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  1. Article ; Online: Hysterectomy for Non-Prolapsed Uterus in Elderly Patients: Predictors of Prolonged Hospital Stay.

    Casarin, Jvan / Ghezzi, Fabio / Pinelli, Ciro / Laganà, Antonio Simone / Ambrosoli, Andrea / Longo, Mariangela / Cromi, Antonella

    Gynecologic and obstetric investigation

    2022  Volume 88, Issue 2, Page(s) 91–97

    Abstract: Objective: The objective of this study was to investigate surgical outcomes and complications of hysterectomy for benign conditions other than prolapse in elderly patients and to define predictors of prolonged hospitalization.: Design: Retrospective ... ...

    Abstract Objective: The objective of this study was to investigate surgical outcomes and complications of hysterectomy for benign conditions other than prolapse in elderly patients and to define predictors of prolonged hospitalization.
    Design: Retrospective analysis of prospectively collected data.
    Setting: This study was conducted in an academic research center.
    Patients: We utilized our institution surgical database to identify patients aged 60 years or more ("elderly") who underwent hysterectomy for benign conditions other than pelvic organ prolapse during a 20-year period (January 2000-December 2019).
    Methods: Length of stay (LOS) of more than 2 days (90th percentile of LOS) was defined as prolonged hospitalization. Patient demographics, comorbid conditions, and surgical approach (vaginal hysterectomy (VH), laparoscopic hysterectomy (LH), and abdominal hysterectomy (AH)) were identified. Patients treated via LH or VH were also grouped as minimally invasive surgery (MIS). Multivariable logistic regression was used to identify factors associated with prolonged LOS.
    Results: Overall, 334 patients were included in this study, 262 (78.4%) of whom underwent LH, 42 (12.6%) VH, and 30 (9.0%) AH. Median LOS was 2 days (1-8), and 63 (18.8%) patients required prolonged LOS. Compared to AH, median hospital stay was shorter in MIS group (2 days vs. 3 days, p < 0.001). No admission variables were associated with prolonged LOS. The only independent predictors of prolonged LOS were AH (odds ratio 24.82, 95% CI 4.84-127.16) and operative time (odds ratio for 30 mins increased 11.34, 95% CI 1.63-78.78). Compared to those who underwent VH, patients having LH had a higher rate of concomitant salpingo-oophorectomy (96.6% vs. 61.9%, p < 0.001).
    Limitations: Retrospective single-center study design, number of patients with prolonged hospitalization, and the setting (tertiary minimally invasive gynecology referral center), which might have reduced the generalizability of our results are the limitations of this study.
    Conclusions: The abdominal route of hysterectomy was found as the main driver of prolonged hospitalization, reinforcing the benefits of MIS for benign hysterectomy in elderly patients with non-prolapsed uteri; the higher chance of performing concomitant salpingo-oophorectomy supports the laparoscopic approach as the first option for these patients.
    MeSH term(s) Female ; Humans ; Length of Stay ; Retrospective Studies ; Laparoscopy/methods ; Hysterectomy/methods ; Uterus/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000528392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Continuous Wound Infiltration of Local Anesthetics in Postoperative Pain Management

    Paladini G / Di Carlo S / Musella G / Petrucci E / Scimia P / Ambrosoli A / Cofini V / Fusco P

    Journal of Pain Research, Vol Volume 13, Pp 285-

    Safety, Efficacy and Current Perspectives

    2020  Volume 294

    Abstract: Giuseppe Paladini,1 Stefano Di Carlo,2 Giuseppe Musella,1 Emiliano Petrucci,3 Paolo Scimia,4 Andrea Ambrosoli,1 Vincenza Cofini,5 Pierfrancesco Fusco3 1Department of Anesthesia, Perioperative Medicine and Intensive Care Therapy, Filippo Del Ponte Women ... ...

    Abstract Giuseppe Paladini,1 Stefano Di Carlo,2 Giuseppe Musella,1 Emiliano Petrucci,3 Paolo Scimia,4 Andrea Ambrosoli,1 Vincenza Cofini,5 Pierfrancesco Fusco3 1Department of Anesthesia, Perioperative Medicine and Intensive Care Therapy, Filippo Del Ponte Women and Children’s Hospital, ASST Sette Laghi, Varese, Italy; 2Department of Medical, Oral and Biotechnological Sciences, University of Chieti, Chieti, Italy; 3Department of Anesthesia and Intensive Care, San Salvatore Academic Hospital of L’Aquila, L’Aquila, Italy; 4Department of Anesthesia and Intensive Care, ASUR Marche AV5, San Benedetto Del Tronto, Italy; 5Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyCorrespondence: Giuseppe PaladiniDepartment of Anesthesia, Perioperative Medicine and Intensive Care Therapy, Filippo Del Ponte Women and Children’s Hospital, ASST Sette Laghi, Via F. Del Ponte 19, Varese CAP 21100, ItalyTel +39 3281477189Fax +39 0332299299Email giuseppepaladini16@gmail.comAbstract: Local infiltration and continuous infusion of surgical wound with anesthetics are parts of multimodal analgesia for postoperative pain control. The techniques, given the simplicity of execution that does not increase the timing of the intervention and does not require additional technical skills, are applied in several kinds of surgeries. The continuous wound infiltration can be used for days and a variety of continuous delivery methods can be chosen, including patient-controlled analgesia, continuous infusion or intermittent bolus. The purpose of this narrative review is to analyze the literature, in particular by researching the safety, efficacy and current perspectives of continuous wound infiltration for postoperative pain management in different surgical settings. We have identified 203 articles and 95 of these have been taken into consideration: 17 for the lower limb surgery; 7 for the upper limb surgery, 51 for the laparotomy/laparoscopic surgery of the abdominopelvic area, 13 studies regarding breast surgery and 7 ...
    Keywords continuous wound infiltration ; postoperative analgesia ; postoperative pain management ; local anesthetics ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Continuous Wound Infiltration of Local Anesthetics in Postoperative Pain Management

    Paladini G / Di Carlo S / Musella G / Petrucci E / Scimia P / Ambrosoli A / Cofini V / Fusco P

    Journal of Pain Research, Vol Volume 13, Pp 659-

    Safety, Efficacy and Current Perspectives [Corrigendum]

    2020  Volume 660

    Abstract: Paladini G, Di Carlo S, Musella G, et al. J Pain Res. 2020;13:285–294.On page 289, line 13, the sentence “The use of epinephrine added to LAs is not recommended by the authors of this review” should read “The use of epinephrine added to LAs is ... ...

    Abstract Paladini G, Di Carlo S, Musella G, et al. J Pain Res. 2020;13:285–294.On page 289, line 13, the sentence “The use of epinephrine added to LAs is not recommended by the authors of this review” should read “The use of epinephrine added to LAs is recommended by the authors of this review”. The authors apologize for this error. Read the original article
    Keywords continuous wound infiltration ; postoperative analgesia ; postoperative pain management ; local anesthetics ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Intrathecal anaesthesia for day-case knee arthroscopy - a reply.

    Ambrosoli, A L / Guzzetti, L / Cappelleri, G

    Anaesthesia

    2016  Volume 71, Issue 7, Page(s) 860–861

    MeSH term(s) Ambulatory Surgical Procedures ; Anesthesia ; Arthroscopy ; Knee Joint/surgery
    Language English
    Publishing date 2016-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.13552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intrathecal anaesthesia for day-case knee arthroscopy - a reply.

    Ambrosoli, A L / Guzzetti, L / Cappelleri, G

    Anaesthesia

    2016  Volume 71, Issue 10, Page(s) 1245–1246

    MeSH term(s) Anesthesia, Spinal ; Anesthetics, Local ; Arthroscopy ; Knee Joint
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2016-09-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.13659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Noninvasive Ventilation for Acute Respiratory Failure in Pediatric Patients: A Systematic Review and Meta-Analysis.

    Boghi, Daniele / Kim, Kyung Woo / Kim, Jun Hyun / Lee, Sang-Il / Kim, Ji Yeon / Kim, Kyung-Tae / Ambrosoli, Andrea / Guarneri, Giovanni / Landoni, Giovanni / Cabrini, Luca

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2022  Volume 24, Issue 2, Page(s) 123–132

    Abstract: Objective: To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) on the use of noninvasive ventilation (NIV) for acute respiratory failure (ARF) in pediatric patients.: Data sources: We searched PubMed, EMBASE, the ... ...

    Abstract Objective: To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) on the use of noninvasive ventilation (NIV) for acute respiratory failure (ARF) in pediatric patients.
    Data sources: We searched PubMed, EMBASE, the Cochrane Central Register of Clinical Trials, and Clinicaltrials.gov with a last update on July 31, 2022.
    Study selection: We included RCTs comparing NIV with any comparator (standard oxygen therapy and high-flow nasal cannula [HFNC]) in pediatric patients with ARF. We excluded studies performed on neonates and on chronic respiratory failure patients.
    Data extraction: Baseline characteristics, intubation rate, mortality, and hospital and ICU length of stays were extracted by trained investigators.
    Data synthesis: We identified 15 RCTs (2,679 patients) for the final analyses. The intubation rate was 109 of 945 (11.5%) in the NIV group, and 158 of 1,086 (14.5%) in the control group (risk ratio, 0.791; 95% CI, 0.629-0.996; p = 0.046; I2 = 0%; number needed to treat = 31). Findings were strengthened after removing studies with intervention duration shorter than an hour and after excluding studies with cross-over as rescue treatment. There was no difference in mortality, and ICU and hospital length of stays.
    Conclusions: In pediatric patients, NIV applied for ARF might reduce the intubation rate compared with standard oxygen therapy or HFNC. No difference in mortality was observed.
    MeSH term(s) Infant, Newborn ; Humans ; Child ; Noninvasive Ventilation ; Oxygen ; Oxygen Inhalation Therapy ; Intubation ; Respiratory Distress Syndrome/therapy ; Cannula ; Respiratory Insufficiency/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Continuous Wound Infiltration of Local Anesthetics in Postoperative Pain Management: Safety, Efficacy and Current Perspectives.

    Paladini, Giuseppe / Di Carlo, Stefano / Musella, Giuseppe / Petrucci, Emiliano / Scimia, Paolo / Ambrosoli, Andrea / Cofini, Vincenza / Fusco, Pierfrancesco

    Journal of pain research

    2020  Volume 13, Page(s) 285–294

    Abstract: Local infiltration and continuous infusion of surgical wound with anesthetics are parts of multimodal analgesia for postoperative pain control. The techniques, given the simplicity of execution that does not increase the timing of the intervention and ... ...

    Abstract Local infiltration and continuous infusion of surgical wound with anesthetics are parts of multimodal analgesia for postoperative pain control. The techniques, given the simplicity of execution that does not increase the timing of the intervention and does not require additional technical skills, are applied in several kinds of surgeries. The continuous wound infiltration can be used for days and a variety of continuous delivery methods can be chosen, including patient-controlled analgesia, continuous infusion or intermittent bolus. The purpose of this narrative review is to analyze the literature, in particular by researching the safety, efficacy and current perspectives of continuous wound infiltration for postoperative pain management in different surgical settings. We have identified 203 articles and 95 of these have been taken into consideration: 17 for the lower limb surgery; 7 for the upper limb surgery, 51 for the laparotomy/laparoscopic surgery of the abdominopelvic area, 13 studies regarding breast surgery and 7 for cardiothoracic surgery. The analysis of these studies reveals that the technique has a variable effectiveness based on the type of structure involved: it is better in structures rich in subcutaneous and connective tissue, while the effectiveness is limited in anatomic districts with a greater variability of innervation. However, regardless the heterogeneity of results, a general reduction in pain intensity and in opioid consumption has been observed with continuous wound infiltration: it is an excellent analgesic technique that can be included in the multimodal treatment of postoperative pain or represents a valid alternative when other options are contraindicated.
    Language English
    Publishing date 2020-01-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S211234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Maxillomandibular advancement in obstructive sleep apnea syndrome patients: a restrospective study on the sagittal cephalometric variables.

    Ronchi, Paolo / Cinquini, Valentina / Ambrosoli, Alessandro / Caprioglio, Alberto

    Journal of oral & maxillofacial research

    2013  Volume 4, Issue 2, Page(s) e5

    Abstract: Objectives: The present retrospective study analyzes sagittal cephalometric changes in patients affected by obstructive sleep apnea syndrome submitted to maxillomandubular advancement.: Material and methods: 15 adult sleep apnea syndrome (OSAS) ... ...

    Abstract Objectives: The present retrospective study analyzes sagittal cephalometric changes in patients affected by obstructive sleep apnea syndrome submitted to maxillomandubular advancement.
    Material and methods: 15 adult sleep apnea syndrome (OSAS) patients diagnosed by polysomnography (PSG) and treated with maxillomandubular advancement (MMA) were included in this study. Pre- (T1) and postsurgical (T2) PSG studies assessing the apnea/hypopnea index (AHI) and the lowest oxygen saturation (LSAT) level were compared. Lateral cephalometric radiographs at T1 and T2 measuring sagittal cephalometric variables (SNA, SNB, and ANB) were analyzed, as were the amount of maxillary and mandibular advancement (Co-A and Co-Pog), the distance from the mandibular plane to the most anterior point of the hyoid bone (Mp-H), and the posterior airway space (PAS).
    Results: Postoperatively, the overall mean AHI dropped from 58.7 ± 16 to 8.1 ± 7.8 events per hour (P < 0.001). The mean preoperative LSAT increased from 71% preoperatively to 90% after surgery (P < 0.001). All the patients in our study were successfully treated (AHI < 20 or reduced by 50%). Cephalometric analysis performed after surgery showed a statistically significant correlation between the mean SNA variation and the decrease in the AHI (P = 0.01). The overall mean SNA increase was 6°.
    Conclusions: Our findings suggest that the improvement observed in the respiratory symptoms, namely the apnea/hypopnea episodes, is correlated with the SNA increase after surgery. This finding may help maxillofacial surgeons to establish selective criteria for the surgical approach to sleep apnea syndrome patients.
    Language English
    Publishing date 2013-07-01
    Publishing country Lithuania
    Document type Journal Article ; Review
    ZDB-ID 2580511-3
    ISSN 2029-283X
    ISSN 2029-283X
    DOI 10.5037/jomr.2013.4205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A randomised controlled trial comparing two popliteal nerve catheter tip positions for postoperative analgesia after day-case hallux valgus repair.

    Ambrosoli, A L / Guzzetti, L / Chiaranda, M / Cuffari, S / Gemma, M / Cappelleri, G

    Anaesthesia

    2016  Volume 71, Issue 11, Page(s) 1317–1323

    Abstract: We compared the effect of two different positions of a sciatic nerve catheter within the popliteal fossa on local anaesthetic consumption and postoperative analgesia in patients undergoing day-case hallux valgus repair. Eighty-four patients were randomly ...

    Abstract We compared the effect of two different positions of a sciatic nerve catheter within the popliteal fossa on local anaesthetic consumption and postoperative analgesia in patients undergoing day-case hallux valgus repair. Eighty-four patients were randomly allocated to receive a sciatic nerve catheter either between the tibial and peroneal components (sciatic group) or medial to the tibial nerve (tibial group). The primary endpoint was postoperative local anaesthetic consumption, while secondary endpoints were pain scores, number of occasions where sleep was disturbed by pain and incidence of insensate limb and foot drop at 24 h and 48 h postoperatively. Postoperative median (IQR [range]) local anaesthetic consumption was 126 (106-146 [98-180]) ml in the sciatic group versus 125 (114-158 [98-200]) ml in the tibial group (p = 0.103). Insensate limb occurred in 14 patients in the sciatic group versus one patient in the tibial group (p < 0.001), while foot drop was reported by six patients in the sciatic group and none in the tibial group (p = 0.012). Sciatic nerve catheter placement medial to the tibial nerve may be a superior analgesic technique for day-case foot surgery.
    MeSH term(s) Adult ; Aged ; Ambulatory Surgical Procedures ; Anesthetics, Local/administration & dosage ; Catheterization/methods ; Drug Administration Schedule ; Female ; Hallux Valgus/surgery ; Humans ; Male ; Middle Aged ; Nerve Block/methods ; Pain Measurement/methods ; Pain, Postoperative/prevention & control ; Sciatic Nerve/diagnostic imaging ; Single-Blind Method ; Tibial Nerve/diagnostic imaging ; Ultrasonography, Interventional/methods
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2016-10-12
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.13577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A randomised controlled trial of intrathecal blockade versus peripheral nerve blockade for day-case knee arthroscopy.

    Ambrosoli, A L / Chiaranda, M / Fedele, L L / Gemma, M / Cedrati, V / Cappelleri, G

    Anaesthesia

    2016  Volume 71, Issue 3, Page(s) 280–284

    Abstract: We allocated 100 patients scheduled for day-case knee arthroscopy to unilateral spinal anaesthesia with 40 mg intrathecal hyperbaric prilocaine or to ultrasound-guided femoral-sciatic nerve blockade with 25 ml mepivacaine 2%, 50 participants each. The ... ...

    Abstract We allocated 100 patients scheduled for day-case knee arthroscopy to unilateral spinal anaesthesia with 40 mg intrathecal hyperbaric prilocaine or to ultrasound-guided femoral-sciatic nerve blockade with 25 ml mepivacaine 2%, 50 participants each. The median (IQR [range]) time to walk was 285 (240-330 [160-515]) min after intrathecal anaesthesia vs 328 (280-362 [150-435]) min after peripheral nerve blockade, p = 0.007. The median (IQR [range]) time to home discharge was 310 (260-350 [160-520]) min after intrathecal anaesthesia vs 335 (290-395 [190-440]) min after peripheral nerve blockade, p = 0.016. There was no difference in time from anaesthetic preparation to readiness for surgery.
    MeSH term(s) Adolescent ; Adult ; Aged ; Ambulatory Surgical Procedures ; Anesthesia Recovery Period ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/therapeutic use ; Arthroscopy ; Female ; Femoral Nerve/diagnostic imaging ; Femoral Nerve/drug effects ; Humans ; Injections, Spinal ; Knee Joint/surgery ; Length of Stay/statistics & numerical data ; Male ; Mepivacaine/administration & dosage ; Mepivacaine/therapeutic use ; Middle Aged ; Nerve Block/methods ; Peripheral Nerves/diagnostic imaging ; Peripheral Nerves/drug effects ; Prilocaine/administration & dosage ; Prilocaine/therapeutic use ; Sciatic Nerve/diagnostic imaging ; Sciatic Nerve/drug effects ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional ; Young Adult
    Chemical Substances Anesthetics, Local ; Prilocaine (046O35D44R) ; Mepivacaine (B6E06QE59J)
    Language English
    Publishing date 2016-01-06
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.13361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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