LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 13

Search options

  1. Article: Is natural variability really natural? The case of Atlantic Multidecadal Oscillation investigated by a neural network model

    Pasini, Antonello / Amendola, Stefano / Federbusch, Emmanuel

    Theoretical and applied climatology. 2022 Oct., v. 150, no. 1-2

    2022  

    Abstract: Is Atlantic Multidecadal Oscillation a genuine representation of natural variability in the climate system? Or perhaps is it strongly forced by external drivers? In this paper, a data-driven attribution investigation has been performed for the Atlantic ... ...

    Abstract Is Atlantic Multidecadal Oscillation a genuine representation of natural variability in the climate system? Or perhaps is it strongly forced by external drivers? In this paper, a data-driven attribution investigation has been performed for the Atlantic Multidecadal Oscillation (AMO) behaviour in the past via a machine learning technique, NN modelling. We clearly see a forced nature of AMO in the last 150 years, with a strong contribution of the forcing coming from anthropogenic sulphates, which induces its typical oscillating behaviour. The following original application of our model to future predictions of the AMO behaviour shows that it shall probably lose its oscillating characteristic features. The only way to recover them is to consider an unrealistic increase in anthropogenic sulphates in the future under a strong mitigation scenario, and possibly a low-power solar regime. Due to the established influence of AMO on climate and meteorological phenomena in several regions of the world, our results can be important to better understand the past and envisage several future scenarios.
    Keywords climate ; climatology ; neural networks
    Language English
    Dates of publication 2022-10
    Size p. 881-892.
    Publishing place Springer Vienna
    Document type Article
    ZDB-ID 1463177-5
    ISSN 1434-4483 ; 0177-798X
    ISSN (online) 1434-4483
    ISSN 0177-798X
    DOI 10.1007/s00704-022-04207-0
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Papillary thyroid carcinoma: ≤ 10 mm does not always mean pN0. A multicentric real-world study.

    Amendola, Stefano / Piticchio, Tommaso / Scappaticcio, Lorenzo / Sellasie, Sium Wolde / Volpe, Salvatore / Le Moli, Rosario / Coppola, Luigi / Guidobaldi, Leo / Pedicini, Francesco / Carbone, Carla / Caruso, Paola / Gamarra, Elena / Docimo, Giovanni / Frasca, Francesco / Uccioli, Luigi / Trimboli, Pierpaolo

    Updates in surgery

    2024  

    Abstract: The incidence of papillary thyroid carcinoma (PTC) is increasing and PTC ≤ 10 mm (PTMC) accounts for most new diagnoses. PTMCs are not always low risk, as detection of lymph nodes metastasis (LNM) may occur. The purpose of the study was to analyze the ... ...

    Abstract The incidence of papillary thyroid carcinoma (PTC) is increasing and PTC ≤ 10 mm (PTMC) accounts for most new diagnoses. PTMCs are not always low risk, as detection of lymph nodes metastasis (LNM) may occur. The purpose of the study was to analyze the clinical pattern, frequency, and independent risk factors of patients with PTMC and LNM. From January 2022 to June 2023, PTCs managed at CTO Hospital, Rome; Policlinico Vanvitelli, Naples; and Garibaldi Nesima Hospital, Catania were included. PTC management followed the same diagnostic-therapeutic procedures according to the ATA guidelines. Variables such as age, sex, maximum diameter, histologic evidence of LNM (HELNM +), Hashimoto's thyroiditis (HT), multifocality, capsule invasion, and histological subtype were considered. PTCs were divided according to HELNM and size. Two hundred ninety-eight PTCs were included. PTMCs were 136 (45.6%) and LNM occurred in 27.2% of them. In the HELNM + group, analysis of PTMC vs 'MacroPTC' (PTC > 10 mm) did not show any statistical difference. Multivariate regression revealed that young age (OR 0.93; CI 95% 0.90-0.96; p < 0.01) and male sex (male OR 3.44; CI 95% 1.16-10.20; p = 0.03) were the only independent risk factors for HELNM + in PTMC. The risk of LNM in PTMC is not negligible; therefore, a careful evaluation by an expert thyroidologist is mandatory for patients with small thyroid nodule, especially in younger and male patients before excluding surgery. In the future, new tools are needed to detect early PTMC with LNM before surgery.
    Language English
    Publishing date 2024-03-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01779-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Evaluation of the Performance of ACR TI-RADS Also Considering Those Nodules with No Indication of FNAC: A Single-Center Experience.

    Amendola, Stefano / Wolde Sellasie, Sium / Pedicini, Francesco / Carlini, Massimo / Russo, Giulia / Ossola, Nicola / Leoncini, Andrea / Botti, Flavia / Bonanno, Elena / Trimboli, Pierpaolo / Uccioli, Luigi

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Background: Several US risk stratification score systems (RSSs) have been developed to standardize a thyroid nodule risk of malignancy. It is still a matter of debate which RSS is the most reliable. The purpose of this study is to evaluate: (1) the ... ...

    Abstract Background: Several US risk stratification score systems (RSSs) have been developed to standardize a thyroid nodule risk of malignancy. It is still a matter of debate which RSS is the most reliable. The purpose of this study is to evaluate: (1) the concordance between the American College of Radiology TI-RADS (ACR TI-RADS) and fine needle aspiration cytology (FNAC), (2) the cancer rate in the ACR TI-RADS categories, (3) the characteristics of nodules evaluated by FNAC even if not formally indicated according to ACR TI-RADS ('not indicated FNACs").
    Methods: From January 2021 to September 2022, patients attending the Endocrinology Unit of the CTO Hospital of Rome for evaluation of thyroid nodules were included.
    Results: 830 nodules had negative cytology, belonging to TIR2 and TIR1C. One hundred and thirteen nodules were determined to be suspicious for or consistent with malignancy belonging to TIR3B/TIR4/TIR5. Of this last group, 94% were classified as TR4/TR5 nodules. In total, 87/113 underwent surgery. Among these, 73 had histologically proven cancer, 14 turned out to be benign. "Not indicated FNACs" was 623. Among these, 42 cancers were present.
    Conclusions: This study confirmed the diagnostic power of ACR TI-RADS. In addition, these data suggest revising the ACR TI-RADS indication to FNAC, especially for TR4.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Attribution of recent temperature behaviour reassessed by a neural-network method.

    Pasini, Antonello / Racca, Paolo / Amendola, Stefano / Cartocci, Giorgio / Cassardo, Claudio

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 17681

    Abstract: Attribution studies on recent global warming by Global Climate Model (GCM) ensembles converge in showing the fundamental role of anthropogenic forcings as primary drivers of temperature in the last half century. However, despite their differences, all ... ...

    Abstract Attribution studies on recent global warming by Global Climate Model (GCM) ensembles converge in showing the fundamental role of anthropogenic forcings as primary drivers of temperature in the last half century. However, despite their differences, all these models pertain to the same dynamical approach and come from a common ancestor, so that their very similar results in attribution studies are not surprising and cannot be considered as a clear proof of robustness of the results themselves. Thus, here we adopt a completely different, non-dynamical, data-driven and fully nonlinear approach to the attribution problem. By means of neural network (NN) modelling, and analysing the last 160 years, we perform attribution experiments and find that the strong increase in global temperature of the last half century may be attributed basically to anthropogenic forcings (with details on their specific contributions), while the Sun considerably influences the period 1910-1975. Furthermore, the role of sulphate aerosols and Atlantic Multidecadal Oscillation for better catching interannual to decadal temperature variability is clarified. Sensitivity analyses to forcing changes are also performed. The NN outcomes both corroborate our previous knowledge from GCMs and give new insight into the relative contributions of external forcings and internal variability to climate.
    Language English
    Publishing date 2017-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-18011-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Safety and efficacy of denosumab in osteoporotic hemodialysed patients.

    Festuccia, Francescaromana / Jafari, Maryam Tayefeh / Moioli, Alessandra / Fofi, Claudia / Barberi, Simona / Amendola, Stefano / Sciacchitano, Salvatore / Punzo, Giorgio / Menè, Paolo

    Journal of nephrology

    2017  Volume 30, Issue 2, Page(s) 271–279

    Abstract: Background and aims: In elderly subjects, renal insufficiency and osteoporosis often coexist with high risk of fracture and elevated socio-economic burden. Today a large number of effective anti-osteoporotic drugs are available but generally they are ... ...

    Abstract Background and aims: In elderly subjects, renal insufficiency and osteoporosis often coexist with high risk of fracture and elevated socio-economic burden. Today a large number of effective anti-osteoporotic drugs are available but generally they are contraindicated in patients with chronic kidney disease (CKD) because of their progressive accumulation. Denosumab, instead, does not require dose adjustments for different degrees of renal impairment so it can be a valid treatment in osteoporotic patients with CKD. Limited data are available in the literature concerning the use of denosumab in hemodialysis (HD). The aim of our study was, therefore, to study the efficacy and tolerability of this drug in this particular subset of patients.
    Methods: We retrospectively reviewed the charts of 12 osteoporotic HD patients who received a single 60-mg subcutaneous dose of denosumab every 6 months for an observation period of 24 months. Serum electrolyte, markers of bone turnover and quantitative ultrasound (QUS) were evaluated.
    Results: Over 24 months, we observed a gradual improvement of bone metabolism: β-CrossLaps from 2567.08 ± 1264 to 1492.5 ± 1182.5 pg/ml; bone alkaline phosphatase (BALP) from 33.5 ± 28.8 to 11.8 ± 3.7 mcg/l, and of QUS index (T-score from -5.33 ± 1.58 to -4.84 ± 1.2; risk of fracture from 13.9 ± 4.7 to 11.07 ± 5.3 %). Few cases of hypocalcemia were detected, more significant after the first and second injection, but with careful monitoring of serum calcium and rapid therapy adjustment we could easily manage serum Ca levels.
    Conclusions: Our pilot experience highlights the safety and efficacy of denosumab in the treatment of osteoporosis in HD patients, potentially supporting its use to reduce the burden of fractures in this patient population.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Bone Remodeling/drug effects ; Calcium/blood ; Denosumab/adverse effects ; Denosumab/therapeutic use ; Female ; Humans ; Hypocalcemia/blood ; Hypocalcemia/chemically induced ; Male ; Middle Aged ; Osteoporosis/blood ; Osteoporosis/diagnostic imaging ; Osteoporosis/drug therapy ; Osteoporosis/physiopathology ; Pilot Projects ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Chemical Substances Biomarkers ; Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-04
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-016-0334-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Galectin-3 and HBME-1 improve the accuracy of core biopsy in indeterminate thyroid nodules.

    Trimboli, Pierpaolo / Guidobaldi, Leo / Amendola, Stefano / Nasrollah, Naim / Romanelli, Francesco / Attanasio, Daniela / Ramacciato, Giovanni / Saggiorato, Enrico / Valabrega, Stefano / Crescenzi, Anna

    Endocrine

    2016  Volume 52, Issue 1, Page(s) 39–45

    Abstract: Core needle biopsy (CNB) has been recently described as an accurate second-line test in thyroid inconclusive cytology (FNA). Here we retrospectively investigated the potential improvement given by Galectin-3, Cytokeratin-19, and HBME-1 on the accuracy of ...

    Abstract Core needle biopsy (CNB) has been recently described as an accurate second-line test in thyroid inconclusive cytology (FNA). Here we retrospectively investigated the potential improvement given by Galectin-3, Cytokeratin-19, and HBME-1 on the accuracy of CNB in thyroid nodules with prior indeterminate FNA report. The study included 74 nodules. At CNB diagnosis, 15 were cancers, 40 were benign, and 19 had uncertain/non-diagnostic CNB report. The above immunohistochemical (IHC) panel was analyzed in all cases. After surgery, 19 malignant and 55 benign lesions were found. All 15 cancers and all 40 benign nodules diagnosed at CNB were confirmed at final histology. Regarding the uncertain CNB group, 4 (21 %) were malignant and 15 (79 %) benign. When we considered all the series, the most accurate IHC combination was Galectin-3 plus HBME-1, while HBME-1 was the most sensitive marker in those nodules with uncertain CNB report. The combination of CNB plus IHC could indentify 19/19 cancers and 53/55 benign lesions. Sensitivity and specificity of CNB increased from 79 to 100 % and from 73 to 96 %, respectively, by adding IHC. CNB can diagnose the majority of thyroid nodules with previous indeterminate FNA cytology, while the accuracy of CNB is increased by adding Galectin-3, Cytokeratin-19, and HBME-1 panel. We suggest to adopt CNB as a second-line approach to indeterminate thyroid FNA, and apply IHC in those lesions with uncertain/non-diagnostic CNB report. This approach should improve the pre-surgical diagnosis of patients. These results should be confirmed in larger prospective series.
    MeSH term(s) Adult ; Aged ; Biomarkers/analysis ; Biomarkers, Tumor/analysis ; Biopsy, Large-Core Needle ; Female ; Galectin 3/analysis ; Humans ; Immunohistochemistry ; Keratins/analysis ; Male ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology ; Thyroid Nodule/metabolism ; Thyroid Nodule/pathology
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; Galectin 3 ; HBME-1 antigen ; Keratins (68238-35-7)
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-015-0678-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Elastographic presentation of medullary thyroid carcinoma.

    Andrioli, Massimiliano / Trimboli, Pierpaolo / Amendola, Stefano / Valabrega, Stefano / Fukunari, Nobuhiro / Mirella, Moro / Persani, Luca

    Endocrine

    2013  Volume 45, Issue 1, Page(s) 153–155

    Abstract: Aim of the study was to evaluate the elastographic appearance of medullary thyroid carcinoma (MTC) by a retrospective evaluation of 18 nodules histologically proven as MTC. Free-hand qualitative elastography was performed using Hitachi Logos EUB 7500. ... ...

    Abstract Aim of the study was to evaluate the elastographic appearance of medullary thyroid carcinoma (MTC) by a retrospective evaluation of 18 nodules histologically proven as MTC. Free-hand qualitative elastography was performed using Hitachi Logos EUB 7500. The elasticity score (ES), was assessed based on a colour elastogram, the blue colour being correlated with hard tissue, red colour with soft tissue, and green with intermediate hardness. Nodules were classified into four classes. A alleged diagnosis of malignancy was assigned to nodules with ES3 or 4 and a presumptive diagnosis of benignity was assigned to nodules with an ES1 or 2. More than half (55.6 %) of MTCs have a low-intermediate grade of elasticity. The hardest lesions (ES4) were those with ultrasonographic features highly suspicious for malignancy. In conclusion, most of MTCs present an elastographic pattern of benignity. Therefore, qualitative elastography does not add useful information in pointing out MTC on the basis of its hardness. Our data suggest a marginal role for this technique in MTC evaluation.
    MeSH term(s) Carcinoma, Neuroendocrine ; Diagnosis, Differential ; Elasticity Imaging Techniques ; Humans ; Neoplasm Staging ; Research Design ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Nodule/diagnostic imaging
    Language English
    Publishing date 2013-09-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-013-0062-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Combined clinical and ultrasound follow-up assists in malignancy detection in Galectin-3 negative Thy-3 thyroid nodules.

    Sciacchitano, Salvatore / Lavra, Luca / Ulivieri, Alessandra / Magi, Fiorenza / Porcelli, Tommaso / Amendola, Stefano / De Francesco, Gian Paolo / Bellotti, Carlo / Trovato, Maria Concetta / Salehi, Leila B / Bartolazzi, Armando

    Endocrine

    2016  Volume 54, Issue 1, Page(s) 139–147

    Abstract: The use of galectin-3 ThyroTest in the preoperative evaluation of cytologically indeterminate (Thy-3) thyroid nodules has been largely validated by retrospective and prospective multicentre studies. Here we report the results of galectin-3 ThyroTest ... ...

    Abstract The use of galectin-3 ThyroTest in the preoperative evaluation of cytologically indeterminate (Thy-3) thyroid nodules has been largely validated by retrospective and prospective multicentre studies. Here we report the results of galectin-3 ThyroTest routinely applied in the management of Thy-3 nodules in combination with clinical and ultrasonography (US) examination, in which galectin-3 positive nodules were directly referred to surgery whereas galectin-3 negative lesions were considered for clinical and US long-term follow-up. A cohort of 331 patients, bearing 340 thyroid Thy-3 nodules, was enrolled and subjected to galectin-3 expression analysis. A total of 256 galectin-3 negative nodules were directed to periodical clinical and US examination, while 84 galectin-3 positive cases were referred to surgery. Excluding 63 dropout patients plus 15 patients that were operated because of clinical reasons the remaining 176 galectin-3 negative nodules were followed with clinical and US examination for an average period of 31 months. During the follow-up, the volume of galectin-3 negative nodules was unchanged in 85 cases (48 %), reduced in 47 (27 %), and increased in 44 (25 %). Based on combined clinical features and US follow-up results, a total of 36 out of 191 galectin-3 negative nodules (19 %) were referred to surgery, with a final histological finding of 28 benign lesions, three follicular tumor of uncertain malignant potential (FT-UMP), and five malignant lesions, corresponding to a 7 % false negative rate. In the group of 84 galectin-3 positive nodules, we detected 65 thyroid cancers with a prevalence of 77 %, 12 FT-UMPs, and 7 false positive lesions, corresponding to a 4 % false positive rate. A total of 150 patients were not operated and are still under clinical and US monitoring while surgery was performed in 118 patients with a final 70 thyroid cancers diagnosed, corresponding to a 59 % prevalence of malignancy detected at surgery and to a 26 % prevalence of malignancy among the entire Thy-3 nodule population. Galectin-3 ThyroTest is an easy and cheap diagnostic procedure that integrates conventional fine-needle-aspiration cytology, reduces the number of unnecessary thyroidectomies and increases the rate of malignancy at surgery. Clinical and US follow-up of galectin-3 negative lesions allows to further reduce false negative cases.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Cytodiagnosis ; Female ; Follow-Up Studies ; Galectin 3/metabolism ; Humans ; Male ; Middle Aged ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/metabolism ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/metabolism ; Thyroid Nodule/pathology ; Ultrasonography ; Young Adult
    Chemical Substances Galectin 3
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-015-0774-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: A cost analysis of thyroid core needle biopsy vs. diagnostic surgery.

    Trimboli, Pierpaolo / Nasrollah, Naim / Amendola, Stefano / Crescenzi, Anna / Guidobaldi, Leo / Chiesa, Carlo / Maglio, Riccardo / Nigri, Giuseppe / Pontecorvi, Alfredo / Romanelli, Francesco / Giacomelli, Laura / Valabrega, Stefano

    Gland surgery

    2015  Volume 4, Issue 4, Page(s) 307–311

    Abstract: Background: Twenty percent of thyroid fine needle aspiration (FNA) is indeterminate. Because 3 in 4 of these are actually benign, a method of clarifying the pathology could help patients to avoid diagnostic thyroidectomy. Recently, core needle biopsy ( ... ...

    Abstract Background: Twenty percent of thyroid fine needle aspiration (FNA) is indeterminate. Because 3 in 4 of these are actually benign, a method of clarifying the pathology could help patients to avoid diagnostic thyroidectomy. Recently, core needle biopsy (CNB) has been proven to be highly reliable for this purpose. However, there are no reports of any potential cost benefit provided by CNB. Here we analyzed the impact on management costs of CNB compared with traditional diagnostic surgery in indeterminate FNA.
    Methods: Over 24 months, 198 patients with thyroid indeterminate cytology underwent CNB at Ospedale Israelitico of Rome or diagnostic surgery at the Department of Surgery of Sapienza University of Rome. We tabulated costs of the medical instruments, operating theater, surgical team, patient recovery, and pathologic examination for each method.
    Results: In CNB group, 42.4% of patients had benign lesions and avoided surgery, 20.8% was cancer, and the remaining 36.8% uncertain. The malignancy rate in CNB group was 26.4%, and mean cost of CNB per nodule was 1,032€. In diagnostic surgery group, 24.7% had cancer and 75.3% had benign lesions, and mean expense for each thyroidectomy was 6,364€. In an ideal cohort of 100 patients with indeterminate FNA, the cost of CNB is 33.8% lower than that of diagnostic surgery.
    Conclusions: CNB can detect a large proportion of the benign thyroid nodules that are classified as indeterminate by FNA. These patients can avoid diagnostic thyroidectomy and hospitals can reduce their surgical costs by one-third.
    Language English
    Publishing date 2015-08-22
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.3978/j.issn.2227-684X.2015.06.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration.

    Trimboli, Pierpaolo / Nasrollah, Naim / Guidobaldi, Leo / Taccogna, Silvia / Cicciarella Modica, Davide Domenico / Amendola, Stefano / Romanelli, Francesco / Lenzi, Andrea / Nigri, Giuseppe / Centanni, Marco / Giovanella, Luca / Valabrega, Stefano / Crescenzi, Anna

    World journal of surgical oncology

    2014  Volume 12, Page(s) 61

    Abstract: Background: The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet ...

    Abstract Background: The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet to be studied. The aim of this study were: 1) to evaluate the potential merit of using CNB first-line instead of conventional FNA in thyroid nodules with suspicious ultrasonographic features; 2) to compare CNB and FNA as a first-line diagnostic procedure in thyroid lesions at higher risk of cancer.
    Methods: Seventy-seven patients with a suspicious-appearing, recently discovered solid thyroid nodule were initially enrolled as study participants. No patients had undergone prior thyroid fine-needle aspiration/biopsy. Based on study design, all patients were proposed to undergo CNB as first-line diagnostic aspiration, while those patients refusing to do so underwent conventional FNA.
    Results: Five patients refused the study, and a total of 31 and 41 thyroid nodules were subjected to CNB and FNA, respectively. At follow-up, the overall rate of malignancy was of 80% (CNB, 77%; FNA, 83%). However, the diagnostic accuracy of CNB (97%) was significantly (P < 0.05) higher than that of FNA (78%). In one benign lesion, CNB was inconclusive. Four (12%) of the 34 cancers of the FNA group were not initially diagnosed because of false negative (N = 1), indeterminate (N = 2) or not adequate (N = 1) samples.
    Conclusions: CNB can reduce the false negative and inconclusive results of conventional FNA and should be considered a first-line method in assessing solid thyroid nodules at high risk of malignancy.
    MeSH term(s) Biopsy, Fine-Needle ; Biopsy, Large-Core Needle ; False Negative Reactions ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Thyroid Gland/pathology ; Thyroid Neoplasms/classification ; Thyroid Neoplasms/diagnosis ; Thyroid Nodule/diagnosis ; Ultrasonography
    Language English
    Publishing date 2014-03-24
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/1477-7819-12-61
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top