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Article ; Online: Anatomical variants of the intercostobrachial nerve and its preservation during surgery, a systematic review and meta-analysis.

Cirocchi, Roberto / Matteucci, Matteo / Randolph, Justus / Duro, Francesca / Properzi, Luca / Avenia, Stefano / Amato, Bruno / Iandoli, Ruggiero / Tebala, Giovanni / Boselli, Carlo / Covarelli, Piero / Sapienza, Paolo

World journal of surgical oncology

2024 Volume 22, Issue 1, Page(s) 92

Abstract: Background: The anatomic variants of the intercostobrachial nerve (ICBN) represent a potential risk of injuries during surgical procedure such as axillary lymph node dissection and sentinel lymph node biopsy in breast cancer and melanoma patients. The ... ...

Abstract	Background: The anatomic variants of the intercostobrachial nerve (ICBN) represent a potential risk of injuries during surgical procedure such as axillary lymph node dissection and sentinel lymph node biopsy in breast cancer and melanoma patients. The aim of this systematic review and meta-analysis was to investigate the different origins and branching patterns of the intercostobrachial nerve also providing an analysis of the prevalence, through the analysis of the literature available up to September 2023. Materials and methods: The protocol for this study was registered on PROSPERO (ID: CRD42023447932), an international prospective database for reviews. The PRISMA guideline was respected throughout the meta-analysis. A systematic literature search was performed using PubMed, Scopus and Web of Science. A search was performed in grey literature through google. Results: We included a total of 23 articles (1,883 patients). The prevalence of the ICBN in the axillae was 98.94%. No significant differences in prevalence were observed during the analysis of geographic subgroups or by study type (cadaveric dissections and in intraoperative dissections). Only five studies of the 23 studies reported prevalence of less than 100%. Overall, the PPE was 99.2% with 95% Cis of 98.5% and 99.7%. As expected from the near constant variance estimates, the heterogeneity was low, I Conclusions: The prevalence of ICBN variants was very high. The dissection of the ICBN during axillary lymph-node harvesting, increases the risk of sensory disturbance. The preservation of the ICBN does not modify the oncological radicality in axillary dissection for patients with cutaneous metastatic melanoma or breast cancer. Therefore, we recommend to operate on these patients in high volume center to reduce post-procedural pain and paresthesia associated with a lack of ICBN variants recognition.
MeSH term(s)	Humans ; Female ; Melanoma/surgery ; Intercostal Nerves/pathology ; Intercostal Nerves/surgery ; Lymph Node Excision/methods ; Sentinel Lymph Node Biopsy ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Axilla/pathology ; Cadaver
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-024-03374-w
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Article ; Online: Hybrid treatment of fibroadipose vascular anomaly

Stillo Francesco / Ruggiero Federica / De Fiores Antonio / Compagna Rita / Amato Bruno

Open Medicine, Vol 15, Iss 1, Pp 890-

A case report

2020 Volume 897

Abstract: First identified in 2014, fibroadipose vascular anomaly (FAVA) is a very rare type of venous and lymphatic malformation. Marked by tough fibrofatty tissue in the extremities overtaking portions of the muscles, it is associated with constant pain and ... ...

Abstract	First identified in 2014, fibroadipose vascular anomaly (FAVA) is a very rare type of venous and lymphatic malformation. Marked by tough fibrofatty tissue in the extremities overtaking portions of the muscles, it is associated with constant pain and contracture of the affected extremity. There is a paucity of literature, and no guidelines on treatment procedure are available. This case highlights the role of hybrid treatment with primary ethanol percutaneous ethanol embolization and additional surgery for radicality in excision of FAVA lesions.
Keywords	fibroadipose vascular anomaly ; ethanol embolization ; case report ; growth syndromes ; pik3ca mutation ; Medicine ; R
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Collagen treatment of complex anorectal fistula

Maternini Matteo / Guttadauro Angelo / Avella Pasquale / Buondonno Antonio / Mascagni Domenico / Milito Giovanni / Stuto Angelo / Renzi Adolfo / Rennis Maria / Bottini Corrado / Quarto Gennaro / Nudo Raffaele / Del Re Luca / Amato Bruno / Gabrielli Francesco

Open Medicine, Vol 18, Iss 1, Pp 501-

3 years follow-up

2023 Volume 6

Abstract: Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should ... ...

Abstract	Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should be considered for complex fistulas. One of the sphincteric preserving treatment is the filling with a dermal extract commonly called “collagen glue” as Salvecoll-E® gel. This is a multicentric, prospective, observational study on the use of Salvecoll-E® gel in treatment of complex anal fistulas. We treated 70 patients from May 2016 to May 2017. In the first phase, we debrided the fistula tract using a loose seton kept for 4–6 weeks. In the second phase, the seton was removed and the fistula tract was filled with Salvecoll-E® gel. In this article, we report results at 36 months of follow-up. Fifty patients (71.4%) had completely healed fistula within 36 months of follow-up. Twenty-eight patients (28.2%) had recurrences. Among these failures, 65% were within 6 months. All low transphincteric fistulas healed. Recurrences occurred only in median and high transphincteric fistulas. No patient had a worsening of continence status measured with Cleveland Clinic Florida Incontinence Severity score. Salvecoll-E® gel is a recent finding among sphincter-sparing treatments. In this study, we demonstrate that it is a safe option in the treatment of complex fistulas. Final results are satisfactory and in line with the best results published in literature among mini-invasive treatments.
Keywords	complex anal fistula ; salvecoll ; permacol ; sphincter-sparing treatment ; non-cutting technique ; mini-invasive treatment ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Dilemma of the Level of the Inferior Mesenteric Artery Ligation in the Treatment of Diverticular Disease: A Systematic Review of the Literature.

Cirocchi, Roberto / Mari, Giulio / Amato, Bruno / Tebala, Giovanni Domenico / Popivanov, Georgi / Avenia, Stefano / Nascimbeni, Riccardo

Journal of clinical medicine

2022 Volume 11, Issue 4

Abstract: Background and aim: Although sigmoidectomy is a well-standardized procedure for diverticular disease, there are still unclear areas related to the varying morphology and vascular supply of the sigmoid colon. The level of vascular ligation could affect ... ...

Abstract	Background and aim: Although sigmoidectomy is a well-standardized procedure for diverticular disease, there are still unclear areas related to the varying morphology and vascular supply of the sigmoid colon. The level of vascular ligation could affect the functional outcomes of patients operated on for diverticular disease. The aim of this review is to primarily evaluate sexual, urinary and defecatory function outcomes, as well as postoperative results, in patients who underwent surgery for diverticular disease, with or without inferior mesenteric artery (IMA) preservation. Materials and methods: The MEDLINE/PubMed, WOS and Scopus databases were interrogated. Comparative studies including patients who underwent sigmoidectomy for diverticular diseases were considered. Bowel function, genitourinary function, anastomotic leak, operation time, conversion to open surgery, anastomotic bleeding, bowel obstruction were the main items of interest. Results: Twelve studies were included in the review, three randomized and nine comparative studies. Bowel and genitourinary function are not differently affected by the level of vascular ligation. The site of ligation of IMA did not influence the rate of functional complications, anastomotic leak and bleeding. Of note, the preservation of IMA is associated with a higher conversion rate and longer operative time. Conclusions: Despite the heterogeneity of patient groups, and although the findings should be interpreted with caution, functional and clinical outcomes after sigmoidectomy for diverticular disease do not seem to be affected by the level of vascular ligation as long as the IMA is ligated far from its origin.
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11040917
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Article: Hybrid treatment of fibroadipose vascular anomaly: A case report.

Stillo, Francesco / Ruggiero, Federica / De Fiores, Antonio / Compagna, Rita / Amato, Bruno

Open medicine (Warsaw, Poland)

2020 Volume 15, Issue 1, Page(s) 890–897

Abstract: Background: First identified in 2014, fibroadipose vascular anomaly (FAVA) is a very rare type of venous and lymphatic malformation. Marked by tough fibrofatty tissue in the extremities overtaking portions of the muscles, it is associated with constant ... ...

Abstract	Background: First identified in 2014, fibroadipose vascular anomaly (FAVA) is a very rare type of venous and lymphatic malformation. Marked by tough fibrofatty tissue in the extremities overtaking portions of the muscles, it is associated with constant pain and contracture of the affected extremity. There is a paucity of literature, and no guidelines on treatment procedure are available. This case highlights the role of hybrid treatment with primary ethanol percutaneous ethanol embolization and additional surgery for radicality in excision of FAVA lesions. Case summary: A 9-year-old girl with FAVA underwent the hybrid treatment. The achievements of complete excision, clinical response, and patient satisfaction in long-term follow-up were assessed. Following the hybrid treatment, the patient experienced significant improvement in pain. Concurrent symptoms of physical limitation, leg swelling, and skin hyperesthesia also improved. The clinical benefit, supported by postoperative physiotherapy, was well stabilized at 6-month follow-up, resulting in complete patient satisfaction at 12- and 36-month follow-ups. No major complications were encountered. Conclusion: Ethanol embolization plus surgery is a safe, effective, and long-term hybrid treatment of symptomatic FAVA lesions.
Language	English
Publishing date	2020-09-11
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2020-0228
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Article ; Online: Bone Marrow of Contention: A Rare Case of Recurrent Acute Hepatitis.

Rocco, Alba / Compare, Debora / Risitano, Antonio Maria / Sgamato, Costantino / Amato, Bruno / Nardone, Gerardo

Digestive diseases and sciences

2020 Volume 66, Issue 2, Page(s) 408–411

Abstract: Hepatitis-associated aplastic anemia is a well-recognized clinical syndrome in which marrow failure follows the development of hepatitis. Although aplastic anemia is intimately related to paroxysmal nocturnal hemoglobinuria, until now, no cases of PNH- ... ...

Abstract	Hepatitis-associated aplastic anemia is a well-recognized clinical syndrome in which marrow failure follows the development of hepatitis. Although aplastic anemia is intimately related to paroxysmal nocturnal hemoglobinuria, until now, no cases of PNH-associated hepatitis have been described. We report a case of recurrent acute hepatitis preceding the clinical onset of PNH. Treatment of PNH with the complement inhibitor eculizumab (Soliris
MeSH term(s)	Anemia, Aplastic/complications ; Anemia, Aplastic/diagnostic imaging ; Anemia, Aplastic/pathology ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Hemoglobinuria, Paroxysmal/diagnostic imaging ; Hemoglobinuria, Paroxysmal/etiology ; Hemoglobinuria, Paroxysmal/pathology ; Hepatitis/complications ; Hepatitis/diagnostic imaging ; Hepatitis/pathology ; Humans ; Male ; Young Adult
Language	English
Publishing date	2020-10-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-020-06670-z
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Article: Collagen treatment of complex anorectal fistula: 3 years follow-up.

Maternini, Matteo / Guttadauro, Angelo / Avella, Pasquale / Buondonno, Antonio / Mascagni, Domenico / Milito, Giovanni / Stuto, Angelo / Renzi, Adolfo / Rennis, Maria / Bottini, Corrado / Quarto, Gennaro / Nudo, Raffaele / Del Re, Luca / Amato, Bruno / Gabrielli, Francesco

Open medicine (Warsaw, Poland)

2023 Volume 18, Issue 1, Page(s) 20220553

Abstract	Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should be considered for complex fistulas. One of the sphincteric preserving treatment is the filling with a dermal extract commonly called "collagen glue" as Salvecoll-E
Language	English
Publishing date	2023-07-11
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2022-0553
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Article ; Online: Different methods of bone marrow harvesting influence cell characteristics and purity, affecting clinical outcomes.

Caradonna, Eugenio / Mormone, Elisabetta / Centritto, Enrico Maria / Mazzanti, Andrea / Papini, Stefano / Fanelli, Mara / Petrella, Lella / Petruzziello, Arnolfo / Farina, Michele Angelo / Farina, Eleonora / Amato, Bruno / De Filippo, Carlo Maria / Vanoli, Emilio

JVS-vascular science

2023 Volume 4, Page(s) 100130

Abstract: Background: Bone marrow (BM)-derived stem cells were implanted to induce angiogenesis in patients with no-option critical limb-threatening ischemia. Considering the potential for this therapy, conflicting results related to BM harvesting methods have ... ...

Abstract	Background: Bone marrow (BM)-derived stem cells were implanted to induce angiogenesis in patients with no-option critical limb-threatening ischemia. Considering the potential for this therapy, conflicting results related to BM harvesting methods have been reported that could affect stem cell concentrations and quality. Methods: A total of 75 patients with no-option critical limb-threatening ischemia were treated with BM implantation. For 58 patients, BM was harvested using a BM aspirate concentrate system (Harvest Technologies; group HT) with a standard aspiration needle, followed by an automated centrifugation process, to produce BM aspirate concentrate. For 17 patients, BM was harvested using the Marrow Cellution system (Aspire Medical Innovation; group MC). CD34 Results: The retrospective analysis of a subset group after adjustment for age shows that the quality of BM obtained using the Marrow Cellution system is better, in terms of purity, than the classic harvesting method before centrifugation. Harvested BM before centrifugation is characterized by a higher percentage of CD133 Conclusions: BM manipulation, such as centrifugation, affects the quality and number of stem cells, with detrimental consequences on clinical outcomes, as reflected by the different amputation rates between the two groups.
Language	English
Publishing date	2023-10-14
Publishing country	United States
Document type	Journal Article
ISSN	2666-3503
ISSN (online)	2666-3503
DOI	10.1016/j.jvssci.2023.100130
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Article ; Online: Surgical treatment for common hepatic aneurysm. Original one-step technique

Amato Bruno / Patrone Renato / Quarto Gennaro / Compagna Rita / Cirocchi Roberto / Popivanov Georgi / Granata Vincenza / Belli Andrea / Izzo Francesco

Open Medicine, Vol 15, Iss 1, Pp 898-

2020 Volume 904

Abstract: Hepatic artery aneurysms are rare, and their treatment represents a challenge for the surgeons. ...

Abstract	Hepatic artery aneurysms are rare, and their treatment represents a challenge for the surgeons.
Keywords	hepatic artery aneurysm ; visceral aneurysm ; aneurysm treatment ; vascular stapler ; Medicine ; R
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Successful transanal removal of unusual foreign body self-inserted in the rectum A case report and review of literature.

Gentile, Maurizio / Cestaro, Giovanni / Di Filippo, Gabriele / Amato, Bruno / Sivero, Luigi

Annali italiani di chirurgia

2019 Volume 90, Page(s) 88–92

Abstract: Foreign bodies in the rectum are a true proctological emergency. The incidence of these cases is increasing in recent years mostly due to auto-erotic acts and behavior disordes and is mainly observed in young patients. Most patients with rectal foreign ... ...

Abstract	Foreign bodies in the rectum are a true proctological emergency. The incidence of these cases is increasing in recent years mostly due to auto-erotic acts and behavior disordes and is mainly observed in young patients. Most patients with rectal foreign bodies present to the emergency room usually exhausted after efforts of removingothe object at home. Many endoscopic and surgical techniques to get such removal have been described in the literature and the reported variety of in foreign bodies is as large as the number of techniques used to remove them. Authors report a case of unusual foreign body in the rectum that required multiple attempts to be removed and an original solution. KEY WORDS: Emergency surgery, Rectal foreign body, Transanal Extraction.
MeSH term(s)	Adult ; Anal Canal ; Digestive System Surgical Procedures/methods ; Foreign Bodies/surgery ; Humans ; Male ; Rectum ; Treatment Outcome
Language	English
Publishing date	2019-02-06
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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