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Article: Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects.

Pais, A I / Belinha, J / Alves, J L

2023 Volume 16, Issue 11

Abstract: Cellular materials have a wide range of applications, including structural optimization and biomedical applications. Due to their porous topology, which promotes cell adhesion and proliferation, cellular materials are particularly suited for tissue ... ...

Abstract	Cellular materials have a wide range of applications, including structural optimization and biomedical applications. Due to their porous topology, which promotes cell adhesion and proliferation, cellular materials are particularly suited for tissue engineering and the development of new structural solutions for biomechanical applications. Furthermore, cellular materials can be effective in adjusting mechanical properties, which is especially important in the design of implants where low stiffness and high strength are required to avoid stress shielding and promote bone growth. The mechanical response of such scaffolds can be improved further by employing functional gradients of the scaffold's porosity and other approaches, including traditional structural optimization frameworks; modified algorithms; bio-inspired phenomena; and artificial intelligence via machine learning (or deep learning). Multiscale tools are also useful in the topological design of said materials. This paper provides a state-of-the-art review of the aforementioned techniques, aiming to identify current and future trends in orthopedic biomechanics research, specifically implant and scaffold design.
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16113946
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Article: Pseudocercospora ixoricola Causing Leaf Spots on Ixora coccinea in Brazil.

Alves, J L / Barreto, R W

Plant disease

2019 Volume 94, Issue 2, Page(s) 278

Abstract: Ixora coccinea, known as jungle geranium, flame of the woods, or flame of the forest, is a shrub in the Rubiaceae native to Eastern India and is widely cultivated for its showy red globose inflorescences. It was introduced in Brazil in the beginning of ... ...

Abstract	Ixora coccinea, known as jungle geranium, flame of the woods, or flame of the forest, is a shrub in the Rubiaceae native to Eastern India and is widely cultivated for its showy red globose inflorescences. It was introduced in Brazil in the beginning of the 19th century where it became a popular ornamental (2). Recently, leaf spots were observed on I. coccinea foliage in Brazil. Severely diseased plants were unsightly with loss of foliage and remaining foliage was heavily spotted and yellowed. Sparse colonies of a fungus were consistently observed to be associated with diseased tissues. Slides were prepared by scraping colonized surfaces with a scalpel and mounting the fungal structures in lactophenol. Observations, measurements, and photographs were prepared with a light microscope (Olympus BX 50). The fungus was isolated in pure culture in plates containing V8 juice agar and incubated at 25°C. Pathogenicity was verified by placing pure culture plugs, obtained from actively growing colonies, onto healthy leaves of I. coccinea still attached to living plants left in a dew chamber. After 48 h, plants were removed and transferred to a greenhouse. Controls consisted of leaves of two separate healthy plants on which sterile culture medium plugs were deposited. Typical leaf spot symptoms appeared 11 days after inoculation and sporulation was observed after 30 days, but was not observed on the controls. Lesions on leaves were subcircular to polygonal or irregular, reddish brown to dark brown, 3.5 to 12 mm in diameter, coalescing, and leading to premature abscission. Fungus morphology was as follows: stromata absent; sporulation nearly indistinct under the dissecting microscope; conidiophores hypophyllous, either emerging from the stomata in small fascicles or isolate and formed from external mycelium, obclavate to cylindrical, 15 to 60 × 3.0 to 6.0 μm, 3 to 7 septate, obliquely constricted at septae, simple or branched, thin walled, brown, smooth; conidiogenous loci inconspicuous, not darkened, unthickened; conidia obclavate to cylindrical, straight to slightly curved, 17.5 to 89.0 × 3.0 to 5.0 μm, apex obtuse, base obconic-truncate, 1 to 7 obliquely septate, subhyaline, thin walled, eguttulate, smooth. Except for minor differences on conidiophore and conidial length, morphology was as described for Pseudocercospora ixoricola (4). Representative samples collected in the states of Minas Gerais (VIC 31216 - May 2009) and Rio de Janeiro (VIC 31217 - July 2009) were deposited in the local herbarium. Additional ad hoc observations indicate a widespread distribution of this disease in southeastern Brazil. Until now the sole cercosporoid fungus recorded on I. coccinea was P. ixorae from Asia and North America. There is also a record of this fungal species from an Ixora sp. from Brazil (1). Features such as the absence of stromata and the shape and size of conidiophores and conidia, separates it readily from P. ixoricola and P. ixoriana (a third species of Pseudocercospora known to be associated with plants in the genus Ixora). To our knowledge, this is the first record of P. ixoricola in South America and the first time it is recorded as a pathogen of I. coccinea. Previously, this fungus was only known in association with I. javanica in Singapore (3). References: (1) U. Braun and F. C. O. Freire. Cryptogam. Mycol. 23:295, 2002. (2) D. Hottz et al. Rev. Bras. Biociências, 5:642, 2007. (3) J. M. Yen. Rev. Mycol. 31:109, 1966. (4) J. M. Yen and G. Lim. Gard. Bull. Singap. 33:151, 1980.
Language	English
Publishing date	2019-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-94-2-0278C
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Article ; Online: Influence of the Adopted Balloon Modeling Strategies in the Stent Deployment Procedure: An In-Silico Analysis.

Gomes, I V / Puga, H / Alves, J L

Cardiovascular engineering and technology

2020 Volume 11, Issue 4, Page(s) 469–480

Abstract: Purpose: As the promoter of the stent expansion, the balloon plays a very important role, offering a strong influence on the deployment process. Balloon-artery interaction is pointed as a probable cause of restenosis, stressing the relevance of balloon ... ...

Abstract	Purpose: As the promoter of the stent expansion, the balloon plays a very important role, offering a strong influence on the deployment process. Balloon-artery interaction is pointed as a probable cause of restenosis, stressing the relevance of balloon modeling when simulating the stenting procedure. In this work, an in-silico study of the balloon modeling strategies is performed. Methods: Ultrasonic-microcasting is a novel technology that allows obtaining stents manufactured in magnesium alloys, being suggested as a promising solution. However, this technique demands superior stent strut thickness, which may have an impact on the stent deployment procedure. The influence of the balloon modeling is studied through the simulation of different balloon geometries (open- or taper-ended) and material constitutive model (linear elastic or hyperelastic) on the expanded configuration of a stent manufactured through ultrasonic-microcasting. Results: The results obtained suggest that the choice of balloon type has small impact in terms of demanded pressure to inflate the balloon and in the stent final radius achieved at fully-expanded configuration. Additionally, it was proved that the balloon-type influences the stent expanded profile along its length and diameter as a result of the different deformation behavior exhibited by the balloon. Conclusion: The hyperelastic taper-ended balloon suggests being the model that better correlates with both experimental and clinical results regarding the expanded balloon profile during the procedure.
MeSH term(s)	Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation ; Computer Simulation ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/therapy ; Coronary Restenosis/etiology ; Coronary Restenosis/physiopathology ; Finite Element Analysis ; Humans ; Models, Cardiovascular ; Prosthesis Design ; Stents ; Treatment Outcome ; Ultrasonics
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2543111-0
ISSN	1869-4098 ; 1869-408X
ISSN (online)	1869-4098
ISSN	1869-408X
DOI	10.1007/s13239-020-00470-2
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Article ; Online: Numerical implementation of an osmo-poro-visco-hyperelastic finite element solver: application to the intervertebral disc.

Castro, A P G / Alves, J L

Computer methods in biomechanics and biomedical engineering

2020 Volume 24, Issue 5, Page(s) 538–550

Abstract: This work deals with the finite element (FE) implementation of a biphasic poroelastic formulation specifically developed to address the intricate behaviour of the Intervertebral Disc (IVD) and other highly hydrated soft tissues. This formulation is ... ...

Abstract	This work deals with the finite element (FE) implementation of a biphasic poroelastic formulation specifically developed to address the intricate behaviour of the Intervertebral Disc (IVD) and other highly hydrated soft tissues. This formulation is implemented in custom FE solver V-Biomech, being the validation performed with a lumbar IVD model, which was compared against the analogous FE model of Williams et al. and the experiments of Tyrrell et al. Good agreement with these benchmarks was achieved, meaning that V-Biomech and its novel poroelastic formulation are a viable alternative for simulation of biphasic soft tissues.
MeSH term(s)	Anisotropy ; Annulus Fibrosus/anatomy & histology ; Annulus Fibrosus/physiology ; Biomechanical Phenomena ; Compressive Strength ; Computer Simulation ; Elasticity ; Finite Element Analysis ; Humans ; Intervertebral Disc/anatomy & histology ; Intervertebral Disc/physiology ; Models, Biological ; Numerical Analysis, Computer-Assisted ; Osmosis ; Pressure ; Stress, Mechanical ; Viscosity
Language	English
Publishing date	2020-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2020.1839059
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Article ; Online: The feasibility of a custom-made endoprosthesis in mandibular reconstruction: Implant design and finite element analysis.

Pinheiro, Manuel / Alves, J L

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2015 Volume 43, Issue 10, Page(s) 2116–2128

Abstract: This work studies the feasibility of custom-made endoprosthesis in the reconstruction of major mandibular defects. The natural anatomical and occlusal relations are used to accurately reconstruct a mandibular defect. The customized implant allows the ... ...

Abstract	This work studies the feasibility of custom-made endoprosthesis in the reconstruction of major mandibular defects. The natural anatomical and occlusal relations are used to accurately reconstruct a mandibular defect. The customized implant allows the accurate restoration of the facial profile and aesthetics. The biomechanical behaviour of mandibular endoprosthesis was validated with Finite Element Analysis for three masticatory tasks, namely incisal, right molar and left group clenching. The implanted mandible shows displacement fields and stress distributions very similar to the intact mandible. The strain fields observed along the bone-implant interface may promote bone maintenance and ingrowth. The preliminary results show that this implant may be a reliable alternative to other prosthetic mandibular reconstruction approaches.
Language	English
Publishing date	2015-12
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2015.10.004
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Article ; Online: In silico evaluation of the stress fields on the cortical bone surrounding dental implants: Comparing root-analogue and screwed implants.

Dantas, T A / Carneiro Neto, J P / Alves, J L / Vaz, Paula C S / Silva, F S

Journal of the mechanical behavior of biomedical materials

2020 Volume 104, Page(s) 103667

Abstract: Tooth loss is a problem that affects both old and young people. It may be caused by several conditions, such as poor oral hygiene, lifestyle choices or even diseases like periodontal disease, tooth grinding or diabetes. Nowadays, replacing a missing ... ...

Abstract	Tooth loss is a problem that affects both old and young people. It may be caused by several conditions, such as poor oral hygiene, lifestyle choices or even diseases like periodontal disease, tooth grinding or diabetes. Nowadays, replacing a missing tooth by an implant is a very common process. However, many limitations regarding the actual strategies can be enumerated. Conventional screwed implants tend to induce high levels of stress in the peri-implant bone area, leading to bone loss, bacterial bio-film formation, and subsequent implant failure. In this sense, root-analogue dental implants are becoming promising solutions for immediate implantation due to their minimally invasive nature, improved bone stress distribution and because they do not require bone drilling, sinus lift, bone augmentation nor other traumatic procedures. The aim of this study was to analyse and compare, by means of FEA, the stress fields of peri-implant bone around root-analogue and screwed conventional zirconia implants. For that purpose, one root-analogue implant, one root-analogue implant with flaps, two conventional implants (with different threads) and a replica of a natural tooth were modelled. COMSOL was used to perform the analysis and implants were subjected to two simultaneous loads: 100 N axially and 100 N oblique (45°). RESULTS: revealed that root-analogue implants, namely with flaps, should be considered as promising alternatives for dental implant solutions since they promote a better stress distribution in the cortical bone when compared with conventional implants.
MeSH term(s)	Adolescent ; Computer Simulation ; Cortical Bone ; Dental Implants ; Dental Stress Analysis ; Finite Element Analysis ; Humans ; Stress, Mechanical
Chemical Substances	Dental Implants
Language	English
Publishing date	2020-02-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2020.103667
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Article: Effect of Oleic Acid on Neuronal Zinc Signals

Alves, J. L / Figueira, A. S. C / Lopes, I. L / Mendes, P. J / Quinta-Ferreira, R. M / Quinta-Ferreira, M. E

Waste and biomass valorization. 2021 June, v. 12, no. 6

2021

Abstract: The culture of olive trees has been spreading worldwide with huge areas being used for this purpose. This activity, in addiction to that of the olive oil industries, has resulted in the formation of much biomass and effluents contaminated with high ... ...

Abstract	The culture of olive trees has been spreading worldwide with huge areas being used for this purpose. This activity, in addiction to that of the olive oil industries, has resulted in the formation of much biomass and effluents contaminated with high concentrations of organic compounds. Oleic acid (OA) is a monounsaturated compound, abundant in olive oil and almonds and used for the production of energy, cosmetics, nutritional products and pharmaceuticals, with many nutritional and medicinal benefits. However, it may be present in toxic amounts in industrial effluents of the food sector. There is an increasing incidence of neurological diseases associated with excessive neuronal zinc release and also with the production of reactive oxygen species (ROS), mainly in mitochondria. This work addresses the impact of oleic acid in neuronal zinc movements and compares OA induced zinc and ROS signals. The measurements were performed using the fluorescent zinc and ROS indicators Newport Green and H2DCFDA, respectively, and oleic acid concentrations in the 10 μM – 100 μM range. The measured zinc and ROS signals, which include autofluorescence, were both enhanced in the presence of the higher concentrations of oleic acid. In general, their amplitude increased with the OA concentration but, upon washout, the zinc changes were reversible while the ROS signals were maintained. These results suggest that there is a correlation between both types of cellular changes.
Keywords	biomass ; cosmetics ; drugs ; energy ; fluorescence ; food industry ; mitochondria ; neurons ; oleic acid ; olive oil ; olives ; reactive oxygen species ; toxicity ; zinc
Language	English
Dates of publication	2021-06
Size	p. 3019-3025.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2541900-6
ISSN	1877-265X ; 1877-2641
ISSN (online)	1877-265X
ISSN	1877-2641
DOI	10.1007/s12649-021-01350-z
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Article ; Online: A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering.

Cortez, S / Freitas, F L / Completo, A / Alves, J L

Computer methods in biomechanics and biomedical engineering

2017 Volume 20, Issue sup1, Page(s) 47–48

Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2017.1382854
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Article ; Online: Different acquisition systems for heart rate variability analysis may lead to diverse outcomes.

Oliveira Júnior, F A de / Pereira, R A / Silva, A S / Brito Alves, J L de / Costa-Silva, J H / Braga, V A / Balarini, C M

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2022 Volume 55, Page(s) e11720

Abstract: Heart rate variability (HRV) is a relevant physiological variable for the estimation of cardiac autonomic function. Although the gold standard for HRV registration is the electrocardiogram (ECG), several applications (APPs) have been increasingly ... ...

Abstract	Heart rate variability (HRV) is a relevant physiological variable for the estimation of cardiac autonomic function. Although the gold standard for HRV registration is the electrocardiogram (ECG), several applications (APPs) have been increasingly developed. The evaluation carried out by these devices must be compatible with ECG standards. The aim of this study was to compare the data obtained simultaneously with ECG and APP with chest heart rate transmitters. Fifty-six healthy individuals (28 men and 28 women) were evaluated at rest through a short simultaneous HRV measurement with both devices. Data from both acquisition systems were analyzed separately using their own analysis software and exported and analyzed using a validated software. Signal recordings were compatible between the two acquisition systems (Pearson r=0.99; P<0.0001). Although a high correlation was found for the HRV variables obtained in the time domain (Spearman r=0.99; P<0.0001), the correlation decreased in the frequency domain (Pearson r=0.85; P<0.0001) when two software programs were used. Comparison of the averages of spectral analysis parameters also showed differences when HRV data were analyzed separately in each device for low-frequency (LF) and high-frequency (HF) bands. Although the portability of these mobile devices allows for optimal HRV evaluation, the direct analysis obtained from these devices must be carefully evaluated with respect to frequency domain parameters.
MeSH term(s)	Autonomic Nervous System ; Electrocardiography ; Female ; Heart ; Heart Rate ; Humans ; Male
Language	English
Publishing date	2022-02-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X2021e11720
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Article ; Online: Maternal protein restriction affects cardiovascular, but not respiratory response to L-glutamate microinjection into the NTS of conscious rats.

Alves, D S / Barbosa, D F S / Nogueira, V O / Tourneur, Y / Fontes, D A F / Brito-Alves, J L / Costa-Silva, J H

Nutritional neuroscience

2019 Volume 24, Issue 11, Page(s) 907–918

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Animals ; Blood Pressure ; Cardiovascular System ; Consciousness ; Diet, Protein-Restricted ; Female ; Glutamic Acid/metabolism ; Heart Rate/physiology ; Humans ; Microinjections ; Pregnancy ; Rats ; Rats, Wistar ; Solitary Nucleus/metabolism
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2019-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1447449-9
ISSN	1476-8305 ; 1028-415X
ISSN (online)	1476-8305
ISSN	1028-415X
DOI	10.1080/1028415X.2019.1692508
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