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Article: Deep inspiration breath hold: dosimetric benefits to decrease cardiac dose during postoperative radiation therapy for breast cancer patients.

Degrande, Fabiana Accioli Miranda / Marta, Gustavo Nader / Alves, Tatiana Midori Martins Teles / Ferreira, Gustavo Bonfilho Squarizzi / Dumaszak, Fábio Vinicius / Carvalho, Heloisa A / Hanna, Samir A

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

2023 Volume 28, Issue 2, Page(s) 172–180

Abstract: Background: Postoperative radiation therapy (RT) is the standard treatment for almost all patients diagnosed with breast cancer. Even with modern RT techniques, parts of the heart may still receive higher doses than those recommended by clinically ... ...

Abstract	Background: Postoperative radiation therapy (RT) is the standard treatment for almost all patients diagnosed with breast cancer. Even with modern RT techniques, parts of the heart may still receive higher doses than those recommended by clinically validated dose limit restrictions, especially when the left breast is irradiated. Deep inspiration breath hold (DIBH) may reduce irradiated cardiac volume compared to free breathing (FB) treatment. This study aimed to evaluate the dosimetric impact on the heart and left anterior descending coronary artery (LAD) in FB and DIBH RT planning in patients with left breast cancer. Materials and methods: A retrospective cohort study of women diagnosed with left-sided breast cancer submitted to breast surgery followed by postoperative RT from 2015 to 2019. All patients were planned with FB and DIBH and hypofractionated dose prescription (40.05 Gy in 15 fractions). Results: 68 patients were included in the study. For the coverage of the planned target volume evaluation [planning target volume (PTV) eval] there was no significant difference between the DIBH versus FB planning. For the heart and LAD parameters, all constraints evaluated favored DIBH planning, with statistical significance. Regarding the heart, median V16.8 Gy was 2.56% in FB Conclusions: The DIBH technique has consistently demonstrated a significant dose reduction in the heart and LAD in all evaluated constraints, while keeping the same dose coverage in the PTV eval.
Language	English
Publishing date	2023-06-26
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2188087-6
ISSN	1507-1367
ISSN	1507-1367
DOI	10.5603/RPOR.a2023.0027
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Article: Bone necrosis as a complication of sodium hypochlorite extrusion. A case report.

Ortiz-Alves, Tatiana / Díaz-Sánchez, RosaRosa / Gutiérrez-Pérez, José-Luis / González-Martín, Maribel / Serrera-Figallo, María-Ángeles / Torres-Lagares, Daniel

Journal of clinical and experimental dentistry

2022 Volume 14, Issue 10, Page(s) e885–e889

Abstract: Sodium hypochlorite is the most used irrigant in endodontics, although its toxic effect on tissue is known. Sodium hypochlorite extrusion to periapical tissue can cause complications of varying severity, from oedemas and haemorrhagic lesions to life- ... ...

Abstract	Sodium hypochlorite is the most used irrigant in endodontics, although its toxic effect on tissue is known. Sodium hypochlorite extrusion to periapical tissue can cause complications of varying severity, from oedemas and haemorrhagic lesions to life-threatening ones due to airway compromise. Our patient attended the Oral and Maxillofacial Surgery department of the Virgen del Rocío University Hospital and was referred by his dentist after bone exposure as a result of irrigant extrusion during endodontics on tooth 14. Sodium hypochlorite caused significant bone and mucosal tissue necrosis to teeth 13-16, with communication to the maxillary sinus. Several surgical procedures were needed to perform the correct debridement of the necrotic tissue and obtain good mucous. Precautions need to be taken during the use of NaOCl to avoid spreading to surrounding tissue. In cases with open apexes and apical lesion, the use of safer irrigants should be considered as an alternative.
Language	English
Publishing date	2022-10-01
Publishing country	Spain
Document type	Case Reports
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.59862
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Article ; Online: High Prevalence of Energy and Nutrients Inadequacy among Brazilian Older Adults.

Magalhães, Natalia Vieira / Waitzberg, Dan Linetzky / Lopes, Natalia Correia / Vicedomini, Ana Carolina Costa / Prudêncio, Ana Paula Aguiar / Jacob-Filho, Wilson / Busse, Alexandre Leopold / Ferdinando, Douglas / Alves, Tatiana Pereira / Pereira, Rosa Maria Rodrigues / Torrinhas, Raquel Susana / Belarmino, Giliane

Nutrients

2023 Volume 15, Issue 14

Abstract: Poor nutrition increases the risk of diseases and adverse health outcomes in older adults. We evaluated the potential inadequacy of nutrient intake among older adults in Brazil and its association with body anthropometry and composition outcomes. Dietary ...

Abstract	Poor nutrition increases the risk of diseases and adverse health outcomes in older adults. We evaluated the potential inadequacy of nutrient intake among older adults in Brazil and its association with body anthropometry and composition outcomes. Dietary intake was obtained from 295 community-living older adults (>60 years old), of both genders, using a seven-day food record. Nutrient inadequacy was further identified based on the Dietary Reference Intakes and European Guidelines. Skeletal muscle mass (SM), strength and performance, and the diagnosis of sarcopenia were assessed using reference methods. Nutritional inadequacy was high, with energy, dietary fiber, and six micronutrients exhibiting the greatest inadequacy levels (>80%). Energy intake was correlated with SM strength (
MeSH term(s)	Female ; Humans ; Male ; Aged ; Middle Aged ; Nutritional Status ; Diet ; Brazil/epidemiology ; Sarcopenia/epidemiology ; Prevalence ; Nutrients ; Energy Intake ; Micronutrients
Chemical Substances	Micronutrients
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143246
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Article ; Online: In silico

Azevedo, Pedro Henrique Rodrigues de Alencar / Peçanha, Bruna Rachel de Britto / Flores-Junior, Luiz Augusto Pinheiro / Alves, Tatiana Fialho / Dias, Luiza Rosaria Sousa / Muri, Estela Maris Freitas / Lima, Camilo Henrique da Silva

Journal of biomolecular structure & dynamics

2023 Volume 42, Issue 3, Page(s) 1417–1428

Abstract: ... O- ... ...

Abstract	O-linked
MeSH term(s)	Molecular Dynamics Simulation ; Molecular Docking Simulation ; Drug Repositioning ; Substrate Specificity ; Machine Learning
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2199868
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Zs.A 2093: Show issues

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Article: Vestibulocochlear Delineation for Vestibular Schwannoma Treated With Radiation Therapy.

Restini, Felipe Cicci Farinha / Brito, Leticia Hernandes / Yoshimoto, Fernanda Hayashida / Pereira, Ana Paula Alves / Neto, David Rodrigues Ferreira / Gomes, Vitor Cunha / Nascimento, Beatriz Cunha / Mancini, Anselmo / Alves, Tatiana Midori Martins Telles / Starling, Maria Thereza Mansur / Chaves, Guilherme Wilson Otaviano Garcia / Passos, Ula Lindoso / Marta, Gustavo Nader / Hanna, Samir Abdallah

Advances in radiation oncology

2023 Volume 8, Issue 4, Page(s) 101171

Abstract: Purpose: To develop a specialist-based consensus of cochlear contouring to be used in patients undergoing stereotactic radiosurgery (SRS) treatment for vestibular schwannoma.: Methods and materials: Representative computed tomography (CT) and ... ...

Abstract	Purpose: To develop a specialist-based consensus of cochlear contouring to be used in patients undergoing stereotactic radiosurgery (SRS) treatment for vestibular schwannoma. Methods and materials: Representative computed tomography (CT) and magnetic resonance imaging (MRI) were used for cochlear contouring. The semicircles, cochlea, vestibule, and internal acoustic meatus were delineated by 7 radiation oncology department physicians and reviewed by neuroradiologists. A total of 12 cases accrued from a single academic institution were studied for a similarity analysis by the Dice coefficient. Results: The suggested guideline is an easily reproductive tool that allows radiation oncologists to accurately contour the vestibulocochlear system to avoid toxicity due to inadequate dosimetry of organs at risk. This could be a useful tool even for non-vestibular schwannoma radiation therapy. The Dice coefficient suggests reproducible results as long as the following contouring recommendations are observed. Conclusions: The template for vestibulocochlear delineation may be useful for an adequate organs at risk definition. Future studies are required to find specific constraints for each segment of the vestibulocochlear system, and to mitigate interobserver variations.
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2022.101171
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Article ; Online: Determination of multi-mycotoxins in cereals and of total fumonisins in maize products using isotope labeled internal standard and liquid chromatography/tandem mass spectrometry with positive ionization.

Andrade, Patrícia Diniz / Dantas, Rebecca Rodrigues / Moura-Alves, Tatiana Loureiro da Silva de / Caldas, Eloisa Dutra

Journal of chromatography. A

2017 Volume 1490, Page(s) 138–147

Abstract: Mycotoxins are secondary fungi metabolites present in foods that cause adverse effects in humans and animals. The aims of this work were to develop and validate a multi-mycotoxin method to determine the presence of aflatoxins, citreoviridin, ... ...

Abstract	Mycotoxins are secondary fungi metabolites present in foods that cause adverse effects in humans and animals. The aims of this work were to develop and validate a multi-mycotoxin method to determine the presence of aflatoxins, citreoviridin, deoxynivalenol, fumonisins ochratoxin A, zearalenone and some metabolites/derivatives in rice, maize-based products and wheat-based products, and a method to determine total fumonisins (free and bound/hidden forms) in maize-based products. The validated multi-mycotoxin method was based on extraction with acidified acetonitrile and LC-ESI
MeSH term(s)	Chromatography, Liquid/methods ; Edible Grain/chemistry ; Fumonisins/analysis ; Isotope Labeling ; Mycotoxins/analysis ; Tandem Mass Spectrometry/methods ; Zea mays/chemistry
Chemical Substances	Fumonisins ; Mycotoxins
Language	English
Publishing date	2017-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2017.02.027
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Zs.A 813: Show issues

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Article ; Online: Eliminating tuberculosis in Latin America: making it the point.

Duarte, Raquel / Silva, Denise Rossato / Rendon, Adrian / Alves, Tatiana Galvẫo / Rabahi, Marcelo Fouad / Centis, Rosella / Kritski, Afrânio / Migliori, Giovanni Battista

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2018 Volume 44, Issue 2, Page(s) 73–76

MeSH term(s)	Caribbean Region/epidemiology ; Disease Eradication/methods ; Humans ; Incidence ; Latin America/epidemiology ; Mexico/epidemiology ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; World Health Organization
Language	Portuguese
Publishing date	2018-05-21
Publishing country	Brazil
Document type	Editorial
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/s1806-37562017000000449
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Article ; Online: Bronchoalveolar Lavage in Systemic Sclerosis Patients: A Systematic Review.

da Silva, Sérgio Oliveira / da Paz, Adriane Souza / Farias, Isla Miranda Vidal Cavalcante / Moreira, Damille Sandes / Ribeiro, Marianna Alegro Fontes / Alves, Tatiana Senna Galvão Nonato / Lemos, Antônio Carlos Moreira / Santiago, Mittermayer Barreto

Current rheumatology reviews

2020 Volume 17, Issue 2, Page(s) 176–183

Abstract: Introduction: We performed a systematic review of the literature to determine the value of bronchoalveolar lavage (BAL) in evaluating the pulmonary involvement of systemic sclerosis (SSc).: Methods: Articles published between 1980 and 2019 were ... ...

Abstract	Introduction: We performed a systematic review of the literature to determine the value of bronchoalveolar lavage (BAL) in evaluating the pulmonary involvement of systemic sclerosis (SSc). Methods: Articles published between 1980 and 2019 were retrieved from the databases: PubMed and Scielo. The search was restricted to clinical trials published in English, utilizing the keywords "scleroderma, systemic sclerosis, interstitial lung disease, and bronchoalveolar lavage". Results: Twenty-two papers were analyzed. A positive correlation was observed between increased BAL cellularity (alveolitis) and worsening clinical symptoms, pulmonary function, and radiological pattern in 2, 11, and 15 studies, respectively. The majority of BAL studies that evaluated interleukin levels, including TNF-α, IL-6, IL-7, and IL-8, observed higher levels in patients with impaired pulmonary function and increased lung involvement. Conclusions: Alveolitis and the increase of some cytokines/chemokines in BAL were related to more severe pulmonary disease in SSc in the majority of the studies and seemed to be markers of worse prognosis, but it is unknown whether BAL adds clinical value to the use of the other non-invasive diagnostic procedures.
MeSH term(s)	Bronchoalveolar Lavage ; Humans ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Scleroderma, Systemic/complications
Language	English
Publishing date	2020-11-13
Publishing country	United Arab Emirates
Document type	Journal Article ; Systematic Review
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397116666201113091655
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Article ; Online: Early Training-Induced Reduction of Angiotensinogen in Autonomic Areas-The Main Effect of Exercise on Brain Renin-Angiotensin System in Hypertensive Rats.

Chaar, Laiali Jurdi / Alves, Tatiana Pereira / Batista Junior, Alvaro Martins / Michelini, Lisete Compagno

PloS one

2015 Volume 10, Issue 9, Page(s) e0137395

Abstract: Background: Exercise training (T) blunts functional deficits and renin-angiotensin system (RAS) hyperactivity in hypertensive individuals. There is no information on T-induced temporal changes of brain RAS. We evaluate now the simultaneous effects of T ... ...

Abstract	Background: Exercise training (T) blunts functional deficits and renin-angiotensin system (RAS) hyperactivity in hypertensive individuals. There is no information on T-induced temporal changes of brain RAS. We evaluate now the simultaneous effects of T on functional responses and time course changes in the expression/activity of brain RAS components in autonomic cardiovascular-controlling areas. Methods and results: Spontaneously hypertensive rats (SHR) and age-matched normotensive controls (WKY) were trained for 0, 1, 2, 4, 8 and 12 weeks. Sedentary (S) groups served as time-controls. After arterial pressure (AP) and heart rate (HR) recordings at rest, fresh and fixed brains were harvested for qPCR and immunofluorescence assays. SHR-S vs. WKY-S exhibited higher mean AP (MAP) and HR, increased pressure variability and sympathetic activity, elevated AT1 receptor (AT1) expression in nucleus tractus solitarii (NTS) and higher Mas receptor expression in the rostroventrolateral medulla (RVLM). In SHR, T promptly (T2 on) reduced sympathetic variability to heart/vessels and largely decreased angiotensinogen expression in the paraventricular hypothalamic nucleus (PVN) and NTS, with a late RVLM reduction (T4). AT1 expression was only reduced at T12 (PVN and NTS) with transient, not maintained Mas receptor changes in PVN and RVLM. These responses were accompanied by baseline MAP and HR reduction in the SHR-T (from T4 on). In the SHR group, PVN angiotensinogen expression correlated positively with sympathetic activity, resting MAP and HR. In WKY-T, a precocious (T2-T12) RVLM AT1 decrease preceded the appearance of resting bradycardia (from T8 on). Conclusions: Early and maintained reduction of angiotensinogen content in autonomic areas of the SHR is the most prominent effect of training on brain RAS. Down-regulation of PVN RAS expression is an essential factor to drive cardiovascular benefits in SHR-T, while resting bradycardia in WKY-T is correlated to RVLM AT1 reduction.
MeSH term(s)	Angiotensinogen/metabolism ; Animals ; Autonomic Nervous System/metabolism ; Autonomic Nervous System/physiopathology ; Blood Pressure ; Brain/metabolism ; Gene Expression Regulation ; Heart Rate ; Hypertension/genetics ; Hypertension/metabolism ; Hypertension/physiopathology ; Male ; Physical Conditioning, Animal ; Proto-Oncogene Proteins/genetics ; Rats ; Rats, Inbred SHR ; Receptor, Angiotensin, Type 1/genetics ; Receptors, G-Protein-Coupled/genetics ; Renin-Angiotensin System ; Time Factors
Chemical Substances	Proto-Oncogene Proteins ; Receptor, Angiotensin, Type 1 ; Receptors, G-Protein-Coupled ; proto-oncogene proteins c-mas-1 ; Angiotensinogen (11002-13-4)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0137395
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Article ; Online: Salmonella enterica serotype Bovismorbificans, a new host for CTX-M-9.

Antunes, Patrícia / Mourão, Joana / Alves, Tatiana / Campos, Joana / Novais, Carla / Novais, Angela / Peixe, Luísa

International journal of antimicrobial agents

2013 Volume 41, Issue 1, Page(s) 91–93

MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Child, Preschool ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/secretion ; Gene Order ; Humans ; Male ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Salmonella Infections/microbiology ; Salmonella enterica/drug effects ; Salmonella enterica/enzymology ; Salmonella enterica/genetics ; Salmonella enterica/isolation & purification ; Sequence Analysis, DNA ; beta-Lactamases/genetics ; beta-Lactamases/secretion
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial ; Escherichia coli Proteins ; CTX-M-9 protein, E coli (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2013-01
Publishing country	Netherlands
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2012.09.009
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