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  1. Book ; Online: Infraestructuras de transporte y disputas territoriales

    Alvarez, Álvaro

    la IIRSA en Santa Fe

    2021  

    Keywords Transport: general interest ; Transportation Studies
    Language Spanish
    Size 1 Online-Ressource
    Publisher CLACSO
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030609269
    ISBN 9789877229851 ; 9877229854
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Combination therapy as a first step of treatment in diabetes: Changing the paradigm in KDIGO guidelines?

    Robles, Nicolás Roberto / Alvarez, Alvaro / Fici, Francesco

    European journal of internal medicine

    2023  Volume 111, Page(s) 21–23

    MeSH term(s) Humans ; Diabetes Mellitus/drug therapy ; Combined Modality Therapy ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Plasticity in the Functional Properties of NMDA Receptors Improves Network Stability during Severe Energy Stress.

    Bueschke, Nikolaus / Amaral-Silva, Lara / Hu, Min / Alvarez, Alvaro / Santin, Joseph M

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  Volume 44, Issue 9

    Abstract: Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brainstem switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia ... ...

    Abstract Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brainstem switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia as they emerge from hibernation. NMDA receptors (NMDARs) are Ca
    MeSH term(s) Humans ; Female ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/physiology ; Hypoxia ; Neuronal Plasticity/physiology
    Chemical Substances Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0502-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Racial disparities in overall survival after the introduction of cyclin-dependent kinase 4/6 inhibitors for patients with hormone receptor-positive, HER2-negative metastatic breast cancer.

    Alvarez, Alvaro / Bernal, Ana M / Anampa, Jesus

    Breast cancer research and treatment

    2022  Volume 198, Issue 1, Page(s) 75–88

    Abstract: Purpose: CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy have improved HR + /HER2- metastatic breast cancer (MBC) outcomes. However, it is still unclear whether the response to CDK4/6i is similar for all races. Therefore, we aimed to assess ... ...

    Abstract Purpose: CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy have improved HR + /HER2- metastatic breast cancer (MBC) outcomes. However, it is still unclear whether the response to CDK4/6i is similar for all races. Therefore, we aimed to assess overall survival (OS) trends stratified by race in patients with HR + /HER2- MBC after the approval of CDK4/6i, as part of the standard of care, in 2015.
    Methods: We performed a population-based study using the SEER database. Patients with HR + /HER2- MBC were divided into two time-based cohorts: 1) pre-CDK4/6i era (diagnosed in 2011-2013) and 2) post-CDK4/6i era (diagnosed in 2015-2017). We used propensity score matching and identified 2,684 patients in each cohort that matched in several characteristics. Kaplan-Meier methods were used to estimate 2-year OS. Association between cohort and OS was evaluated using marginal Cox proportional hazards models with robust sandwich variance estimator. We conducted competing risk analysis to estimate the risk of breast cancer death in both cohorts.
    Results: The 2-year OS rate was 65% for the post-CDK4/6i era and 62% for the pre-CDK4/6i era (stratified log-rank p = 0.025). The 2-year OS for non-Hispanic White (NHW) patients improved in the post-CDK4/6i era compared to the pre-CDK4/6i era (67% vs. 63%, p = 0.033). However, OS did not improve for non-Hispanic Black (NHB) (54% vs. 54%, p = 0.876) or Hispanic (67% vs. 65%, p = 0.617) groups. The risk of breast cancer death decreased in the post-CDK4/6i era as compared to the pre-CDK4/6i era (2-year risk of breast cancer death: 33% vs. 30%, p = 0.015); however, this effect was observed only in NHW (sHR 0.84, p = 0.005) women, but not in NHB (sHR 0.94, p = 0.630) or Hispanic (sHR 0.91, p = 0.550) women.
    Conclusions: Our study confirms that outcomes for HR + /HER2- MBC have improved after CDK4/6i were introduced in 2015. However, this effect is primarily driven by the improved OS in NHW patients, without significant improvement in OS in NHB or Hispanics.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/pathology ; Cyclin-Dependent Kinase 4 ; Ethnicity ; Hispanic or Latino ; Proportional Hazards Models
    Chemical Substances Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; CDK4 protein, human (EC 2.7.11.22) ; CDK6 protein, human (EC 2.7.11.22) ; ERBB2 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-12-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-022-06847-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Plasticity in the functional properties of NMDA receptors improves network stability during severe energy stress.

    Bueschke, Nikolaus / Amaral-Silva, Lara / Hu, Min / Alvarez, Alvaro / Santin, Joseph M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brainstem switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia ... ...

    Abstract Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brainstem switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia as they emerge from hibernation. NMDA receptors (NMDARs) are Ca
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.19.524811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Racial disparities in treatment and outcomes between non-Hispanic Black and non-Hispanic White women with nonmetastatic inflammatory breast cancer.

    Carbajal-Ochoa, Walter H / Johnson, Devin / Alvarez, Alvaro / Bernal, Ana M / Anampa, Jesus D

    Breast cancer research and treatment

    2023  Volume 201, Issue 2, Page(s) 275–287

    Abstract: Purpose: The incidence rate of inflammatory breast cancer (IBC) is higher among non-Hispanic Black (NHB) than non-Hispanic White (NHW) women. We examined the differences in treatment and outcomes between NHB and NHW women with IBC, accounting for ... ...

    Abstract Purpose: The incidence rate of inflammatory breast cancer (IBC) is higher among non-Hispanic Black (NHB) than non-Hispanic White (NHW) women. We examined the differences in treatment and outcomes between NHB and NHW women with IBC, accounting for demographic, clinicopathological, and socioeconomic factors.
    Methods: We collected data from the Surveillance, Epidemiology, and End Results database for NHB and NHW women with IBC diagnosed between 2010-2016. We analyzed the odds of receiving chemotherapy, radiation, and surgery between NHB and NHW women. We evaluated overall survival (OS) with Kaplan-Meier methods and Cox proportional hazards methods. Competing risk analysis was used to compare the risk of breast cancer death between NHB and NHW women. We also evaluated the magnitude of survival disparities within the strata of demographic, socioeconomic, and treatment factors.
    Results: Among 1,652 NHW and 371 NHB women with IBC, the odds of receiving chemotherapy, surgery, and radiation were similar for NHB and NHW. After 39-month follow-up, the median OS was 40 and 81 months for NHB and NHW, respectively (p < 0.0001). The risk of breast cancer death was higher for NHB than NHW women (5-year risk of breast cancer death, 51% vs. 35%, p < 0.0001).
    Conclusion: After adjustment for demographic, clinicopathological, and socioeconomic factors; NHB women with IBC had similar odds of receiving surgery, chemotherapy, and radiation therapy, but were more likely to die of the disease compared to their NHW counterparts. Our findings suggest the presence of masked tumor biology, treatment, or socioeconomic factors associated with race that can lead to worse IBC outcomes.
    MeSH term(s) Female ; Humans ; Black or African American ; Breast Neoplasms/epidemiology ; Breast Neoplasms/ethnology ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Inflammatory Breast Neoplasms/epidemiology ; Inflammatory Breast Neoplasms/ethnology ; Inflammatory Breast Neoplasms/mortality ; Inflammatory Breast Neoplasms/therapy ; Treatment Outcome ; White People ; Healthcare Disparities/ethnology ; Healthcare Disparities/statistics & numerical data ; United States/epidemiology ; SEER Program/statistics & numerical data ; Survival Analysis ; Risk
    Language English
    Publishing date 2023-07-13
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-07018-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply. Residency training in Fontcalent Prison Psychiatric Hospital.

    Muro Álvarez, Álvaro

    Revista española de sanidad penitenciaria

    2016  Volume 18, Issue 1, Page(s) 37

    MeSH term(s) Hospitals, Psychiatric ; Humans ; Internship and Residency ; Prisons
    Language English
    Publishing date 2016
    Publishing country Spain
    Document type Comment ; Letter
    ZDB-ID 2424262-7
    ISSN 2013-6463 ; 1575-0620
    ISSN (online) 2013-6463
    ISSN 1575-0620
    DOI 10.4321/S1575-06202016000100007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Racial disparities in neutrophil counts among patients with metastatic breast cancer during treatment with CDK4/6 inhibitors.

    Schreier, Ashley / Munoz-Arcos, Laura / Alvarez, Alvaro / Sparano, Joseph A / Anampa, Jesus D

    Breast cancer research and treatment

    2022  Volume 194, Issue 2, Page(s) 337–351

    Abstract: Purpose: The three CDK4/6 inhibitors (CDK4/6i) approved for use in HR-positive/HER2-negative metastatic breast cancer (MBC), palbociclib, ribociclib, and abemaciclib, are generally well tolerated; however, neutropenia is a common toxicity. Within the ... ...

    Abstract Purpose: The three CDK4/6 inhibitors (CDK4/6i) approved for use in HR-positive/HER2-negative metastatic breast cancer (MBC), palbociclib, ribociclib, and abemaciclib, are generally well tolerated; however, neutropenia is a common toxicity. Within the general population, neutropenia has been shown to be more common in individuals of African descent. The landmark CDK4/6i trials in MBC lacked racial diversity in their patient populations. We aimed to assess the toxicity profiles of CDK4/6is in a racially diverse population.
    Methods: We conducted a retrospective study at Montefiore Medical Center in patients with HR-positive/HER2-negative MBC prescribed CDK4/6i as first or subsequent line therapy between January 2015 and April 2020. Baseline characteristics and laboratory data at various treatment timepoints were collected.
    Results: The final analysis included 182 patients, of whom 46% were Black. Baseline absolute neutrophil count (ANC) was lower in the Black vs. Non-Black cohort (p = 0.001) but the change in ANC from baseline (delta-ANC) was smaller in the Black cohort, and the ANC at different treatment timepoints was similar between groups. There was no difference in the rate of infection or number of dose delays/reductions between racial groups. We did not find any difference in PFS between Black and Non-Black groups, regardless of the presence of CDK4/6i-induced neutropenia.
    Conclusion: We analyzed toxicity profiles of 182 patients with HR-positive/HER2-negative MBC treated with CDK4/6i. Despite the lower baseline ANC seen in our Black cohort, treatment toxicities were similar between racial groups. Long-term outcomes with CDK4/6i therapy, measured by PFS, were similar between Black vs. Non-Black patients.
    MeSH term(s) Breast Neoplasms/pathology ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Female ; Humans ; Neutropenia/chemically induced ; Neutropenia/drug therapy ; Neutropenia/epidemiology ; Neutrophils/pathology ; Protein Kinase Inhibitors/adverse effects ; Racial Groups ; Retrospective Studies
    Chemical Substances Protein Kinase Inhibitors ; CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2022-05-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-022-06574-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Electron-phonon mediated superconductivity in R$_6$Ni$_5$O$_{12}$ nickel oxides

    Alvarez, Alvaro Adrian Carrasco / Petit, Sebastien / Iglesias, Lucia / Bibes, Manuel / Prellier, Wilfrid / Varignon, Julien

    2023  

    Abstract: Nickel oxide superconductors offer an alternative playground for understanding the formation of Cooper pairs in correlated materials such as the famous cuprates. By studying the La$_{n+1}$Ni$_n$O$_{2n+2}$ phase diagram on the basis of hybrid and spin- ... ...

    Abstract Nickel oxide superconductors offer an alternative playground for understanding the formation of Cooper pairs in correlated materials such as the famous cuprates. By studying the La$_{n+1}$Ni$_n$O$_{2n+2}$ phase diagram on the basis of hybrid and spin-polarized density functional theory simulations, we reveal the existence of charge and bond ordered (CBO) insulating phases that are quenched by doping effects, ultimately resulting in a metallic phase at the $n=5$ member. Nevertheless, the phonons associated with the CBO identified in the phase diagram remain sufficiently large to mediate Cooper pairs in La$_6$Ni$_5$O$_{12}$, yielding a computed critical temperature between $T_c=11-19$ K consistent with the 13 K observed experimentally in Nd$_6$Ni$_5$O$_{12}$. Thus, in order to identify the superconducting mechanism, extracting the relevant instabilities in the doping phase diagram of superconductors appears critical.
    Keywords Condensed Matter - Superconductivity ; Condensed Matter - Materials Science
    Publishing date 2023-11-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Standardised packs and larger health warnings: visual attention and perceptions among Colombian smokers and non-smokers.

    Sillero-Rejon, Carlos / Mahmoud, Osama / Tamayo, Ricardo M / Clavijo-Alvarez, Alvaro Arturo / Adams, Sally / Maynard, Olivia M

    Addiction (Abingdon, England)

    2022  Volume 117, Issue 6, Page(s) 1737–1747

    Abstract: Aims: To measure how cigarette packaging (standardised packaging and branded packaging) and health warning size affect visual attention and pack preferences among Colombian smokers and non-smokers.: Design: To explore visual attention, we used an eye- ...

    Abstract Aims: To measure how cigarette packaging (standardised packaging and branded packaging) and health warning size affect visual attention and pack preferences among Colombian smokers and non-smokers.
    Design: To explore visual attention, we used an eye-tracking experiment where non-smokers, weekly smokers and daily smokers were shown cigarette packs varying in warning size (30%-pictorial on top of the text, 30%-pictorial and text side-by-side, 50%, 70%) and packaging (standardised packaging, branded packaging). We used a discrete choice experiment (DCE) to examine the impact of warning size, packaging and brand name on preferences to try, taste perceptions and perceptions of harm.
    Setting: Eye-tracking laboratory, Universidad Nacional de Colombia, Bogotá, Colombia.
    Participants: Participants (n = 175) were 18 to 40 years old.
    Measurements: For the eye-tracking experiment, our primary outcome measure was the number of fixations toward the health warning compared with the branding. For the DCE, outcome measures were preferences to try, taste perceptions and harm perceptions.
    Findings: We observed greater visual attention to warning labels on standardised versus branded packages (F[3,167] = 22.87, P < 0.001) and when warnings were larger (F[9,161] = 147.17, P < 0.001); as warning size increased, the difference in visual attention to warnings between standardised and branded packaging decreased (F[9,161] = 4.44, P < 0.001). Non-smokers visually attended toward the warnings more than smokers, but as warning size increased these differences decreased (F[6,334] = 2.92, P = 0.009). For the DCE, conditional trials showed that increasing the warning size from 30% to 70% reduced preferences to try (odds ratio [OR] = 0.48, 95% CI = [0.42,0.54], P < 0.001), taste perceptions (OR = 0.61, 95% CI = [0.54,0.68], P < 0.001); and increased harm perceptions (OR = 0.78, 95% CI = [0.76,0.80], P < 0.001). Compared with branded packaging, standardised packaging reduced our DCE outcome measures with ORs ranging from OR = 0.25 (95% CI = [0.17,0.38], P < 0.001) to OR = 0.79 (95% CI = [0.67,0.93], P < 0.001) across two brands. These effects were more pronounced among non-smokers, males and younger participants. Unconditional trials showed similar results.
    Conclusions: Standardised cigarette packaging and larger health warnings appear to decrease positive pack perceptions and have the potential to reduce the demand for cigarette products in Colombia.
    MeSH term(s) Adolescent ; Adult ; Colombia ; Humans ; Male ; Non-Smokers ; Product Labeling/methods ; Product Packaging ; Smokers ; Smoking ; Tobacco Products ; Young Adult
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.15779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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