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  1. Article: Hyperthermic intraperitoneal chemotherapy and colorectal cancer: From physiology to surgery.

    Ammerata, Giorgio / Filippo, Rosalinda / Laface, Carmelo / Memeo, Riccardo / Solaini, Leonardo / Cavaliere, Davide / Navarra, Giuseppe / Ranieri, Girolamo / Currò, Giuseppe / Ammendola, Michele

    World journal of clinical cases

    2022  Volume 10, Issue 30, Page(s) 10852–10861

    Abstract: The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) used in colorectal cancer (CRC). We focus on principal biological aspects of CRC, ... ...

    Abstract The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) used in colorectal cancer (CRC). We focus on principal biological aspects of CRC, hyperthermia effects, and surgical procedures. We searched PubMed/MEDLINE for the principal reviews and systematic reviews published from 2010 to 2021 regarding the bimodal treatment (CRS + HIPEC) against local and advanced CRC. In the literature, from several studies, it seems that the efficacy of bimodal treatment with an accurate CRS can extend overall survival. Despite these studies, there are not still any straight guidelines more detailed and scheduled about the use of combined treatment in patients with CRC. Even if the concept is still not very clear and shared, after a careful evaluation of the published data, and after some technical and pathophysiological descriptions, we concluded that it is possible to improve the overall survival and quality of life and to reduce the tumor relapse in patients affected by locally advanced (pT4) CRC with peritoneal metastases.
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i30.10852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anastomotic Leak Rate and Prolonged Postoperative Paralytic Ileus in Patients Undergoing Laparoscopic Surgery for Colo-Rectal Cancer After Placement of No-Coil Endoanal Tube.

    Ammendola, Michele / Ammerata, Giorgio / Filice, Francesco / Filippo, Rosalinda / Ruggiero, Michele / Romano, Roberto / Memeo, Riccardo / Pessaux, Patrick / Navarra, Giuseppe / Montemurro, Severino / Currò, Giuseppe

    Surgical innovation

    2022  Volume 30, Issue 1, Page(s) 20–27

    Abstract: Background: Colorectal cancer (CRC) is the second most common gastrointestinal tumor in men and the third in women. Left-hemicolectomy (LC) and low anterior resection (LAR) are considered the gold standard curative treatment. In this retrospective study, ...

    Abstract Background: Colorectal cancer (CRC) is the second most common gastrointestinal tumor in men and the third in women. Left-hemicolectomy (LC) and low anterior resection (LAR) are considered the gold standard curative treatment. In this retrospective study, we evaluated the presence or absence of post-operative complications, in all patients who underwent Video-laparoscopic (VLS) LAR/LC with No Coil trans-anal tube positioning, and compared the data with the current literature on the topic.
    Methods: Thirty-nine patients diagnosed with CRC of the descending colon, splenic flexure, sigma, and rectum were recruited. LC was performed for sigmoid and descending colon cancers, while LAR was applied for tumors of the upper two-thirds of the rectum. The No Coil trans-anal tube (SapiMed Spa, Alessandria, Italy) was placed in all patients of the study at the end of surgical treatment.
    Results: Eighteen patients received a LAR-VLS (46%) and 21 patients received a LC-VLS (54%). The average length of hospital stay after surgery was 7 days. PPOI occurred in only one in 39 patients (2.6%) who had undergone LAR-VLS. As for complications, in no patient of the study did AL (0%) occur.
    Conclusion: In patients undergoing LAR-VLS and LC-VLS, we performed colorectal anastomosis and in the same surgical operation we introduced the No-Coil device. Although this is a preliminary study and subject to further investigation, we believe that the No Coil tube positioning may reduce the time of presence of first flatus and feces and the risk of AL.
    MeSH term(s) Male ; Humans ; Female ; Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Retrospective Studies ; Rectal Neoplasms/surgery ; Anastomosis, Surgical/adverse effects ; Laparoscopy/adverse effects ; Intestinal Pseudo-Obstruction/etiology ; Intestinal Pseudo-Obstruction/surgery
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506221090995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: No Coil® placement in patients undergoing left hemicolectomy and low anterior resection for colorectal cancer.

    Ammendola, Michele / Ruggiero, Michele / Talarico, Carlo / Memeo, Riccardo / Ammerata, Giorgio / Capomolla, Antonella / Filippo, Rosalinda / Romano, Roberto / Pallio, Socrate / Navarra, Giuseppe / Montemurro, Severino / Currò, Giuseppe

    World journal of surgical oncology

    2020  Volume 18, Issue 1, Page(s) 327

    Abstract: Background: Colorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged postoperative ileus (PPOI) are two important complications of colorectal surgery. In this observational retrospective study, ... ...

    Abstract Background: Colorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged postoperative ileus (PPOI) are two important complications of colorectal surgery. In this observational retrospective study, we evaluated the positive effects of transanal tube No Coil® in patients with CRC undergoing low anterior resection (LAR) and left hemicolectomy (LC).
    Methods: Thirty-eight cases and forty controls resulted eligible for the final sample. No Coil® placement (SapiMed Spa, Alessandria, Italy) was considered an inclusion criteria for the case group. No Coil® was placed immediately after the end of surgical treatment.
    Results: PPOI was significantly more frequent in the control group. AL was evident in 1 patient (2.6%) of cases and 3 patients (7.5%) of controls. No statistical difference was found in AL occurrence between groups. POI days and AL resulted associated with hospital stay. POI days were negatively associated with No Coil placement and positively with AL.
    Conclusion: With our preliminary data, we suggest that No Coil® placement can be considered as a valuable procedure assisting colorectal surgery, but further studies are required to confirm and enlarge actual evidence.
    MeSH term(s) Anastomotic Leak ; Colectomy ; Colorectal Neoplasms/surgery ; Humans ; Italy ; Postoperative Complications/epidemiology ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2020-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-020-02096-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study.

    Ursini, Francesco / D Angelo, Salvatore / Russo, Emilio / Ammerata, Giorgio / Abenavoli, Ludovico / Mauro, Daniele / Bruno, Caterina / Naty, Saverio / Grembiale, Rosa Daniela / Olivieri, Ignazio / De Sarro, Giovambattista

    Reviews on recent clinical trials

    2018  Volume 13, Issue 3, Page(s) 215–221

    Abstract: Background: Recent evidence demonstrated a potential role of complement C3 as a candidate biomarker of cardiometabolic risk in the general population.: Objective: Aim of the present study was to investigate the correlation between complement C3 ... ...

    Abstract Background: Recent evidence demonstrated a potential role of complement C3 as a candidate biomarker of cardiometabolic risk in the general population.
    Objective: Aim of the present study was to investigate the correlation between complement C3 levels and comorbid Type 2 Diabetes (T2DM) in Rheumatoid Arthritis (RA) patients.
    Methods: For the present study, 40 consecutive diabetic RA patients (RA/T2DM+ group) and 80 consecutive RA patients without diabetes (RA/T2DM- group) were recruited.
    Results: Patients in the RA/T2DM+ group were significantly older (p < 0.0001), had a longer RA duration (p < 0.0001) and higher disease activity (p = 0.006) compared to controls. Moreover, patients in the RA/T2DM+ group had significantly higher levels of ESR (p < 0.0001), CRP (p < 0.0001) and complement C3 (p < 0.0001). A logistic regression model was built to ascertain the effect of selected variables (age, RA duration, BMI, ESR, C3, lnCRP, corticosteroid use) on the likelihood that patients have T2DM. Longer RA duration, ESR and C3 were associated with an increased likelihood of being classified as T2DM. Finally, we built ROC curves to evaluate the predictivity of RA duration, complement C3 and the combination of both variables on the likelihood of being diagnosed with T2DM. The area under the ROC curve was 0.79 (p < 0.0001) for RA duration, 0.71 (p < 0.0001) for complement C3 and 0.89 (p < 0.0001) for the combination of both variables.
    Conclusion: According to our data complement C3 levels can predict the presence of T2DM in RA patients.
    MeSH term(s) Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Biomarkers/blood ; Case-Control Studies ; Complement C3/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; ROC Curve ; Risk Factors
    Chemical Substances Biomarkers ; Complement C3
    Language English
    Publishing date 2018-03-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887113666180314092757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6436: Show issues Location:
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  5. Article ; Online: Vitamin D deficiency in systemic sclerosis: a possible role of subclinical liver fibrosis? Retrospective analysis from an Italian cohort.

    Ursini, Francesco / D'Angelo, Salvatore / Padula, Angela / Leccese, Pietro / Abignano, Giuseppina / Mennillo, Gianna Angela / Ammerata, Giorgio / De Sarro, Giovambattista / Olivieri, Ignazio

    Clinical rheumatology

    2017  Volume 36, Issue 12, Page(s) 2871–2872

    Language English
    Publishing date 2017-12
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-017-3709-3
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    Zs.A 1740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Complement C3 and fatty liver disease in Rheumatoid arthritis patients: a cross-sectional study.

    Ursini, Francesco / Russo, Emilio / Mauro, Daniele / Abenavoli, Ludovico / Ammerata, Giorgio / Serrao, Alfonso / Grembiale, Rosa Daniela / De Sarro, Giovambattista / Olivieri, Ignazio / D'angelo, Salvatore

    European journal of clinical investigation

    2017  Volume 47, Issue 10, Page(s) 728–735

    Abstract: Background: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of nonalcoholic fatty liver disease (NAFLD) in the general population. Aim of this study was to evaluate the performance of C3 for prediction of NAFLD in RA ... ...

    Abstract Background: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of nonalcoholic fatty liver disease (NAFLD) in the general population. Aim of this study was to evaluate the performance of C3 for prediction of NAFLD in RA patients.
    Materials and methods: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated.
    Results: Of 164 consecutive RA patients, 41 (25%) were diagnosed with NAFLD. The NAFLD group had a significant lower proportion of females (P = 0·04), higher BMI (P < 0·0001), C-reactive protein (P = 0·04), complement C3 (P = 0·001) and HSI (P = 0·003). In a logistic regression model, only male sex (OR 2·65, 95% CI: 1·08-6·50, P = 0·03), increasing BMI (OR 1·22, 95% CI: 1·02-1·46, P = 0·03) and complement C3 (OR 5·05, 95% CI: 1·06-23·93, P = 0·04) were associated with higher likelihood of being diagnosed with NAFLD. Finally, we built ROC curves for BMI, complement C3 and their combination for prediction of having NAFLD. The best cut-off for BMI was 28·5 kg/m
    Conclusions: Our results provide preliminary evidence for a potential role of complement C3 as a surrogate biomarker of NAFLD in RA patients.
    MeSH term(s) Age Distribution ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Biomarkers/metabolism ; Comorbidity ; Complement C3/metabolism ; Cross-Sectional Studies ; Female ; Humans ; Italy/epidemiology ; Logistic Models ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/epidemiology ; Prevalence ; Prognosis ; ROC Curve ; Risk Assessment ; Severity of Illness Index ; Sex Distribution ; Survival Rate ; Ultrasonography, Doppler
    Chemical Substances Biomarkers ; Complement C3
    Language English
    Publishing date 2017-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.12798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

    De Simone, Belinda / Abu-Zidan, Fikri M / Chouillard, Elie / Di Saverio, Salomone / Sartelli, Massimo / Podda, Mauro / Gomes, Carlos Augusto / Moore, Ernest E / Moug, Susan J / Ansaloni, Luca / Kluger, Yoram / Coccolini, Federico / Landaluce-Olavarria, Aitor / Estraviz-Mateos, Begoña / Uriguen-Etxeberria, Ana / Giordano, Alessio / Luna, Alfonso Palmieri / Amín, Luz Adriana Hernández / Hernández, Adriana María Palmieri /
    Shabana, Amanda / Dzulkarnaen, Zakaria Andee / Othman, Muhammad Asyraf / Sani, Mohamad Ikhwan / Balla, Andrea / Scaramuzzo, Rosa / Lepiane, Pasquale / Bottari, Andrea / Staderini, Fabio / Cianchi, Fabio / Cavallaro, Andrea / Zanghì, Antonio / Cappellani, Alessandro / Campagnacci, Roberto / Maurizi, Angela / Martinotti, Mario / Ruggieri, Annamaria / Jusoh, Asri Che / Rahman, Karim Abdul / Zulkifli, Anis Suraya M / Petronio, Barbara / Matías-García, Belén / Quiroga-Valcárcel, Ana / Mendoza-Moreno, Fernando / Atanasov, Boyko / Campanile, Fabio Cesare / Vecchioni, Ilaria / Cardinali, Luca / Travaglini, Grazia / Sebastiani, Elisa / Chooklin, Serge / Chuklin, Serhii / Cianci, Pasquale / Restini, Enrico / Capuzzolo, Sabino / Currò, Giuseppe / Filippo, Rosalinda / Rispoli, Michele / Aparicio-Sánchez, Daniel / Muñóz-Cruzado, Virginia Durán / Barbeito, Sandra Dios / Delibegovic, Samir / Kesetovic, Amar / Sasia, Diego / Borghi, Felice / Giraudo, Giorgio / Visconti, Diego / Doria, Emanuele / Santarelli, Mauro / Luppi, Davide / Bonilauri, Stefano / Grossi, Ugo / Zanus, Giacomo / Sartori, Alberto / Piatto, Giacomo / De Luca, Maurizio / Vita, Domenico / Conti, Luigi / Capelli, Patrizio / Cattaneo, Gaetano Maria / Marinis, Athanasios / Vederaki, Styliani-Aikaterini / Bayrak, Mehmet / Altıntas, Yasemin / Uzunoglu, Mustafa Yener / Demirbas, Iskender Eren / Altinel, Yuksel / Meric, Serhat / Aktimur, Yunus Emre / Uymaz, Derya Salim / Omarov, Nail / Azamat, Ibrahim / Lostoridis, Eftychios / Nagorni, Eleni-Aikaterini / Pujante, Antonio / Anania, Gabriele / Bombardini, Cristina / Bagolini, Francesco / Gonullu, Emre / Mantoglu, Baris / Capoglu, Recayi / Cappato, Stefano / Muzio, Elena / Colak, Elif / Polat, Suleyman / Koylu, Zehra Alan / Altintoprak, Fatih / Bayhan, Zülfü / Akin, Emrah / Andolfi, Enrico / Rezart, Sulce / Kim, Jae Il / Jung, Sung Won / Shin, Yong Chan / Enciu, Octavian / Toma, Elena Adelina / Medas, Fabio / Canu, Gian Luigi / Cappellacci, Federico / D'Acapito, Fabrizio / Ercolani, Giorgio / Solaini, Leonardo / Roscio, Francesco / Clerici, Federico / Gelmini, Roberta / Serra, Francesco / Rossi, Elena Giulia / Fleres, Francesco / Clarizia, Guglielmo / Spolini, Alessandro / Ferrara, Francesco / Nita, Gabriela / Sarnari, Jlenia / Gachabayov, Mahir / Abdullaev, Abakar / Poillucci, Gaetano / Palini, Gian Marco / Veneroni, Simone / Garulli, Gianluca / Piccoli, Micaela / Pattacini, Gianmaria Casoni / Pecchini, Francesca / Argenio, Giulio / Armellino, Mariano Fortunato / Brisinda, Giuseppe / Tedesco, Silvia / Fransvea, Pietro / Ietto, Giuseppe / Franchi, Caterina / Carcano, Giulio / Martines, Gennaro / Trigiante, Giuseppe / Negro, Giulia / Vega, Gustavo Machain / González, Agustín Rodríguez / Ojeda, Leonardo / Piccolo, Gaetano / Bondurri, Andrea / Maffioli, Anna / Guerci, Claudio / Sin, Boo Han / Zuhdi, Zamri / Azman, Azlanudin / Mousa, Hussam / Al Bahri, Shadi / Augustin, Goran / Romic, Ivan / Moric, Trpimir / Nikolopoulos, Ioannis / Andreuccetti, Jacopo / Pignata, Giusto / D'Alessio, Rossella / Kenig, Jakub / Skorus, Urszula / Fraga, Gustavo Pereira / Hirano, Elcio Shiyoiti / de Lima Bertuol, Jackson Vinícius / Isik, Arda / Kurnaz, Eray / Asghar, Mohammad Sohail / Afzal, Ameer / Akbar, Ali / Nikolouzakis, Taxiarchis Konstantinos / Lasithiotakis, Konstantinos / Chrysos, Emmanuel / Das, Koray / Özer, Nazmi / Seker, Ahmet / Ibrahim, Mohamed / Hamid, Hytham K S / Babiker, Ahmed / Bouliaris, Konstantinos / Koukoulis, George / Kolla, Chrysoula-Christina / Lucchi, Andrea / Agostinelli, Laura / Taddei, Antonio / Fortuna, Laura / Agostini, Carlotta / Licari, Leo / Viola, Simona / Callari, Cosimo / Laface, Letizia / Abate, Emmanuele / Casati, Massimiliano / Anastasi, Alessandro / Canonico, Giuseppe / Gabellini, Linda / Tosi, Lorenzo / Guariniello, Anna / Zanzi, Federico / Bains, Lovenish / Sydorchuk, Larysa / Iftoda, Oksana / Sydorchuk, Andrii / Malerba, Michele / Costanzo, Federico / Galleano, Raffaele / Monteleone, Michela / Costanzi, Andrea / Riva, Carlo / Walędziak, Maciej / Kwiatkowski, Andrzej / Czyżykowski, Łukasz / Major, Piotr / Strzałka, Marcin / Matyja, Maciej / Natkaniec, Michal / Valenti, Maria Rosaria / Di Vita, Maria Domenica Pia / Sotiropoulou, Maria / Kapiris, Stylianos / Massalou, Damien / Veroux, Massimiliano / Volpicelli, Alessio / Gioco, Rossella / Uccelli, Matteo / Bonaldi, Marta / Olmi, Stefano / Nardi, Matteo / Livadoti, Giada / Mesina, Cristian / Dumitrescu, Theodor Viorel / Ciorbagiu, Mihai Calin / Ammendola, Michele / Ammerata, Giorgio / Romano, Roberto / Slavchev, Mihail / Misiakos, Evangelos P / Pikoulis, Emmanouil / Papaconstantinou, Dimitrios / Elbahnasawy, Mohamed / Abdel-Elsalam, Sherief / Felsenreich, Daniel M / Jedamzik, Julia / Michalopoulos, Nikolaos V / Sidiropoulos, Theodoros A / Papadoliopoulou, Maria / Cillara, Nicola / Deserra, Antonello / Cannavera, Alessandro / Negoi, Ionuţ / Schizas, Dimitrios / Syllaios, Athanasios / Vagios, Ilias / Gourgiotis, Stavros / Dai, Nick / Gurung, Rekha / Norrey, Marcus / Pesce, Antonio / Feo, Carlo Vittorio / Fabbri, Nicolo' / Machairas, Nikolaos / Dorovinis, Panagiotis / Keramida, Myrto D / Mulita, Francesk / Verras, Georgios Ioannis / Vailas, Michail / Yalkin, Omer / Iflazoglu, Nidal / Yigit, Direnc / Baraket, Oussama / Ayed, Karim / Ghalloussi, Mohamed Hedi / Patias, Parmenion / Ntokos, Georgios / Rahim, Razrim / Bala, Miklosh / Kedar, Asaf / Sawyer, Robert G / Trinh, Anna / Miller, Kelsey / Sydorchuk, Ruslan / Knut, Ruslan / Plehutsa, Oleksandr / Liman, Rumeysa Kevser / Ozkan, Zeynep / Kader, Saleh Abdel / Gupta, Sanjay / Gureh, Monika / Saeidi, Sara / Aliakbarian, Mohsen / Dalili, Amin / Shoko, Tomohisa / Kojima, Mitsuaki / Nakamoto, Raira / Atici, Semra Demirli / Tuncer, Gizem Kilinc / Kaya, Tayfun / Delis, Spiros G / Rossi, Stefano / Picardi, Biagio / Del Monte, Simone Rossi / Triantafyllou, Tania / Theodorou, Dimitrios / Pintar, Tadeja / Salobir, Jure / Manatakis, Dimitrios K / Tasis, Nikolaos / Acheimastos, Vasileios / Ioannidis, Orestis / Loutzidou, Lydia / Symeonidis, Savvas / de Sá, Tiago Correia / Rocha, Mónica / Guagni, Tommaso / Pantalone, Desiré / Maltinti, Gherardo / Khokha, Vladimir / Abdel-Elsalam, Wafaa / Ghoneim, Basma / López-Ruiz, José Antonio / Kara, Yasin / Zainudin, Syaza / Hayati, Firdaus / Azizan, Nornazirah / Khei, Victoria Tan Phooi / Yi, Rebecca Choy Xin / Sellappan, Harivinthan / Demetrashvili, Zaza / Lekiashvili, Nika / Tvaladze, Ana / Froiio, Caterina / Bernardi, Daniele / Bonavina, Luigi / Gil-Olarte, Angeles / Grassia, Sebastiano / Romero-Vargas, Estela / Bianco, Francesco / Gumbs, Andrew A / Dogjani, Agron / Agresta, Ferdinando / Litvin, Andrey / Balogh, Zsolt J / Gendrikson, George / Martino, Costanza / Damaskos, Dimitrios / Pararas, Nikolaos / Kirkpatrick, Andrew / Kurtenkov, Mikhail / Gomes, Felipe Couto / Pisanu, Adolfo / Nardello, Oreste / Gambarini, Fabrizio / Aref, Hager / Angelis, Nicola De' / Agnoletti, Vanni / Biondi, Antonio / Vacante, Marco / Griggio, Giulia / Tutino, Roberta / Massani, Marco / Bisetto, Giovanni / Occhionorelli, Savino / Andreotti, Dario / Lacavalla, Domenico / Biffl, Walter L / Catena, Fausto

    World journal of emergency surgery : WJES

    2022  Volume 17, Issue 1, Page(s) 61

    Abstract: Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis ... ...

    Abstract Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.
    Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.
    Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].
    Conclusions: The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-022-00466-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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