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Article ; Online: Young minds, deeper insights: a recap of the BMAS Summer School 2023, ranging from basic research to clinical implications of bone marrow adipose tissue.

Amorim, Tânia / Trivanovic, Drenka / Benova, Andrea / Li, Hongshuai / Tencerova, Michaela / Palmisano, Biagio

2024 Volume 13, Issue 2

Abstract: Bone marrow adiposity (BMA) is a rapidly growing yet very young research field that is receiving worldwide attention based on its intimate relationship with skeletal and metabolic diseases, as well as hematology and cancer. Moreover, increasing numbers ... ...

Abstract	Bone marrow adiposity (BMA) is a rapidly growing yet very young research field that is receiving worldwide attention based on its intimate relationship with skeletal and metabolic diseases, as well as hematology and cancer. Moreover, increasing numbers of young scientists and students are currently and actively working on BMA within their research projects. These developments led to the foundation of the International Bone Marrow Adiposity Society (BMAS), with the goal to promote BMA knowledge worldwide, and to train new generations of researchers interested in studying this field. Among the many initiatives supported by BMAS, there is the BMAS Summer School, inaugurated in 2021 and now at its second edition. The aim of the BMAS Summer School 2023 was to educate and train students by disseminating the latest advancement on BMA. Moreover, Summer School 2023 provided suggestions on how to write grants, deal with negative results in science, and start a laboratory, along with illustrations of alternative paths to academia. The event was animated by constructive and interactive discussions between early-career researchers and more senior scientists. In this report, we highlight key moments and lessons learned from the event.
MeSH term(s)	Humans ; Bone Marrow ; Adiposity ; Adipose Tissue ; Schools
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.060263
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuroendocrine adaptations to starvation.

Amorim, Tânia / Khiyami, Anamil / Latif, Tariq / Fazeli, Pouneh K

Psychoneuroendocrinology

2023 Volume 157, Page(s) 106365

Abstract: Famine and starvation have punctuated the evolutionary past of the human species. As such, we have developed hormonal responses to undernutrition that minimize energy expenditure on processes that are not critical for the survival of the individual, such ...

Abstract	Famine and starvation have punctuated the evolutionary past of the human species. As such, we have developed hormonal responses to undernutrition that minimize energy expenditure on processes that are not critical for the survival of the individual, such as reproduction. In this review, we discuss neuroendocrine adaptations to starvation including hypogonadotropic hypogonadism, growth hormone resistance, hypercortisolemia, and the downregulation of the hypothalamic-pituitary-thyroid axis. We review the time-course of these adaptations by describing studies involving the short-term fasting of healthy individuals as well as studies describing the hormonal changes in states of chronic undernutrition, using individuals with anorexia nervosa as a model of chronic starvation. Lastly, we review representative clinical effects of chronic undernutrition.
MeSH term(s)	Humans ; Anorexia Nervosa ; Neurosecretory Systems ; Hypogonadism ; Human Growth Hormone ; Malnutrition
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2023.106365
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Article: Impact of Long-Term Swimming Exercise on Rat Femur Bone Quality.

Freitas, Laura / Bezerra, Andrea / Resende-Coelho, Ana / Gomez-Lazaro, Maria / Maciel, Leonardo / Amorim, Tânia / Fernandes, Ricardo J / Fonseca, Hélder

Biomedicines

2023 Volume 12, Issue 1

Abstract: Considering the conflicting evidence regarding the potential long-term detrimental effect of swimming during growth on femur quality and fracture risk, our aim was to investigate the effect of eight months of swimming on femur quality. Twenty male eight- ... ...

Abstract	Considering the conflicting evidence regarding the potential long-term detrimental effect of swimming during growth on femur quality and fracture risk, our aim was to investigate the effect of eight months of swimming on femur quality. Twenty male eight-week-old
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010035
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Article: Effects of Low Dose Caffeine on Post-Exercise Heart Rate Variability: A Double-Blind Placebo-Controlled Trial.

Sargent, Cagney T / Shahbal, Tareq K / Carrillo, Andres E / Amorim, Tania / Edsall, Jason R / Ryan, Emily J / Ryan, Edward J

International journal of exercise science

2021 Volume 15, Issue 2, Page(s) 103–112

Abstract: Caffeine may impact post-exercise heart rate variability (HRV); although, studies have yielded inconsistent findings. We examined the effects of low dose caffeine on post-exercise HRV. Healthy, college-aged adults [ ...

Abstract	Caffeine may impact post-exercise heart rate variability (HRV); although, studies have yielded inconsistent findings. We examined the effects of low dose caffeine on post-exercise HRV. Healthy, college-aged adults [
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411342-6
ISSN	1939-795X
ISSN	1939-795X
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Article: Evidence for conservation of primordial ~12-hour ultradian gene programs in humans under free-living conditions.

Zhu, Bokai / Liu, Silvia / David, Natalie L / Dion, William / Doshi, Nandini K / Siegel, Lauren B / Amorim, Tânia / Andrews, Rosemary E / Naveen Kumar, G V / Li, Hanwen / Irfan, Saad / Pesaresi, Tristan / Sharma, Ankit X / Sun, Michelle / Fazeli, Pouneh K / Steinhauser, Matthew L

bioRxiv : the preprint server for biology

2023

Abstract: While circadian rhythms are entrained to the once daily light-dark cycle of the sun, many marine organisms exhibit ~12h ultradian rhythms corresponding to the twice daily movement of the tides. Although human ancestors emerged from circatidal environment ...

Abstract	While circadian rhythms are entrained to the once daily light-dark cycle of the sun, many marine organisms exhibit ~12h ultradian rhythms corresponding to the twice daily movement of the tides. Although human ancestors emerged from circatidal environment millions of years ago, direct evidence of ~12h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells and identified robust ~12h transcriptional rhythms from three healthy participants. Pathway analysis implicated ~12h rhythms in RNA and protein metabolism, with strong homology to the circatidal gene programs previously identified in Cnidarian marine species. We further observed ~12h rhythms of intron retention events of genes involved in MHC class I antigen presentation, synchronized to expression of mRNA splicing genes in all three participants. Gene regulatory network inference revealed XBP1, and GABP and KLF transcription factor family members as potential transcriptional regulators of human ~12h rhythms. These results suggest that human ~12h biological rhythms have a primordial evolutionary origin with important implications for human health and disease.
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.02.539021
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Article ; Online: Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction.

Sabol, Hayley M / Amorim, Tânia / Ashby, Cody / Halladay, David / Anderson, Judith / Cregor, Meloney / Sweet, Megan / Nookaew, Intawat / Kurihara, Noriyoshi / Roodman, G David / Bellido, Teresita / Delgado-Calle, Jesus

Neoplasia (New York, N.Y.)

2022 Volume 28, Page(s) 100785

Abstract: In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We ...

Abstract	In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We show here that Notch3 inhibition in MM cells reduced MM proliferation, decreased Rankl expression, and abrogated the ability of MM cells to promote osteoclastogenesis. Further, Notch3 inhibition in MM cells partially prevented the Notch activation and increased proliferation induced by osteocytes, demonstrating that Notch3 mediates MM-osteocyte communication. Consistently, pro-proliferative and pro-osteoclastogenic pathways were upregulated in CD138
MeSH term(s)	Animals ; Cell Communication ; Humans ; Mice ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Osteocytes/metabolism ; Osteocytes/pathology ; Osteogenesis ; Osteolysis ; Receptor, Notch3/genetics ; Receptor, Notch3/metabolism ; Signal Transduction
Chemical Substances	NOTCH3 protein, human ; Receptor, Notch3
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2022.100785
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Zs.A 5203: Show issues

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Article ; Online: A Neuroprotective Bovine Colostrum Attenuates Apoptosis in Dexamethasone-Treated MC3T3-E1 Osteoblastic Cells.

Martin-Aragon, Sagrario / Bermejo-Bescós, Paloma / Benedí, Juana / Raposo, Carlos / Marques, Franklim / Kydonaki, Eirini K / Gkiata, Paraskevi / Koutedakis, Yiannis / Ntina, Georgia / Carrillo, Andres E / Amorim, Tânia

International journal of molecular sciences

2021 Volume 22, Issue 19

Abstract: Glucocorticoid-induced osteoporosis (GIO) is one of the most common secondary forms of osteoporosis. GIO is partially due to the apoptosis of osteoblasts and osteocytes. In addition, high doses of dexamethasone (DEX), a synthetic glucocorticoid receptor ... ...

Abstract	Glucocorticoid-induced osteoporosis (GIO) is one of the most common secondary forms of osteoporosis. GIO is partially due to the apoptosis of osteoblasts and osteocytes. In addition, high doses of dexamethasone (DEX), a synthetic glucocorticoid receptor agonist, induces neurodegeneration by initiating inflammatory processes leading to neural apoptosis. Here, a neuroprotective bovine colostrum against glucocorticoid-induced neuronal damage was investigated for its anti-apoptotic activity in glucocorticoid-treated MC3T3-E1 osteoblastic cells. A model of apoptotic osteoblastic cells was developed by exposing MC3T3-E1 cells to DEX (0-700 μM). Colostrum co-treated with DEX was executed at 0.1-5.0 mg/mL. Cell viability was measured for all treatment schedules. Caspase-3 activation was assessed to determine both osteoblast apoptosis under DEX exposure and its potential prevention by colostrum co-treatment. Glutathione reduced (GSH) was measured to determine whether DEX-mediated oxidative stress-driven apoptosis is alleviated by colostrum co-treatment. Western blot was performed to determine the levels of p-ERK1/2, Bcl-XL, Bax, and Hsp70 proteins upon DEX or DEX plus colostrum exposure. Colostrum prevented the decrease in cell viability and the increase in caspase-3 activation and oxidative stress caused by DEX exposure. Cells, upon colostrum co-treated with DEX, exhibited higher levels of p-ERK1/2 and lower levels of Bcl-XL, Bax, and Hsp70. Our data support the notion that colostrum may be able to reduce DEX-induced apoptosis possibly via the activation of the ERK pathway and modulation of the Hsp70 system. We provided preliminary evidence on how bovine colostrum, as a complex and multi-component dairy product, in addition to its neuroprotective action, may affect osteoblastic cell survival undergoing apoptosis.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Caspase 3/metabolism ; Cattle ; Cell Line ; Cell Survival/drug effects ; Colostrum/metabolism ; Dexamethasone/pharmacology ; Female ; Glucocorticoids ; Glutathione/analysis ; Inflammation/chemically induced ; Mice ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacology ; Osteoblasts/drug effects ; Osteoblasts/physiology ; Osteoporosis/chemically induced ; Osteoporosis/prevention & control ; Oxidative Stress/drug effects ; Pregnancy
Chemical Substances	Glucocorticoids ; Neuroprotective Agents ; Dexamethasone (7S5I7G3JQL) ; Caspase 3 (EC 3.4.22.-) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2021-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221910195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model.

Kydonaki, Eirini K / Freitas, Laura / Reguengo, Henrique / Simón, Carlos Raposo / Bastos, Ana R / Fernandes, Emanuel M / Canadas, Raphaël F / Oliveira, Joaquim M / Correlo, Vitor M / Reis, Rui L / Vliora, Maria / Gkiata, Paraskevi / Koutedakis, Yiannis / Ntina, Georgia / Pinto, Rui / Carrillo, Andres E / Marques, Franklim / Amorim, Tânia

Nutrients

2022 Volume 14, Issue 14

Abstract: Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation ... ...

Abstract	Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (p < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (p < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (p < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE.
MeSH term(s)	Alendronate/pharmacology ; Animals ; Body Weight ; Bone Density ; Cattle ; Colostrum/metabolism ; Dietary Supplements ; Female ; Humans ; Osteoporosis/drug therapy ; Ovariectomy ; Pregnancy ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Alendronate (X1J18R4W8P)
Language	English
Publishing date	2022-07-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14142837
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Associations between nutrition, energy expenditure and energy availability with bone mass acquisition in dance students: a 3-year longitudinal study.

Amorim, Tânia / Freitas, Laura / Metsios, George S / Gomes, Thayse Natacha / Wyon, Matthew / Flouris, Andreas D / Maia, José / Marques, Franklim / Nogueira, Luísa / Adubeiro, Nuno / Koutedakis, Yiannis

Archives of osteoporosis

2021 Volume 16, Issue 1, Page(s) 141

Abstract: Three years of study showed that female and male vocational dancers displayed lower bone mass compared to controls, at forearm, lumbar spine and femoral neck. Energy intake was found to positively predict bone mass accruals only in female dancers at ... ...

Abstract	Three years of study showed that female and male vocational dancers displayed lower bone mass compared to controls, at forearm, lumbar spine and femoral neck. Energy intake was found to positively predict bone mass accruals only in female dancers at femoral neck. Vocational dancers can be a risk population to develop osteoporosis. Purpose: To determine whether risk factors normally associated with low bone mass in athletic populations (i.e. nutrition intake, energy expenditure and energy availability) are significant predictors of bone mass changes in vocational dance students. Methods: The total of 101 vocational dancers (63 females, 12.8 ± 2.2 years; 38 males, 12.7 ± 2.2 years) and 115 age-matched controls (68 females, 13.0 ± 2.1 years; 47 males, 13.0 ± 1.8 years) were monitored for 3 consecutive years. Bone mass parameters were measured annually at impact sites (femoral neck, FN; lumber spine, LS) and non-impact site (forearm) using DXA. Nutrition (3-day record), energy expenditure (accelerometer), energy availability and IGF-1 serum concentration (immunoradiometric assays) were also assessed. Results: Female and male vocational dancers had consistently reduced bone mass at all anatomical sites (p < 0.001) than controls. IGF-1 did not differ between male vocational dancers and controls, but female dancers showed it higher than controls. At baseline, calcium intake was significantly greater in female vocational dancers than controls (p < 0.05). Male vocational dancers' fat and carbohydrate intakes were significantly lower than matched controls (p < 0.001 and p < 0.05, respectively). Energy availability of both female and male vocational dancers was within the normal range. A significant group effect was found at the FN regarding energy intake (p < 0.05) in female dancers. No significant predictors were found to explain bone mass differences in males. Conclusion: Our 3-year study revealed that both female and male vocational dancers displayed lower bone mass compared to controls, at both impact and non-impact sites. The aetiology of these findings may be grounded on factors different than those usually considered in athletic populations.
MeSH term(s)	Adolescent ; Bone Density ; Child ; Dancing ; Energy Metabolism ; Female ; Humans ; Longitudinal Studies ; Male ; Students
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-021-01005-5
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Article: Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model

Kydonaki, Eirini K. / Freitas, Laura / Reguengo, Henrique / Simón, Carlos Raposo / Bastos, Ana R. / Fernandes, Emanuel M. / Canadas, Raphaël F. / Oliveira, Joaquim M. / Correlo, Vitor M. / Reis, Rui L. / Vliora, Maria / Gkiata, Paraskevi / Koutedakis, Yiannis / Ntina, Georgia / Pinto, Rui / Carrillo, Andres E. / Marques, Franklim / Amorim, Tânia

Nutrients. 2022 July 11, v. 14, no. 14

2022

Abstract	Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (p < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (p < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (p < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE.
Keywords	animal models ; blood serum ; body weight ; bone density ; bone formation ; bone health ; calcium ; cow colostrum ; osteoporosis ; ovariectomy ; placebos
Language	English
Dates of publication	2022-0711
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14142837
Database	NAL-Catalogue (AGRICOLA)

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