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  1. Article: Primary Transitional Cell Carcinoma of the Endometrium: A Case Report and Review of Literature.

    Amjad, Razan / Mogharbel, Hussain

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21365

    Abstract: Transitional cell carcinoma of the endometrium is a rare cancer. We present a 58-year-old Caucasian female was diagnosed with high-grade polyploid transitional cell carcinoma of the endometrium. The pathological findings included a dense serosal adhesion ...

    Abstract Transitional cell carcinoma of the endometrium is a rare cancer. We present a 58-year-old Caucasian female was diagnosed with high-grade polyploid transitional cell carcinoma of the endometrium. The pathological findings included a dense serosal adhesion over the fundus and the posterior wall, necrotic and polyploid papillary mass in the endometrial cavity, serosal adhesions and unremarkable parenchyma in the fallopian tubes. Others were the presence of cancer antigen 125 and cytokeratin 7 and absence of cytokeratin 20, actin, estrogen receptor, soluble protein 100, vimentin, and cytokeratin high molecular weight. The case is relevant to practice as it identifies the histological patterns for primary transitional cell carcinoma of the endometrium, including expressing cytokeratin 7 instead of cytokeratin 20. The tumor showed a papillary and solid architecture and composed of undifferentiated to poorly differentiated cells with no defined glandular nor squamous differentiation.
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Noise-induced hormonal & morphological malformations in breeding pigeons.

    Amjad, R / Ruby, T / Talib, S / Zahra, S / Liaquat, M / Batool, A

    Brazilian journal of biology = Revista brasleira de biologia

    2023  Volume 84, Page(s) e271945

    Abstract: Environmental pollution has the potential to have a significant impact on animal's health especially on birds due to daily exposure and habitat. This experimental study was carried out for a 60 days period in which, a total of 24 pigeon birds with ... ...

    Abstract Environmental pollution has the potential to have a significant impact on animal's health especially on birds due to daily exposure and habitat. This experimental study was carried out for a 60 days period in which, a total of 24 pigeon birds with suitable weight (80-100 g) were kept in Animal house with suitable environmental conditions viz, controlled temperature, humidity & light source to minimize any other stress. Out of twenty-four, eighteen birds were divided into three treatment groups (6 birds in each group). Whole experiment was run in triplicate manner in breeding season. One served as Control (Group 1) and remaining three were experimental groups including Road traffic noise (Group 2), Military noise (Group 3) & Human activities noise (Group 4). Noise was applied as recorded high intensity music (1125 Hz/ 90 dB) through speakers for 5-6 hrs. daily. Blood sampling was done after 20, 40 and 60 days by sacrificing treatment birds. Noise stress significantly (p<0.05) increase the serum levels of corticosterone and thyroid stimulating hormone (TSH) in Group 2 while significantly (p<0.05) decrease the serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) of Group 3 birds. Moreover, major fault bars formation was seen both in Group 2 and Group 3. It was concluded as that Noise stress caused rise in serum levels of Corticosterone and TSH but fall in LH and FSH. Along with fault bars formation was also prominent in all treatment groups due to stress hormone.
    MeSH term(s) Animals ; Humans ; Columbidae ; Corticosterone ; Luteinizing Hormone ; Follicle Stimulating Hormone ; Thyrotropin
    Chemical Substances Corticosterone (W980KJ009P) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2023-05-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2036257-2
    ISSN 1678-4375 ; 1519-6984
    ISSN (online) 1678-4375
    ISSN 1519-6984
    DOI 10.1590/1519-6984.271945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The negative pressure wound therapy for prevention of sternal wound infection: Can we reduce infection rate after the use of bilateral internal thoracic arteries? A systematic literature review and meta-analysis.

    Elhassan, Hind / Amjad, Ridha / Palaniappan, Unna / Loubani, Mahmoud / Rose, David

    Journal of cardiothoracic surgery

    2024  Volume 19, Issue 1, Page(s) 87

    Abstract: Background: Negative pressure wound therapy (NPWT) is traditionally used to treat postoperative wound infections. However, its use in closed wound sternotomy post cardiac surgery in high-risk patients has become increasingly popular. The potential ... ...

    Abstract Background: Negative pressure wound therapy (NPWT) is traditionally used to treat postoperative wound infections. However, its use in closed wound sternotomy post cardiac surgery in high-risk patients has become increasingly popular. The potential preventive benefit of reducing sternal wound infections has been recently acknowledged. Bilateral internal mammary artery (BIMA) grafts are used in coronary artery bypass grafting but have been associated with an increased risk of sternal wound infections (SWIs).
    Objectives: This systematic analysis examines whether NPWT can reduce the incidence of SWI following BIMA grafts, leading to more patients benefiting from the better survival outcome associated with BIMA grafting.
    Method: A comprehensive systematic search and meta-analysis were performed to identify studies on the use of NPWT in closed wound sternotomy. Ovid MEDLINE (in-process and other nonindexed citations and Ovid MEDLINE 1990 to present), Ovid EMBASE (1990 to present), and The Cochrane Library (Wiley), PubMed, and Google Scholar databases were searched from their inception to May 2022 using keywords and MeSH terms. Thirty-four articles from 1991 to May 2022 were selected.
    Result: Three studies reported on the outcome of NPWT following BIMA grafting. The pooled analysis did not show any significant difference in the incidence of sternal wound infection between NPWT and standard dressing (RR 0.48 95% CI 0.17-1.37; P = 0.17) with substantial heterogeneity (I
    Conclusion: The literature identified that NPWT significantly decreased the incidence of sternal wound complications when applied to sutured sternotomy incisions in high-risk patients, and in some cases, it eliminated the risk. However, the inadequate number of randomized controlled trials assessing the effectiveness of NPWT in BIMA grafting emphasizes the need for further, robust studies.
    MeSH term(s) Adult ; Humans ; Mammary Arteries ; Negative-Pressure Wound Therapy ; Wound Healing ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/epidemiology ; Surgical Wound Dehiscence/prevention & control
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Review
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-024-02589-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hypofractionated Radiotherapy in Gynecologic Malignancies-A Peek into the Upcoming Evidence.

    Amjad, Razan / Moldovan, Nataliya / Raziee, Hamid / Leung, Eric / D'Souza, David / Mendez, Lucas C

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Radiotherapy (RT) has a fundamental role in the treatment of gynecologic malignancies, including cervical and uterine cancers. Hypofractionated RT has gained popularity in many cancer sites, boosted by technological advances in treatment delivery and ... ...

    Abstract Radiotherapy (RT) has a fundamental role in the treatment of gynecologic malignancies, including cervical and uterine cancers. Hypofractionated RT has gained popularity in many cancer sites, boosted by technological advances in treatment delivery and image verification. Hypofractionated RT uptake was intensified during the COVID-19 pandemic and has the potential to improve universal access to radiotherapy worldwide, especially in low-resource settings. This review summarizes the rationale, the current challenges and investigation efforts, together with the recent developments associated with hypofractionated RT in gynecologic malignancies. A comprehensive search was undertaken using multiple databases and ongoing trial registries. In the definitive radiotherapy setting for cervical cancers, there are several ongoing clinical trials from Canada, Mexico, Iran, the Philippines and Thailand investigating the role of a moderate hypofractionated external beam RT regimen in the low-risk locally advanced population. Likewise, there are ongoing ultra and moderate hypofractionated RT trials in the uterine cancer setting. One Canadian prospective trial of stereotactic hypofractionated adjuvant RT for uterine cancer patients suggested a good tolerance to this treatment strategy in the acute setting, with a follow-up trial currently randomizing patients between conventional fractionation and the hypofractionated dose regimen delivered in the former trial. Although not yet ready for prime-time use, hypofractionated RT could be a potential solution to several challenges that limit access to and the utilization of radiotherapy for gynecologic cancer patients worldwide.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical Evaluation of an Automatic Oxygen Control System for Premature Infants Receiving High-Flow Nasal Cannula for Respiratory Support: A Pilot Study.

    Hou, Xuefeng / Faqeeh, Akram / Amjad, Ramak / Pardalos, John / Fales, Roger

    Journal of medical devices

    2022  Volume 16, Issue 3, Page(s) 31005

    Abstract: A pilot clinical study was conducted that compared the peripheral oxygen saturation ( ... ...

    Abstract A pilot clinical study was conducted that compared the peripheral oxygen saturation (SpO
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6181
    ISSN 1932-6181
    DOI 10.1115/1.4054250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hemoglobin Levels, Anemia, and Their Associations with Body Mass Index among Pregnant Women in Hail Maternity Hospital, Saudi Arabia: A Cross-Sectional Study.

    Eltayeb, Reem / Binsaleh, Naif K / Alsaif, Ghaida / Ali, Reem M / Alyahyawi, Amjad R / Adam, Ishag

    Nutrients

    2023  Volume 15, Issue 16

    Abstract: The level of association between hemoglobin level/anemia and obesity during pregnancy is not yet fully understood. A cross-sectional study was conducted in Hail Maternity Hospital in northern Saudi Arabia from March to May 2023 to assess the associations ...

    Abstract The level of association between hemoglobin level/anemia and obesity during pregnancy is not yet fully understood. A cross-sectional study was conducted in Hail Maternity Hospital in northern Saudi Arabia from March to May 2023 to assess the associations between hemoglobin levels, anemia, and obesity among pregnant women. Reproductive history was gathered through a questionnaire. Body mass index (BMI) was calculated/computed from the women's weight and height. Linear and binary regression analyses were performed. A total of 334 pregnant women were enrolled. The median (interquartile range (IQR)) age and parity were 33.2 (27.4-37.8) years and 3 (1-5), respectively. Of the 334 women, 52 (15.6%) were normal weight, while 87 (26.0%) were overweight and 195 (58.4%) were obese. In the multiple linear regression, parity (coefficient = -0.121,
    MeSH term(s) Pregnancy ; Humans ; Female ; Male ; Body Mass Index ; Cross-Sectional Studies ; Hospitals, Maternity ; Pregnant Women ; Saudi Arabia/epidemiology ; Obesity/epidemiology ; Overweight/epidemiology ; Anemia/epidemiology ; Hemoglobins
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15163508
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  7. Article: Reply to Marino et al. Choroidal Thickness Measurements in the Case of Diabetic Macular Edema. Comment on "Amjad et al. Choroidal Thickness in Different Patterns of Diabetic Macular Edema.

    Amjad, Rida / Lee, Cheong-Ah / Farooqi, Hafiz Muhammad Umer / Khan, Hina / Paeng, Dong-Guk

    Journal of clinical medicine

    2023  Volume 12, Issue 8

    Abstract: We are pleased to see that Marino et al. have written a Comment: "Choroidal Thickness Measurements in the Case of Diabetic Macular Edema" [ ... ]. ...

    Abstract We are pleased to see that Marino et al. have written a Comment: "Choroidal Thickness Measurements in the Case of Diabetic Macular Edema" [...].
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12082877
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  8. Article ; Online: Early pigment spot segmentation and classification from iris cellular image analysis with explainable deep learning and multiclass support vector machine.

    Khan, Amjad R / Javed, Rabia / Sadad, Tariq / Bahaj, Saeed Ali / Sampedro, Gabriel Avelino / Abisado, Mideth

    Biochemistry and cell biology = Biochimie et biologie cellulaire

    2023  

    Abstract: Globally, retinal disorders impact thousands of individuals. Early diagnosis and treatment of these anomalies might halt their development and prevent many people from developing preventable blindness. Iris spot segmentation is critical due to acquiring ... ...

    Abstract Globally, retinal disorders impact thousands of individuals. Early diagnosis and treatment of these anomalies might halt their development and prevent many people from developing preventable blindness. Iris spot segmentation is critical due to acquiring iris cellular images that suffer from the off-angle iris, noise, and specular reflection. Most currently used iris segmentation techniques are based on edge data and noncellular images. The size of the pigment patches on the surface of the iris increases with eye syndrome. In addition, iris images taken in uncooperative settings frequently have negative noise, making it difficult to segment them precisely. The traditional diagnosis processes are costly and time consuming since they require highly qualified personnel and have strict environments. This paper presents an explainable deep learning model integrated with a multiclass support vector machine to analyze iris cellular images for early pigment spot segmentation and classification. Three benchmark datasets MILE, UPOL, and Eyes SUB were used in the experiments to test the proposed methodology. The experimental results are compared on standard metrics, demonstrating that the proposed model outperformed the methods reported in the literature regarding classification errors. Additionally, it is observed that the proposed parameters are highly effective in locating the micro pigment spots on the iris surfaces.
    Language English
    Publishing date 2023-10-31
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 54104-7
    ISSN 1208-6002 ; 0829-8211
    ISSN (online) 1208-6002
    ISSN 0829-8211
    DOI 10.1139/bcb-2023-0183
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  9. Article ; Online: Management Of Self-Concept, Disruptive Behavior And Aggression Through Art And Behavior Therapy Among Internally Displaced Children.

    Gul, Ruqaia / Irshad, Erum / Amjad, Rabia

    Journal of Ayub Medical College, Abbottabad : JAMC

    2021  Volume 33, Issue 1, Page(s) 105–108

    Abstract: Background: This study was conducted to explore the occurrence of aggression, disruptive behavior and nature of self-concept among internally displaced and un-displaced children. This study also examines the effectiveness of art therapy and progressive ... ...

    Abstract Background: This study was conducted to explore the occurrence of aggression, disruptive behavior and nature of self-concept among internally displaced and un-displaced children. This study also examines the effectiveness of art therapy and progressive muscle relaxation (PMR) technique of behavior therapy in the treatment of psychological problems among internally displaced children.
    Methods: In this cross-sectional study a semi-structured interview and Beck Youth Inventory for children and adolescents (2nd edition) were used for assessment. The sample comprised 192 internally displaced and 90 un-displaced children. After taking formal permission from head of the schools, internally displaced children were assessed in their schools arranged for them at Jalozi camp, whereas un-displaced children were assessed at different schools of settled areas in Peshawar. Independent sample t-test was used to analyze mean differences, standard deviation and t-values.
    Results: Results supported the hypothesis. Internally displaced children showed higher levels of aggression (39.38±6.60) with t (280) = 8.57, and disruptive behavior (40.97±3.90) with t (280) = 6.76, and lower levels of self-concept (48.71±8.31) with t (280) = -15.32.
    Conclusions: Internally displaced children showed high levels of aggression and disruptive behavior, whereas their self-esteem was lower than the un-displaced children. This study also provides support to the idea that art therapy and technique of behavior therapy can be helpful in treatment of post trauma psychological issues in children.
    MeSH term(s) Adolescent ; Aggression/psychology ; Art Therapy ; Behavior Therapy ; Child ; Cross-Sectional Studies ; Humans ; Problem Behavior/psychology ; Self Concept
    Language English
    Publishing date 2021-01-05
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
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  10. Article ; Online: Diet in Food Insecurity: A Mediator of Metabolic Health?

    Morselli, Lisa L / Amjad, Rabia / James, Roland / Kindel, Tammy L / Kwitek, Anne E / Williams, Joni S / Grobe, Justin L / Kidambi, Srividya

    Journal of the Endocrine Society

    2024  Volume 8, Issue 6, Page(s) bvae062

    Abstract: Objective: Food insecurity (FI) is associated with poor metabolic health. It is assumed that energy intake and diet quality underlie this association. We tested the hypothesis that dietary factors (quantity and quality) mediate the association of FI ... ...

    Abstract Objective: Food insecurity (FI) is associated with poor metabolic health. It is assumed that energy intake and diet quality underlie this association. We tested the hypothesis that dietary factors (quantity and quality) mediate the association of FI with excess weight, waist circumference and glycemic control [glycohemoglobin (A1C)].
    Methods: A mediation analysis was performed on data from the National Health And Nutrition Examination Survey using FI as an independent variable; body mass index (BMI), waist circumference, and A1C as metabolic outcome variables and total energy intake, macronutrients, and diet quality measured by the Healthy Eating Index-2015 (HEI-2015) as potential mediators.
    Results: Despite a greater prevalence of obesity in participants experiencing FI, daily reported energy intake was similar in food-secure and -insecure subjects. In adjusted analyses of the overall cohort, none of the examined dietary factors mediated associations between FI and metabolic outcomes. In race-stratified analyses, total sugar consumption was a partial mediator of BMI in non-Hispanic Whites, while diet quality measures (HEI-2015 total score and added sugar subscore) were partial mediators of waist circumference and BMI, respectively, for those in the "other" ethnic group.
    Conclusion: Dietary factors are not the main factors underlying the association of FI with metabolic health. Future studies should investigate whether other social determinants of health commonly present in the context of FI play a role in this association.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvae062
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