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  1. Article ; Online: The role of ESAT-6 in tuberculosis immunopathology.

    Passos, Beatriz B S / Araújo-Pereira, Mariana / Vinhaes, Caian L / Amaral, Eduardo P / Andrade, Bruno B

    Frontiers in immunology

    2024  Volume 15, Page(s) 1383098

    Abstract: Despite major global efforts to eliminate tuberculosis, which is caused ... ...

    Abstract Despite major global efforts to eliminate tuberculosis, which is caused by
    MeSH term(s) Humans ; Antigens, Bacterial ; Bacterial Proteins ; Tuberculosis ; Mycobacterium tuberculosis ; Disease Progression
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1383098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Modulation of Inflammation and Immune Responses by Heme Oxygenase-1: Implications for Infection with Intracellular Pathogens.

    Costa, Diego L / Amaral, Eduardo P / Andrade, Bruno B / Sher, Alan

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 12

    Abstract: Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators ... ...

    Abstract Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators with antioxidant, anti-inflammatory and immunosuppressive consequences for the host. Interestingly, several intracellular pathogens responsible for major human diseases have been shown to be powerful inducers of HO-1 expression in both host cells and in vivo. Studies have shown that this HO-1 response can be either host detrimental by impairing pathogen control or host beneficial by limiting infection induced inflammation and tissue pathology. These properties make HO-1 an attractive target for host-directed therapy (HDT) of the diseases in question, many of which have been difficult to control using conventional antibiotic approaches. Here we review the mechanisms by which HO-1 expression is induced and how the enzyme regulates inflammatory and immune responses during infection with a number of different intracellular bacterial and protozoan pathogens highlighting mechanistic commonalities and differences with the goal of identifying targets for disease intervention.
    Language English
    Publishing date 2020-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9121205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhancement of CD4

    Costa, Diego L / Amaral, Eduardo P / Namasivayam, Sivaranjani / Mittereder, Lara R / Andrade, Bruno B / Sher, Alan

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 672527

    Abstract: Tuberculosis (TB), caused ... ...

    Abstract Tuberculosis (TB), caused by
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Antigens, Bacterial ; Bacterial Proteins ; CD4-Positive T-Lymphocytes ; Mice ; Mycobacterium tuberculosis ; Tuberculosis/drug therapy ; Tuberculosis Vaccines
    Chemical Substances Anti-Bacterial Agents ; Antigens, Bacterial ; Bacterial Proteins ; Tuberculosis Vaccines
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.672527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Modulation of Inflammation and Immune Responses by Heme Oxygenase-1: Implications for Infection with Intracellular Pathogens

    Costa, Diego L / Amaral, Eduardo P / Andrade, Bruno B / Sher, Alan

    Antioxidants. 2020 Nov. 30, v. 9, no. 12

    2020  

    Abstract: Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators ... ...

    Abstract Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators with antioxidant, anti-inflammatory and immunosuppressive consequences for the host. Interestingly, several intracellular pathogens responsible for major human diseases have been shown to be powerful inducers of HO-1 expression in both host cells and in vivo. Studies have shown that this HO-1 response can be either host detrimental by impairing pathogen control or host beneficial by limiting infection induced inflammation and tissue pathology. These properties make HO-1 an attractive target for host-directed therapy (HDT) of the diseases in question, many of which have been difficult to control using conventional antibiotic approaches. Here we review the mechanisms by which HO-1 expression is induced and how the enzyme regulates inflammatory and immune responses during infection with a number of different intracellular bacterial and protozoan pathogens highlighting mechanistic commonalities and differences with the goal of identifying targets for disease intervention.
    Keywords Protozoa ; antibiotics ; carbon monoxide ; catalytic activity ; cells ; degradation ; heme ; heme oxygenase (biliverdin-producing) ; human diseases ; immune response ; immunosuppression ; infection ; inflammation ; iron ; pathogens ; reactive oxygen species ; stress response ; therapeutics
    Language English
    Dates of publication 2020-1130
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9121205
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Co-infection of mice with SARS-CoV-2 and

    Baker, Paul J / Amaral, Eduardo P / Castro, Ehydel / Bohrer, Andrea C / Torres-Juárez, Flor / Jordan, Cassandra M / Nelson, Christine E / Barber, Daniel L / Johnson, Reed F / Hilligan, Kerry L / Mayer-Barber, Katrin D

    Frontiers in immunology

    2023  Volume 14, Page(s) 1240419

    Abstract: Viral co-infections have been implicated in worsening tuberculosis (TB) and during the COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in over a decade. We and others have previously shown that a resolved prior or ...

    Abstract Viral co-infections have been implicated in worsening tuberculosis (TB) and during the COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in over a decade. We and others have previously shown that a resolved prior or concurrent influenza A virus infection in
    MeSH term(s) Mice ; Animals ; Humans ; Mycobacterium tuberculosis ; SARS-CoV-2 ; Coinfection ; Pandemics ; COVID-19 ; Mice, Transgenic ; Interferon Type I ; Mice, Inbred C57BL
    Chemical Substances K-18 conjugate ; Interferon Type I
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1240419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.

    Baker, Paul J / Bohrer, Andrea C / Castro, Ehydel / Amaral, Eduardo P / Snow-Smith, Maryonne / Torres-Juárez, Flor / Gould, Sydnee T / Queiroz, Artur T L / Fukutani, Eduardo R / Jordan, Cassandra M / Khillan, Jaspal S / Cho, Kyoungin / Barber, Daniel L / Andrade, Bruno B / Johnson, Reed F / Hilligan, Kerry L / Mayer-Barber, Katrin D

    bioRxiv : the preprint server for biology

    2024  

    Abstract: SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known to affect disease severity. Yet, how the inflammatory milieu of ... ...

    Abstract SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known to affect disease severity. Yet, how the inflammatory milieu of the lung at the time of SARS-CoV-2 exposure impacts the control of viral replication remains poorly understood. We demonstrate here that immune events in the mouse lung closely preceding SARS-CoV-2 infection significantly impact viral control and we identify key innate immune pathways required to limit viral replication. A diverse set of pulmonary inflammatory stimuli, including resolved antecedent respiratory infections with
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.27.586885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis.

    Amaral, Eduardo P / Vinhaes, Caian L / Oliveira-de-Souza, Deivide / Nogueira, Betania / Akrami, Kevan M / Andrade, Bruno B

    Antioxidants & redox signaling

    2020  Volume 34, Issue 6, Page(s) 471–485

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Inflammation/immunology ; Inflammation/pathology ; Oxidative Stress/immunology ; Tuberculosis/immunology ; Tuberculosis/pathology
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2020.8124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death.

    Amaral, Eduardo P / Lasunskaia, Elena B / D'Império-Lima, Maria Regina

    Microbes and infection

    2016  Volume 18, Issue 1, Page(s) 11–20

    Abstract: The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the ... ...

    Abstract The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the cell death pathways in infected macrophages and, consequently, the pathogenesis of tuberculosis.
    MeSH term(s) Cell Death ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Macrophages/immunology ; Macrophages/physiology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/pathology
    Language English
    Publishing date 2016-01
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2015.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Mycobacterium tuberculosis

    Bomfim, Caio C B / Fisher, Logan / Amaral, Eduardo P / Mittereder, Lara / McCann, Katelyn / Correa, André A S / Namasivayam, Sivaranjani / Swamydas, Muthulekha / Moayeri, Mahtab / Weiss, Jonathan M / Chari, Raj / McVicar, Daniel W / Costa, Diego L / D'Império Lima, Maria R / Sher, Alan

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 862582

    Abstract: Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage ... ...

    Abstract Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Enzyme Induction ; Hydro-Lyases/biosynthesis ; Hydro-Lyases/immunology ; Macrophages/immunology ; Macrophages/microbiology ; Membrane Proteins/metabolism ; Mice ; Mycobacterium tuberculosis/metabolism ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Phagocytosis ; Receptor, Interferon alpha-beta/metabolism ; Toll-Like Receptor 2/metabolism ; Tuberculosis/metabolism ; Tuberculosis/microbiology
    Chemical Substances Adaptor Proteins, Signal Transducing ; Membrane Proteins ; Myeloid Differentiation Factor 88 ; NF-kappa B ; Sting1 protein, mouse ; Tlr2 protein, mouse ; Toll-Like Receptor 2 ; Receptor, Interferon alpha-beta (156986-95-7) ; Hydro-Lyases (EC 4.2.1.-) ; Irg1 protein, mouse (EC 4.2.1.79)
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.862582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs.

    Cubillos-Angulo, Juan M / Nogueira, Betânia M F / Arriaga, María B / Barreto-Duarte, Beatriz / Araújo-Pereira, Mariana / Fernandes, Catarina D / Vinhaes, Caian L / Villalva-Serra, Klauss / Nunes, Vanessa M / Miguez-Pinto, João P / Amaral, Eduardo P / Andrade, Bruno B

    Frontiers in medicine

    2022  Volume 9, Page(s) 970408

    Abstract: Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage. Pulmonary TB treatment depends ... ...

    Abstract Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage. Pulmonary TB treatment depends on the prolonged use of multiple drugs ranging from 6 months for drug-susceptible TB to 6-20 months in cases of multi-drug resistant disease, with limited patient tolerance resulting from side effects. Treatment success rates remain low and thus represent a barrier to TB control. Adjunct host-directed therapy (HDT) is an emerging strategy in TB treatment that aims to target the host immune response to
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.970408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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