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  1. Article ; Online: Assessment of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography Before and After Ranibizumab Intravitreal Injection in Patients with Diabetic Macular Edema

    Amr Khaled Mohammed Emam Hassan* / Ahmed Abdalla Mohalhal / Osama Abdelmoneim Elsoghair Ali / Ahmed Hassan Aldghaimy

    SVU - International Journal of Medical Sciences, Vol 6, Iss 2, Pp 120-

    2023  Volume 139

    Abstract: Background: Anti-Vascular Endothelial Growth Factor (Anti-VEGF) therapy serves to decrease central retinal thickness in eyes affected with diabetic macular edema (DME). The Retinal Nerve Fiber Layer (RNFL) forms the basis of the optic nerve. Objectives: ... ...

    Abstract Background: Anti-Vascular Endothelial Growth Factor (Anti-VEGF) therapy serves to decrease central retinal thickness in eyes affected with diabetic macular edema (DME). The Retinal Nerve Fiber Layer (RNFL) forms the basis of the optic nerve. Objectives: Our study is concerned with studying the effects of Anti-VEGF injections in patients with DME on RNFL thickness. Patients and methods: This was a prospective cohort interventional study conducted at South Valley University Hospital, Ophthalmology department outpatient clinic. It included 50 diabetic patients with diabetic macular edema whose RNFL thickness was measured before the anti-VEGF injections and again after the completion of the three injections treatment course using spectral domain optical coherence tomography (SD-OCT). Results: This study included 50 eyes from 50 patients. 35 (70%) of them were females and 15 (30%) of them were males. 26 patients (52%) had their right eye injected, and 24 patient (48%) had their left eye injected. The superior quadrant of the RNFL showed a mean increase of 1.2 microns (SD = 38.4, 95% Confidence Interval CI = -9.7:12.1, p value = 0.829). The inferior quadrant showed a mean increase of 7.5 microns (SD = 35.6, 95% CI = -2.6:17.6, p value = 0.144). The nasal quadrant showed a mean increase of 8.3 microns (SD = 23, 95% CI = 1.8:14.9, p value = 0.014). The temporal quadrant showed a mean increase of 4.1 microns (SD = 33.2, 95% CI = -5.3:13.6, p value = 0.386). Conclusion: There is no statistically significant correlation between intra-vitreal injections of anti-VEGF and the RNFL thickness.
    Keywords anti-vegf ; retina ; dme ; cme rnfl ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A single-stage computer-guided gap arthroplasty with simultaneous patient-specific total joint replacement with a novel flat fossa design: A case report.

    Shawky, Mohamed / Elbehairy, Mohamed S / Atef, Mohammed / Amr, Khaled

    International journal of surgery case reports

    2021  Volume 79, Page(s) 440–449

    Abstract: Introduction and importance: The computer-guided approach for the patient-specific TMJ replacement is considered an ultimate reliable option in advanced cases. However, dislocation of the condylar head could happen with the concave fossa design. A flat ... ...

    Abstract Introduction and importance: The computer-guided approach for the patient-specific TMJ replacement is considered an ultimate reliable option in advanced cases. However, dislocation of the condylar head could happen with the concave fossa design. A flat design was described and used in this case.
    Case presentation: A 15 years old male patient with mandibular asymmetry and class IV recurrent ankylosis of the right TMJ received a patient-specific artificial joint with computer-guided gap arthroplasty and orthognathic corrective mandibular surgery for the left side. The fossa component was made entirely flat, and the patient was followed up over the next year.
    Clinical discussion: Customized TMJ prosthetic solutions are reliable in advanced cases, especially when facial corrections are indicated; however, the commonly used concave design showed reported dislocations requiring some design modifications as proposed in the presented case.
    Conclusion: The flat fossa design of the artificial TMJ secures the same results as the anatomical fossa design without the incidence of dislocation.
    Language English
    Publishing date 2021-01-22
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2021.01.078
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  3. Article ; Online: Relation between palatal index and the incidence of postoperative fistula in patients with complete unilateral cleft palate (a prospective cohort study).

    Obad Saleh, Hiba / Nasr, Kadry Mohammed / Abdull Sattar, Ayman Hussien / Amr, Khaled

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2019  Volume 72, Issue 12, Page(s) 2064–2094

    MeSH term(s) Cleft Palate/surgery ; Humans ; Mouth Diseases/etiology ; Nose Diseases/etiology ; Oral Fistula/etiology ; Postoperative Complications/etiology ; Prospective Studies
    Language English
    Publishing date 2019-10-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2019.09.042
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  4. Article ; Online: Adductor canal block versus femoral nerve block for pain control after total knee arthroplasty: A systematic review and Meta-analysis.

    Hasabo, Elfatih A / Assar, Ahmed / Mahmoud, Maysa Madny / Abdalrahman, Hamid Ali / Ibrahim, EzzElDien A / Hasanin, Menna Allah / Emam, Amr Khaled / AbdelQadir, Yossef Hassan / AbdelAzim, Ahmed Alaa / Ali, Ahmed Said

    Medicine

    2022  Volume 101, Issue 34, Page(s) e30110

    Abstract: Background: Femoral nerve block is a widely accepted nerve block method with evident reduction in consumption of opioid painkiller and minimization of the duration of hospital stay but may cause weakness of quadriceps muscle strength. Adductor canal ... ...

    Abstract Background: Femoral nerve block is a widely accepted nerve block method with evident reduction in consumption of opioid painkiller and minimization of the duration of hospital stay but may cause weakness of quadriceps muscle strength. Adductor canal block is another nerve block technique that attracts the attention of scientific community nowadays because of its possible superiority over Femoral nerve block regarding mobility and muscle strength.
    Methods: This is a systematic review and meta-analysis of 33 studies, aiming to compare femoral nerve block with adductor canal block following total knee arthroplasty regarding pain control and mobilization.
    Results: Adductor canal block showed better preservation of quadriceps muscle strength (MD = 0.28, 95% CI [0.11, 0.46], P = .002), and better mobilization up to 2 days postoperatively. However, no significant difference was found between the 2 interventions regarding pain control (MD = 0.06, 95% CI [-0.06, 0.17], P = .33) or opioid consumption (SMD = 0.08, 95% CI [-0.06, 0.22], P = .28) up to 2 days postoperatively. The better mobilization results of adductor canal block did not translate into a significant difference in the risk of falls or patients' satisfaction; however, adductor canal block patients had less mean length of hospital stay than the patients with femoral nerve block.
    Conclusion: Both femoral nerve block and adductor canal block provide similar results regarding pain control and opioid consumption, however adductor canal block provides better preservation of quadriceps strength and mobilization, giving it more advantage over femoral nerve block.
    MeSH term(s) Analgesics, Opioid/therapeutic use ; Anesthetics, Local ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Femoral Nerve ; Humans ; Nerve Block/methods ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control
    Chemical Substances Analgesics, Opioid ; Anesthetics, Local
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.

    Abdelaziz, Dalia H / Amr, Khaled / Amer, Amal O

    The international journal of biochemistry & cell biology

    2010  Volume 42, Issue 6, Page(s) 789–791

    Abstract: Nlrc4 is a member of the Nod-like receptors (NLRs), a family of cytosolic receptors involved in sensing bacterial molecules. NLRs are a group of proteins containing spans of leucine-rich repeats that senses bacterial factors within the eukaryotic cytosol. ...

    Abstract Nlrc4 is a member of the Nod-like receptors (NLRs), a family of cytosolic receptors involved in sensing bacterial molecules. NLRs are a group of proteins containing spans of leucine-rich repeats that senses bacterial factors within the eukaryotic cytosol. The recognition of bacterial factors provokes the formation of the inflammasome complex which includes specific NLRs. The inflammasome is responsible for caspase-1 activation which leads to the cleavage and maturation of inflammatory cytokines such as IL-1beta and IL-18. Nlrc4 was considered to be a devoted flagellin sensor in eukaryotic cells. However, studies using a variety of pathogens such as Salmonella, Legionella, Shigella and Pseudomonas at high bacterial burdens revealed that Nlrc4 can mediate caspase-1 activation independent of bacterial flagellin. On the other hand, new reports showed that Nlrc4 can restrict bacterial infection independently of caspase-1. Therefore, Nlrc4 maybe involved in sensing more than one bacterial molecule and may participate in several immune complexes.
    MeSH term(s) Animals ; Bacterial Infections/immunology ; Bacterial Infections/metabolism ; CARD Signaling Adaptor Proteins/genetics ; CARD Signaling Adaptor Proteins/immunology ; CARD Signaling Adaptor Proteins/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/immunology ; Calcium-Binding Proteins/metabolism ; Caspase 1/metabolism ; Flagellin/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Mucocutaneous Lymph Node Syndrome/genetics ; Mucocutaneous Lymph Node Syndrome/immunology ; Mucocutaneous Lymph Node Syndrome/metabolism ; Multiprotein Complexes/immunology
    Chemical Substances CARD Signaling Adaptor Proteins ; Calcium-Binding Proteins ; Interleukin-18 ; Interleukin-1beta ; Multiprotein Complexes ; NLRC4 protein, human ; Flagellin (12777-81-0) ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2010-01-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2010.01.003
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