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  1. Article ; Online: COVID-19

    Amariles, Pedro

    Agenda Cultural Alma Máter; Núm.; 0124-0854

    enfermedad que nos demanda acciones para engrandecer a la Nación

    2020  Volume 275, Issue : Pandemia: COVID-19

    Keywords covid19
    Language Spanish
    Publishing date 2020-07-16
    Publisher Universidad de Antioquia
    Publishing country co
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Clinical Relevance of Drug Interactions in People Living with Human Immunodeficiency Virus on Antiretroviral Therapy-Update 2022: Systematic Review.

    Amariles, Pedro / Rivera-Cadavid, Mónica / Ceballos, Mauricio

    Pharmaceutics

    2023  Volume 15, Issue 10

    Abstract: Background: The clinical outcomes of antiretroviral drugs may be modified through drug interactions; thus, it is important to update the drug interactions in people living with HIV (PLHIV).: Aim: To update clinically relevant drug interactions in ... ...

    Abstract Background: The clinical outcomes of antiretroviral drugs may be modified through drug interactions; thus, it is important to update the drug interactions in people living with HIV (PLHIV).
    Aim: To update clinically relevant drug interactions in PLHIV on antiretroviral therapy with novel drug interactions published from 2017 to 2022.
    Methods: A systematic review in Medline/PubMed database from July 2017 to December 2022 using the Mesh terms antiretroviral agents and drug interactions or herb-drug interactions or food-drug interactions. Publications with drug interactions in humans, in English or Spanish, and with full-text access were retrieved. The clinical relevance of drug interactions was grouped into five levels according to the gravity and probability of occurrence.
    Results: A total of 366 articles were identified, with 219 (including 87 citation lists) were included, which allowed for the identification of 471 drug interaction pairs; among them, 291 were systematically reported for the first time. In total 42 (14.4%) and 137 (47.1%) were level one and two, respectively, and 233 (80.1%) pairs were explained with the pharmacokinetic mechanism. Among these 291 pairs, protease inhibitors (PIs) and ritonavir/cobicistat-boosted PIs, as well as integrase strand transfer inhibitors (InSTIs), with 70 (24.1%) and 65 (22.3%) drug interaction pairs of levels one and two, respectively, were more frequent.
    Conclusions: In PLHIV on antiretroviral therapy, we identify 291 drug interaction pairs systematically reported for the first time, with 179 (61.5%) being assessed as clinically relevant (levels one and two). The pharmacokinetic mechanism was the most frequently identified. PIs, ritonavir/cobicistat-boosted PIs, and InSTIs were the antiretroviral groups with the highest number of clinically relevant drug interaction pairs (levels one and two).
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15102488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drugs as Possible Triggers of Takotsubo Cardiomyopathy- Update 2022: Systematic Review.

    Lopera, Valentina / Pereañez, Jaime Andrés / Amariles, Pedro Jose

    Current vascular pharmacology

    2023  Volume 21, Issue 5, Page(s) 304–315

    Abstract: Background: A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. The aim of the present review was to update this list.: Methods: Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports ...

    Abstract Background: A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. The aim of the present review was to update this list.
    Methods: Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports of druginduced TCM were identified by a comprehensive search in Medline/PubMed database. The search terms were: takotsubo cardiomyopathy, tako-tsubo cardiomyopathy, stress cardiomyopathy, transientleft- ventricular ballooning syndrome, apical ballooning syndrome, ampulla cardiomyopathy OR broken heart syndrome; together with "iatrogenic", "induced by" OR "drug-induced". Registers published in English or Spanish, in humans, and with full texts were retrieved. Articles that recognized any drug associated with the development of TCM were selected.
    Results: Overall, 184 manuscripts were identified by the search. A total of 39 articles were included after an exhaustive revision. Eighteen drugs as possible triggers of TCM were identified in the current update. Of them, 3 (16.7%) have been previously identified, and 15 (83.3%) are different from the previous reports. Thus, the list of drugs as possible triggers of TCM updated in 2022 includes 72 drugs.
    Conclusion: There are new case reports that link drugs with the development of TCM. The current list is principally made up of drugs that generate sympathetic overstimulation. However, some of the listed drugs do not have a clear link with sympathetic activation.
    MeSH term(s) Humans ; Takotsubo Cardiomyopathy/chemically induced ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/complications ; Heart Ventricles
    Language English
    Publishing date 2023-11-24
    Publishing country United Arab Emirates
    Document type Systematic Review ; Journal Article
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/1570161121666230517121037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical Relevance of Drug Interactions with Cannabis: A Systematic Review.

    Lopera, Valentina / Rodríguez, Adriana / Amariles, Pedro

    Journal of clinical medicine

    2022  Volume 11, Issue 5

    Abstract: Concomitant use of cannabis with other drugs may lead to cannabis-drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information ... ...

    Abstract Concomitant use of cannabis with other drugs may lead to cannabis-drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information regarding clinical relevance of cannabis-drug interactions. We utilized the PubMed/Medline database for this systematic review, using the terms drug interactions and cannabis, between June 2011 and June 2021. Articles with cannabis-drug interactions in humans, in English or Spanish, with full-text access were selected. Two researchers evaluated the article's inclusion. The level of clinical relevance was determined according to the severity and probability of the interaction. Ninety-five articles were identified and twenty-six were included. Overall, 19 pairs of drug interactions with medicinal or recreational cannabis were identified in humans. According to severity and probability, 1, 2, 12, and 4 pairs of cannabis-drug interactions were classified at levels 1 (very high risk), 2 (high risk), 3 (medium risk), and 5 (without risk), respectively. Cannabis-warfarin was classified at level 1, and cannabis-buprenorphine and tacrolimus at level 2. This review provides evidence for both the low probability of the occurrence of clinically relevant drug interactions and the lack of evidence regarding cannabis-drug interactions.
    Language English
    Publishing date 2022-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11051154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ethical, Economic, Societal, Clinical, and Pharmacology Uncertainties Associated With Milasen and Other Personalized Drugs.

    Amariles, Pedro / Madrigal-Cadavid, Juliana

    The Annals of pharmacotherapy

    2020  Volume 54, Issue 9, Page(s) 937–938

    Language English
    Publishing date 2020-03-04
    Publishing country United States
    Document type Letter
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028020909118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Relevancia clínica de las interacciones medicamentosas: Propuesta de actualización de la clasificación, acorde con su gravedad y probabilidad.

    Amariles, Pedro / Madrigal-Cadavid, Juliana / Giraldo, Newar A

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Volume 38, Issue 2, Page(s) 304–305

    Title translation Clinical relevance of drug interactions: Proposal to update the classification based on the severity and probability of its occurrence.
    MeSH term(s) Drug Interactions ; Pharmaceutical Preparations ; Probability
    Chemical Substances Pharmaceutical Preparations
    Language Spanish
    Publishing date 2021-06-29
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182021000200304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Proposed Individual Risk Score for Educational Institutions: The Role of Health Surveillance for the SARS-CoV-2 Risk Assessment in the Schools.

    Granados, Johan / Ceballos, Mauricio / Amariles, Pedro

    Journal of occupational and environmental medicine

    2021  Volume 63, Issue 4, Page(s) e257–e258

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Colombia/epidemiology ; Humans ; Morbidity ; Occupational Exposure ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Schools ; Transportation
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 155: Show issues Location:
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  8. Article: Primary health care policy and vision for community pharmacy and pharmacists in Colombia.

    Amariles, Pedro / Ceballos, Mauricio / González-Giraldo, Cesar

    Pharmacy practice

    2020  Volume 18, Issue 4, Page(s) 2159

    Abstract: Colombia is a decentralized republic with a population of 50 million, constituted by 32 departments (territorial units) and 1,204 municipalities. The health system provides universal coverage and equal access to health care services to 95% of the ... ...

    Abstract Colombia is a decentralized republic with a population of 50 million, constituted by 32 departments (territorial units) and 1,204 municipalities. The health system provides universal coverage and equal access to health care services to 95% of the population. Primary health care is seen as a practical approach that guarantees the health and well-being of whole-of-society. The National Pharmaceutical Policy (NPP, 2012) goal is "to develop strategies that enable the Colombian population equitable access to effective medicines, through quality pharmaceutical services (PS)". There are 4,351 providers certified to deliver PS: 3,699 (85%) ambulatory and 652 (15%) hospital care. The goals for PS are: a) promoting healthy lifestyles; b) preventing risk factors arising from medication errors; c) promoting rational use of medicines; and d) implementing Pharmaceutical Care. There are a number of ways that ambulatory patients access medications: through intermediary private companies, public and private hospitals pharmacies, and retail establishments (drugstores and pharmacies). Intermediary private companies are similar to Pharmaceutical Benefits Management in the U.S. health system, and act as intermediaries between health insurers, pharmaceutical laboratories, and patients. Pharmacists are being employed by these companies and in health insurance companies managing, auditing and delivering rational use of medicines programs. In 2014 there were approximately 20,000 pharmacies and drugstores, (private establishments) where a significant number of prescription-only medicines are sold without medical prescription. Colombian laws allow personal without pharmacy education to be a "director" in these establishments, so the training and education of persons working in drugstores and pharmacies is an important challenge. There about 8,000 registered pharmaceutical chemists with 25% to 30% working in patient care. Since the 90´s, there are more favorable conditions for pharmacist's participation and contribution to health system and patient's health outcome. These environmental facilitators include: a) laws and regulations regarding pharmaceutical services (2005-2007), b) establishment of a NPP (2012), and c) opportunities associated with the consolidation of private health management companies providing health services with an interest in pharmaceutical services (since 1995). Finally, telepharmacy, comprehensive care routes for pharmaceutical services, and further strengthen of postgraduate training in pharmacy practice are future strategies to improve the pharmacy profession in Colombia. They provide an opportunity to influence the recognition and value of the pharmacist as the health care professional.
    Language English
    Publishing date 2020-11-23
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2414565-8
    ISSN 1886-3655 ; 1885-642X
    ISSN (online) 1886-3655
    ISSN 1885-642X
    DOI 10.18549/PharmPract.2020.4.2159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Proposed Individual Risk Score for Educational Institutions Utilizing Risk of Morbidity/Mortality by SARS-CoV-2, Occupational Exposure, and Type of Transportation.

    Granados, Johan / Ceballos, Mauricio / Amariles, Pedro

    Journal of occupational and environmental medicine

    2020  Volume 62, Issue 12, Page(s) e770–e772

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/prevention & control ; COVID-19/transmission ; Clinical Decision Rules ; Colombia/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/prevention & control ; Occupational Exposure/prevention & control ; Occupational Exposure/statistics & numerical data ; Risk Assessment ; Risk Factors ; Transportation/methods ; Universities ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 155: Show issues Location:
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  10. Article ; Online: A comprehensive literature search: drugs as possible triggers of Takotsubo cardiomyopathy.

    Amariles, Pedro

    Current clinical pharmacology

    2011  Volume 6, Issue 1, Page(s) 1–11

    Abstract: Background: Takotsubo cardiomyopathy (TCM) is a syndrome of transient cardiac dysfunction precipitated by intense emotional or physical stress. Excessive sympathetic stimulation is believed to be central to the pathogenesis of this condition, thus drugs ...

    Abstract Background: Takotsubo cardiomyopathy (TCM) is a syndrome of transient cardiac dysfunction precipitated by intense emotional or physical stress. Excessive sympathetic stimulation is believed to be central to the pathogenesis of this condition, thus drugs with sympathetic effect could precipitate TCM. The aim of this study was to conduct a comprehensive literature search to identify drugs that could precipitate TCM.
    Methods: Published case reports of TCM associated with drug-used were identified by a comprehensive literature search using the Medline/PubMed database, from January 1990 to November 2010. Search terms included Takotsubo cardiomyopathy, Tako-tsubo cardiomyopathy, stress cardiomyopathy, transient-left-ventricular ballooning syndrome, ampulla cardiomyopathy, apical ballooning syndrome, OR broken heart syndrome; together with "iatrogenic", "drug-induced", OR "induced by". Only publications in English or Spanish, in Humans, and with links to full text were retrieved. Then, articles that recognized any drug as a possible drug-induced TCM were selected. Additionally, citation lists from identified articles were subsequently reviewed to identify additional relevant articles.
    Results: Overall, 401 different references were retrieved and 42 selected. Additionally, 5 articles were identified from citation list of selected articles. Thus, 47 articles with one report of more drugs as a possible trigger of 58 cases of SCM were reviewed, in which 20 different drugs were recognized as possible drug-induced TCM.
    Conclusion: There are some reports that linked the drug-used, mainly associated to sympathetic overstimulation, with the development of TCM. Consequently, drug-induced TCM would be considered in patients with TCM, particularly those in which no clear emotional or stress trigger could be identified.
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions ; Emotions ; Humans ; Stress, Psychological/complications ; Sympathetic Nervous System/metabolism ; Takotsubo Cardiomyopathy/chemically induced ; Takotsubo Cardiomyopathy/etiology
    Language English
    Publishing date 2011-01-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2250809-0
    ISSN 2212-3938 ; 1574-8847
    ISSN (online) 2212-3938
    ISSN 1574-8847
    DOI 10.2174/157488411794941340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6392: Show issues Location:
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