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  1. Article: Positive Pressure Ventilation Treatment Based on Daytime and Night-time Titration in Patients with Obesity Hypoventilation Syndrome: A Randomized Controlled Trial.

    Amra, Babak / Ghasemi, Marzieh / Soltaninejad, Forogh / Salmasi, Mehrzad

    Sleep science (Sao Paulo, Brazil)

    2023  Volume 16, Issue 3, Page(s) e278–e283

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2023-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659
    ISSN (online) 1984-0063
    ISSN 1984-0659
    DOI 10.1055/s-0043-1773790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association between Sleep Quality and Gastroesophageal Reflux in Medical Students.

    Teimouri, Azam / Amra, Babak

    Middle East journal of digestive diseases

    2021  Volume 13, Issue 2, Page(s) 139–144

    Abstract: BACKGROUND Due to stressful occupational conditions, irregular dietary and sleep schedules, medical students are at increased risk of developing gastrointestinal disorders, gastroesophageal reflux (GERD) in particular, as well as sleep disturbances. ... ...

    Abstract BACKGROUND Due to stressful occupational conditions, irregular dietary and sleep schedules, medical students are at increased risk of developing gastrointestinal disorders, gastroesophageal reflux (GERD) in particular, as well as sleep disturbances. Therefore, for the first time, we aimed to assess the correlation between GERD and sleep disturbances among medical students. METHODS The current cross-sectional study was done on 290 medical students at different study periods in Iran during 2018-2019. Age, sex, stage of studying, residence, and body mass index were gathered. The frequency scale for the symptoms of gastroesophageal reflux (FSSG) was utilized to assess gastrointestinal symptoms among them and the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality. Eventually, the association of sleep disturbances with demographic factors and gastrointestinal symptoms was evaluated. RESULTS Living in the dormitory (
    Language English
    Publishing date 2021-05-29
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2623796-9
    ISSN 2008-5249 ; 2008-5230
    ISSN (online) 2008-5249
    ISSN 2008-5230
    DOI 10.34172/mejdd.2021.217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of sleep quality in faculty members of Isfahan university of medical sciences.

    Naderi, Zohre / Amra, Babak / Ahmadi, Fatemeh / Emami Ardestani, Mohammad

    International journal of physiology, pathophysiology and pharmacology

    2023  Volume 15, Issue 4, Page(s) 125–133

    Abstract: Background: Sleep disorders can significantly impair the quality of life and daily functions. Evaluating sleep quality can provide valuable information about working conditions. This study aims to evaluate the sleep quality of faculty members at Isfahan ...

    Abstract Background: Sleep disorders can significantly impair the quality of life and daily functions. Evaluating sleep quality can provide valuable information about working conditions. This study aims to evaluate the sleep quality of faculty members at Isfahan University of Medical Sciences (IUMS).
    Methods: This descriptive-analytic study was conducted from 2020 to 2021, involving 106 faculty members from the medical school. A questionnaire collected demographic information, including age, sex, height, weight, body mass index (BMI), level of education, history of faculty membership, major, working hours during the day and night, residency place, and medical history. The Pittsburgh Sleep Quality Index (PSQI) and Symptom Checklist-25 (SCL-25) questionnaire were used to assess participants' sleep quality. Data were compared between clinicians and basic science faculty members.
    Results: PSQI subtypes were examined among the participants. The total PSQI score was 6.20±3.4. A comparison of PSQI scores and subtypes based on age categories did not show any significant differences (P > 0.05 for all). Clinicians had significantly lower total PSQI scores (P=0.044), sleep latency (P=0.024), sleep disturbances (P=0.012), and daytime dysfunction (P=0.022). Additionally, clinicians had a lower severity of sleep latency (P=0.024), sleep disturbances (P=0.012), and total PSQI score (P=0.044). However, clinicians exhibited a higher intensity of daytime dysfunction (P=0.022).
    Conclusion: Faculty members exhibited a high prevalence of sleep disorders, with the most common disorders being sleep disturbance and high sleep latency. The prevalence of sleep disorders was higher among basic science faculty members compared to clinicians.
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478821-1
    ISSN 1944-8171
    ISSN 1944-8171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Positive Pressure Ventilation Treatment Based on Daytime and Night-time Titration in Patients with Obesity Hypoventilation Syndrome: A Randomized Controlled Trial

    Amra, Babak / Ghasemi, Marzieh / Soltaninejad, Forogh / Salmasi, Mehrzad

    Sleep Science

    2023  Volume 16, Issue 03, Page(s) e278–e283

    Abstract: Objectives: The aim of the present study was to investigate the improvements of gas exchange and excessive daytime sleepiness in patients with obesity hypoventilation syndrome (OHS) in daytime and night-time split polysomnography (DSPSG and NSPSG).: ... ...

    Abstract Objectives: The aim of the present study was to investigate the improvements of gas exchange and excessive daytime sleepiness in patients with obesity hypoventilation syndrome (OHS) in daytime and night-time split polysomnography (DSPSG and NSPSG).
    Materials and Methods: In the present randomized controlled trial, patients with OHS were enrolled in two DSPSG (51 patients) and NSPSG (50 patients) groups in the Bamdad respiratory and sleep research center in Isfahan, Iran. In both groups, the diagnostic polysomnography (PSG) and titration were conducted in one session according to the guidelines of NSPSG. SpO2, PaCO2, and the Epworth Sleepiness Scale (ESS), were measured initially and 12 weeks after treatment. Furthermore, the PSG parameters and the type of treatments for the two groups were recorded and analyzed.
    Results: A total of 101 OHS patients (age: 62.02 ± 12.4 year old; 61 females [60.4%]) were evaluated. There were no significant differences regarding BMI, gender, and AHI between groups ( p  > 0.05). Primary SpO2, PaCO2, and ESS were not significantly different between the two groups. After 12 weeks of treatment by continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP), there were significant improvement of SpO2, PaCO2, and ESS score ( p < 0.001). The amount of change of these variables was not different between groups. Among all variables, only the lower SpO2 and higher PaCO2 were associated with response to BiPAP.
    Discussion: There were no significant differences in the number of changes of SpO2, PaCO2, and ESS by treatment in the DSPSG and NSPSG groups. Therefore, DSPSG may be considered as a valuable alternative method for the diagnosis and titration in OHS patients.
    Clinical Trials: IRCT20170512033930N2
    Keywords continuous positive airway pressure ; obesity hypoventilation syndrome ; noninvasive ventilation ; polysomnography ; obesity
    Language English
    Publishing date 2023-09-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.1055/s-0043-1773790
    Database Thieme publisher's database

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  5. Article: The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients with Obstructive Sleep Apnea Syndrome: A Case-Control Study.

    Amra, Babak / Shafiei, Amin / Soltaninejad, Forogh / Asgari, Abdollah / Farajzadegan, Ziba

    International journal of preventive medicine

    2022  Volume 13, Page(s) 76

    Abstract: Background: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA ... ...

    Abstract Background: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls.
    Methods: 39 FDR (parents, siblings, and children) of patients diagnosed with OSA at Bamdad Respiratory and Research Center as cases and age- and sex-matched healthy controls were included in the current case-control pilot study. The sampling method was convenience sampling based on having inclusion criteria and consent to participate in the study. Demographic characteristics and essential criteria for diagnosing MS included blood pressure, anthropometric [weight (kg), height (cm), waist circumference (cm) and body mass index (BMI) (kg/m
    Results: In the comparison of the demographic and clinical characteristics of two39 cases and control groups, weight and diastolic blood pressure were significantly higher in case group than controls (
    Conclusions: The present study demonstrates that the frequency of MS is not significantly different between FDRs of OSA patients and controls. However, further large-scale studies are warranted to detect the frequency of MS in people with hereditary background for OSA compared to general population.
    Language English
    Publishing date 2022-04-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2574680-7
    ISSN 2008-8213 ; 2008-7802
    ISSN (online) 2008-8213
    ISSN 2008-7802
    DOI 10.4103/ijpvm.IJPVM_602_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Favipiravir in the Treatment of Outpatient COVID-19: A Multicenter, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.

    Vaezi, Atefeh / Salmasi, Mehrzad / Soltaninejad, Forogh / Salahi, Mehrdad / Javanmard, Shaghayegh Haghjooy / Amra, Babak

    Advances in respiratory medicine

    2023  Volume 91, Issue 1, Page(s) 18–25

    Abstract: Background: Finding effective outpatient treatments to prevent COVID-19 progression and hospitalization is necessary and is helpful in managing limited hospital resources. Repurposing previously existing treatments is highly desirable. In this study, we ...

    Abstract Background: Finding effective outpatient treatments to prevent COVID-19 progression and hospitalization is necessary and is helpful in managing limited hospital resources. Repurposing previously existing treatments is highly desirable. In this study, we evaluate the efficacy of Favipiravir in the prevention of hospitalization in symptomatic COVID-19 patients who were not eligible for hospitalization.
    Methods: This study was a triple-blind randomized controlled trial conducted between 5 December 2020 and 31 March 2021 in three outpatient centers in Isfahan, Iran. Patients in the intervention group received Favipiravir 1600 mg daily for five days, and the control group received a placebo. Our primary outcome was the proportion of hospitalized participants from day 0 to day 28. The outcome was assessed on days 3, 7, 14, 21, and 28 through phone calls.
    Results: Seventy-seven patients were randomly allocated to Favipiravir and placebo groups. There was no significant difference between groups considering baseline characteristics. During the study period, 10.5% of patients in the Favipiravir group and 5.1% of patients in the placebo group were hospitalized, but there was no significant difference between them (
    Conclusions: Our study shows that Favipiravir did not reduce the hospitalization rate of mild to moderate COVID-19 patients in outpatient settings.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Outpatients ; Amides/adverse effects
    Chemical Substances favipiravir (EW5GL2X7E0) ; Amides
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.3390/arm91010004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Steroid in the Treatment of Outpatient COVID-19: A Multicenter Randomized Controlled Trial.

    Amra, Babak / Vaezi, Atefeh / Soltaninejad, Forogh / Salahi, Mehrdad / Salmasi, Mehrzad / Haghjooy Javanmard, Shaghayegh

    Advanced biomedical research

    2023  Volume 12, Page(s) 122

    Abstract: Background: Early treatment of COVID-19 patients could reduce hospitalization and death. The effect of corticosteroids in the outpatient setting is still unknown. This study aimed to determine the effect of corticosteroids in the prevention of ... ...

    Abstract Background: Early treatment of COVID-19 patients could reduce hospitalization and death. The effect of corticosteroids in the outpatient setting is still unknown. This study aimed to determine the effect of corticosteroids in the prevention of hospitalization of nonsevere cases.
    Materials and methods: This study is a multicenter randomized controlled trial. Seventy five nonsevere COVID-19 patients presented between days 7 and 14 of their symptoms received either prednisolone or placebo. The primary outcome was hospitalization. The study protocol was registered in the Iranian Registry of Clinical Trials on December 2, 2020 (IRCT20171219037964N2).
    Results: Although the rate of hospitalization in the prednisolone group was higher than the placebo group (10.8% vs. 7.9%, respectively), it was not statistically significant (
    Conclusion: Considering the null effect of corticosteroids in the prevention of hospitalization in outpatient settings, it is suggested not to consider corticosteroids for outpatient treatment.
    Language English
    Publishing date 2023-05-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_72_22
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  8. Article: Effect of CPAP Therapy on Serum Lipids and Blood Pressure in Patients with Obstructive Sleep Apnea Syndrome.

    Asgari, Abdolah / Soltaninejad, Forogh / Farajzadegan, Ziba / Amra, Babak

    Tanaffos

    2020  Volume 18, Issue 2, Page(s) 126–132

    Abstract: Background: Most of patients with Obstructive Sleep Apnea (OSA) are at risk of metabolic syndrome. The treatment of choice for OSA patients is the Continuous Positive Airway Pressure (CPAP). Reports about the effect of CPAP on metabolic parameters are ... ...

    Abstract Background: Most of patients with Obstructive Sleep Apnea (OSA) are at risk of metabolic syndrome. The treatment of choice for OSA patients is the Continuous Positive Airway Pressure (CPAP). Reports about the effect of CPAP on metabolic parameters are controversial. So, we aimed to evaluate the effect of CPAP therapy on blood pressure, Fasting Blood Sugar (FBS), and serum lipids including: Triglycerides (TG), total cholesterol (Chol), High Density Lipoproteins (HDL), and Low Density Lipoproteins (LDL).
    Materials and methods: This study included 35 OSA patients. Initially, their baseline demographic and clinical characteristics were recorded. Then, the patients underwent CPAP therapy on average 4-7 hours for 8 weeks. The level of FBS, TG, Cholesterol, HDL, LDL, and blood pressure were measured and recorded before and after treatment. Finally, the collected data were analyzed with SPSS version 22.
    Results: This study included 35 OSA patients [24 men (68.6%)], with mean age of 45.58±8.02 years. Results indicated that CPAP therapy led to decrease of 9.76 and 3.49 mmHg in systolic and diastolic blood pressures, respectively. Also, LDL decreased to 6.27mg/dl and HDL increased to 0.75 mg/dl (P<0.001) with treatment. The changes of other variables were not significant (P>0.05).
    Conclusion: Treatment of OSA with CPAP has beneficial effects on blood pressure and some items of lipid profile. Regarding the importance of metabolic disturbances in OSA complications, choosing an appropriate treatment for OSA patients can play an important role in improvement of patients status as well as prevention of these complications.
    Language English
    Publishing date 2020-05-22
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome.

    Amra, Babak / Samadi, Behrooz / Soltaninejad, Forogh

    Tanaffos

    2020  Volume 18, Issue 4, Page(s) 315–320

    Abstract: Background: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS).: Materials and methods: In this prospective observational study, a total of 30 ... ...

    Abstract Background: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS).
    Materials and methods: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, were included. The peripheral capillary oxygen saturation (SPO
    Results: The results revealed that all study variables, except for TBF, changed significantly during the study in both males and females (P<0.001). There was a significant positive association between changes in PCO
    Conclusion: The present results indicated no significant association between the improvement of gas exchange and changes in BMI, TBP, and TBF during the study. However, further large-scale studies are required to examine the effects of BIPAP therapy on body composition in patients with OHS.
    Language English
    Publishing date 2020-06-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of lymphocyte subsets with mortality in severe COVID-19 pneumonia patients.

    Ashrafi, Farzaneh / Nematollahi, Pardis / Salmasi, Mehrzad / Hedayat, Arash / Amra, Babak

    Journal of clinical laboratory analysis

    2021  Volume 35, Issue 11, Page(s) e24046

    Abstract: Background: Few studies have investigated the alterations in the T and B cell counts and related subgroups in pulmonary infections especially COVID-19. Here, we aimed to evaluate total T and B lymphocytes and T cell subgroup counts to find the possible ... ...

    Abstract Background: Few studies have investigated the alterations in the T and B cell counts and related subgroups in pulmonary infections especially COVID-19. Here, we aimed to evaluate total T and B lymphocytes and T cell subgroup counts to find the possible correlation between number of these cells and severity and mortality in COVID-19 patients.
    Methods: This study was performed on 40 patients with severe COVID-19 infection confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and chest HRCT in August 2020. By the time of admission, T lymphocytes profile in peripheral blood was investigated using multicolor flow cytometry. The total number of T lymphocytes, CD4+ T cells, CD8+ T cells, and B lymphocytes were calculated. Expression of CD2, CD3, CD5, and CD7 as pan T cell surface markers and expression of CD38 and HLA-DR as activated markers on T lymphocytes were also evaluated.
    Results: Nine patients (22.5%) died during the study and 16 patients (40%) were admitted to ICU. Deceased patients demonstrated lower amounts of T cell count and CD4+ T cell count (with a marginal difference (p = 0.07)) compared with survived patients at the time of admission. The chance of mortality was significantly higher for patients with CD7 loss (OR = 14.89). A marginally significant relationship was also indicated between CD4<200/ml and mortality (OR = 8.65), but no other significant relationships were observed between variables and ICU admission.
    Conclusion: Altogether, CD7 loss on T lymphocytes and CD4+ T cell count below 200/ml revealed a significant relationship with mortality. Considering T lymphocytes and T cell subgroup count could have a predictive value for patients suffering from COVID-19.
    MeSH term(s) ADP-ribosyl Cyclase 1/analysis ; Antigens, CD7/analysis ; COVID-19/immunology ; COVID-19/mortality ; Female ; Humans ; Lymphocyte Subsets ; Male ; Middle Aged ; SARS-CoV-2 ; Severity of Illness Index
    Chemical Substances Antigens, CD7 ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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