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  1. Article ; Online: Effects of the COVID-19 lockdown on Canadian ophthalmologists: a survey.

    Fathalla, Zina / Chaudry, Emaan / Aminnejad, Minoo / Farrokhyar, Forough / Albreiki, Danah

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2022  Volume 58, Issue 2, Page(s) e55–e57

    MeSH term(s) Humans ; COVID-19/epidemiology ; Ophthalmologists ; Canada/epidemiology ; Communicable Disease Control ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2022.06.022
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    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Long-term outcomes of surgical clipping of saccular middle cerebral artery aneurysms: a consecutive series of 92 patients.

    Yang, Kaiyun / Begley, Sabrina L / Lynch, Daniel / Turpin, Justin / Aminnejad, Minoo / Farrokhyar, Forough / Dehdashti, Amir R

    Neurosurgical review

    2023  Volume 46, Issue 1, Page(s) 271

    Abstract: Despite advances in endovascular treatment, microsurgical clipping of middle cerebral artery (MCA) aneurysms remains appropriate. We review the high occlusion rate and treatment durability seen with surgical clipping of MCA aneurysms. We retrospectively ... ...

    Abstract Despite advances in endovascular treatment, microsurgical clipping of middle cerebral artery (MCA) aneurysms remains appropriate. We review the high occlusion rate and treatment durability seen with surgical clipping of MCA aneurysms. We retrospectively reviewed patients who underwent microsurgical clipping of saccular MCA aneurysms by a single surgeon. Outcomes included aneurysm occlusion rate and durability, modified Rankin scale (mRS), and postoperative neurological morbidities. Ninety-two patients with 92 saccular MCA aneurysms were included, 50% of which were ruptured aneurysms. The mean follow-up period was 59 months. Complete aneurysm occlusion was achieved in all except one patient (99%) with near-complete occlusion. MCA aneurysm clipping was durable, with only one patient (1%) requiring retreatment after 4 years due to regrowth. Of the cohort, 79.3% achieved mRS 0-2 at last follow-up, including all with unruptured aneurysms. Poor outcome at discharge was associated with age > 65 (p = .03), postoperative neurological morbidities (p = .006), and aneurysm rupture (p < .001). Older age remained the single correlate for poor long-term outcome (p = .04). For ruptured aneurysms, predictors of poor long-term outcome included hemiparesis on presentation (p = .017), clinical vasospasm requiring treatment (p = .026), and infarction related to vasospasm (p = .041). Older age (p = .046) and complex anatomy (p = .036) were predictors of new postoperative neurological morbidities in the unruptured group. MCA aneurysm clipping is safe, durable, and should be considered first-line treatment for patients with saccular MCA aneurysms, especially in centers with abundant surgical experience.
    MeSH term(s) Humans ; Intracranial Aneurysm/surgery ; Retrospective Studies ; Treatment Outcome ; Microsurgery ; Aneurysm, Ruptured/surgery ; Endovascular Procedures ; Middle Cerebral Artery/surgery
    Language English
    Publishing date 2023-10-16
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02167-1
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    Zs.A 1445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Conference proceedings: Patient Outcomes from 92 Consecutive Saccular Middle Cerebral Artery Aneurysm Clipping

    Yang, Kaiyun / Lynch, Daniel / Begley, Sabrina / Turpin, Justin / Aminnejad, Minoo / Farrokhyar, Forough / Dehdashti, Amir

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762089
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    Zs.A 3425: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Stein-type shrinkage estimators in gamma regression model with application to prostate cancer data.

    Mandal, Saumen / Arabi Belaghi, Reza / Mahmoudi, Akram / Aminnejad, Minoo

    Statistics in medicine

    2019  Volume 38, Issue 22, Page(s) 4310–4322

    Abstract: Gamma regression is applied in several areas such as life testing, forecasting cancer incidences, genomics, rainfall prediction, experimental designs, and quality control. Gamma regression models allow for a monotone and no constant hazard in survival ... ...

    Abstract Gamma regression is applied in several areas such as life testing, forecasting cancer incidences, genomics, rainfall prediction, experimental designs, and quality control. Gamma regression models allow for a monotone and no constant hazard in survival models. Owing to the broad applicability of gamma regression, we propose some novel and improved methods to estimate the coefficients of gamma regression model. We combine the unrestricted maximum likelihood (ML) estimators and the estimators that are restricted by linear hypothesis, and we present Stein-type shrinkage estimators (SEs). We then develop an asymptotic theory for SEs and obtain their asymptotic quadratic risks. In addition, we conduct Monte Carlo simulations to study the performance of the estimators in terms of their simulated relative efficiencies. It is evident from our studies that the proposed SEs outperform the usual ML estimators. Furthermore, some tabular and graphical representations are given as proofs of our assertions. This study is finally ended by appraising the performance of our estimators for a real prostate cancer data.
    MeSH term(s) Computer Simulation ; Humans ; Likelihood Functions ; Male ; Monte Carlo Method ; Prostatic Neoplasms ; Regression Analysis ; Survival Analysis
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8297
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    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection.

    Kameda-Smith, Michelle M / Ragulojan, Malavan / Elliott, Cameron / Bliss, Lori / Moore, Hanna / Sader, Nicholas / Alsuwaihel, Mosaab / Tso, Michael K / Dakson, Ayoub / Ajani, Olufemi / Yarascavitch, Blake / Fleming, Adam / Mehta, Vivek / Aminnejad, Minoo / Farrokhyar, Forough / Singh, Sheila K

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2024  Volume 40, Issue 5, Page(s) 1339–1347

    Abstract: Background: Cerebellar mutism (CM) is characterized by a significant loss of speech in children following posterior fossa (PF) surgery. The biological origin of CM remains unclear and is the subject of ongoing debate. Significant recovery from CM is ... ...

    Abstract Background: Cerebellar mutism (CM) is characterized by a significant loss of speech in children following posterior fossa (PF) surgery. The biological origin of CM remains unclear and is the subject of ongoing debate. Significant recovery from CM is less likely than previously described despite rigorous multidisciplinary neuro-rehabilitational efforts.
    Methods: A national multi-centered retrospective review of all children undergoing PF resection in four midsized Canadian academic pediatric institutions was undertaken. Patient, tumor and surgical factors associated with the post-operative development of CM were reviewed. Retrospective identification of PF surgery patients including those developing and those that did not (internal control).
    Results: The study identified 258 patients across the 4 centers between 2010 and 2020 (mean age 6.73 years; 42.2% female). Overall, CM was experienced in 19.5% of patients (N = 50). Amongst children who developed CM histopathology included medulloblastoma (35.7%), pilocytic astrocytoma (32.6%) and ependymoma (17.1%). Intraoperative impression of adherence to the floor of the 4th ventricle was positive in 36.8%. Intraoperative abrupt changes in blood pressure and/or heart rate were identified in 19.4% and 17.8% of cases. The clinical resolution of CM was rated to be complete, significant resolution, slight improvement, no improvement and deterioration in 56.0%, 8.0%, 20.0%, 14.0% and 2.0%, respectively. In the cohort of children who experienced post-operative CM as compared to their no-CM counterpart, proportionally more tumors were felt to be adherent to the floor of the 4th ventricle (56.0% vs 49.5%), intraoperative extent of resection was a GTR (74% vs 68.8%) and changes in heart rate were noted (≥ 20% from baseline) (26.0% vs 15.9%). However, a multiple regression analysis identified only abrupt changes in HR (OR 5.97, CI (1.53, 23.1), p = 0.01) to be significantly associated with the development of post-operative CM.
    Conclusion: As a devastating surgical complication after posterior fossa tumor surgery with variable clinical course, identifying and understanding the operative cues and revising intraoperative plans that optimizes the child's neurooncological and clinical outcome are essential.
    MeSH term(s) Humans ; Child ; Female ; Male ; Retrospective Studies ; Mutism/etiology ; Postoperative Complications ; Canada ; Infratentorial Neoplasms/surgery ; Medulloblastoma/surgery ; Syndrome ; Cerebellar Neoplasms/surgery
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-024-06292-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2036: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: A Canadian National Survey of the Neurosurgical Management of Intracranial Abscesses.

    Kameda-Smith, Michelle M / Ragulojan, Malavan / Hart, Shannon / Duda, Taylor R / MacLean, Mark A / Chainey, Jonathan / Aminnejad, Minoo / Rizzuto, Michael / Bergeron, David / Eagles, Mathew / Chalil, Alan / Langlois, Anne-Mare / Gariepy, Charles / Persad, Amit / Hasen, Mohammed / Wang, Alick / Elkaim, Lior / Christie, Sean / Farrokhyar, Forough /
    Reddy, Kesava

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2022  Volume 50, Issue 5, Page(s) 679–686

    Abstract: Objective: Intracerebral abscess is a life-threatening condition for which there are no current, widely accepted neurosurgical management guidelines. The purpose of this study was to investigate Canadian practice patterns for the medical and surgical ... ...

    Abstract Objective: Intracerebral abscess is a life-threatening condition for which there are no current, widely accepted neurosurgical management guidelines. The purpose of this study was to investigate Canadian practice patterns for the medical and surgical management of primary, recurrent, and multiple intracerebral abscesses.
    Methods: A self-administered, cross-sectional, electronic survey was distributed to active staff and resident members of the Canadian Neurosurgical Society and Canadian Neurosurgery Research Collaborative. Responses between subgroups were analyzed using the Chi-square test.
    Results: In total, 101 respondents (57.7%) completed the survey. The majority (60.0%) were staff neurosurgeons working in an academic, adult care setting (80%). We identified a consensus that abscesses >2.5 cm in diameter should be considered for surgical intervention. The majority of respondents were in favor of excising an intracerebral abscess over performing aspiration if located superficially in non-eloquent cortex (60.4%), located in the posterior fossa (65.4%), or causing mass effect leading to herniation (75.3%). The majority of respondents were in favor of reoperation for recurrent abscesses if measuring greater than 2.5 cm, associated with progressive neurological deterioration, the index operation was an aspiration and did not include resection of the abscess capsule, and if the recurrence occurred despite prior surgery combined with maximal antibiotic therapy. There was no consensus on the use of topical intraoperative antibiotics.
    Conclusion: This survey demonstrated heterogeneity in the medical and surgical management of primary, recurrent, and multiple brain abscesses among Canadian neurosurgery attending staff and residents.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Canada ; Brain Abscess/surgery ; Neurosurgical Procedures ; Neurosurgery ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2022.299
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    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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