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  1. Article ; Online: Cancer Research Challenges and Potential Solutions in Saudi Arabia: A Qualitative Discussion Group Study.

    Alessy, Saleh A / Almotlak, Abdulaziz A / Alattas, Maha / Alshareef, Abdulraheem / Alwosaibai, Kholoud / Alghamdi, Majed A / Razack, Habeeb I A / Alqahtani, Saleh A

    JCO global oncology

    2024  Volume 10, Page(s) e2300189

    Abstract: Purpose: Cancer incidence in Saudi Arabia has recently shown an upward trend. Research efforts within the different cancer continuum are pivotal to strengthening control measures. Since cancer research is evolving in the country, it is crucial to ... ...

    Abstract Purpose: Cancer incidence in Saudi Arabia has recently shown an upward trend. Research efforts within the different cancer continuum are pivotal to strengthening control measures. Since cancer research is evolving in the country, it is crucial to understand the current challenges and implement defined interventions to overcome them. The present qualitative study aimed to assess cancer research barriers among researchers and identify potential solutions from their perspectives.
    Methods: We conducted a focus group discussion among 17 Saudi-based cancer researchers from diverse research backgrounds, provinces, and institutions. We used descriptive-interpretive thematic analysis following an open-ended approach to investigate the challenges in conducting cancer research. We also captured the solutions suggested based on the researchers' experiences.
    Results: Six major themes emerged from the analysis: requirements of the data landscape, organizational support, national research roadmap, sustainable funding, clearer policies and regulations, and capacity building. To address challenges in these areas, researchers stressed the need for improved interinstitutional collaborations, immediate availability of research materials, and unlimited and easy access to research data.
    Conclusion: Improving health research is one of the primary goals of Saudi Vision 2030. It is, therefore, essential to overcome the current challenges in cancer research, enabling research findings to inform policies related to cancer control and care provision.
    MeSH term(s) Humans ; Saudi Arabia/epidemiology ; Qualitative Research ; Delivery of Health Care ; Neoplasms/epidemiology ; Neoplasms/prevention & control
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.23.00189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PAX2 induces vascular-like structures in normal ovarian cells and ovarian cancer.

    Alwosaibai, Kholoud / Al-Hujaily, Ensaf M / Alamri, Salmah / Ghandorah, Salim / Garson, Kenneth / Vanderhyden, Barbara C

    Experimental and therapeutic medicine

    2022  Volume 23, Issue 6, Page(s) 412

    Abstract: In adult tissue, the paired box 2 (PAX2) protein is expressed in healthy oviductal, but not normal ovarian surface epithelial cells. PAX2 is expressed in a subset of cases of serous ovarian carcinoma; however, the role of PAX2 in the initiation and ... ...

    Abstract In adult tissue, the paired box 2 (PAX2) protein is expressed in healthy oviductal, but not normal ovarian surface epithelial cells. PAX2 is expressed in a subset of cases of serous ovarian carcinoma; however, the role of PAX2 in the initiation and progression of ovarian cancer remains unknown. The aim of the present study was to determine the biological effects of PAX2 expression in normal and cancerous epithelial cells. By culturing the normal and cancerous ovarian cells that express PAX2 in 3D culture and staining the cells with vasculogenic mimicry markers such as CD31 and PAS, it was shown that PAX2 overexpression in both normal and cancerous ovarian epithelial cells induced formation of vascular-like structures both
    Language English
    Publishing date 2022-04-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synergistic anti-cancer effects of

    Baig, Waheed A / Alwosaibai, Kholoud / Al-Jubran, Khalid M / Chaudhry, Tariq M / Al-Dowish, Nouf / Alsaffar, Fatimah / Alam, Md Anzar

    Drug metabolism and personalized therapy

    2022  Volume 37, Issue 3, Page(s) 315–321

    Abstract: Objectives: Breast cancer is the most commonly diagnosed invasive non-skin malignancy in women worldwide, and it is the leading cause of cancer-related deaths in them. : Methods: Nigella sativa: Results: Results showed that higher concentrations ( ... ...

    Abstract Objectives: Breast cancer is the most commonly diagnosed invasive non-skin malignancy in women worldwide, and it is the leading cause of cancer-related deaths in them.
    Methods: Nigella sativa
    Results: Results showed that higher concentrations (50 μg/mL) of
    Conclusions: There was decreased cell proliferation and cell viability when
    MeSH term(s) Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Carum ; Cytotoxins ; Doxorubicin/pharmacology ; Female ; Humans ; Nigella sativa ; Plant Extracts/pharmacology ; Plant Oils/pharmacology
    Chemical Substances Antineoplastic Agents ; Cytotoxins ; Plant Extracts ; Plant Oils ; Doxorubicin (80168379AG) ; caraway oil (C2J9B08Q3I)
    Language English
    Publishing date 2022-04-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2822040-7
    ISSN 2363-8915 ; 2363-8907
    ISSN (online) 2363-8915
    ISSN 2363-8907
    DOI 10.1515/dmpt-2021-0229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state.

    Alwosaibai, Kholoud / Abedini, Atefeh / Al-Hujaily, Ensaf M / Tang, Yong / Garson, Kenneth / Collins, Olga / Vanderhyden, Barbara C

    Oncotarget

    2017  Volume 8, Issue 44, Page(s) 76881–76897

    Abstract: Recent studies have provided evidence that the secretory cells of the fallopian tube (oviduct) are a probable origin for high-grade serous ovarian carcinoma. In addition to secretory cells, the fallopian tube epithelium consists of ciliated cells and ... ...

    Abstract Recent studies have provided evidence that the secretory cells of the fallopian tube (oviduct) are a probable origin for high-grade serous ovarian carcinoma. In addition to secretory cells, the fallopian tube epithelium consists of ciliated cells and CD44+ undifferentiated stem-like cells. Loss of PAX2 expression is recognized as an early event in epithelial transformation, but the specific role of PAX2 in this transition is unknown. The aim of this study was to define the role of PAX2 in oviductal epithelial (OVE) cells and its response to transforming growth factor β1 (TGFβ), characterizing specifically its potential involvement in regulating stem cell-like behaviors that may contribute to formation of cancer-initiating cells. Treatment of primary cultures of mouse OVE cells with TGFβ induced an epithelial-mesenchymal transition (EMT) associated with decreased expression of PAX2 and an increase in the fraction of cells expressing CD44. PAX2 knockdown in OVE cells and overexpression in ovarian epithelial cells confirmed that PAX2 inhibits stem cell characteristics and regulates the degree of epithelial differentiation of OVE cells. These results suggest that loss of PAX2, as occurs in serous tubal intraepithelial carcinomas, may shift secretory cells to a more mesenchymal phenotype associated with stem-like features.
    Language English
    Publishing date 2017-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.20173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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