Bolivia, we found that at bivariate analyses, age (±60 years old), hypertension, chronic heart failure, diabetes, and obesity, as well as the requirement of ICU, were significantly exposure variables associated with death. At the multivariate analysis (logistic regression), two variables remained significantly associated, age, ±60 years-old (OR=9.4, 95%CI 1.8-104.1) and hypertension (OR=3.3, 95%CI 1.3-6.3). As expected, age and comorbidities, particularly hypertension, were independent risk factors for mortality in Bolivia in the first 107 cases group. More further studies are required to better define risk factors and preventive measures related to COVID-19 in this and other Latin American countries.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Betacoronavirus ; Bolivia/epidemiology ; COVID-19 ; Child ; Confidence Intervals ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Cross-Sectional Studies ; Diabetes Complications/mortality ; Female ; Heart Failure/mortality ; Humans ; Hypertension/mortality ; Male ; Middle Aged ; Obesity/mortality ; Odds Ratio ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Regression Analysis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Sex Distribution ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-06-02
Publishing country	Italy
Document type	Journal Article ; Observational Study
ZDB-ID	2041081-5
ISSN	1124-9390
ISSN	1124-9390
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Article ; Online: Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain.

Escalera-Antezana, Juan Pablo / Lizon-Ferrufino, Nicolas Freddy / Maldonado-Alanoca, Americo / Alarcón-De-la-Vega, Gricel / Alvarado-Arnez, Lucia Elena / Balderrama-Saavedra, María Alejandra / Bonilla-Aldana, D Katterine / Rodríguez-Morales, Alfonso J

Travel medicine and infectious disease

2020 Volume 35, Page(s) 101653

Abstract: Introduction: In March 2020, Coronavirus Disease 2019 (COVID-19) arrived in Bolivia. Here, we report the main clinical findings, and epidemiological features of the first series of cases, and a cluster, confirmed in Bolivia.: Methods: For this ... ...

Abstract	Introduction: In March 2020, Coronavirus Disease 2019 (COVID-19) arrived in Bolivia. Here, we report the main clinical findings, and epidemiological features of the first series of cases, and a cluster, confirmed in Bolivia. Methods: For this observational, retrospective and cross-sectional study, information was obtained from the Hospitals and the Ministry of Health for the cases that were laboratory-diagnosed and related, during March 2020. rRT-PCR was used for the detection of the RNA of SARS-CoV-2 following the protocol Charité, Berlin, Germany, from nasopharyngeal swabs. Results: Among 152 suspected cases investigated, 12 (7.9%) were confirmed with SARS-CoV-2 infected by rRT-PCR. The median age was 39 years (IQR 25-43), six of them male. Two cases proceed from Italy and three from Spain. Nine patients presented fever, and cough, five sore throat, and myalgia, among other symptoms. Only a 60 y-old woman with hypertension was hospitalized. None of the patients required ICU nor fatalities occurred in this group. Conclusions: This is the first report of surveillance of COVID-19 in Bolivia, with patients managed mainly with home isolation. Preparedness for a significant epidemic, as is going on in other countries, and the deployment of response plans for it, in the country is now taking place to mitigate the impact of the COVID-19 pandemic in the population.
MeSH term(s)	Adolescent ; Adult ; Betacoronavirus/genetics ; Bolivia/epidemiology ; COVID-19 ; Cluster Analysis ; Communicable Diseases, Imported/epidemiology ; Communicable Diseases, Imported/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Cough ; Cross-Sectional Studies ; Epidemiological Monitoring ; Female ; Fever ; Humans ; Italy ; Male ; Middle Aged ; Pandemics ; Patient Isolation/methods ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; RNA, Viral/genetics ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Spain ; Young Adult
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-04-02
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2020.101653
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Article ; Online: Clinical features of fatal cases of Chapare virus hemorrhagic fever originating from rural La Paz, Bolivia, 2019: A cluster analysis.

Escalera-Antezana, Juan Pablo / Rodriguez-Villena, Omar J / Arancibia-Alba, Ariel Weimar / Alvarado-Arnez, Lucia Elena / Bonilla-Aldana, D Katterine / Rodríguez-Morales, Alfonso J

Travel medicine and infectious disease

2020 Volume 36, Page(s) 101589

Abstract: Introduction: In 2003 an emerging mammarenavirus (formerly arenaviruses) was discovered in Bolivia and named Chapare (CHAPV). It was associated with severe and fatal hemorrhagic fever, being similar in clinical features to Machupo (MACV). In mid-2019, ... ...

Abstract	Introduction: In 2003 an emerging mammarenavirus (formerly arenaviruses) was discovered in Bolivia and named Chapare (CHAPV). It was associated with severe and fatal hemorrhagic fever, being similar in clinical features to Machupo (MACV). In mid-2019, CHAPV was the cause of a cluster of five cases, two of them laboratory confirmed, three of them fatal. Here, we report the main clinical findings, epidemiological features and the potential ecological aspects, of that cluster of cases in rural La Paz, Bolivia. Methods: For this observational, retrospective and cross-sectional study, information was obtained from the Hospitals and the Ministry of Health for the cases that were laboratory-diagnosed and related, during 2019. RT-PCR was used for the detection of the RNA of CHAPV in the blood samples. Results: Two cases were RT-PCR + for CHAPV. The median age of patients was 42 y-old (IQR 25-45), four out of five were male. All patients were hospitalized, admitted to the ICU and had fever, upper digestive hemorrhage, with two of them, presenting ARDS, and requiring mechanical ventilation. Three patients died (case fatality rate, CFR 60%). Conclusions: Mammarenaviruses led to a high fatality rate. These cases occurred in areas with suitable ecoepidemiological conditions for rodent-borne diseases, including CHAPV infection. Socioenvironmental and occupational factors in rural areas of Bolivia may contribute with the risk of zoonotic spillover and transmission to humans.
MeSH term(s)	Arenaviruses, New World ; Bolivia/epidemiology ; Cluster Analysis ; Cross-Sectional Studies ; Hemorrhagic Fever, American/epidemiology ; Humans ; Male ; Retrospective Studies
Language	English
Publishing date	2020-02-17
Publishing country	Netherlands
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2020.101589
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Article ; Online: Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A.

Azamor, Tamiris / da Silva, Andréa Marques Vieira / Melgaço, Juliana Gil / Dos Santos, Ana Paula / Xavier-Carvalho, Caroline / Alvarado-Arnez, Lucia Elena / Batista-Silva, Leonardo Ribeiro / de Souza Matos, Denise Cristina / Bayma, Camilla / Missailidis, Sotiris / Ano Bom, Ana Paula Dinis / Moraes, Milton Ozorio / da Costa Neves, Patrícia Cristina

Viruses

2021 Volume 13, Issue 1

Abstract: The yellow fever vaccine (YF17DD) is highly effective with a single injection conferring protection for at least 10 years. The YF17DD induces polyvalent responses, with a TH1/TH2 ... ...

Abstract	The yellow fever vaccine (YF17DD) is highly effective with a single injection conferring protection for at least 10 years. The YF17DD induces polyvalent responses, with a TH1/TH2 CD4
MeSH term(s)	Adult ; Animals ; Female ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity ; Immunogenicity, Vaccine ; Interferon-gamma/metabolism ; Lectins, C-Type/genetics ; Male ; Middle Aged ; Polymorphism, Genetic ; Receptors, Cell Surface/genetics ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Vaccination ; Yellow Fever/etiology ; Yellow Fever/prevention & control ; Yellow Fever Vaccine/immunology ; Young Adult
Chemical Substances	CLEC5A protein, human ; Lectins, C-Type ; Receptors, Cell Surface ; Yellow Fever Vaccine ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13010096
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