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  1. Article: Ameliorating effects of

    Bejeshk, Mohammad Abbas / Aminizadeh, Amir Hashem / Rajizadeh, Mohammad Amin / Rostamabadi, Fahimeh / Bagheri, Fatemeh / Khaksari, Mohammad / Azimi, Maryam

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e22355

    Abstract: Introduction: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum. The disease is characterized by oxidative stress and severe inflammation. Research has shown the anti-oxidative and anti-inflammatory ... ...

    Abstract Introduction: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum. The disease is characterized by oxidative stress and severe inflammation. Research has shown the anti-oxidative and anti-inflammatory effects induced by consuming the
    Methods: A total number of 50 male rats were selected and randomly assigned to five groups of 10 rats each. Colitis was induced in rats by enemas with a 4 % acetic acid solution. Four days after the colitis induction, the rats were orally treated for the next 4 days with saline or a combination of A. arabica and O. basilicum (1000 mg/kg) or sulfasalazine (100 mg/kg).
    Results: Acetic acid-induced colitis increased the colon's macroscopic and histopathological damage scores; increased colon levels of MDA (Malondialdehyde), MPO (Myeloperoxidase), TNF-α (Tissue necrosis factor α), IL6 (Interleukin 6), and IL17 (Interleukin 17); and decreased SOD (Superoxide Dismutase), GPx (Glutathione Peroxidase), and IL10 (Interleukin 10) levels in the treated rats compared with the control group (P < 0.001). Overall, a combination of
    Conclusion: A. arabica
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perillyl alcohol (PA) mitigates inflammatory, oxidative, and histopathological consequences of allergic asthma in rats.

    Bejeshk, Mohammad Abbas / Beik, Ahmad / Aminizadeh, Amir Hashem / Salimi, Fouzieh / Bagheri, Fatemeh / Sahebazzamani, Maryam / Najafipour, Hamid / Rajizadeh, Mohammad Amin

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 6, Page(s) 1235–1245

    Abstract: Allergic asthma is an inflammatory and chronic condition, which is the most common asthma phenotype. It is usually defined by sensitivity to environmental allergens and leads to the narrowing of the airways. Around 300 million individuals are suffering ... ...

    Abstract Allergic asthma is an inflammatory and chronic condition, which is the most common asthma phenotype. It is usually defined by sensitivity to environmental allergens and leads to the narrowing of the airways. Around 300 million individuals are suffering from asthma worldwide. The purpose of the current research was to evaluate the effect of perillyl alcohol (PA) on oxidative stress and inflammation parameters in rats with allergic asthma. Experimental asthma was induced by ovalbumin (OVA) sensitization and inhalation in five groups of rats including control, asthma, asthma + vehicle, asthma + PA, and asthma + dexamethasone (Dexa). PA (50 mg/kg) or Dexa (2.5 mg/kg) were administered intraperitoneally for seven consecutive days following asthma induction. Histopathological evaluation was performed via hematoxylin and eosin (H&E) and Masson's trichrome staining. The enzyme-linked immunosorbent assay (ELISA) was used for the evaluation of the cytokine levels, including tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-17, and IL-10, as well as oxidative stress biomarkers including reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione peroxidase (GPx) in the lung tissue and bronchoalveolar lavage fluid (BALF). Real-time polymerase chain reaction (PCR) was utilized for assessing the mRNA expression of FOXP3 and GATA3 and western blot analysis was used for the measurement of nuclear factor kappa B (NF-κB) protein expression. PA and Dexa decreased the pathological alterations and the expression levels of inflammatory factors (cytokines, GATA3, and NF-κB) in the lung tissue and BALF of asthmatic rats. PA restored GPx, SOD, and TAC levels and reduced ROS, MDA, nitrite, and total protein in the lung and BALF. Overall, our findings demonstrated that PA can be used as a therapeutic agent in asthma patients, but it is essential to monitor its effects in future clinical studies.
    MeSH term(s) Rats ; Animals ; Mice ; NF-kappa B/metabolism ; Reactive Oxygen Species/metabolism ; Asthma/metabolism ; Lung ; Cytokines/metabolism ; Bronchoalveolar Lavage Fluid ; Superoxide Dismutase/metabolism ; Oxidative Stress ; Ovalbumin/adverse effects ; Ovalbumin/metabolism ; Disease Models, Animal ; Mice, Inbred BALB C
    Chemical Substances perillyl alcohol (319R5C7293) ; NF-kappa B ; Reactive Oxygen Species ; Cytokines ; Superoxide Dismutase (EC 1.15.1.1) ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2023-01-28
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02398-5
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    Ud II Zs.5: Show issues Location:
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  3. Article ; Online: Investigating the effects of

    Rajizadeh, Mohammad Amin / Aminizadeh, Amir Hashem / Esmaeilpour, Khadijeh / Bejeshk, Mohammad Abbas / Sadeghi, Asie / Salimi, Fouzieh

    The International journal of neuroscience

    2021  Volume 133, Issue 4, Page(s) 343–355

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Rats ; Male ; Animals ; Citrullus colocynthis ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Rats, Wistar ; Plant Extracts/pharmacology ; Citrullus ; Hypoglycemic Agents ; Anxiety/drug therapy ; Anxiety/etiology ; Cognition
    Chemical Substances Plant Extracts ; Hypoglycemic Agents
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1563-5279 ; 1543-5245 ; 0020-7454
    ISSN (online) 1563-5279 ; 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207454.2021.1916743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 657: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: A comparative study on the effect of blood collection tubes on stress oxidative markers.

    Bastin, Alireza / Fooladi, Saba / Doustimotlagh, Amir Hossein / Vakili, Sina / Aminizadeh, Amir Hashem / Faramarz, Sanaz / Shiri, Hamidreza / Nematollahi, Mohammad Hadi

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0266567

    Abstract: Oxidative stress has a major role in disease pathogenesis. However, limited studies have investigated the effect of various sample collection tubes on oxidative biomarkers. The present study aimed to evaluate the effect of different collection tubes on ... ...

    Abstract Oxidative stress has a major role in disease pathogenesis. However, limited studies have investigated the effect of various sample collection tubes on oxidative biomarkers. The present study aimed to evaluate the effect of different collection tubes on the variation of malondialdehyde (MDA), nitric oxide (NO), total thiol (t-SH), and ferric reducing ability of plasma (FRAP) levels. A total of 35 individuals participated in this study and each collected sample was separated into three different tubes: glass tubes (GTs), plain plastic tubes (PTs), and gel separator tubes (GSTs). The results of PTs and GSTs were compared to those of GTs as the reference tube. The comparison between the means of biomarkers in various tubes indicated that there was no significant difference in MDA results between tubes. In contrast, t-SH and NO content were significantly decreased in GSTs and PTs compared to GTs. However, the Bland-Altman analysis showed an acceptable concordance for the mentioned analytes and the statistically significant differences were not clinically significant for NO, MDA, and t-SH antioxidant parameters. Moreover, the FRAP level was considerably lower in GSTs compared to GTs. Nevertheless, the Bland-Altman analysis showed a high bias percentage for the FRAP assay when using PTs and GSTs. According to the present results, it can be concluded that switching to plastic blood collection tubes or serum separation tubes could influence the FRAP results. However, there was no interference for the interpretation of other antioxidant assays in different types of collection tubes. Hence, it is suggested to use GTs for total antioxidant capacity evaluations, especially the FRAP assay.
    MeSH term(s) Antioxidants ; Biomarkers ; Blood Specimen Collection/methods ; Humans ; Oxidative Stress ; Plastics
    Chemical Substances Antioxidants ; Biomarkers ; Plastics
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0266567
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  5. Article: The effect of combining basil seeds and gum Arabic on the healing process of experimental acetic acid-induced ulcerative colitis in rats.

    Bejeshk, Mohammad Abbas / Aminizadeh, Amir Hashem / Rajizadeh, Mohammad Amin / Khaksari, Mohammad / Lashkarizadeh, Mahdiyeh / Shahrokhi, Nader / Zahedi, Mohammad Javad / Azimi, Maryam

    Journal of traditional and complementary medicine

    2022  Volume 12, Issue 6, Page(s) 599–607

    Abstract: Background & aim: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum that oxidative stress and severe inflammation are the main features of this disease. Previous studies have shown that separate ... ...

    Abstract Background & aim: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum that oxidative stress and severe inflammation are the main features of this disease. Previous studies have shown that separate consumption of basil and gum arabic can reduce inflammation and oxidative stress. The aim of the study was evaluating the effect of treatment with basil seeds given together with gum arabic on healing, inflammation and oxidative stress in the course of experimental colitis in rats.
    Experimental procedure: A total number of 50 male rats were used, randomly assigned to five groups of 10 rats each. Colitis was induced in rats by enemas with 4% solution od acetic acid. Four days after induction of colitis, rats were treated for next 4 days with saline or combination of basil seeds plus gum arabic (1 mg/kg) or sulfasalazine (100 mg/g) rectally. The experiment was terminated after last dose of treatment. Rats without induction of colitis were used as a sham group.
    Results: Acetic acid-induced colitis increased the macroscopic and histopathological damage scores of the colon as well as colon levels of MDA(Malondialdehyde), MPO(Myeloperoxidase), TNFα(Tissue necrosis factor α), IL6 (Interleukin 6)and IL17(Interleukin 17) and decreased SOD(Superoxide Dismutase), GPx (Glutathione Peroxidase) and IL10 (Interleukin 10) levels compared with the control group(P < 0.001). Treatment with basil and gum arabic reduced macroscopic and histopathological damage scores (P < 0.01) of the colon, MDA, MPO, TNFα, IL6(P < 0.001) and IL17 (P < 0.01) levels of the colon and increased SOD, GPx and IL10 levels compared to the colitis group (P < 0.01).
    Conclusion: Rectal administration of combination of basil seeds plus gum arabic after induction of colitis, exhibits antioxidant and anti-inflammatory effects, and accelerates the healing of the colon in experimental colitis evoked by acetic acid.
    Language English
    Publishing date 2022-09-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2709698-1
    ISSN 2225-4110
    ISSN 2225-4110
    DOI 10.1016/j.jtcme.2022.08.001
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  6. Article ; Online: Myrtenol Ameliorates Recognition Memories' Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats.

    Bejeshk, Mohammad Abbas / Aminizadeh, Amir Hashem / Jafari, Elham / Motamedi, Sina / Zangiabadi, Iman / Ghasemi, Ahmad / Fathi, Mazyar / Nezhadi, Akram / Akhgarandouz, Faezeh / Bejeshk, Fatemeh / Mohammadi, Leila / Mohammadi, Fatemeh / Rajizadeh, Mohammad Amin

    Neuroimmunomodulation

    2023  Volume 30, Issue 1, Page(s) 42–54

    Abstract: Introduction: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of ... ...

    Abstract Introduction: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation, and oxidative stress in the hippocampus of asthmatic rats.
    Methods: Rats were allocated to five groups: control, asthma, asthma/vehicle, asthma/myrtenol, and asthma/budesonide. Asthma was elicited in the rats by ovalbumin, and the animals were then exposed to myrtenol inhalation. Anxiety-like behavior and memory were assessed by elevated plus maze (EPM) and novel object and location recognition tests. Interleukins (interleukin-6, -17, and -10), tumor necrosis factor α (TNF-α), and oxidative stress biomarkers such as malondialdehyde (MDA), superoxide dismutase (SOD), Glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in the hippocampus were assessed by the ELISA method.
    Results: The levels of IL-6, IL-17, TNF-α, and MDA decreased, but GPX, SOD, and TAC levels increased in the hippocampus of asthmatic animals due to myrtenol inhalation.
    Conclusion: Myrtenol diminished asthma-induced anxiety-like behaviors and cognitive deficits in asthmatic rats; these effects might have been typically mediated by a reduction in inflammation and oxidative stress.
    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism ; Oxidative Stress ; Asthma/chemically induced ; Asthma/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Memory Disorders ; Hippocampus/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Interleukin-6 ; Anxiety/drug therapy ; Superoxide Dismutase/metabolism
    Chemical Substances myrtenol (S1B8392IQY) ; Tumor Necrosis Factor-alpha ; Antioxidants ; Interleukin-6 ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1184368-8
    ISSN 1423-0216 ; 1021-7401
    ISSN (online) 1423-0216
    ISSN 1021-7401
    DOI 10.1159/000528626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3975: Show issues Location:
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