Article: Blimp-1 and c-Maf regulate
Wellcome open research
2023 Volume 8, Page(s) 403
Abstract: Background: CD4 : Methods: We applied computational analysis of gene regulation derived from temporal profiling of gene expression clusters obtained from bulk RNA sequencing (RNA-seq) of flow cytometry sorted naïve CD4 : Results: We show that the ... ...
| Abstract | Background: CD4 Methods: We applied computational analysis of gene regulation derived from temporal profiling of gene expression clusters obtained from bulk RNA sequencing (RNA-seq) of flow cytometry sorted naïve CD4 Results: We show that the transcription factors Blimp-1 and c-Maf each have unique and common effects on cytokine gene regulation and not only co-operate to induce Conclusions: These data show that Blimp-1 and c-Maf positively and negatively regulate a network of both unique and common anti-inflammatory and pro-inflammatory genes to reinforce a Th1 response in mice that will eradicate pathogens with minimum immunopathology. |
|---|---|
| Language | English |
| Publishing date | 2023-12-01 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2398-502X |
| ISSN | 2398-502X |
| DOI | 10.12688/wellcomeopenres.19680.2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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