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  1. Article ; Online: Virus-Encoded Circular RNAs: Role and Significance in Viral Infections.

    Sberna, Giuseppe / Maggi, Fabrizio / Amendola, Alessandra

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Circular RNAs (circRNAs) have been the focus of intense scientific research to understand their biogenesis, mechanisms of action and regulatory functions. CircRNAs are single stranded, covalently closed RNA molecules lacking the 5'-terminal cap and the 3' ...

    Abstract Circular RNAs (circRNAs) have been the focus of intense scientific research to understand their biogenesis, mechanisms of action and regulatory functions. CircRNAs are single stranded, covalently closed RNA molecules lacking the 5'-terminal cap and the 3'-terminal polyadenine chain, characteristics that make them very stable and resistant. Synthesised by both cells and viruses, in the past circRNAs were considered to have no precise function. Today, increasing evidence shows that circRNAs are ubiquitous, some of them are tissue- and cell-specific, and critical in multiple regulatory processes (i.e., infections, inflammation, oncogenesis, gene expression). Moreover, circRNAs are emerging as important biomarkers of viral infection and disease progression. In this review, we provided an updated overview of current understanding of virus-encoded and cellular-encoded circRNAs and their involvement in cellular pathways during viral infection.
    MeSH term(s) Humans ; RNA, Circular/genetics ; RNA/genetics ; Virus Diseases/genetics ; Biomarkers/metabolism ; Viruses/genetics
    Chemical Substances RNA, Circular ; RNA (63231-63-0) ; Biomarkers
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Solution Structure and Dynamics of Hf-Al and Hf-Zn Heterobimetallic Adducts Mimicking Relevant Intermediates in Chain Transfer Reactions.

    Tensi, Leonardo / Moretti, Francesca / Amendola, Alessandra / Froese, Robert D J / Macchioni, Alceo / Kuhlman, Roger L / Pearson, David M / Zuccaccia, Cristiano

    Inorganic chemistry

    2024  

    Abstract: Cationic cyclometalated hafnocenes [ ... ...

    Abstract Cationic cyclometalated hafnocenes [Cp
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating the Dual-Target Aptima HIV-1 Quant Dx Assay: Comparison between Viral Loads Measured with

    Sberna, Giuseppe / Sarti, Silvia / Cicalini, Stefania / Antinori, Andrea / Garbuglia, Anna Rosa / Amendola, Alessandra

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0136122

    Abstract: For effective management of HIV-1 patients, accurate measurement of HIV-1-RNA viral load (VL) is fundamental. The latest generation molecular assays for monitoring VL perform simultaneous detection of two regions of the viral genome, but without ... ...

    Abstract For effective management of HIV-1 patients, accurate measurement of HIV-1-RNA viral load (VL) is fundamental. The latest generation molecular assays for monitoring VL perform simultaneous detection of two regions of the viral genome, but without specifying the target used for VL quantitation. By using the "open" software (research use only [RUO]) of Aptima HIV-1 Quant Dx Assay (Aptima) which provides both results obtained with the
    MeSH term(s) Humans ; Viral Load/methods ; HIV-1/genetics ; RNA, Viral/genetics ; RNA, Viral/analysis ; Reagent Kits, Diagnostic ; Molecular Diagnostic Techniques/methods ; Sensitivity and Specificity ; HIV Infections/diagnosis ; HIV Infections/drug therapy
    Chemical Substances RNA, Viral ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01361-22
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  4. Article ; Online: Changes in the Circulation of Common Respiratory Pathogens among Hospitalized Patients with Influenza-like Illnesses in the Lazio Region (Italy) during Fall Season of the Past Three Years.

    Sberna, Giuseppe / Lalle, Eleonora / Valli, Maria Beatrice / Bordi, Licia / Garbuglia, Anna Rosa / Amendola, Alessandra

    International journal of environmental research and public health

    2022  Volume 19, Issue 10

    Abstract: A descriptive analysis of common respiratory pathogens (CRPs) detected in nasopharyngeal swabs (NPSs) from hospitalized patients with influenza-like illness during the fall seasons of the past three years, 2019-2021, in the Lazio region, Italy, was ... ...

    Abstract A descriptive analysis of common respiratory pathogens (CRPs) detected in nasopharyngeal swabs (NPSs) from hospitalized patients with influenza-like illness during the fall seasons of the past three years, 2019-2021, in the Lazio region, Italy, was conducted to assess whether or not CRP circulation changed because of COVID-19 during the fall season. The results observed in a total of 633 NPSs subjected to molecular diagnosis for CRPs by multiplex PCR assay during the autumn seasons (exactly from week 41 to week 50) were compared with each other. In 2019, in 144 NPSs, the more represented CRPs were rhinovirus/enterovirus (7.6%) and influenza A/B (4.2%). In 2020, 55 (21.6%) out of 255 NPSs resulted positive for SARS-CoV-2 and, except for one case of
    MeSH term(s) Adult ; COVID-19/epidemiology ; Humans ; Influenza, Human/epidemiology ; Italy/epidemiology ; Pandemics ; Respiratory Syncytial Viruses ; SARS-CoV-2 ; Seasons ; Virus Diseases/epidemiology ; Viruses
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19105962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Virological characterization of HIV-1 RNA elements detected exclusively through the LTR region by the dual-target Aptima HIV-1 Quant Dx assay in a subset of positive patients.

    Sberna, Giuseppe / Nardacci, Roberta / Berno, Giulia / Rozera, Gabriella / Giombini, Emanuela / Fabeni, Lavinia / Specchiarello, Eliana / Maggi, Fabrizio / Amendola, Alessandra

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2023  Volume 167, Page(s) 105575

    Abstract: Background: In a restricted subset of HIV patients with suppressed viral load (i.e., pol-undetected HIV-RNA), the Aptima HIV-1 Quant Dx Assay (Aptima), a dual-target (pol and LTR) and dual-probe test for viral load (VL) monitoring, can detect HIV-RNA ... ...

    Abstract Background: In a restricted subset of HIV patients with suppressed viral load (i.e., pol-undetected HIV-RNA), the Aptima HIV-1 Quant Dx Assay (Aptima), a dual-target (pol and LTR) and dual-probe test for viral load (VL) monitoring, can detect HIV-RNA exclusively through amplification of the LTR region.
    Objectives: To analyze the virological characteristics of the HIV-RNA elements detected only through LTR amplification (LTR-e).
    Study design: LTR-e isolated from plasma and peripheral blood mononuclear cells (PBMC) were evaluated for their ability to trigger productive infections. Viral pellets morphology and ultrastructural characteristics of PBMC from LTR-e patients were examined by electron microscopy. Plasma LTR-e underwent Sanger sequencing. Exosomes were examined with Aptima for LTR-e content.
    Results: In-vitro, LTR-e could not infect PBMC, induce cytopathic effects, or cause syncytia, even at high VL (e.g., >10,000 copies/mL). Under the electron microscope, plasma pellets and PBMC from patients with LTR-e showed atypical vesicles. Sanger sequencing of LTR-e yielded no results. Moreover, in plasma samples, LTR-e were associated with cell debris, never with exosomes.
    Conclusions: Differently from other dual-target but single-probe assays, Aptima unveils VL based only on LTR amplification in some HIV patients. Here, we show that LTR-e represent partial/incomplete/non-canonical transcripts unable to trigger productive infection or transmit HIV-1 infection. The recognition of VL based only on LTR-e in infected individuals is crucial as it allows to avoid inappropriate decisions in the clinical management of HIV patients, such as retesting of VL and switching of ART. Physicians and HIV-RNA dual-target assay manufacturers should consider the important implications of not recognizing this singular type of VL.
    MeSH term(s) Humans ; HIV Infections/diagnosis ; HIV-1/genetics ; Leukocytes, Mononuclear ; RNA, Viral/genetics ; Sensitivity and Specificity ; HIV Seropositivity ; Viral Load/methods
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-08-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2023.105575
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Comparing multivariate volatility forecasts by direct and indirect approaches

    Amendola, Alessandra / Candila, Vincenzo

    Journal of risk Vol. 19, No. 6 , p. 33-57

    2017  Volume 19, Issue 6, Page(s) 33–57

    Author's details Alessandra Amendola and Vincenzo Candila
    Keywords volatility evaluation ; MGARCH ; realized covariance ; value-at-risk (VaR) ; forecasting
    Language English
    Publisher Incisive Media Plc
    Publishing place London
    Document type Article
    ZDB-ID 1476260-2
    ISSN 1465-1211
    Database ECONomics Information System

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  7. Article ; Online: Letter of concern re: "Immunochromatographic test for the detection of SARS-CoV-2 in saliva. J Infect Chemother. 2021 Feb;27(2):384-386. doi: 10.1016/j.jiac.2020.11.016."

    Sberna, Giuseppe / Lalle, Eleonora / Capobianchi, Maria Rosaria / Bordi, Licia / Amendola, Alessandra

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2021  Volume 27, Issue 7, Page(s) 1129–1130

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunologic Tests ; SARS-CoV-2 ; Saliva
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-04-13
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2021.04.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: Fiscal incentives and firm performance

    Amendola, Alessandra / Boccia, Marinella / Mele, Gianluca / Sensini, Luca

    evidence from the Dominican Republic

    (Policy research working paper ; 8382)

    2018  

    Author's details Alessandra Amendola, Marinella Boccia, Gianluca Mele, Luca Sensini
    Series title Policy research working paper ; 8382
    Keywords Körperschaftsteuer ; Unternehmenserfolg ; Panel ; Fixed-Effects-Modell ; Mehrebenenanalyse ; Dominikanische Republik
    Language English
    Size 1 Online-Ressource (circa 23 Seiten), Illustrationen
    Document type Book ; Online
    Database ECONomics Information System

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  9. Article: Model uncertainty and forecast combination in high-dimensional multivariate volatility prediction

    Amendola, Alessandra / Storti, Giuseppe

    Journal of forecasting Vol. 34, No. 2 , p. 83-91

    2015  Volume 34, Issue 2, Page(s) 83–91

    Author's details Alessandra Amendola and Giuseppe Storti
    Keywords forecast combination ; volatility ; multivariate GARCH ; realized covariance matrices ; predictive ability
    Language English
    Publisher Wiley
    Publishing place Chichester
    Document type Article
    ZDB-ID 783432-9 ; 2001645-1
    ISSN 1099-131X ; 0277-6693
    ISSN (online) 1099-131X
    ISSN 0277-6693
    Database ECONomics Information System

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  10. Article: Detection of SARS-CoV-2 Variants via Different Diagnostics Assays Based on Single-Nucleotide Polymorphism Analysis.

    Specchiarello, Eliana / Matusali, Giulia / Carletti, Fabrizio / Gruber, Cesare Ernesto Maria / Fabeni, Lavinia / Minosse, Claudia / Giombini, Emanuela / Rueca, Martina / Maggi, Fabrizio / Amendola, Alessandra / Garbuglia, Anna Rosa

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by fast evolution with the appearance of several variants. Next-Generation Sequencing (NGS) technology is considered the gold standard for monitoring known and new SARS-CoV-2 ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by fast evolution with the appearance of several variants. Next-Generation Sequencing (NGS) technology is considered the gold standard for monitoring known and new SARS-CoV-2 variants. However, the complexity of this technology renders this approach impracticable in laboratories located in areas with limited resources. We analyzed the capability of the ThermoFisher TaqPath COVID-19 RT-PCR (TaqPath) and the Seegene Novaplex SARS-CoV-2 Variant assay (Novaplex) to detect Omicron variants; the Allplex VariantII (Allplex) was also evaluated for Delta variants. Sanger sequencing (SaS) was the reference method. The results obtained with
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13091573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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