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Book ; Online: There is a vulnerable group we must not leave behind in our response to COVID-19

Amira, Guirguis

people who are dependent on illicit drugs

2020

Keywords	covid19
Publisher	Royal Pharmaceutical Society
Publishing country	uk
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of fermentation medium.

El-Sayed, El-Sayed R / Zaki, Amira G

Biotechnology and applied biochemistry

2022 Volume 70, Issue 1, Page(s) 306–317

Abstract: Based on the broad clinical utility of the immunosuppressant mycophenolic acid (MPA), this article aims to intensify the biosynthetic potential of Penicillium roqueforti for more effective hyperproduction of the drug. Several mutants were generated from ... ...

Abstract	Based on the broad clinical utility of the immunosuppressant mycophenolic acid (MPA), this article aims to intensify the biosynthetic potential of Penicillium roqueforti for more effective hyperproduction of the drug. Several mutants were generated from irradiation mutagenesis and screened. Two strains (GM1013 and GM1093) presented an elevated MPA productivity with significant yield constancy over 10 subsequent generations. By investigating the effect of some phosphorous sources and mineral salts on MPA production by the two mutants, KH
MeSH term(s)	Mycophenolic Acid ; Immunosuppressive Agents ; Fermentation ; Gamma Rays ; Prospective Studies ; Penicillium/genetics ; Mutagenesis
Chemical Substances	Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	883433-7
ISSN	1470-8744 ; 0885-4513
ISSN (online)	1470-8744
ISSN	0885-4513
DOI	10.1002/bab.2353
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Article ; Online: Ketoconazole 2% cream versus a combination of ketoconazole 2% cream and adapalene 0.1% gel in the treatment of pityriasis versicolor

Khaled M Tawfik / Waleed A Mahmmoud / Amira G.E. Ali

Al-Azhar Assiut Medical Journal, Vol 20, Iss 1, Pp 100-

2022 Volume 103

Abstract: Background and aim Pityriasis versicolor is a common chronic superficial fungal infection that manifests during or after puberty in hot humid temperatures. Topical treatments, which are the first line of treatment, are divided into nonspecific and ... ...

Abstract	Background and aim Pityriasis versicolor is a common chronic superficial fungal infection that manifests during or after puberty in hot humid temperatures. Topical treatments, which are the first line of treatment, are divided into nonspecific and specific antifungal agents; however, the therapeutic approaches for pityriasis versicolor depend mainly on synthetic antifungal drugs, in particular ketoconazole. However, due to the frequent recurrence of this disease, and the widespread application of azole drugs, resistant strains have emerged leading to increasingly failed treatment rates. Retinoic acid creams are also effective against pityriasis versicolor. Especially adapalene gel that has less irritation compared with other topical retinoid products and also has rapid onset of action. Therefore, we aimed to evaluate the efficacy and safety of a combination treatment of ketoconazole cream 2% and adapalene gel 0.01% in the treatment of pityriasis versicolor. Patients and methods In all, 100 patients were divided equally into two groups: group 1 patients were treated with topical application ketoconazole 2% cream and adapalene 0.1% gel once daily for a total duration of 2 weeks. Group 2 patients were treated with a topical application ketoconazole 2% cream for a total duration of 2 weeks. Results There was significant improvement rates in the combined group than ketoconazole-only group with P value=0.023. Adepalene+ketoconacole group had more irritation as a side effect than the ketoconazole group with significant P value=0.001. Conclusion The combination of adapalene 0.1% gel and ketoconazole 2% cream is safe, rapid, and effective in the treatment of pityriasis versicolor.
Keywords	adapalene ; efficacy ; ketoconazole ; pityriasis versicolor ; side effects ; Internal medicine ; RC31-1245
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
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Article: Novel fabrication of SiO

Zaki, Amira G / Hasanien, Yasmeen A / El-Sayyad, Gharieb S

AMB Express

2022 Volume 12, Issue 1, Page(s) 25

Abstract: The bacterial wilt is a global destructive plant disease that initiated by the phytopathogenic Ralstonia solanacearum. This study display a novel biofabrication of silica/silver nanocomposite using Fusarium oxysporum-fermented rice husk (RH) under solid ... ...

Abstract	The bacterial wilt is a global destructive plant disease that initiated by the phytopathogenic Ralstonia solanacearum. This study display a novel biofabrication of silica/silver nanocomposite using Fusarium oxysporum-fermented rice husk (RH) under solid state fermentation (SSF). The biofabricated nanocomposite was characterized by XRD, UV-Vis. spectroscopy, DLS, SEM, EDX elemental mapping, and TEM analyses as well as investigated for anti-R. solanacearum activity. Response surface methodology was also processed for optimizing the biofabrication process and improving the anti-bacterial activity of the fabricated nanocomposite. Maximum suppression zone of 29.5 mm against R. solanacearum was reached at optimum RH content of 6.0 g, AgNO
Language	English
Publishing date	2022-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2621432-5
ISSN	2191-0855
ISSN	2191-0855
DOI	10.1186/s13568-022-01372-3
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Article ; Online: Biosorption optimization of lead(II) and cadmium(II) ions by two novel nanosilica-immobilized fungal mutants.

Zaki, Amira G / Hasanien, Yasmeen A / Abdel-Razek, Alaa S

Journal of applied microbiology

2022 Volume 133, Issue 2, Page(s) 987–1000

Abstract: Aims: This study aims at immobilization of fungal mutants on nanosilica (NSi)-carriers for designing efficient biosorbents as a significant new technology for decontamination practices and maximizing their heavy metal (HM) sorption proficiency through ... ...

Abstract	Aims: This study aims at immobilization of fungal mutants on nanosilica (NSi)-carriers for designing efficient biosorbents as a significant new technology for decontamination practices and maximizing their heavy metal (HM) sorption proficiency through the experimental design methodology. Materials and results: Endophytic fungal mutant strains, Chaetomium globosum El26 mutant and Alternaria alternata S5 mutant were heat inactivated and then immobilized, each separately, on NSi carriers to formulate two separated nano-biosorbents. The formulated NSi-Chaetomium globosum El26 mutant (NSi-Chae El26 m) was investigated for Pb Conclusions: The formulated nano-biosorbents resulted in higher HM biosorption of metal ions from aqueous solution than that obtained by the free fungal biomass. The biosorption statistical modelling described the interactions between the tested sorption parameters and predicted the optimum values for maximum HM biosorption capacity by the two designed nano-biosorbents. Significance and impact of the study: These findings verify that members of the endophytic fungal genera Alternaria and Chaetomium are suitable to produce nano-biosorbents for decontamination practices after treatment by gamma mutagenesis, heat inactivation, and NSi immobilization. Moreover, statistical optimization can assist to evaluate the optimal conditions to produce such bioremediation material.
MeSH term(s)	Adsorption ; Alternaria ; Biomass ; Cadmium/chemistry ; Chaetomium ; Hydrogen-Ion Concentration ; Ions ; Kinetics ; Lead ; Metals, Heavy ; Water Pollutants, Chemical
Chemical Substances	Ions ; Metals, Heavy ; Water Pollutants, Chemical ; Cadmium (00BH33GNGH) ; Lead (2P299V784P)
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15624
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Article ; Online: Optimization, purification, and structure elucidation of anthraquinone pigment derivative from Talaromyces purpureogenus as a novel promising antioxidant, anticancer, and kidney radio-imaging agent.

Hasanien, Yasmeen A / Nassrallah, Amr A / Zaki, Amira G / Abdelaziz, Gamal

Journal of biotechnology

2022 Volume 356, Page(s) 30–41

Abstract: This study aims to investigate the bioproduction and prospective biological applications of a natural red pigment from Talaromyces purpureogenus AUMC2603. Maximum pigment yield was achieved by a numerical optimization at pH 6, temperature 25 °C, and an ... ...

Abstract	This study aims to investigate the bioproduction and prospective biological applications of a natural red pigment from Talaromyces purpureogenus AUMC2603. Maximum pigment yield was achieved by a numerical optimization at pH 6, temperature 25 °C, and an 18-day incubation period on Yeast Malt Broth (YMB) media. The crude pigment was separated and purified into two pigment fractions via solid-phase extraction and then characterized as anthraquinone (dominant) and herquinone by LC/MS and
MeSH term(s)	Anthraquinones/pharmacology ; Antioxidants/pharmacology ; Culture Media ; Iodine Radioisotopes ; Kidney ; Prospective Studies ; Talaromyces ; Tissue Distribution
Chemical Substances	Anthraquinones ; Antioxidants ; Culture Media ; Iodine Radioisotopes
Language	English
Publishing date	2022-07-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2022.07.002
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Zs.A 2299: Show issues

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Article: Ammi-visnaga

Harb, Nashwa / Sarhan, Amira G / El Dougdoug, Khalid A / Gomaa, Hanna H A

Virusdisease

2023 Volume 34, Issue 1, Page(s) 76–87

Abstract: The spread of bovine rotavirus has a great impact on animal productivity, milk products, and human public health. Thus, this study aimed to develop a novel, effective and accessible Phyto-antiviral treatment made from ... ...

Abstract	The spread of bovine rotavirus has a great impact on animal productivity, milk products, and human public health. Thus, this study aimed to develop a novel, effective and accessible Phyto-antiviral treatment made from methanolic
Language	English
Publishing date	2023-01-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-022-00803-w
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Article ; Online: New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.

Zaki, Amira G / El-Sayed, El-Sayed R

Applied microbiology and biotechnology

2021 Volume 105, Issue 23, Page(s) 8869–8880

Abstract: Huperzine-A (HupA) is an emerging, powerful, and promising natural acetylcholinesterase inhibitor. Despite that, the achieved yields of HupA from microbial sources are still far from the industrial applications. Accordingly, this paper was conducted to ... ...

Abstract	Huperzine-A (HupA) is an emerging, powerful, and promising natural acetylcholinesterase inhibitor. Despite that, the achieved yields of HupA from microbial sources are still far from the industrial applications. Accordingly, this paper was conducted to valorize solid-state fermentation (SSF) as an efficient production platform of HupA. Four agro-industrial wastes, namely rice bran, potato peel, sugarcane bagasse, and wheat bran, were tested and screened as cultural substrates for the production of HupA by the endophytic Alternaria brassica under SSF. Maximum HupA production was attained on using rice bran moistened by Czapex's dox mineral broth. In the effort to increase the HupA titer, supplementation of the best moistening agent by different carbon and nitrogen sources was successfully investigated. Additionally, factors affecting HupA production under SSF including substrate concentration, moistening level, and inoculum concentration were optimized using response surface methodology. A Box-Behnken design was applied for generating a predictive model of the interactions between these factors. Under the optimum conditions of 15 g rice bran, inoculum concentration of 5 × 10
MeSH term(s)	Acetylcholinesterase ; Alkaloids ; Alternaria ; Cholinesterase Inhibitors ; Fermentation ; Gamma Rays ; Sesquiterpenes
Chemical Substances	Alkaloids ; Cholinesterase Inhibitors ; Sesquiterpenes ; huperzine A (0111871I23) ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2021-11-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-021-11678-0
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Zs.A 2229: Show issues

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Article: Analgesic effect of ketorolac as an adjuvant to bupivacaine in ultrasound-guided pectoral nerve block (I + II) for patients undergoing modified radical mastectomy: A randomized controlled clinical trial.

Al-Touny, Shimaa A / Abd Elnasser, Amira G / Al-Taher, Ezzat M / El-Lilly, Ahmed A

Journal of anaesthesiology, clinical pharmacology

2023 Volume 39, Issue 1, Page(s) 61–66

Abstract: Background and aims: Many drugs have been tried as adjuvant to local anesthetic in different nerve blocks. Ketorolac is one of them, but it has never been used in pectoral nerve block. In this study, we evaluated its adjuvant effect with local ... ...

Abstract	Background and aims: Many drugs have been tried as adjuvant to local anesthetic in different nerve blocks. Ketorolac is one of them, but it has never been used in pectoral nerve block. In this study, we evaluated its adjuvant effect with local anesthetic on postoperative analgesia in ultrasound (US)-guided pectoral nerve (PECS) blocks. The aim was to assess the quality and the duration of analgesia by the addition of ketorolac in the PECS block. Material and methods: 46 patients who underwent modified radical mastectomies under general anesthesia were randomized into two groups: control group, where pectoral nerve block was given with bupivacaine 0.25% only; and ketorolac group, where the block was given with bupivacaine 0.25% and ketorolac 30 mg. Results: Patients who needed postoperative supplemental analgesia were significantly less in the ketorolac group (9 vs 21 patients, Conclusion: Adding ketorolac to bupivacaine in pectoral nerve block safely increases postoperative duration of analgesia.
Language	English
Publishing date	2023-01-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1401760-x
ISSN	0970-9185
ISSN	0970-9185
DOI	10.4103/joacp.joacp_149_21
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Article: New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation

Zaki, Amira G. / El-Sayed, El-Sayed R.

Applied microbiology and biotechnology. 2021 Dec., v. 105, no. 23

2021

Abstract	Huperzine-A (HupA) is an emerging, powerful, and promising natural acetylcholinesterase inhibitor. Despite that, the achieved yields of HupA from microbial sources are still far from the industrial applications. Accordingly, this paper was conducted to valorize solid-state fermentation (SSF) as an efficient production platform of HupA. Four agro-industrial wastes, namely rice bran, potato peel, sugarcane bagasse, and wheat bran, were tested and screened as cultural substrates for the production of HupA by the endophytic Alternaria brassica under SSF. Maximum HupA production was attained on using rice bran moistened by Czapex’s dox mineral broth. In the effort to increase the HupA titer, supplementation of the best moistening agent by different carbon and nitrogen sources was successfully investigated. Additionally, factors affecting HupA production under SSF including substrate concentration, moistening level, and inoculum concentration were optimized using response surface methodology. A Box-Behnken design was applied for generating a predictive model of the interactions between these factors. Under the optimum conditions of 15 g rice bran, inoculum concentration of 5 × 10⁶ spores mL⁻¹, and 60% moisture level, HupA concentration was intensified to 518.93 μg g⁻¹. Besides, HupA production by the fungal strain was further enhanced using gamma-irradiation mutagenesis. The final HupA production was significantly intensified following exposure to 0.5 KGy gamma radiation to 1327 μg g⁻¹, which represents a 12.85-fold increase. This is the first report on the successful production of the natural fungal metabolite HupA under SSF. Moreover, the achieved yield in this study using agro-industrial wastes may contribute to reducing the cost of HupA manufacture.Key points• Different agro-industrial by-products were tried as cultural substrates for the production of the acetylcholinesterase inhibitor HupA under SSF for the first time.• Factors affecting HupA production under SSF were optimized using response surface methodology.• The final HupA production was intensified following exposure to gamma radiation recording 1327 μg g⁻¹, which represents a 12.85-fold increase.
Keywords	Alternaria brassicae ; Brassica ; biotechnology ; carbon ; cholinesterase inhibitors ; endophytes ; experimental design ; fungi ; gamma radiation ; inoculum ; metabolites ; models ; mutagenesis ; nitrogen ; potato peels ; response surface methodology ; rice bran ; solid state fermentation ; sugarcane bagasse ; water content ; wheat bran
Language	English
Dates of publication	2021-12
Size	p. 8869-8880.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-021-11678-0
Database	NAL-Catalogue (AGRICOLA)

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