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Article ; Online: [Il paziente in dialisi peritoneale: terapie tipiche, modalità somministrative, farmacocinetica e farmacodinamica].

Amici, Gianpaolo

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2021 Volume 38, Issue Suppl 77

Language	Italian
Publishing date	2021-09-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: Calcium, phosphate, and PTH circadian rhythm in peritoneal dialysis: seven cases and something to think about.

Martino, Francesca K / Zanetti, Fiammetta / Fanton, Giulia / Amici, Gianpaolo

Journal of nephrology

2022 Volume 35, Issue 5, Page(s) 1539–1541

MeSH term(s)	Calcium ; Circadian Rhythm ; Humans ; Parathyroid Hormone ; Peritoneal Dialysis/adverse effects ; Phosphates
Chemical Substances	Parathyroid Hormone ; Phosphates ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-03-29
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-022-01312-1
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Article: Gadolinium-Based Contrast Media Nephrotoxicity in Kidney Impairment: The Physio-Pathological Conditions for the Perfect Murder.

Martino, Francesca / Amici, Gianpaolo / Rosner, Mitchell / Ronco, Claudio / Novara, Giacomo

Journal of clinical medicine

2021 Volume 10, Issue 2

Abstract: Gadolinium-based contrast media (GBCM) toxicity in patients with kidney disease is a concern for the possible development of systemic nephrogenic fibrosis and possible renal complications. This review focuses on the pathological mechanisms underlying the ...

Abstract	Gadolinium-based contrast media (GBCM) toxicity in patients with kidney disease is a concern for the possible development of systemic nephrogenic fibrosis and possible renal complications. This review focuses on the pathological mechanisms underlying the potential kidney toxicity of gadolinium. Gadolinium, as a free compound (Gd3+), is highly toxic in humans because it competes with divalent calcium (Ca2+) and magnesium (Mg2+) ions, interfering in some relevant biologic processes. Its toxicity is blunted by the complexing of Gd3+ with a carrier, allowing its use in magnetic resonance imaging. The binding reaction between gadolinium and a carrier is thermodynamically reversible. Consequently, under some conditions, gadolinium can be released in the interstitial space as a free Gd3+ compound with the possibility of toxicity. Other metals such as iron, copper, and calcium can interfere with the binding between gadolinium and its carrier because they compete for the same binding site. This process is known as transmetallation. In patients with kidney impairment, conditions such as low clearance of the Gd-carrier complex, acid-base derangements, and high serum phosphorous can increase the presence of free Gd3+, leading to a higher risk for toxicity.
Language	English
Publishing date	2021-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10020271
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Article: Analysis of the Clinical and Epidemiological Meaning of Screening Test for SARS-CoV-2: Considerations in the Chronic Kidney Disease Patients during the COVID-19 Pandemic.

Martino, Francesca / Amici, Gianpaolo / Grandesso, Stefano / Ferraro Mortellaro, Rosella / Lo Cicero, Antonina / Novara, Giacomo

Journal of clinical medicine

2021 Volume 10, Issue 5

Abstract: The COronaVIrus Disease 19 (COVID-19) pandemic is an emerging reality in nephrology. In a continuously changing scenario, we need to assess our patients' additional risk in terms of attending hemodialysis treatments, follow-up peritoneal dialysis, and ... ...

Abstract	The COronaVIrus Disease 19 (COVID-19) pandemic is an emerging reality in nephrology. In a continuously changing scenario, we need to assess our patients' additional risk in terms of attending hemodialysis treatments, follow-up peritoneal dialysis, and kidney transplant visits. The prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-20 infection in the general population plays a pivotal role in estimating the additional COVID-19 risk in chronic kidney disease (CKD) patients. Unfortunately, local prevalence is often obscure, and when we have an estimation, we neglect the number of asymptomatic subjects in the same area and, consequently, the risk of infection in CKD patients. Furthermore, we still have the problem of managing COVID-19 diagnosis and the test's accuracy. Currently, the gold standard for SARS-CoV-2 detection is a real-time reverse transcription-polymerase chain reaction (rRT-PCR) on respiratory tract samples. rRT-PCR presents some vulnerability related to pre-analytic and analytic problems and could impact strongly on its diagnostic accuracy. Specifically, the operative proceedings to obtain the samples and the different types of diagnostic assay could affect the results of the test. In this scenario, knowing the local prevalence and the local screening test accuracy helps the clinician to perform preventive measures to limit the diffusion of COVID-19 in the CKD population.
Language	English
Publishing date	2021-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10051139
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Article ; Online: Pilot health technology assessment study: organizational and economic impact of remote monitoring system for home automated peritoneal dialysis.

Amici, Gianpaolo / D'Angela, Daniela / Lo Cicero, Antonina / Romanini, Dino / Martino, Francesca K / Spandonaro, Federico

International urology and nephrology

2021 Volume 53, Issue 9, Page(s) 1933–1940

Abstract: Purpose: Follow-up of automated peritoneal dialysis (APD) has been improved by data transmission by cellular modem and internet cloud. With the new remote patient monitoring (RPM) technology, clinical control and prescription of dialysis are performed ... ...

Abstract	Purpose: Follow-up of automated peritoneal dialysis (APD) has been improved by data transmission by cellular modem and internet cloud. With the new remote patient monitoring (RPM) technology, clinical control and prescription of dialysis are performed by software (Baxter Claria-Sharesource), which allows the center to access home operational data. The objective of this pilot study was to determine the impact of RPM compared to traditional technology, in clinical, organizational, social, and economic terms in a single center. Methods: We studied 21 prevalent APD patients aged 69 ± 13 years, on dialysis for a median of 9 months, for a period of 6 months with the traditional technology and 6 months with the new technology. A relevant portion of patients lived in mountainous or hilly areas. Results: Our study shows more proactive calls from the center to patients after the consultation of RPM software, reduction of calls from patients and caregivers, early detection of clinical problems, a significant reduction of unscheduled visits, and a not significant reduction of hospitalizations. The analysis also highlighted how the RPM system lead to relevant economic savings, which for the health system have been calculated € 335 (mean per patient-month). With the social costs represented by the waste of time of the patient and the caregiver, we calculated € 685 (mean per patient-month). Conclusion: In our pilot report, the RPM system allowed the accurate assessment of daily APD sessions to suggest significative organizational and economic advantages, and both patients and healthcare providers reported good subjective experiences in terms of safety and quality of follow-up.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Hemodialysis, Home/economics ; Hemodialysis, Home/methods ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic/economics ; Monitoring, Physiologic/methods ; Peritoneal Dialysis ; Pilot Projects ; Technology Assessment, Biomedical ; Telemedicine/economics ; Telemedicine/organization & administration
Language	English
Publishing date	2021-03-06
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-021-02816-8
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Article: Effect of small vs large muscle mass endurance training on maximal oxygen uptake in organ transplanted recipients

del Torto, Alessio / Capelli, Carlo / Peressutti, Roberto / di Silvestre, Adriana / Livi, Ugolino / Nalli, Chiara / Sponga, Sandro / Amici, Gianpaolo / Baccarani, Umberto / Lazzer, Stefano

Applied physiology, nutrition and metabolism. 2021, v. 46, no. 8

2021

Abstract: Maximal oxygen consumption (V̇O₂ₘₐₓ) is impaired in heart (HTx), kidney (KTx), and liver (LTx) transplanted recipients and the contribution of the cardiovascular, central, and peripheral (muscular) factors in affecting V̇O₂ₘₐₓ improvement after endurance ...

Abstract	Maximal oxygen consumption (V̇O₂ₘₐₓ) is impaired in heart (HTx), kidney (KTx), and liver (LTx) transplanted recipients and the contribution of the cardiovascular, central, and peripheral (muscular) factors in affecting V̇O₂ₘₐₓ improvement after endurance training (ET) has never been quantified in these patients. ET protocols involving single leg cycling (SL) elicit larger improvements of the peripheral factors affecting O₂ diffusion and utilization than the double leg (DL) cycling ET. Therefore, this study aimed to compare the effects of SL-ET vs DL-ET on V̇O₂ₘₐₓ. We determined the DL-V̇O₂ₘₐₓ and maximal cardiac output before and after 24 SL-ET vs DL-ET sessions on 33 patients (HTx = 13, KTx = 11 and LTx = 9). The DL-V̇O₂ₘₐₓ increased by 13.8% ± 8.7 (p < 0.001) following the SL-ET, due to a larger maximal O₂ systemic extraction; meanwhile, V̇O₂ₘₐₓ in DL-ET increased by 18.6% ± 12.7 (p < 0.001) because of concomitant central and peripheral adaptations. We speculate that in transplanted recipients, SL-ET is as effective as DL-ET to improve V̇O₂ₘₐₓ and that the impaired peripheral O₂ extraction and/or utilization play an important role in limiting V̇O₂ₘₐₓ in these types of patients. Novelty: SL-ET increases V̇O₂ₘₐₓ in transplanted recipients because of improved peripheral O₂ extraction and/or utilization. SL-ET is as successful as DL-ET to improve the cardiorespiratory fitness in transplanted recipients. The model of V̇O₂ₘₐₓ limitation indicates the peripheral factors as a remarkable limitation to the V̇O₂ₘₐₓ in these patients.
Keywords	cardiac output ; cardiorespiratory fitness ; heart ; kidneys ; liver ; metabolism ; models ; muscle tissues ; nutrition ; oxygen ; peak oxygen uptake
Language	English
Size	p. 994-1003.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2020-0987
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Home dialysis and home assistance: from institutional aids to a sustainable model

Amici, Gianpaolo / Vidotti, Elisa / Turello, David / Martino, Francesca Katiana / Benedetti, Giacomo / Castenetto, Enza / Lo Cicero, Antonina / Gobetti, Antonio

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2020 Volume 37, Issue Suppl 75

Title translation	[Dialisi domiciliare e assistenza a domicilio: dalle provvidenze istituzionali verso un modello sostenibile].
MeSH term(s)	Hemodialysis, Home/statistics & numerical data ; Humans ; Italy ; Kidney Failure, Chronic/therapy ; Models, Theoretical ; Peritoneal Dialysis/statistics & numerical data
Language	Italian
Publishing date	2020-08-03
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of small vs large muscle mass endurance training on maximal oxygen uptake in organ transplanted recipients.

Del Torto, Alessio / Capelli, Carlo / Peressutti, Roberto / di Silvestre, Adriana / Livi, Ugolino / Nalli, Chiara / Sponga, Sandro / Amici, Gianpaolo / Baccarani, Umberto / Lazzer, Stefano

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2021 Volume 46, Issue 8, Page(s) 994–1003

Abstract: Maximal oxygen consumption ( ...

Abstract	Maximal oxygen consumption (
MeSH term(s)	Adaptation, Physiological/physiology ; Body Composition/physiology ; Endurance Training/methods ; Female ; Humans ; Male ; Middle Aged ; Muscles/physiology ; Oxygen Consumption/physiology ; Physical Endurance/physiology ; Transplant Recipients/statistics & numerical data
Language	English
Publishing date	2021-07-27
Publishing country	Canada
Document type	Comparative Study ; Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2020-0987
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Article ; Online: Gadolinium-based contrast media exposure and the possible risk of subclinical kidney damage: a pilot study.

Martino, Francesca / Amici, Gianpaolo / Godi, Ilaria / Baretta, Michele / Biasi, Caterina / Carta, Mariarosa / Corradi, Valentina / De Cal, Massimo / Knust, MaÍra / Tamayod, Claudia / Varotto, Alessia / Iannucci, Giuseppe / Giavarina, Davide / Savastano, Sergio / Ronco, Claudio

International urology and nephrology

2021 Volume 53, Issue 9, Page(s) 1883–1889

Abstract: Purpose: We performed a pilot study to evaluate the feasibility of future research about the presence of subclinical kidney damage after Gadolinium-based contrast media exposure. The future study aims to understand which are the behaviors of two markers ...

Abstract	Purpose: We performed a pilot study to evaluate the feasibility of future research about the presence of subclinical kidney damage after Gadolinium-based contrast media exposure. The future study aims to understand which are the behaviors of two markers of kidney damage, such as urinary NephroCheck (NC) and/or neutrophil gelatinase-associated lipocalin (NGAL). Specifically, after GBCM exposure, NC urinary detection should identify proximal tubule damage while NGAL urinary detection should be related to distal tubule damage. Methods: We performed a pilot study in patients who had Gadolinium exposure. The feasibility of future study is reached when at least 90% of candidates completed the pilot study. In each patient, we tested urinary NC and NGAL levels 24 h before magnetic resonance imaging (MRI) and 12-24 h after the exposure. Furthermore, we evaluated the administration of other nephrotoxic agents, the presence of comorbidity, and kidney function by S-creatinine and urine protein before the MRI. Results: We enrolled 35 candidates of whom 33 patients completed all study procedures. Our population had a mean age of 60.7 ± 14.8 years with normal kidney function with a median S-creatinine equal to 0.7 mg/dl (Interquartile range [IQR] 0.6-0.91). Urinary NC levels increased from 0.21 ng Conclusion: Our pilot study seems adequate in terms of feasibility and encourages us to focus our future research on renal proximal tubule, as the principal site of subclinical kidney damage after Gadolinium exposure.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/urine ; Aged ; Biomarkers/urine ; Biomedical Research ; Contrast Media/adverse effects ; Feasibility Studies ; Female ; Gadolinium/adverse effects ; Humans ; Kidney Function Tests ; Lipocalin-2/urine ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Pilot Projects ; Risk Assessment
Chemical Substances	Biomarkers ; Contrast Media ; Lipocalin-2 ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2021-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-020-02779-2
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Article ; Online: [The advantages of remote patient monitoring in automated peritoneal dialysis].

Amici, Gianpaolo / Lo Cicero, Antonina / Presello, Fabiana / Zuccolo, Mery / Romanini, Dino / Bellina, Barbara / Janczar, Mariusz / Castenetto, Enza / Chiodarelli, Consuelo / Martino, Francesca Katiana

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2020 Volume 37, Issue 3

Abstract: The follow-up automated peritoneal dialysis (APD) patients has been recently improved as data can be transmitted remotely to an internet cloud. The introduction of remote patient monitoring (RPM) technologies also allows a better clinical control and ... ...

Abstract	The follow-up automated peritoneal dialysis (APD) patients has been recently improved as data can be transmitted remotely to an internet cloud. The introduction of remote patient monitoring (RPM) technologies also allows a better clinical control and tailoring of dialysis treatment through a web-based software (Claria-Sharesource Baxter). The aim of the present study is to determine the impact of RPM in a single center, both in clinical and organizational terms, compared to traditional technologies. We studied 26 prevalent APD patients aged 69±13 years, observing them for a period of six months while using the traditional technology and then further six months using the new technology. The patients had been on dialysis for 9 months before the start of the study and a relevant portion of them lived in mountainous or hilly areas. Our study shows an increase in the number of proactive calls from the center to the patients, a reduction of anxiety in patients and caregivers, an earlier detection of clinical problems, a reduction of unscheduled (urgent) visits and finally a reduction of hospitalizations after the adoption of RPM software. In our experience, the RPM system showed a good performance and a simple interface, allowing for the precise assessment of daily APD. Furthermore, RPM system improved the interaction between patients and healthcare providers, with a significant benefit in terms of safety and of care quality.
MeSH term(s)	Aged ; Cloud Computing ; Female ; Hospitalization ; Humans ; Male ; Monitoring, Physiologic/methods ; Peritoneal Dialysis/methods ; Telemedicine/methods ; Telemedicine/organization & administration ; Telemetry/methods ; Time Factors
Language	Italian
Publishing date	2020-06-10
Publishing country	Italy
Document type	Comparative Study ; Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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