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  1. AU="Ambrosino, Teresa"
  2. AU=Antipova Tatiana
  3. AU="Moens, Pierre D J"
  4. AU="Abdel-Megied, Ahmed M."
  5. AU="Jain, Aseem"
  6. AU="Marcos, Jose F"
  7. AU="Furr-Stimming, Erin"
  8. AU="Schüle, Birgit"
  9. AU="Travieso-González, Alejandro"
  10. AU=Turilli Emily Samuela
  11. AU="Rueckert, Erroll H"
  12. AU=Keestra-Gounder A. Marijke
  13. AU="María José Endara"
  14. AU="Li, Lin-Zi"
  15. AU="Shirvanian, Moein"
  16. AU="Capaldo, Bianca D"
  17. AU="Matose, Takunda"
  18. AU=Plouffe Brian D.
  19. AU=Kuter David J
  20. AU="Moore, I D"
  21. AU="Schreibing, Felix"
  22. AU=Kang Keunsoo
  23. AU="de Pedro-Múñez, Álvaro"

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  1. Artikel ; Online: Distinct effects of racial and socioeconomic disparities on biliary atresia diagnosis and outcome.

    Bonn, Julie / Gamm, Kristen / Ambrosino, Teresa / Orkin, Sarah H / Taylor, Amy / Peters, Anna L

    Journal of pediatric gastroenterology and nutrition

    2024  Band 78, Heft 5, Seite(n) 1038–1046

    Abstract: Objectives: To identify and distinguish between racial and socioeconomic disparities in age at hepatology care, diagnosis, access to surgical therapy, and liver transplant-free survival in patients with biliary atresia (BA).: Methods: Single-center ... ...

    Abstract Objectives: To identify and distinguish between racial and socioeconomic disparities in age at hepatology care, diagnosis, access to surgical therapy, and liver transplant-free survival in patients with biliary atresia (BA).
    Methods: Single-center retrospective cohort study of 69 BA patients from 2010 to 2021. Patients were grouped into White and non-White cohorts. The socioeconomic milieu was analyzed utilizing neighborhood deprivation index, a census tract-based calculation of six socioeconomic variables. The primary outcomes of this study were timing of the first hepatology encounter, surgical treatment with hepatic portoenterostomy (HPE), and survival with native liver (SNL) at 2 years.
    Results: Patients were 55% male and 72% White. White patients were referred at a median of 34 days (interquartile range [IQR]: 17-65) vs. 67 days (IQR: 42-133; p = 0.001) in non-White patients. White infants were more likely to undergo HPE (42/50 patients; 84%) compared to non-White (10/19; 53%), odds ratio (OR) 4.73 (95% confidence interval: 1.46-15.31; p = 0.01). Independent of race, patients exposed to increased neighborhood-level deprivation were less likely to receive HPE (OR: 0.49, p = 0.04) and achieve SNL (OR: 0.54, p = 0.02).
    Conclusions: Racial and socioeconomic disparities are independently associated with timely BA diagnosis, access to surgical treatment, and transplant-free survival. Public health approaches to improve screening for pathologic jaundice in infants of diverse racial backgrounds and to test and implement interventions for socioeconomically at-risk families are needed.
    Mesh-Begriff(e) Humans ; Biliary Atresia/surgery ; Biliary Atresia/diagnosis ; Biliary Atresia/ethnology ; Biliary Atresia/mortality ; Male ; Retrospective Studies ; Female ; Infant ; Healthcare Disparities/statistics & numerical data ; Healthcare Disparities/ethnology ; Portoenterostomy, Hepatic ; Socioeconomic Factors ; Liver Transplantation/statistics & numerical data ; Infant, Newborn ; Health Services Accessibility/statistics & numerical data ; White People/statistics & numerical data ; Socioeconomic Disparities in Health
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Anti-thymocyte globulin induction with delayed introduction of tacrolimus preserves renal function in pediatric liver transplant recipients.

    Rogers, Michael E / Ambrosino, Teresa / Hatcher, Laura / Bondoc, Alex / Tiao, Greg / Peters, Anna L

    Pediatric transplantation

    2023  Band 27, Heft 4, Seite(n) e14509

    Abstract: Background: Tacrolimus (TAC)-mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal-sparing immunosuppression using anti-thymocyte globulin (ATG) induction and delayed TAC ... ...

    Abstract Background: Tacrolimus (TAC)-mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal-sparing immunosuppression using anti-thymocyte globulin (ATG) induction and delayed TAC administration has not been studied in children. We evaluated the safety and efficacy of ATG induction on preserving renal function in children within the first year (Y1) post-LT in a single-center retrospective cohort study.
    Methods: Children under age 18 years of who received isolated LT from 2008 to 2020 with a GFR < 70 received renal-sparing (RS) protocol consisting of ATG with methylprednisolone (MP), delayed TAC administration, lower initial TAC trough goals, and mycophenolate mofetil (MMF). The RS group was matched 1:2 by age and LT indication with standard immunosuppression (SI) group. Changes in renal function as well as adverse events within Y1 post-LT were compared.
    Results: Forty-four pediatric patients were included in the analysis, of which 13 received RS. As expected, the RS group had significantly lower mean TAC trough levels at 30 days (10.3 vs. 13.2, p = .001) post-LT. Renal function was significantly preserved at 6 (-0.26 vs. 0.21, p = .004) and 12 months (-0.33 vs. 0.11, p = .003) post-LT in the RS versus SI group as measured by mean change in serum creatinine, with similar trends observed in eGFR and cystatin C. ACR, sepsis, viremia, graft loss and mortality occurred at similar rates in both RS and SI groups.
    Conclusion: Induction immunosuppression with ATG and delayed TAC administration in children with renal impairment is safe and effectively preserves renal function during Y1 post-LT.
    Mesh-Begriff(e) Humans ; Child ; Adolescent ; Tacrolimus/therapeutic use ; Antilymphocyte Serum/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Retrospective Studies ; Liver Transplantation/adverse effects ; Mycophenolic Acid/therapeutic use ; Kidney/physiology ; Graft Rejection/prevention & control ; Graft Survival
    Chemische Substanzen Tacrolimus (WM0HAQ4WNM) ; Antilymphocyte Serum ; Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4947: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: Flexible bronchoscopy in pediatric lung transplantation.

    Wannes Daou, Antoinette / Wallace, Carolyn / Barker, Mitzi / Ambrosino, Teresa / Towe, Christopher / Morales, David L S / Wikenheiser-Brokamp, Kathryn A / Hayes, Don / Burg, Gregory

    Pediatric transplantation

    2023  Band 28, Heft 4, Seite(n) e14757

    Abstract: Pediatric lung transplantation represents a treatment option for children with advanced lung disease or pulmonary vascular disorders who are deemed an appropriate candidate. Pediatric flexible bronchoscopy is an important and evolving field that is ... ...

    Abstract Pediatric lung transplantation represents a treatment option for children with advanced lung disease or pulmonary vascular disorders who are deemed an appropriate candidate. Pediatric flexible bronchoscopy is an important and evolving field that is highly relevant in the pediatric lung transplant population. It is thus important to advance our knowledge to better understand how care for children after lung transplant can be maximally optimized using pediatric bronchoscopy. Our goals are to continually improve procedural skills when performing bronchoscopy and to decrease the complication rate while acquiring adequate samples for diagnostic evaluation. Attainment of these goals is critical since allograft assessment by bronchoscopic biopsy is required for histological diagnosis of acute cellular rejection and is an important contributor to establishing chronic lung allograft dysfunction, a common complication after lung transplant. Flexible bronchoscopy with bronchoalveolar lavage and transbronchial lung biopsy plays a key role in lung transplant graft assessment. In this article, we discuss the application of bronchoscopy in pediatric lung transplant evaluation including historical approaches, our experience, and future directions not only in bronchoscopy but also in the evolving pediatric lung transplantation field. Pediatric flexible bronchoscopy has become a vital modality for diagnosing lung transplant complications in children as well as assessing therapeutic responses. Herein, we review the value of flexible bronchoscopy in the management of children after lung transplant and discuss the application of novel techniques to improve care for this complex pediatric patient population and we provide a brief update about new diagnostic techniques applied in the growing lung transplantation field.
    Mesh-Begriff(e) Humans ; Lung Transplantation/methods ; Bronchoscopy/methods ; Child ; Graft Rejection/diagnosis ; Biopsy/methods ; Bronchoalveolar Lavage/methods ; Lung ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Lung Diseases/diagnosis ; Lung Diseases/surgery
    Sprache Englisch
    Erscheinungsdatum 2023-12-01
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14757
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4947: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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