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  1. Article ; Online: COVID-19 vaccines protect children of all ages.

    Amarin, Justin Z / Hayek, Haya / Halasa, Natasha B

    The Journal of clinical investigation

    2022  Volume 132, Issue 17

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI164102
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  2. Article ; Online: Lymph node ratio is a more robust predictor of overall survival than N stage in stage III colorectal adenocarcinoma.

    Beirat, Amir F / Amarin, Justin Z / Suradi, Haya H / Qwaider, Yasmeen Z / Muhanna, Adel / Maraqa, Bayan / Al-Ani, Abdallah / Al-Hussaini, Maysa

    Diagnostic pathology

    2024  Volume 19, Issue 1, Page(s) 44

    Abstract: Background: Lymph node ratio (LNR) may offer superior prognostic stratification in colorectal adenocarcinoma compared with N stage. However, candidate cutoff ratios require validation. We aimed to study the prognostic significance of LNR and its optimal ...

    Abstract Background: Lymph node ratio (LNR) may offer superior prognostic stratification in colorectal adenocarcinoma compared with N stage. However, candidate cutoff ratios require validation. We aimed to study the prognostic significance of LNR and its optimal cutoff ratio.
    Methods: We reviewed the pathology records of all patients with stage III colorectal adenocarcinoma who were managed at the King Hussein Cancer Center between January 2014 and December 2019. We then studied the clinical characteristics of the patients, correlates of lymph node count, prognostic significance of positive lymph nodes, and value of sampling additional lymph nodes.
    Results: Among 226 included patients, 94.2% had ≥ 12 lymph nodes sampled, while 5.8% had < 12 sampled lymph nodes. The median number of lymph nodes sampled varied according to tumor site, neoadjuvant therapy, and the grossing pathologist's level of training. According to the TNM system, 142 cases were N1 (62.8%) and 84 were N2 (37.2%). Survival distributions differed according to LNR at 10% (p = 0.022), and 16% (p < 0.001), but not the N stage (p = 0.065). Adjusted Cox-regression analyses demonstrated that both N stage and LNR at 10% and 16% predicted overall survival (p = 0.044, p = 0.010, and p = 0.001, respectively).
    Conclusions: LNR is a robust predictor of overall survival in patients with stage III colorectal adenocarcinoma. At a cutoff ratio of 0.10 and 0.16, LNR offers better prognostic stratification in comparison with N stage and is less susceptible to variation introduced by the number of lymph nodes sampled, which is influenced both by clinical variables and grossing technique.
    MeSH term(s) Humans ; Neoplasm Staging ; Lymph Node Ratio ; Lymphatic Metastasis/pathology ; Colorectal Neoplasms/pathology ; Lymph Nodes/pathology ; Prognosis ; Adenocarcinoma/pathology ; Retrospective Studies
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2210518-9
    ISSN 1746-1596 ; 1746-1596
    ISSN (online) 1746-1596
    ISSN 1746-1596
    DOI 10.1186/s13000-024-01449-6
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  3. Article: "Sidedness" as a standard hypernym for "right" and "left" in anatomy.

    Amarin, Justin Z / Suradi, Haya H / Badran, Darwish H

    Anatomy & cell biology

    2021  Volume 54, Issue 3, Page(s) 407–408

    Language English
    Publishing date 2021-06-16
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2590173-4
    ISSN 2093-3673 ; 2093-3665
    ISSN (online) 2093-3673
    ISSN 2093-3665
    DOI 10.5115/acb.21.024
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  4. Article ; Online: Adrenal Incidentaloma.

    Suradi, Haya H / Amarin, Justin Z / Zayed, Ayman A

    The New England journal of medicine

    2021  Volume 385, Issue 8, Page(s) 768

    MeSH term(s) Adrenal Gland Neoplasms/diagnostic imaging ; Humans ; Incidental Findings
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2108550
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  5. Article ; Online: Liraglutide for Adolescents with Obesity.

    Amarin, Justin Z / Dahbour, Aladdin S / Zayed, Ayman A

    The New England journal of medicine

    2020  Volume 383, Issue 12, Page(s) 1193

    MeSH term(s) Adolescent ; Humans ; Liraglutide ; Obesity ; Weight Loss
    Chemical Substances Liraglutide (839I73S42A)
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2023284
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  6. Article ; Online: Incidence of Cancer in Adolescents and Young Adults in Jordan, 2000-2017.

    Amarin, Justin Z / Mansour, Razan / Nimri, Omar F / Al-Hussaini, Maysa

    JCO global oncology

    2021  Volume 7, Page(s) 934–946

    Abstract: Purpose: The epidemiology of cancer in adolescents and young adults (AYAs) is distinct and underinvestigated. Therefore, we investigated the incidence of cancer in AYAs in Jordan.: Patients and methods: We accessed all records submitted to the Jordan ...

    Abstract Purpose: The epidemiology of cancer in adolescents and young adults (AYAs) is distinct and underinvestigated. Therefore, we investigated the incidence of cancer in AYAs in Jordan.
    Patients and methods: We accessed all records submitted to the Jordan Cancer Registry between 2000 and 2017. We included all patients, age 15-39 years, who were ordinarily resident in Jordan. We then calculated frequencies, age-adjusted incidence rates (AAIRs), and annual percentage changes (APCs) and performed subgroup analyses by biologic sex, age subgroups, and site (SEER AYA site recode/WHO 2008). We also performed site-specific trend analyses using joinpoint models.
    Results: We identified 14,115 eligible patients, of whom 1,531 (10.8%), 4,278 (30.3%), and 8,306 (58.8%) were 15-19, 20-29, and 30-39 years old at diagnosis, respectively. The numbers of male and female AYAs were 5,792 (41.0%) and 8,323 (59.0%), respectively. The crude number of cases increased from 654 in 2000 to 954 in 2017 (APC, 2.6%). The overall AAIR ranged from 32.3 in 2000 to 24.3 in 2017 (APC, -1.7%). The AAIR was 27.6 over the full study period and was higher in females (34.1) than in males (21.6). Carcinomas, lymphomas, and leukemias were the most common cancers. The incidence rates of the majority of cancers trended downward over the study period.
    Conclusion: The incidence of cancer in AYAs in Jordan is relatively low and declining. However, the absolute number of cases is increasing because this downtrend does not offset the effect of a high population growth rate; almost a 1,000 cases of cancer are now diagnosed every year, which represents a significant increase in the burden of cancer in a developing country with limited healthcare resources.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Incidence ; Jordan/epidemiology ; Male ; Neoplasms/epidemiology ; Registries ; Young Adult
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.21.00007
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  7. Article: Palestinian Patients with Cancer at King Hussein Cancer Center.

    Mansour, Razan / Amarin, Justin Z / Al-Ani, Abdallah / Al-Hussaini, Maysa / Mansour, Asem

    Frontiers in oncology

    2022  Volume 12, Page(s) 997492

    Abstract: Background: The Palestinian Ministry of Health (MoH) routinely refers Palestinian patients with cancer to King Hussein Cancer Center (KHCC), the largest cancer center in the Middle East.: Aims: We aimed to describe the characteristics of Palestinian ... ...

    Abstract Background: The Palestinian Ministry of Health (MoH) routinely refers Palestinian patients with cancer to King Hussein Cancer Center (KHCC), the largest cancer center in the Middle East.
    Aims: We aimed to describe the characteristics of Palestinian patients with cancer.
    Methods: We performed a retrospective chart review of all Palestinian patients with cancer who were treated at KHCC during 2018 and 2019, of which demographic and clinical characteristics were presented.
    Results: We initially started with 521 cases, out of which 41 (7.9%) cases were excluded due to misdiagnosis as malignant on pathology review. We included 480 patients with a confirmed diagnosed of cancer. Most patients were adults (88.8%) with a mean age of 50.0 ± 15.0 years ranging from 19 to 87 years. The most common cancer sites in adult men, who comprised 46.9% of the cohort were the hematolymphoid system (23.5%), followed by the digestive system (17.5%), and lung and pleura (11.5%). In women (53.1%), the most common cancer sites were the breast (46.0%), followed by the digestive system (15.0%), and the hematolymphoid system (10.2%). Children and adolescents accounted for 11.3% of the total cases, among which the hematolymphoid system was the most common cancer site (50%), followed by the brain (14.8%). About 36.0% of all patients presented with advanced-stage disease (i.e., distant metastasis).
    Conclusion: The most common cancer sites in our cohort are generally similar to data from the Palestinian territories. Many patients presented with advanced-stage disease, which signals the need for awareness campaigns and screening programs. Benign tumors are misdiagnosed in many patients as cancer. The limited resources and facilities including human resources remain important challenges to the proper and timely diagnosis and management of cancer among Palestinians living in the Palestinian Territories.
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.997492
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  8. Article ; Online: Sex differences in cancer incidence and mortality among patients managed at King Hussein Cancer Center.

    Al-Ani, Abdallah / Amarin, Justin Z / Al-Huneidy, Leen / Al-Hussaini, Maysa

    International journal of cancer

    2022  Volume 151, Issue 11, Page(s) 1960–1968

    Abstract: We investigated if female survival advantage trends in cancer are consistent within Jordanian patients with cancer across different age groups and nonsex specific cancer types. We explored the King Hussein Cancer Center registry for primary malignant ... ...

    Abstract We investigated if female survival advantage trends in cancer are consistent within Jordanian patients with cancer across different age groups and nonsex specific cancer types. We explored the King Hussein Cancer Center registry for primary malignant tumors from 2006 to 2019. The registry (n = 16 454) was stratified into three groups based on age: children (<15 years), adolescents and young adults (AYA) (modified; 15-49 years), and older adults (≥50 years). Kaplan-Meier analysis was used to estimate the 5-year all-site cancer-specific survival probabilities, which were compared using the log-rank test by sex and age group. Out of 16 454 eligible records, 2286 (13.9%) were children, 5975 (36.3%) were AYAs, and 8193 (49.8%) were older adults. Males outnumbered females 10 339 (62.8%) to 6115 (37.2%). The 5-year OS rates were 74.0% (71.6%-76.4%) and 72.7% (69.9%-75.5%) for pediatric males and females, respectively, 57.3% (55.6%-59.0%) and 64.5% (62.6%-66.4%) for male and female AYAs, respectively, and 37.5% (36.2%-38.9%) and 44.2% (42.3%-46.2%) for older adult males and females, respectively. Females demonstrated significantly better overall survival in the AYA and older adults' groups. In conclusion, females exhibit a survival advantage in terms of nonsex specific cancers. This advantage peaks at the AYA age stratum and mitigates thereafter. Further studies are warranted to examine the etiological factors behind such discrepancy on a site-by-site basis so that sex-specific interventions can be designed and validated.
    MeSH term(s) Adolescent ; Aged ; Child ; Female ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Neoplasms/epidemiology ; Registries ; Sex Characteristics ; Young Adult
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.34213
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  9. Article ; Online: The Pervasive Culture of Abuse in Medical Education: A Focus on Developing Countries.

    Amarin, Justin Z / Borgan, Saif M

    Academic medicine : journal of the Association of American Medical Colleges

    2017  Volume 92, Issue 5, Page(s) 578–579

    MeSH term(s) Developing Countries/statistics & numerical data ; Education, Medical/statistics & numerical data ; Harassment, Non-Sexual/statistics & numerical data ; Humans ; Social Discrimination/statistics & numerical data
    Language English
    Publishing date 2017-08-08
    Publishing country United States
    Document type Letter
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000001652
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  10. Article ; Online: Drug Effects on the Thyroid.

    Abualia, Mohammad / Amarin, Justin Z / Zayed, Ayman A

    The New England journal of medicine

    2019  Volume 381, Issue 20, Page(s) 1979–1980

    MeSH term(s) Cell Line, Tumor ; Humans ; Thyroid Neoplasms
    Language English
    Publishing date 2019-11-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1912672
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