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  1. Article ; Online: Women’s Stories Transforming Understandings of Abortion

    Amy Walsh

    Feminist Encounters: A Journal of Critical Studies in Culture and Politics, Vol 6, Iss 1, Pp - (2022)

    2022  

    Abstract: This paper is a self-reflective account of my experience of receiving a diagnosis of a fatal foetal anomaly in pregnancy in Ireland. It re-tells my story within the context of my memories of abortion in Ireland during the years 1992 to 2015. Placing my ... ...

    Abstract This paper is a self-reflective account of my experience of receiving a diagnosis of a fatal foetal anomaly in pregnancy in Ireland. It re-tells my story within the context of my memories of abortion in Ireland during the years 1992 to 2015. Placing my memories within a specific historical and social frame, this paper outlines how abortion was positioned in Ireland during these periods and reflects on how this positioning of abortion impacted upon my pregnancy. It further analyses the role that story-telling and personal experience played in the campaign to repeal the 8th Amendment and questions how these stories were treated differently from other forms of knowledge and epistemology.
    Keywords abortion ; story-telling ; status-quo ; fatal foetal abnormality ; transformation ; Social Sciences ; H ; Women. Feminism ; HQ1101-2030.7
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Lectito Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Anxiety associated with perceived uncontrollable stress enhances expectations of environmental volatility and impairs reward learning

    Marc Guitart-Masip / Amy Walsh / Peter Dayan / Andreas Olsson

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Unavoidable stress can lead to perceived lack of control and learned helplessness, a risk factor for depression. Avoiding punishment and gaining rewards involve updating the values of actions based on experience. Such updating is however useful ... ...

    Abstract Abstract Unavoidable stress can lead to perceived lack of control and learned helplessness, a risk factor for depression. Avoiding punishment and gaining rewards involve updating the values of actions based on experience. Such updating is however useful only if action values are sufficiently stable, something that a lack of control may impair. We examined whether self-reported stress uncontrollability during the first wave of the COVID-19 pandemic predicted impaired reward-learning. In a preregistered study during the first-wave of the COVID-19 pandemic, we used self-reported measures of depression, anxiety, uncontrollable stress, and COVID-19 risk from 427 online participants to predict performance in a three-armed-bandit probabilistic reward learning task. As hypothesised, uncontrollable stress predicted impaired learning, and a greater proportion of probabilistic errors following negative feedback for correct choices, an effect mediated by state anxiety. A parameter from the best-fitting hidden Markov model that estimates expected beliefs that the identity of the optimal choice will shift across images, mediated effects of state anxiety on probabilistic errors and learning deficits. Our findings show that following uncontrollable stress, anxiety promotes an overly volatile representation of the reward-structure of uncertain environments, impairing reward attainment, which is a potential path to anhedonia in depression.
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Research priorities for children’s cancer

    Nigel J Hall / David Weller / Bob Phillips / Faith Gibson / Susie Aldiss / Rachel Dommett / Jessica Elizabeth Morgan / Alex Brownsdon / Helen Morris / Julia Chisholm / Sonia Malik / Jonathan Gower / Andy Stewart / Dan Saunders / Ashley Ball-Gamble / Helen Hartley / Rachel Hollis / Scott Crowther / Jenni Hatton /
    Louise Henry / Loveday Langton / Kirsty Maddock / Keeley McEvoy / Simon Parke / Sue Picton / Rosa Reed-Berendt / Wendy Tarplee-Morris / Amy Walsh / Anna Watkins

    BMJ Open, Vol 13, Iss

    a James Lind Alliance Priority Setting Partnership in the UK

    2023  Volume 12

    Abstract: Objectives To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.Design James ... ...

    Abstract Objectives To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.Design James Lind Alliance Priority Setting Partnership.Setting UK health service and community.Methods A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.Participants Children and survivors of childhood cancer, diagnosed before age 16, their families, friends and professionals who work with this population.Results Four hundred and eighty-eight people submitted 1299 potential questions. These were refined into 108 unique questions; 4 were already answered and 3 were under active study, therefore, removed. Three hundred and twenty-seven respondents completed the shortlisting survey. Seventy-one children submitted questions in the children’s surveys, eight children attended a workshop to prioritise these questions. The Top 5 questions from children were taken to the final workshop where 23 questions in total were discussed by 25 participants (young adults, carers and professionals). The top priority was ‘can we find effective and kinder (less burdensome, more tolerable, with fewer short and long-term effects) treatments for children with cancer, including relapsed cancer?’Conclusions We have identified research priorities for children’s cancer from the perspectives of children, survivors, their families and the professionals who care for them. Questions reflect the breadth of the cancer experience, including diagnosis, relapse, hospital experience, support during/after treatment and the long-term impact of cancer. These should inform funding of future research as they are the ...
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans.

    Cleo Robinson / Helman Alfonso / Samantha Woo / Amy Walsh / Nola Olsen / Arthur W Musk / Bruce W S Robinson / Anna K Nowak / Richard A Lake

    PLoS ONE, Vol 9, Iss 8, p e

    2014  Volume 103025

    Abstract: Mesothelioma is principally caused by asbestos and may be preventable because there is a long latent period between exposure and disease development. The most at-risk are a relatively well-defined population who were exposed as a consequence of their ... ...

    Abstract Mesothelioma is principally caused by asbestos and may be preventable because there is a long latent period between exposure and disease development. The most at-risk are a relatively well-defined population who were exposed as a consequence of their occupations. Although preventative agents investigated so far have not been promising, discovery of such an agent would have a significant benefit world-wide on healthcare costs and personal suffering. Statins are widely used for management of hypercholesterolemia and cardiovascular risk; they can induce apoptosis in mesothelioma cells and epidemiological data has linked their use to a lower incidence of cancer. We hypothesised that statins would inhibit the development of asbestos-induced mesothelioma in mice and humans. An autochthonous murine model of asbestos-induced mesothelioma was used to test this by providing atorvastatin daily in the feed at 100 mg/kg, 200 mg/kg and 400 mg/kg. Continuous administration of atorvastatin did not alter the rate of disease development nor increase the length of time that mice survived. Latency to first symptoms of disease and disease progression were also unaffected. In a parallel study, the relationship between the use of statins and development of mesothelioma was investigated in asbestos-exposed humans. In a cohort of 1,738 asbestos exposed people living or working at a crocidolite mine site in Wittenoom, Western Australia, individuals who reported use of statins did not have a lower incidence of mesothelioma (HR = 1.01; 95% CI = 0.44-2.29, p = 0.99). Some individuals reported use of both statins and non-steroidal anti-inflammatory drugs or COX-2 inhibitors, and these people also did not have an altered risk of mesothelioma development (HR = 1.01; 95% CI = 0.61-1.67, p = 0.97). We conclude that statins do not moderate the rate of development of mesothelioma in either a mouse model or a human cohort exposed to asbestos.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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