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Article ; Online: Local and Systemic Management Options for Melanoma Brain Metastases.

Amouzegar, Afsaneh / Tawbi, Hussein A

2024 Volume 30, Issue 2, Page(s) 102–107

Abstract: Abstract: Development of brain metastasis is one of the most serious complications of advanced melanoma, carrying a significant burden of morbidity and mortality. Although advances in local treatment modalities such as stereotactic radiosurgery and ... ...

Abstract	Abstract: Development of brain metastasis is one of the most serious complications of advanced melanoma, carrying a significant burden of morbidity and mortality. Although advances in local treatment modalities such as stereotactic radiosurgery and breakthrough systemic therapies including immunotherapy and targeted therapies have improved the outcomes of patients with metastatic melanoma, management of patients with melanoma brain metastases (MBMs) remains challenging. Notably, patients with MBMs have historically been excluded from clinical trials, limiting insights into their specific treatment responses. Encouragingly, a growing body of evidence shows the potential of systemic therapies to yield durable intracranial responses in these patients, highlighting the need for inclusion of patients with MBMs in future clinical trials. This is pivotal for expediting the advancement of novel therapies tailored to this distinct patient population. In this review, we will highlight the evolving landscape of MBM management, focusing on local and systemic treatment strategies.
MeSH term(s)	Humans ; Melanoma/drug therapy ; Brain Neoplasms/therapy ; Combined Modality Therapy ; Immunotherapy ; Radiosurgery
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2018400-1
ISSN	1540-336X ; 1528-9117 ; 1081-4442
ISSN (online)	1540-336X
ISSN	1528-9117 ; 1081-4442
DOI	10.1097/PPO.0000000000000711
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Zs.A 4470: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 163: Show issues

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Article ; Online: Next-Generation Immunotherapy Approaches in Melanoma.

Buchanan, Tyler / Amouzegar, Afsaneh / Luke, Jason J

Current oncology reports

2021 Volume 23, Issue 10, Page(s) 116

Abstract: Purpose of review: For patients with metastatic melanoma, immune checkpoint inhibition has drastically changed outcomes. Here, we review the current and next generations of immune-based anti-cancer therapeutics for patients with metastatic melanoma.: ... ...

Abstract	Purpose of review: For patients with metastatic melanoma, immune checkpoint inhibition has drastically changed outcomes. Here, we review the current and next generations of immune-based anti-cancer therapeutics for patients with metastatic melanoma. Recent findings: The need for new anti-cancer therapeutics in patients with metastatic melanoma who have progression of disease despite immune checkpoint blockade is evident. Several novel agents are expected to have FDA approval within the next few years, as they have yielded impressive responses. Despite these optimistic agents, the field of immuno-oncology continues to expand and produce agents with novel mechanisms of action. The next generation of immunotherapy is based upon years of thoroughly researched immuno-oncology. Many of these agents are currently being evaluated in early phase clinical trials, and much of the preliminary data looks promising.
MeSH term(s)	Cell- and Tissue-Based Therapy ; Cytokines/immunology ; Cytokines/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Proteins/immunology ; Immunity, Innate ; Immunotherapy/trends ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/therapy ; T-Lymphocytes/immunology ; T-Lymphocytes/transplantation ; Toll-Like Receptors/agonists ; Toll-Like Receptors/immunology
Chemical Substances	Cytokines ; Immune Checkpoint Inhibitors ; Immune Checkpoint Proteins ; Toll-Like Receptors
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-021-01104-z
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Zs.A 5521: Show issues

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Article ; Online: Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection.

Amouzegar, Afsaneh / Chauhan, Sunil K

Mediators of inflammation

2017 Volume 2017, Page(s) 8670280

Abstract: Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process that ... ...

Abstract	Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process that involves elaborate interactions between cells of innate and adaptive immunity. The migration of immune cells to regional lymphoid tissues and to the site of graft plays a central role in the immunopathogenesis of graft rejection. Intricate interactions between adhesion molecules and their counter receptors on immune cells in conjunction with tissue-specific chemokines guide the trafficking of these cells to the draining lymph nodes and ultimately to the site of graft. In this review, we discuss the cascade of chemokines and adhesion molecules that mediate the trafficking of effector and regulatory T cells during corneal allograft rejection.
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2017/8670280
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Zs.A 3575: Show issues

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Article: STING Agonists as Cancer Therapeutics.

Amouzegar, Afsaneh / Chelvanambi, Manoj / Filderman, Jessica N / Storkus, Walter J / Luke, Jason J

Cancers

2021 Volume 13, Issue 11

Abstract: The interrogation of intrinsic and adaptive resistance to cancer immunotherapy has identified lack of antigen presentation and type I interferon signaling as biomarkers of non-T-cell-inflamed tumors and clinical progression. A myriad of pre-clinical ... ...

Abstract	The interrogation of intrinsic and adaptive resistance to cancer immunotherapy has identified lack of antigen presentation and type I interferon signaling as biomarkers of non-T-cell-inflamed tumors and clinical progression. A myriad of pre-clinical studies have implicated the cGAS/stimulator of interferon genes (STING) pathway, a cytosolic DNA-sensing pathway that drives activation of type I interferons and other inflammatory cytokines, in the host immune response against tumors. The STING pathway is also increasingly understood to have other anti-tumor functions such as modulation of the vasculature and augmentation of adaptive immunity via the support of tertiary lymphoid structure development. Many natural and synthetic STING agonists have entered clinical development with the first generation of intra-tumor delivered cyclic dinucleotides demonstrating safety but only modest systemic activity. The development of more potent and selective STING agonists as well as novel delivery systems that would allow for sustained inflammation in the tumor microenvironment could potentially augment response rates to current immunotherapy approaches and overcome acquired resistance. In this review, we will focus on the latest developments in STING-targeted therapies and provide an update on the clinical development and application of STING agonists administered alone, or in combination with immune checkpoint blockade or other approaches.
Language	English
Publishing date	2021-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13112695
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Article: Regulatory T cell modulation of cytokine and cellular networks in corneal graft rejection.

Tahvildari, Maryam / Inomata, Takenori / Amouzegar, Afsaneh / Dana, Reza

Current ophthalmology reports

2018 Volume 6, Issue 4, Page(s) 266–274

Abstract: Purpose of review: Corneal allografts placed in vascularized or inflamed host beds are at increased risk of graft rejection due to the preponderance of activated immune cells in the host bed. Regulatory T cells (Tregs) are master regulators of the ... ...

Abstract	Purpose of review: Corneal allografts placed in vascularized or inflamed host beds are at increased risk of graft rejection due to the preponderance of activated immune cells in the host bed. Regulatory T cells (Tregs) are master regulators of the adaptive immune response and play a key role in the induction of immune tolerance. The aim of this review is to discuss mechanisms through which Tregs mediate tolerance in corneal transplantation and the novel therapeutic approaches that target Tregs to promote transplant survival. Recent findings: The inflammatory environment of high-risk allografts not only promotes activation of effector T cells and their infiltration to graft site, but also impairs Treg immunomodulatory function. Recent studies have shown that expansion of Tregs and enhancing their modulatory function significantly improve graft survival. Summary: As our understanding of the cellular and molecular pathways in corneal transplantation has deepened, novel therapeutic strategies have been developed to improve allograft survival. In this review, we discuss therapeutic approaches that focus on Tregs to promote corneal allograft survival.
Language	English
Publishing date	2018-10-06
Publishing country	United States
Document type	Journal Article
ISSN	2167-4868
ISSN	2167-4868
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Article ; Online: Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.

Tahvildari, Maryam / Amouzegar, Afsaneh / Foulsham, William / Dana, Reza

Cellular and molecular life sciences : CMLS

2018 Volume 75, Issue 9, Page(s) 1509–1520

Abstract: The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the ... ...

Abstract	The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.
MeSH term(s)	Adaptive Immunity ; Animals ; Antigen-Presenting Cells/immunology ; Cornea/blood supply ; Cornea/immunology ; Cornea/physiology ; Corneal Transplantation/methods ; Graft Survival ; Humans ; Immune Tolerance ; Lymphangiogenesis ; Mesenchymal Stem Cells/immunology ; Neovascularization, Physiologic ; T-Lymphocytes/immunology
Language	English
Publishing date	2018-01-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2739-y
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Zs.A 195: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Peripheral Blood or Bone Marrow Stem Cells? Practical Considerations in Hematopoietic Stem Cell Transplantation.

Amouzegar, Afsaneh / Dey, Bimalangshu R / Spitzer, Thomas R

Transfusion medicine reviews

2018 Volume 33, Issue 1, Page(s) 43–50

Abstract: Although peripheral blood stem cells (PBSC) have worldwide become the predominant source of progenitor cells for hematopoietic stem cell transplantation (HSCT), debate about their role compared with bone marrow (BM) has recently intensified, in large ... ...

Abstract	Although peripheral blood stem cells (PBSC) have worldwide become the predominant source of progenitor cells for hematopoietic stem cell transplantation (HSCT), debate about their role compared with bone marrow (BM) has recently intensified, in large part based on the results of a multicenter Clinical Trials Network study which showed lower incidence of chronic graft-versus-host disease (cGVHD) and improved quality of life in recipients of myeloablative HLA-matched unrelated BM compared with PBSC transplants. However, in certain patient populations, PBSC may lead to improved clinical outcomes due to faster hematologic recovery, a lower risk of graft failure, and possibly a lower probability of relapse. This review will provide a comprehensive summary of studies comparing PBSC with BM as the graft source in terms of acute and chronic GVHD incidence, time to engraftment, and disease-free and overall survival probabilities after HLA-matched related and unrelated donor transplantation and haploidentical donor transplantation. Recommendations based on these studies regarding the use of PBSC versus BM for HSCT are offered.
MeSH term(s)	Blood Donors ; Bone Marrow Cells/cytology ; Bone Marrow Transplantation/methods ; Disease-Free Survival ; Graft vs Host Disease/etiology ; HLA Antigens/chemistry ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/cytology ; Humans ; Multicenter Studies as Topic ; Quality of Life ; Randomized Controlled Trials as Topic ; Recurrence ; Stem Cells/cytology ; T-Lymphocytes/cytology ; Transplantation, Homologous/adverse effects ; Unrelated Donors
Chemical Substances	HLA Antigens
Language	English
Publishing date	2018-11-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639107-2
ISSN	1532-9496 ; 0887-7963
ISSN (online)	1532-9496
ISSN	0887-7963
DOI	10.1016/j.tmrv.2018.11.003
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Zs.A 2239: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation

Tahvildari, Maryam / Amouzegar, Afsaneh / Foulsham, William / Dana, Reza

Cellular and molecular life sciences. 2018 May, v. 75, no. 9

2018

Abstract	The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.
Keywords	T-lymphocytes ; antigen-presenting cells ; cornea ; stem cells
Language	English
Dates of publication	2018-05
Size	p. 1509-1520.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2739-y
Database	NAL-Catalogue (AGRICOLA)

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Z 4' 47/14: Show issues

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Article ; Online: Animal models of high-risk corneal transplantation: A comprehensive review.

Singh, Rohan Bir / Marmalidou, Anna / Amouzegar, Afsaneh / Chen, Yihe / Dana, Reza

Experimental eye research

2020 Volume 198, Page(s) 108152

Abstract: Over the past century, corneal transplantation has become the most commonly performed allogeneic solid tissue transplantation. Although more than 80% of the corneal transplantations have favorable outcomes, immune-mediated rejection continues to be the ... ...

Abstract	Over the past century, corneal transplantation has become the most commonly performed allogeneic solid tissue transplantation. Although more than 80% of the corneal transplantations have favorable outcomes, immune-mediated rejection continues to be the major cause of failure in well over 50% of graft recipients that have inflamed and vascularized host beds. Over the past two decades, the progress in our understanding of the immunological pathways that mediate graft rejection has aided in the development of novel therapeutic strategies. In order to successfully test the efficacy of these interventions, it is essential to model the immunological processes occurring as a consequence of corneal transplantation. Herein, we have comprehensively reviewed the established animal models used for replicating the immunopathological processes causing graft rejection in high-risk corneal transplantation settings. We have also discussed the practical and technical differences, as well as biological and immunological variations in different animal models.
MeSH term(s)	Animals ; Corneal Diseases/surgery ; Corneal Transplantation/methods ; Disease Models, Animal ; Graft Rejection/prevention & control
Language	English
Publishing date	2020-07-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2020.108152
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Zs.A 163: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Kinetics of Corneal Antigen Presenting Cells in Experimental Dry Eye Disease.

Lee, Hyun Soo / Amouzegar, Afsaneh / Dana, Reza

BMJ open ophthalmology

2017 Volume 1, Issue 1, Page(s) e000078

Abstract: Objective: To evaluate dry eye disease (DED)-induced alterations in subsets of corneal antigen presenting cells (APCs) in a mouse model of experimental DED.: Methods and analysis: Seven to 8-week-old female C57BL/6 mice were housed in a controlled ... ...

Abstract	Objective: To evaluate dry eye disease (DED)-induced alterations in subsets of corneal antigen presenting cells (APCs) in a mouse model of experimental DED. Methods and analysis: Seven to 8-week-old female C57BL/6 mice were housed in a controlled environment chamber and were treated with subcutaneous scopolamine to induce DED. Normal mice were used as controls. The frequencies of different subsets of dendritic cells (DCs) and macrophages in the cornea were evaluated using immunohistochemistry and flow cytometry at days 2, 7 and 14 after DED induction. Real-time PCR was used to assess the functional phenotype of macrophages in the cornea of DED mice. Results: Our results demonstrated significant corneal infiltration of CD11b Conclusion: Although the frequencies of total CD11b
Language	English
Publishing date	2017-06-29
Publishing country	England
Document type	Journal Article
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2017-000078
Database	MEDical Literature Analysis and Retrieval System OnLINE

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