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  1. Article ; Online: An Unusual Cause of Kidney Allograft Dysfunction.

    Rosenstiel, Paul E / Markowitz, Glen S / Amante, Brigani

    Kidney360

    2021  Volume 2, Issue 7, Page(s) 1207–1208

    MeSH term(s) Allografts ; Foscarnet ; Kidney/diagnostic imaging ; Transplantation, Homologous/adverse effects
    Chemical Substances Foscarnet (364P9RVW4X)
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0001062021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Quality of meta-analyses for randomized trials in the field of hypertension: a systematic review.

    Roush, George C / Amante, Brigani / Singh, Tanveer / Ayele, Hiwot / Araoye, Morakinyo / Yang, Danwen / Kostis, William J / Elliott, William J / Kostis, John B / Berlin, Jesse A

    Journal of hypertension

    2016  Volume 34, Issue 12, Page(s) 2305–2317

    Abstract: Objectives: Doubling on average every 6 years, hypertension-related meta-analyses are now published twice weekly and are often considered the highest level of evidence for clinical practice. However, some hypertension specialists and guideline authors ... ...

    Abstract Objectives: Doubling on average every 6 years, hypertension-related meta-analyses are now published twice weekly and are often considered the highest level of evidence for clinical practice. However, some hypertension specialists and guideline authors view meta-analyses with skepticism. This article evaluates the quality of hypertension-related meta-analyses of clinical trials.
    Methods: A systematic search was conducted for meta-analyses of clinical trials recently published over 3.3 years. Specific criteria reproducibly assessed 26 features in the four domains of meta-analysis quality, domains justified by fundamental analytics and extensive research: analyzing trial quality, analyzing heterogeneity, analyzing publication bias, and providing transparency.
    Results: A total of 143 meta-analyses were identified. A total of 44% had 8+ deficient features with no relation to journal impact factor: odds ratio relating 8+ deficient features to the upper third versus lower third of impact factor = 1.3 (95% confidence limit 0.6-2.9). A total of 56% had all four domains deficient. Quality did not improve over time. Thirty articles (21%) reported statistically significant results (P < 0.05) from inappropriate DerSimonian-Laird models, whereas unreported, appropriate, Knapp-Hartung models gave statistical nonsignificance; 88% of these 30 articles reported the incorrect results in their abstracts. A total of 60% of all meta-analyses failed to conduct analyses in subgroups of quality when indicated, 63% failed to report Tau and Tau, 57% omitted testing for publication bias, none conducted a cumulative analysis for publication bias, and 71-77% omitted mentioning in their abstracts problems of trial quality, heterogeneity, and publication bias.
    Conclusion: Although widespread, deficiencies in hypertension-related meta-analyses are readily corrected and do not represent flaws inherent in the meta-analytic method.
    MeSH term(s) Humans ; Hypertension/therapy ; Journal Impact Factor ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Research Report/standards
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000001094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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