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  1. Article ; Online: Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats.

    Baali, B / Kirane-Amrani, L / Tichati, L / Soual, R / Ouali, K

    Toxicology and industrial health

    2023  Volume 39, Issue 11, Page(s) 664–678

    Abstract: The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, ... ...

    Abstract The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, respectively, by oral gavage, three increasing doses of CuQ: 47; 67.1; and 94 mg/kg b.w corresponding, respectively, LD
    MeSH term(s) Rats ; Male ; Animals ; Antioxidants/pharmacology ; Lipid Peroxidation ; Copper/toxicity ; Fungicides, Industrial/toxicity ; Rats, Wistar ; Oxidative Stress ; Glutathione/metabolism ; Liver
    Chemical Substances Antioxidants ; Copper (789U1901C5) ; Fungicides, Industrial ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/07482337231203075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Avian Influenza Virus Tropism in Humans.

    AbuBakar, Umarqayum / Amrani, Lina / Kamarulzaman, Farah Ayuni / Karsani, Saiful Anuar / Hassandarvish, Pouya / Khairat, Jasmine Elanie

    Viruses

    2023  Volume 15, Issue 4

    Abstract: An influenza pandemic happens when a novel influenza A virus is able to infect and transmit efficiently to a new, distinct host species. Although the exact timing of pandemics is uncertain, it is known that both viral and host factors play a role in ... ...

    Abstract An influenza pandemic happens when a novel influenza A virus is able to infect and transmit efficiently to a new, distinct host species. Although the exact timing of pandemics is uncertain, it is known that both viral and host factors play a role in their emergence. Species-specific interactions between the virus and the host cell determine the virus tropism, including binding and entering cells, replicating the viral RNA genome within the host cell nucleus, assembling, maturing and releasing the virus to neighboring cells, tissues or organs before transmitting it between individuals. The influenza A virus has a vast and antigenically varied reservoir. In wild aquatic birds, the infection is typically asymptomatic. Avian influenza virus (AIV) can cross into new species, and occasionally it can acquire the ability to transmit from human to human. A pandemic might occur if a new influenza virus acquires enough adaptive mutations to maintain transmission between people. This review highlights the key determinants AIV must achieve to initiate a human pandemic and describes how AIV mutates to establish tropism and stable human adaptation. Understanding the tropism of AIV may be crucial in preventing virus transmission in humans and may help the design of vaccines, antivirals and therapeutic agents against the virus.
    MeSH term(s) Animals ; Humans ; Influenza in Birds ; Influenza A virus/genetics ; Influenza A virus/metabolism ; Influenza, Human ; Birds ; Tropism
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15040833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The learning curve of laparoscopic rectal cancer surgery of millennial surgeons: Lessons for a safe implementation in low- and middle-income countries.

    Sekkat, Hamza / Souadka, Amine / Alaoui, Leila / Rafik, Ali / Belkhadir, Zakaria / Amrani, Laila / Benkabbou, Amine / Mohsine, Raouf / Majbar, Anass Mohammed

    Journal of minimal access surgery

    2023  Volume 19, Issue 2, Page(s) 296–304

    Abstract: Objective: This study aimed to analyse the learning curve (LC) in laparoscopic rectal cancer resections of 2 millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery programme in low- and middle-income country (LMIC) ...

    Abstract Objective: This study aimed to analyse the learning curve (LC) in laparoscopic rectal cancer resections of 2 millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery programme in low- and middle-income country (LMIC) cancer centre.
    Methods: All consecutive patients operated by two millennial surgeons for primary rectal adenocarcinoma between January 2018 and March 2020 were included. The LC was analysed for operative duration and conversion to open surgery using both cumulative sum (CUSUM) and/or variable life-adjusted display (VLAD) charts.
    Results: Eighty-four patients were included, 45 (53.6%) men with a mean age of 57.3 years. Abdominoperineal resection was performed in 31 (36.9%) cases and resections were extended to other organs in 20 (23.8%) patients. Thirteen patients (15.5%) had conversion to open surgery. Using CUSUM, Learning curve based on conversion was completed at 12 cases for the first surgeon versus 10 cases for the second. While using VLAD and learning curve-CUSUM (LC-CUSUM), the cases needed were 26 vs 24 respectively. The median operative duration was 314 min with a LC completed at cases (17 vs. 26), and (18 vs. 29) using, respectively, standard and LC-CUSUM.
    Conclusions: This study shows a safe and short LC of millennial surgeons during the implementation of a laparoscopic rectal cancer surgery in an LMIC cancer centre, and the valuable use of modern statistical methods in the prospective assessment of LC safety during surgical training.
    Language English
    Publishing date 2023-04-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2186884-0
    ISSN 1998-3921 ; 0972-9941
    ISSN (online) 1998-3921
    ISSN 0972-9941
    DOI 10.4103/jmas.jmas_78_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Endoscopic management of anastomotic leakage after colorectal cancer surgery in a Moroccan center: A case series and literature review.

    Aourarh, Benayad / Souadka, Amine / Majbar, Mohamed Anass / Benkabbou, Amine / Chakkor, Amal / Bakkar, Meriem / Mohsine, Raouf / Amrani, Laila

    SAGE open medical case reports

    2023  Volume 11, Page(s) 2050313X231205716

    Abstract: Endoscopic management has become an alternate treatment to a revision surgery for colorectal fistulas. Eight patients who were treated by endoscopy for postoperative anastomotic leakage to colorectal cancer were included. A univariate analysis was ... ...

    Abstract Endoscopic management has become an alternate treatment to a revision surgery for colorectal fistulas. Eight patients who were treated by endoscopy for postoperative anastomotic leakage to colorectal cancer were included. A univariate analysis was carried out to determine the predictive factors of success. All our patients were treated using metallic clips. The primary efficiency of this technique was 50%. In a univariate analysis, the size of the fistula and its distance from the anal margin had an influence on the efficiency of the endoscopic treatment, which was not the case for either the surgical technique or the use of neoadjuvant radiotherapy. This endoscopic treatment is effective and represents a more secure alternative than revision surgery. In our study, the use of metallic clips showed a 50% success rate, going up to 100% for the group of patients with a fistula ostium of a size ⩽1 cm, proving the necessity of using this technique.
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231205716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Do we have enough Foreknowledge to predict the low anterior resection syndrome (LARS) score preoperatively?

    Essangri, H / Majbar, M A / Benkabbou, A / Belkhadir, Z / Amrani, L / Mohsine, R / Souadka, A

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2020  Volume 22, Issue 10, Page(s) 1445

    MeSH term(s) Consensus ; Humans ; Postoperative Complications ; Rectal Diseases ; Rectal Neoplasms ; Syndrome
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transcultural adaptation and validation of the Moroccan Arabic dialect version of the Wexner incontinence score in patients with low anterior resection syndrome after rectal surgery.

    Essangri, Hajar / Majbar, Mohammed Anass / Benkabbou, Amine / Amrani, Laila / Mohsine, Raouf / Souadka, Amine

    Surgery

    2021  Volume 170, Issue 1, Page(s) 47–52

    Abstract: Background: Bowel dysfunction symptoms such as stool clustering, urgency, incomplete voiding, and fecal incontinence are frequent after colorectal surgery and known as the low anterior resection syndrome. The Wexner score is the most widely used tool ... ...

    Abstract Background: Bowel dysfunction symptoms such as stool clustering, urgency, incomplete voiding, and fecal incontinence are frequent after colorectal surgery and known as the low anterior resection syndrome. The Wexner score is the most widely used tool for fecal incontinence assessment. We aimed to translate and test the psychometric properties of the Moroccan Arabic dialect version of the Wexner questionnaire in patients with low anterior resection syndrome after rectal surgery.
    Methods: The Wexner questionnaire was translated to Moroccan Arabic and administered to a group of 158 patients, among which a subgroup of 43 patients took the test for a second time to examine test-retest reliability. Cronbach alpha coefficient was used to determine internal consistency and correlation, and the European Organisation for the Research and Treatment of Cancer Quality of Life C30 and the low anterior resection syndrome questionnaires were assessed for convergent validity. Discriminant validity was demonstrated through the Wexner score ability to detect differences based on the patients' different clinical and pathological characteristics.
    Results: One hundred and fifty-eight patients completed the Moroccan Arabic dialect version of the Wexner score, which showed an excellent internal consistency with a Cronbach alpha score of 0.91. Test-retest reliability was established by a Bland-Altman plot with 95% limits of agreement. The score showed positive correlation to the low anterior resection syndrome score (r = 0.748; P < .001) and the European Organisation for the Research and Treatment of Cancer Quality of Life C30 diarrhea symptom scale (r = 0.519; P < .001). A negative correlation was also demonstrated for each one of the 5 European Organisation for the Research and Treatment of Cancer quality of life C30 functional scales, namely physical functioning (r = -0.217

    P = .006), role functioning (r = -0.267; P = .001), emotional functioning (r = -0.266; P = .001), cognitive functioning (r = -0.283; P < .001), and social functioning (r = -0,283; P < .001). The Wexner score differed between patients according to tumor location, chemoradiotherapy, type of mesorectal excision, and anastomosis.
    Conclusion: The Moroccan Arabic dialect version of the Wexner score shows good psychometric properties and can be used for fecal incontinence assessment, particularly in colorectal cancer patients.
    MeSH term(s) Adult ; Aged ; Cross-Cultural Comparison ; Fecal Incontinence/diagnosis ; Fecal Incontinence/etiology ; Female ; Humans ; Male ; Middle Aged ; Morocco ; Proctectomy/adverse effects ; Proctectomy/methods ; Prospective Studies ; Psychometrics ; Quality of Life ; Rectal Neoplasms/surgery ; Reproducibility of Results ; Surveys and Questionnaires ; Syndrome ; Translating
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evaluation of the implementation of a quality improvement program through morbidity and mortality reviews in a developing country.

    Lahnaoui, Oumayma / Souadka, Amine / El Ahmadi, Brahim / Ghannam, Abdelilah / Belkhadir, Zakaria / Amrani, Laila / Benkabbou, Amine / Mohsine, Raouf / Majbar, Mohammed Anass

    Annals of medicine and surgery (2012)

    2022  Volume 80, Page(s) 103987

    Abstract: Background: Morbidity and mortality reviews represent an opportunity to discuss adverse events and healthcare issues. Aim: Report the first experience of implementing a procedure of MMR, and assess its impact on quality improvement.: Methods: From ... ...

    Abstract Background: Morbidity and mortality reviews represent an opportunity to discuss adverse events and healthcare issues. Aim: Report the first experience of implementing a procedure of MMR, and assess its impact on quality improvement.
    Methods: From July 2019 to December 2019, members of the surgical and ICU departments designed and implemented a regular procedure of MMR. Cases of severe postoperative complications after curative resection for digestive cancer were selected to be presented by a surgical resident and discussed in an interdisciplinary conference following a standardized presentation based on an analysis tool adapted from the ALARM framework. Process was assessed by the number of MMRs held, number and type of recommendations issued and implemented.
    Results: Among 13 serious complications during the study period, 10 were discussed. The "Tasks" category was activated in 90% of the cases where lack or misuse of protocols was identified in 90% of the events discussed. Test results availability or accuracy were incarnated in 30% of cases. Poor communication was a contributing factor in 60% of the cases. Written medical records were defective in 40% of the cases. From 16 recommendations for improvement emitted, 87.5% (14/16) were translated into projects and successfully implemented.
    Conclusions: a standardized and regular procedure of morbidity and mortality reviews in a tertiary care facility in a developing country allowed a significant improvement in patient care through quality initiatives implementation. MMRs might be a strong tool for the improvement of surgical care particularly for low-mid income countries.
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Beware of lethal Wernicke's encephalopathy after cytoreductive surgery with HIPEC for peritoneal pseudomyxoma: Case report of morbidity and mortality review.

    Lahnaoui, Oumayma / El Bahaoui, Nezha / El Atiq, Sara / Amrani, Laila / Majbar, Mohammed Anass / Benkabbou, Amine / Mohsine, Raouf / Souadka, Amine

    International journal of surgery case reports

    2022  Volume 98, Page(s) 107500

    Abstract: Background: Pseudomyxoma peritonei (PMP) arising from the appendix is a rare entity. Complete cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is the only established curative treatment, and is reputedly linked ...

    Abstract Background: Pseudomyxoma peritonei (PMP) arising from the appendix is a rare entity. Complete cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is the only established curative treatment, and is reputedly linked to high morbidity and mortality. We report, to our knowledge, the first case of delayed lethal Wernicke encephalopathy (WE) complicating CRS with HIPEC for an appendicular PMP. WE, caused by a thiamine deficiency, is characterized by ataxia, nystagmus and changes in consciousness.
    Methods: A patient underwent complete CRS with HIPEC for a low grade mucinous appendicular tumor at the stage of PMP with a peritoneal index of 31, and was readmitted at POD 36 for persistent vomiting and vague neurological symptoms of mental confusion. The classic triad of WE appeared tardily. Although thiamine substitution was promptly applied, the patient died at POD53.
    Conclusion: WE is an uncommon and severe neurological disorder with a mortality rate up to 20 % and only 16 % of treated patients can fully recover. This diagnosis should always be anticipated in patients undergoing major surgery such as CRS- HIPEC. Efficient treatment should be quickly introduced in order to avoid a lethal outcome.
    Language English
    Publishing date 2022-08-11
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.107500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Piekdrinken op jonge leeftijd: gevolgen voor neurocognitieve functies en genderverschillen.

    Amrani, L / De Backer, L / Dom, G

    Tijdschrift voor psychiatrie

    2013  Volume 55, Issue 9, Page(s) 677–689

    Abstract: Background: Binge drinking by adolescents and young adults is on the increase and is having serious medical and social consequences. Over the last ten years more and more research has been done into the neurocognitive effects of binge drinking and into ... ...

    Title translation Adolescent binge drinking: neurocognitive consequences and gender differences.
    Abstract Background: Binge drinking by adolescents and young adults is on the increase and is having serious medical and social consequences. Over the last ten years more and more research has been done into the neurocognitive effects of binge drinking and into the possibility that these effects are gender-specific. However, so far, findings have been inconsistent.
    Aim: To collect evidence for the negative impact of binge drinking on the neurocognitive functioning of adolescents and young adults and to find out whether binge drinking has a more serious effect on neurocognition in females than in males.
    Method: We searched the literature using PubMed and Web of Science.
    Results: Nineteen studies satisfied our selection criteria. Eleven studies examined the binge/gender interaction.
    Conclusion: There is considerable evidence that binge drinking does have a negative effect on neurocognition in adolescents and young adults, particularly with regard to executive functioning and memory. Females seem to be more susceptible than males to deficits in spatial working memory and impulse control.
    MeSH term(s) Adolescent ; Age Factors ; Binge Drinking/complications ; Executive Function/drug effects ; Executive Function/physiology ; Female ; Humans ; Male ; Memory Disorders/chemically induced ; Memory Disorders/epidemiology ; Neuropsychological Tests ; Sex Factors ; Young Adult
    Language Dutch
    Publishing date 2013
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 604662-9
    ISSN 0303-7339
    ISSN 0303-7339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Validation of the Moroccan arabic version of the low anterior resection syndrome score.

    Essangri, Hajar / Majbar, Mohammed Anass / Benkabbou, Amine / Amrani, Laila / Mohsine, Raouf / Souadka, Amine

    BMC gastroenterology

    2020  Volume 20, Issue 1, Page(s) 333

    Abstract: Background: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this observational study is to ...

    Abstract Background: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this observational study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research.
    Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach's alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment, while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria.
    Results: The Moroccan Arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, chemoradiotherapy, type of mesorectal excision and anastomosis.
    Conclusion: The Moroccan Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.
    MeSH term(s) Anal Canal ; Humans ; Organ Sparing Treatments ; Postoperative Complications ; Psychometrics ; Quality of Life ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Reproducibility of Results ; Surveys and Questionnaires ; Syndrome
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 1471-230X
    ISSN (online) 1471-230X
    DOI 10.1186/s12876-020-01463-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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