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  1. Article: A Comprehensive Review and Practical Guide of the Applications of Evoked Potentials in Neuroprognostication After Cardiac Arrest.

    Portell Penadés, Eduard / Alvarez, Vincent

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57014

    Abstract: Cardiorespiratory arrest is a very common cause of morbidity and mortality nowadays, and many therapeutic strategies, such as induced coma or targeted temperature management, are used to reduce patient sequelae. However, these procedures can alter a ... ...

    Abstract Cardiorespiratory arrest is a very common cause of morbidity and mortality nowadays, and many therapeutic strategies, such as induced coma or targeted temperature management, are used to reduce patient sequelae. However, these procedures can alter a patient's neurological status, making it difficult to obtain useful clinical information for the reliable estimation of neurological prognosis. Therefore, complementary investigations are conducted in the early stages after a cardiac arrest to clarify functional prognosis in comatose cardiac arrest survivors in the first few hours or days. Current practice relies on a multimodal approach, which shows its greatest potential in predicting poor functional prognosis, whereas the data and tools to identify patients with good functional prognosis remain relatively limited in comparison. Therefore, there is considerable interest in investigating alternative biological parameters and advanced imaging technique studies. Among these, somatosensory evoked potentials (SSEPs) remain one of the simplest and most reliable tools. In this article, we discuss the technical principles, advantages, limitations, and prognostic implications of SSEPs in detail. We will also review other types of evoked potentials that can provide useful information but are less commonly used in clinical practice (e.g., visual evoked potentials; short-, medium-, and long-latency auditory evoked potentials; and event-related evoked potentials, such as mismatch negativity or P300).
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of co-contaminated soil amended by graphene oxide: Effects on pollutants, microbial communities and soil health.

    Peña-Álvarez, V / Baragaño, D / Prosenkov, A / Gallego, J R / Peláez, A I

    Ecotoxicology and environmental safety

    2024  Volume 272, Page(s) 116015

    Abstract: Graphene oxide (GOx) is a nanomaterial with demonstrated capacity to remove metals from water. However, its effects on organic pollutants and metal(loid)s present in polluted soils when used for remediation purposes have not been extensively addressed. ... ...

    Abstract Graphene oxide (GOx) is a nanomaterial with demonstrated capacity to remove metals from water. However, its effects on organic pollutants and metal(loid)s present in polluted soils when used for remediation purposes have not been extensively addressed. Likewise, few studies describe the effects of GOx on edaphic properties and soil biology. In this context, here we assessed the potential of GOx for remediating polluted soil focusing also on different unexplored effects of GOx in soil. To achieve this, we treated soil contaminated with concurrent inorganic (As and metals) and organic pollution (TPH and PAHs), using GOx alone and in combination with nutrients (N and P sources). In both cases increased availability of As and Zn was observed after 90 days, whereas Cu and Hg availability was reduced and the availability of Pb and the concentration of organic pollutants were not significantly affected. The application of GOx on the soil induced a significant and rapid change (within 1 week) in microbial populations, leading to a transient reduction in biodiversity, consistent with the alteration of several soil properties. Concurrently, the combination with nutrients exhibited a distinct behaviour, manifesting a more pronounced and persistent shift in microbial populations without a decrease in biodiversity. On the basis of these findings, GOx emerges as a versatile amendment for soil remediation approaches.
    MeSH term(s) Environmental Pollutants ; Soil/chemistry ; Soil Pollutants/analysis ; Metals ; Microbiota ; Metals, Heavy/analysis ; Graphite
    Chemical Substances Environmental Pollutants ; Soil ; graphene oxide ; Soil Pollutants ; Metals ; Metals, Heavy ; Graphite (7782-42-5)
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Field‐ and Pilot‐Scale Approaches to Assess Finished Water Storage Tanks

    Gomez‐Alvarez, Vicente

    Journal ‐ American Water Works Association. 2023 Dec., v. 115, no. 10 p.24-32

    2023  

    Abstract: The US Environmental Protection Agency released its Storage Tank Assessment Study Protocol in 2021 as an optional tool to help water utilities gauge water quality issues. Knowledge about the complexity of storage tank ecosystems and associated potential ... ...

    Abstract The US Environmental Protection Agency released its Storage Tank Assessment Study Protocol in 2021 as an optional tool to help water utilities gauge water quality issues. Knowledge about the complexity of storage tank ecosystems and associated potential public health risks can be included in water management programs. Pilot‐scale and field‐based testing with genomic data yielded insights into biogeochemical processes of tank ecosystems that can help utilities minimize bacterial growth.
    Keywords United States Environmental Protection Agency ; bacterial growth ; genomics ; protocols ; public health ; water management ; water quality ; water storage ; water utilities
    Language English
    Dates of publication 2023-12
    Size p. 24-32.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 241726-1
    ISSN 0003-150X
    ISSN 0003-150X
    DOI 10.1002/awwa.2196
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration.

    Hidalgo-Alvarez, Veronica / Madl, Christopher M

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Aging is a complex multifactorial process that results in tissue function impairment across the whole organism. One of the common consequences of this process is the loss of muscle mass and the associated decline in muscle function, known as sarcopenia. ... ...

    Abstract Aging is a complex multifactorial process that results in tissue function impairment across the whole organism. One of the common consequences of this process is the loss of muscle mass and the associated decline in muscle function, known as sarcopenia. Aging also presents with an increased risk of developing other pathological conditions such as neurodegeneration. Muscular and neuronal degeneration cause mobility issues and cognitive impairment, hence having a major impact on the quality of life of the older population. The development of novel therapies that can ameliorate the effects of aging is currently hindered by our limited knowledge of the underlying mechanisms and the use of models that fail to recapitulate the structure and composition of the cell microenvironment. The emergence of bioengineering techniques based on the use of biomimetic materials and biofabrication methods has opened the possibility of generating 3D models of muscular and nervous tissues that better mimic the native extracellular matrix. These platforms are particularly advantageous for drug testing and mechanistic studies. In this review, we discuss the developments made in the creation of 3D models of aging-related neuronal and muscular degeneration and we provide a perspective on the future directions for the field.
    MeSH term(s) Humans ; Biocompatible Materials/therapeutic use ; Quality of Life ; Nerve Tissue ; Sarcopenia/therapy
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ceftriaxone-induced encephalopathy in a patient with a normal renal function.

    Zarauskas, Audrius / Rodrigues, Bruno / Alvarez, Vincent

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Ceftriaxone-induced encephalopathy is an exceptionally rare adverse effect of this commonly used cephalosporin and is generally observed in patients undergoing haemodialysis or suffering from severe renal failure. We present a case of a fit woman in her ... ...

    Abstract Ceftriaxone-induced encephalopathy is an exceptionally rare adverse effect of this commonly used cephalosporin and is generally observed in patients undergoing haemodialysis or suffering from severe renal failure. We present a case of a fit woman in her mid-80s with a normal renal function who developed severe fluctuating neurological symptoms (aphasia, loss of contact, chorea-like tongue movements) while being treated with ceftriaxone for a urinary tract infection with bacteraemia. The symptoms began on day 4 of treatment and an adverse drug reaction was suspected on day 7, after exhaustive investigations failed to reveal another cause. A complete recovery was observed 3 days after discontinuing ceftriaxone. Our case highlights the need to consider the diagnosis of ceftriaxone encephalopathy, even if the traditional risk factors are lacking. In this article, we also provide a brief overview of the pathophysiology as well as a literature review concerning the subject.
    MeSH term(s) Female ; Humans ; Ceftriaxone/adverse effects ; Anti-Bacterial Agents/adverse effects ; Cephalosporins/adverse effects ; Brain Diseases/chemically induced ; Brain Diseases/drug therapy ; Kidney
    Chemical Substances Ceftriaxone (75J73V1629) ; Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Dog: Man's Best Friend, but Not Always.

    Sánchez, Irene Rastrollo / Fernández-Alvarez, Verónica

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2024  

    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Innate immune and chronic heat stress responses in sturgeons: Advances and insights from studies on Russian sturgeons.

    Ferreira, A M / Aversa-Marnai, M / Villarino, A / Silva-Álvarez, V

    Fish and shellfish immunology reports

    2023  Volume 5, Page(s) 100121

    Abstract: Chronic stress deteriorates the immune function of fish, thereby increasing their vulnerability to infections. However, the molecular and cellular mechanisms underlying stress-mediated immunosuppression and infection susceptibility in fish remain largely ...

    Abstract Chronic stress deteriorates the immune function of fish, thereby increasing their vulnerability to infections. However, the molecular and cellular mechanisms underlying stress-mediated immunosuppression and infection susceptibility in fish remain largely unknown. Understanding these mechanisms will contribute to improving fish welfare and their farm production. Herein, we review the challenges of sturgeon aquaculture in subtropical countries, where current climate change has giving rise to significant temperature increments during summer. This leads to the exposure of fish to stressful conditions during these months. Chronic heat stress deserves attention considering the rapid warming rate of the planet. It is already affecting wild fish populations, with disastrous consequences for sturgeons, which are one of the most endangered fish species in the world. In this context, we discuss the most recent advances through the studies on the effects of chronic heat stress on the innate immune components of sturgeons. To this end, we summarise the findings of studies focusing on the aquaculture of Russian sturgeons and observations made on other
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article
    ISSN 2667-0119
    ISSN (online) 2667-0119
    DOI 10.1016/j.fsirep.2023.100121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Isolated invasive fungal sphenoid sinusitis-induced extensive bone erosion and severe meningoencephalitis: diagnosis and multidisciplinary management.

    Hallak, Bassel / Teiga, Pedro / Hedjoudje, Abderrahmane / Alvarez, Vincent

    BMJ case reports

    2023  Volume 16, Issue 4

    Abstract: Invasive fungal sinusitis (IFS) is more common in immunosuppressed patients but can also occur in immunocompetent hosts. While the non-invasive type of fungal sinusitis has usually a good prognosis, IFS is a potentially lethal condition.We report the ... ...

    Abstract Invasive fungal sinusitis (IFS) is more common in immunosuppressed patients but can also occur in immunocompetent hosts. While the non-invasive type of fungal sinusitis has usually a good prognosis, IFS is a potentially lethal condition.We report the case of a woman in her 60s presenting an isolated fungal infection by
    MeSH term(s) Female ; Humans ; Sphenoid Sinusitis/diagnosis ; Sphenoid Sinusitis/diagnostic imaging ; Sinusitis/diagnosis ; Sinusitis/diagnostic imaging ; Mycoses/diagnosis ; Paranasal Sinuses/pathology ; Sphenoid Sinus/diagnostic imaging ; Sphenoid Sinus/pathology ; Invasive Fungal Infections
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Importance of Lifelong Surveillance after Endovascular Repair of a Ruptured Aortic Aneurysm.

    Linares-Sanchez, Miriam / Fernandez-Alvarez, Veronica

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2023  Volume 65, Issue 6, Page(s) 904

    MeSH term(s) Humans ; Aortic Rupture/diagnostic imaging ; Aortic Rupture/etiology ; Aortic Rupture/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Endovascular Procedures/adverse effects ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2023.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Update on the management of status epilepticus.

    Rossetti, Andrea O / Alvarez, Vincent

    Current opinion in neurology

    2021  Volume 34, Issue 2, Page(s) 172–181

    Abstract: Purpose of review: Randomized controlled trials investigating the initial pharmacological treatment of status epilepticus have been recently published. Furthermore, status epilepticus arising in comatose survivors after cardiac arrest has received ... ...

    Abstract Purpose of review: Randomized controlled trials investigating the initial pharmacological treatment of status epilepticus have been recently published. Furthermore, status epilepticus arising in comatose survivors after cardiac arrest has received increasing attention in the last years. This review offers an updated assessment of status epilepticus treatment in these different scenarios.
    Recent findings: Initial benzodiazepines underdosing is common and correlates with development of status epilepticus refractoriness. The recently published ESETT trial provides high-level evidence regarding the equivalence of fosphenytoin, valproate, and levetiracetam as a second-line option. Myoclonus or epileptiform transients on electroencephalography occur in up to 1/3 of patients surviving a cardiac arrest. Contrary to previous assumptions regarding an almost invariable association with death, at least 1/10 of them may awaken with reasonably good prognosis, if treated. Multimodal prognostication including clinical examination, EEG, somatosensory evoked potentials, biochemical markers, and neuroimaging help identifying patients with a chance to recover consciousness, in whom a trial with antimyoclonic compounds and at times general anesthetics is indicated.
    Summary: There is a continuous, albeit relatively slow progress in knowledge regarding different aspect of status epilepticus; recent findings refine some treatment strategies and help improving patients' outcomes. Further high-quality studies are clearly needed to further improve the management of these patients, especially those with severe, refractory status epilepticus forms.
    MeSH term(s) Anticonvulsants/therapeutic use ; Electroencephalography ; Humans ; Levetiracetam/therapeutic use ; Randomized Controlled Trials as Topic ; Status Epilepticus/diagnosis ; Status Epilepticus/drug therapy
    Chemical Substances Anticonvulsants ; Levetiracetam (44YRR34555)
    Language English
    Publishing date 2021-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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