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Article ; Online: Human dental pulp mesenchymal stem cells isolation and osteoblast differentiation

Moustafa Alkhalil / Amer Smajilagić / Amira Redžić

Medicinski Glasnik, Vol 12, Iss 1, Pp 27-

2015 Volume 32

Abstract: Aim This study was focused on the isolation and characterization of mesenchymal stem cells (MSCs) from human dental pulp (DPSC). Methods The study was performed in the Department for Oral and Cranio-Maxillo- Facial Surgey Hamad Medical Corporation, Doha, ...

Abstract	Aim This study was focused on the isolation and characterization of mesenchymal stem cells (MSCs) from human dental pulp (DPSC). Methods The study was performed in the Department for Oral and Cranio-Maxillo- Facial Surgey Hamad Medical Corporation, Doha, Qatar and Weill Cornell Medical Colleague Doha, Qatar, in period 2010-2011. Dental pulp was extracted from premolars and third molars of 19 healthy patients. The pulp was digested in a solution of 3 mg/mL collagenase type I and 4 mg/mL dispase for 1 hour at 37C. After filtration, cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM Low Glucoses) with 20% Fetal Bovine Serum (FBS), 2mM L-glutamine and antibiotics (100 U/mL penicillin, 100 ug/mL streptomycin) at 37 °C under 5% CO2. Cultures were treated with osteoinductive medium for differentiation MSC in to the osteoblast cell line. Staining with Alizarin red were used for the detection of the osteoblast production and calcification new formed tissue. Results On the total of three out of 19 patients it was possible to isolate DPMSCs after 2 to 3 weeks: in one patient it was not possible to expand MSCs because of infection, and in other two patients positive Alizarin red staining reaction showed osteogenic differentiation capability and strong mineralization in vitro. Conclusion The main advantage of using DPSC is absence of morbidity. MSCs could be isolated noninvasively from teeth, routinely extracted in the clinic and discarded as medical waste. Standardization of clinical and laboratory protocols for DPMSCs isolation and team work coordination could lead to significantly improved result.
Keywords	regenerative medicine ; bone ; tissue engineering ; osteoblast ; Medicine ; R
Subject code	616
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	Medical Association of Zenica-Doboj Canton
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of reversionary and other etiological factors on prognosis and course of schizophrenia

Ifeta Ličanin / Amira Redžić

Medicinski Glasnik, Vol 07, Iss 2, Pp 148-

2010 Volume 152

Abstract: Aim To identify the presence of schizophrenia among patients andtheir relatives, factors affecting duration and prognosis of the disease and other etiological factors related to schizophrenia.Methods This retrospective, descriptive, analytical and ... ...

Abstract	Aim To identify the presence of schizophrenia among patients andtheir relatives, factors affecting duration and prognosis of the disease and other etiological factors related to schizophrenia.Methods This retrospective, descriptive, analytical and epidemiological research, which was conducted at the Psychiatric hospital of the Clinical Center of the University of Sarajevo during 2007, covered randomly selected 100 hospitalized patients with schizophrenia according to diagnostic criteria of the Diagnostic andStatistical Manual of Mental Disorders (DSM-IV). Diagnosis of schizophrenia among relatives was based on anamnesis- Structural Clinical Interview (SCID) and it was applied to confirm DSM-IV diagnosis of schizophrenia. Results The presence of schizophrenia among patient relatives was the most important in etiology of schizophrenia (62%), and etiological factors were represented in 38 % of examinees (p=0,0001). Among relatives of examinees aged 20 – 30 years, schizophrenia was present in 37 (59.7%) cases. Schizophrenia among relatives caused earlier appearance of the disease. Duration of hospitalization of over 60 days was in the group of examinees which have the relatives with schizophrenia, 18 (29.0%); multiple hospitalizations were noted in the group of relatives in 40 (64.5%) cases; in one case (8.3%) traumatic experience was noted, in three (42.8%) acute stress, and in four 4 cases (28.6%) non-adequate living conditions. Conclusions The results of this study show that reversionary factors are responsible for inducing schizophrenia, which leads towards chronic course of the disease and worsened prognosis.
Keywords	schizophrenia ; relatives ; reversion ; stress ; etiology ; epidemiology ; Medicine ; R
Subject code	150
Language	English
Publishing date	2010-08-01T00:00:00Z
Publisher	Medical Association of Zenica-Doboj Canton
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic Examination of Children Suffering from Cystic Fibrosis

Ediba Saračević / Amira Redžić

Bosnian Journal of Basic Medical Sciences, Vol 5, Iss

2005 Volume 1

Abstract: CFTR protein (cystic fibrosis trans membrane conductance regulator) is expressed in multiple epithelial tissues, including upper and lower respiratory tracts, pancreas, sweat glands and gastrointestinal tract. More than 800 mutations and 100 polymorphic ... ...

Abstract	CFTR protein (cystic fibrosis trans membrane conductance regulator) is expressed in multiple epithelial tissues, including upper and lower respiratory tracts, pancreas, sweat glands and gastrointestinal tract. More than 800 mutations and 100 polymorphic variants of DNA sequences were identified in patients with CF (Cystic fibrosis) and CFTR- diseases. In this study, genetic CFTR analysis of the children suffering from chronic lung disease (cystic fibrosis) is presented. They are treated and regularly controlled at the Pediatric hospital Sarajevo. CFTR analysis was done in 9 cases, 4 boys (44.4%) and 5 girls (55.55%). There are 3 children (33.3%) in the age group 1 to 3 years, 1 child (11.1%) in the age group 3 to 6 years, 3 children (33.3%) in the age group 6 to 9 years and 2 children (22.2%) in the age group 9 to 12 years. Genetic analysis was conducted at the Medical center for molecular biology School of Medicine, Ljubljana. PCR method with PAGE and direct sequestration on ABI PRISM 31 was applied. The majority of children (7 children, i.e. 7777%) had CFTR mutation Δ F 508 whilst one child had G542X mutation and one child R1174 mutation. The purpose of this study is to emphasize the need for CFTR gene identification in the institutes of our country.
Keywords	cystic fibrosis ; CFTR gene ; children who suffer from cystic fibrosis ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2005-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Psycho-Social Characteristics of Cannabis Abusing Youth

Ifeta Ličanin / Amira Redžić

Bosnian Journal of Basic Medical Sciences, Vol 5, Iss

2005 Volume 1

Abstract: It is a well known fact that drug abuse is most common in early adolescence. The most popular substances among youth are cannabis products (made from Cannabis sativa L., Cannaba-ceae). The majority of heroin and cocaine addicts have started with ... ...

Abstract	It is a well known fact that drug abuse is most common in early adolescence. The most popular substances among youth are cannabis products (made from Cannabis sativa L., Cannaba-ceae). The majority of heroin and cocaine addicts have started with marijuana. The aim of this study is to show some psycho-social characteristics of adolescents who abuse cannabis. Research conducted during the year 2001 was epidemiological and prospective. The study group included 600 adolescents of equal gender and age distribution. Q 2000 questionnaire was used, as a comprehensive tool for all aspects of adolescent life. The results show strong peer impact on one’s behavior. Youth who use cannabis had 2-3 friends of the same behavior, compared to others who had none. We found positive correlation between life stressful events and cannabis abuse. We also noticed tendency to delinquent behavior related to cannabis abuse (35%).
Keywords	adolescence ; cannabis ; abuse ; psychosocial ; peer ; delinquency ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2005-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rat bone marrow stem cells isolation and culture as a bone formative experimental system

Amer Smajilagić / Mufida Aljičević / Amira Redžić / Selma Filipović / Alena C. Lagumdžija

Bosnian Journal of Basic Medical Sciences, Vol 13, Iss

2013 Volume 1

Abstract: Bone marrow mesenchymal cells have been identified as a source of pluripotent stem cells with multipotential potential and differentiation in to the different cells types such as are osteoblast, chondroblast, adipoblast. In this research we describe ... ...

Abstract	Bone marrow mesenchymal cells have been identified as a source of pluripotent stem cells with multipotential potential and differentiation in to the different cells types such as are osteoblast, chondroblast, adipoblast. In this research we describe pioneering experiment of tissue engineering in Bosnia and Herzegovina, of the isolation and differentiation rat bone marrow stromal cells in to the osteoblast cells lineages. Rat bone marrow stromal cells were isolated by method described by Maniatopulos using their plastic adherence capatibility. The cells obtained by plastic adherence were cultured and serially passaged in the osteoinductive medium to differentiate into the osteocytes. Bone marrow samples from rats long bones used for isolation of stromal cells (BMSCs). Under determinate culture conditions BMSCs were differentiated in osteogenic cell lines detected by Alizarin red staining three weeks after isolation. BMSCs as autologue cells model showed high osteogenetic potential and calcification capatibility in vitro. In future should be used as alternative method for bone transplantation in Regenerative Medicine.
Keywords	Adult stem cells ; bone marrow ; bone marrow stem cells ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Posttraumatic stress disorder (ptsd) and co-morbidity

Ifeta Ličanin / Amira Redžić

Bosnian Journal of Basic Medical Sciences, Vol 2, Iss 1-

2002 Volume 2

Abstract: Posttraumatic Stress Disorder (PTSD) very often occurs accompanied with other psychiatric disorders such as: Alcohol and Drug abuse, Personality Disorder, General Anxiety Disorder, Obsessive Compulsive Disorder, Schizophrenia etc. Sometimes it might be a ...

Abstract	Posttraumatic Stress Disorder (PTSD) very often occurs accompanied with other psychiatric disorders such as: Alcohol and Drug abuse, Personality Disorder, General Anxiety Disorder, Obsessive Compulsive Disorder, Schizophrenia etc. Sometimes it might be a problem for clinicians to differ PTSD symptoms from symptoms of coexisting psychic disorders. The aim of this study was to present the most common PTSD coexisting psycho-disorders. This research was conducted during the period from April 1998 to October 1999. Participants were divided in two groups each containing 30 examinees. The first group consisted of 30 participants with symptoms of PTSD only while the second group included participants who suffered from both PTSD and other psychic disorders (co-morbidity). Both groups were quite similar regarding participants gender and age. The scientific tools used in the research were: Standard Psychiatric Interview, Harvard Trauma Questionnaire (HTQ), Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, and Drug and Alcohol Abuse Checklist. Our research results are indicating that PTSDsymptoms are most common in middle-aged persons, regardless of their gender and age. We have found following coexisting psychic disorders: personality disorder 46.6% (from which 13.3% is permanent personality disorder after the traumatic experience); depression 29.9% (depression without psychotic symptoms 23.3% and depression with coexisting psychotic symptoms 6.6%); drug abuse 13.3; alcohol abuse 6.7% and dissociative (conversion) disorder 3.3%. The results of our work are suggesting that co-morbid psychic symptoms have significant regressive influence on PTSD course and prognosis.
Keywords	Medicine (General) ; R5-920
Subject code	150
Language	English
Publishing date	2002-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Frequency of rh phenotypes in relation to the outcome of pregnancy in the two groups of pregnant women

Amira Redžić / Fatima Begić

Bosnian Journal of Basic Medical Sciences, Vol 2, Iss 1-

2002 Volume 2

Abstract: Lethal and sublethal genetical factors, including Rh factor, represent endogenous risk factors of the pregnancy outcome. These factors are most frequently inherited in recessive way and they often lead to the negative outcome of pregnancies. They ... ...

Abstract	Lethal and sublethal genetical factors, including Rh factor, represent endogenous risk factors of the pregnancy outcome. These factors are most frequently inherited in recessive way and they often lead to the negative outcome of pregnancies. They represent pregnancy (a prirori) risk of various degrees. Inheritance of Rh system blood groups is linked to chromosome 1 and it could be explained by two alternative theories; molecular Rh system genetics has not yet been completely explained. The first formal-genetic theory postulates three closely linked gene sites (loci C, D and E) while the second theory has a monogenic character (one locus with several allele genes). Data on 755 pregnancies, which were (for various reasons) estimated as increased risk pregnancies, were registered at Gynaecology Clinic, Clinical Centre of University of Sarajevo, during the period from 1989 to 1992. These data were collected from pregnant women who, according to the certain indications from their familiar and personal anamnesis, demanded genetic consultations. The result of investigation of the basic Rh system phenotype distribution shows no statistically significant difference between monitored pregnant women. This result is assumed as valid for both pregnant women and their partners. The same result is suggesting that the observed increased risk pregnancy samples do not significantly differ from the previously studied population samples. Therefore, it has been concluded that Rh factor is not closely related to the increased risk of individual pregnancy outcomes, that is, it does not have relevant influence on the observed reproduction parameters. This result is very interesting and deserves particular medical attention and further evaluation in the future, particularly considering known immunological phenomena resulting from relations between reproduction partners belonging to the basic Rh system phenotypes.
Keywords	Rh system ; chromosome 1 ; prenatal diagnostics ; human reproduction ; Sarajevo ; pregnancy risks ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2002-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of ABO blood groups on the fertility of different parental pairs

Ljubomir Berberović / Amira Redžić / Bojan Sosić

Bosnian Journal of Basic Medical Sciences, Vol 4, Iss

2004 Volume 4

Abstract: Classical works dealing with the possibility of mother-child incompatibility with regard to basic ABO blood groups give contradictory conclusions. Bioreproductive and population-genetic indicators have been studied in a sample of live births and in two ... ...

Abstract	Classical works dealing with the possibility of mother-child incompatibility with regard to basic ABO blood groups give contradictory conclusions. Bioreproductive and population-genetic indicators have been studied in a sample of live births and in two pregnancy samples with different "a priori" and "a posteriori" risk assessment. The analysis points out that ABO blood groups can influence fertility of differentparental pairs, and consequently--assessment of the individual pregnancy risk.
Keywords	ABO blood groups ; bioreproductive ; population-genetics indicators ; Medicine (General) ; R5-920
Language	English
Publishing date	2004-11-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Some aspects of the psychoactive substances abuse in adolescents

Amira Redžić / Ifeta Ličanin / Jasminka Hadžihalilović

Bosnian Journal of Basic Medical Sciences, Vol 4, Iss

2004 Volume 2

Abstract: Cannabis is a plant whose consumption causes hallucinations soon after it has been inhaled. This study was conducted with 600 adolescentsof age 12 to 17 with even gender distribution from two residence locations (rural and urban). Epidemiological- ... ...

Abstract	Cannabis is a plant whose consumption causes hallucinations soon after it has been inhaled. This study was conducted with 600 adolescentsof age 12 to 17 with even gender distribution from two residence locations (rural and urban). Epidemiological-analytic study was prospectively conducted, whose results were analysed with standard statistical methods. The results showed that the use of cannabis is greater by the adolescents in high school (15-17 years old), than the adolescents in the elementary school (12-14 years old). The x2 test showed great significance. Among the tested adolescents the consumption of cannabis is more present in urban than in rural type of residency. However, gender structure did not show significant differences. It is obvious that the prevention of the use of psychoactive substances should be at its maximum.
Keywords	Cannabis ; adolescents ; pleasure ; Medicine (General) ; R5-920
Language	English
Publishing date	2004-05-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simultaneous abuse of different psychoactive substances among adolescents.

Amira Redžić / Ifeta Ličanin / Sanja Kronjar

Bosnian Journal of Basic Medical Sciences, Vol 3, Iss

2003 Volume 1

Abstract: Although the drug abuse has been evidenced in every age of the human life, it seems that its occurrence is crucial during adolescence period with its well-known consequences on the further personality development. Adolescents like to experiment with ... ...

Abstract	Although the drug abuse has been evidenced in every age of the human life, it seems that its occurrence is crucial during adolescence period with its well-known consequences on the further personality development. Adolescents like to experiment with risky lifestyles without adequate knowledge about their possible harmful effects and consequences. International experiences have represented that early onset of the risky behaviour predisposes young persons for serious problems in social, psychological and physical future lives. It has been noticed that adolescents like to combine different psychoactive substances. Therefore the aim of this study was to present the most important and the most actual substances abused by young adolescents together with the substance characteristics. This research included 600 adolescents with the same prevalence regarding age, sex and living zone (rural-urban). Our research showed that simultaneous abuse of various harmful psychoactive substances (polydrug abuse) is the most common (tobacco smoking and cannabis consumption in 75% of cases, alcohol consumption and cannabis consumption in 80% of cases).
Keywords	adolescence ; genetic factors ; biogenetic factors ; cannabis ; tobacco ; alcoholism ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2003-02-01T00:00:00Z
Publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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