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  1. Article ; Online: Geriatric cutaneous leishmaniasis: a retrospective analysis of 622 cases.

    Doni, Nebiye Yentur / An, İsa

    Postgraduate medical journal

    2024  

    Abstract: Background: Cutaneous leishmaniasis (CL) is most common in childhood because children are exposed to the parasite early and, unlike adults, do not have immunity to CL. Since CL is less common in geriatric patients, clinical and epidemiological data in ... ...

    Abstract Background: Cutaneous leishmaniasis (CL) is most common in childhood because children are exposed to the parasite early and, unlike adults, do not have immunity to CL. Since CL is less common in geriatric patients, clinical and epidemiological data in this age group are limited. This study aims to compare the clinical and demographic characteristics of geriatric patients diagnosed with CL with young patients.
    Methods: In this retrospective study, 622 patients aged 65 and over and 6350 patients aged 19-64, who applied to Şanlıurfa Oriental Boil Diagnosis and Treatment Center between January 2013 and February 2024 and were diagnosed with CL by parasitological examination, were included. Clinical and demographic characteristics of patients diagnosed with CL, such as age, gender, location of the lesion, lesion size, duration of the lesion, and treatments applied due to the diagnosis of CL, were recorded. Clinical and demographic characteristics of geriatric and young patients were compared.
    Results: The mean age of elderly CL cases was 72.95 ± 6.54 years, and 65.2% were female. The most common clinical forms were ulcers (51.9%) and plaques (41%), respectively, in young and elderly patients. The most common locations of the lesions were upper limbs (54.8%) in all patients. The most preferred treatment method was intralesional (IL) meglumine antimoniate (MA) treatment (98.3%) in all patients. There were no difference between young and elderly CL cases in terms of mean number of lesions, average lesion duration, average lesion size, lesion location, clinical forms of lesions, and treatments options (P > 0.05).
    Conclusions: Based on the results of our study, it can be said that the clinical and demographic characteristics of CL are similar in young and old patients and systemic MA treatment shows similar clinical benefit in both age groups. In addition, it can be said that systemic MA therapy can be used safely in young patients and elderly patients without contraindications. IL MA therapy can be used in elderly patients where systemic MA therapy is contraindicated.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1093/postmj/qgae048
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  2. Article ; Online: Cutaneous leishmaniasis of the eyelids: Retrospective evaluation of 18 patients.

    Ozgur, Armagan / An, Isa

    Northern clinics of Istanbul

    2023  Volume 10, Issue 5, Page(s) 651–656

    Abstract: Objective: Although eyelid involvement is rare in cutaneous leishmaniasis (CL), it can cause severe ocular complications if the diagnosis is delayed and not treated. Our purpose in this study is to examine the clinical characteristics, diagnosis, and ... ...

    Abstract Objective: Although eyelid involvement is rare in cutaneous leishmaniasis (CL), it can cause severe ocular complications if the diagnosis is delayed and not treated. Our purpose in this study is to examine the clinical characteristics, diagnosis, and treatment methods as well as accompanying ocular complications in patients with CL diagnosis and eyelid involvement.
    Methods: In this retrospective study, the clinical characteristics, diagnosis, and treatment methods of the disease as well as accompanying ocular complications were examined for 18 patients with CL diagnosis and eyelid involvement between May 2018 and October 2022 in our Dermatology and venereal diseases clinic.
    Results: 10 (55%) of the patients were male and 8 (45%) were female. Unilateral lower eyelid involvement was most common (9 patients [50%]). Chalazion-like lesions (8 patients [45%]) were observed most commonly. All patients were diagnosed with CL by direct microscopic examination and were given systemic meglumine antimonate treatment. No ocular complications were observed in any of the patients.
    Conclusion: It should be kept in mind that eyelid involvement may occur in CL, and ophthalmological examinations of these cases should be performed and treatment should be initiated in the early period to prevent possible ocular complications.
    Language English
    Publishing date 2023-08-25
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3031921-3
    ISSN 2536-4553 ; 2148-4902
    ISSN (online) 2536-4553
    ISSN 2148-4902
    DOI 10.14744/nci.2023.71205
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  3. Article ; Online: Evaluation of choroidal thickness and ocular manifestations in lipoid proteinosis.

    Özgür, Armağan / An, İsa

    International ophthalmology

    2022  Volume 43, Issue 1, Page(s) 239–247

    Abstract: Purpose: To assess choroidal thickness in patients with lipoid proteinosis versus healthy subjects using enhanced depth imaging optical coherence tomography.: Methods: Twenty eyes of 20 patients and the same number of age and sex-matched healthy ... ...

    Abstract Purpose: To assess choroidal thickness in patients with lipoid proteinosis versus healthy subjects using enhanced depth imaging optical coherence tomography.
    Methods: Twenty eyes of 20 patients and the same number of age and sex-matched healthy individuals were enrolled. Comprehensive ocular examinations including measurement of best-corrected visual acuity, spherical equivalent values of refractive errors, and axial length were performed. Choroidal thickness at three points (subfoveal, 500 µm nasal and temporal regions) were measured automatically using MATLAB software.
    Results: The mean age was 15.68 ± 5.98 years in the patient group and 16.48 ± 5.69 years in the control group. Mean choroidal thickness was statistically significantly thicker at each point in patients with lipoid proteinosis compared to the healthy controls: subfoveal, temporal and nasal choroidal thickness measurements were 425.65 ± 51.42, 380.20 ± 69.66, 334.05 ± 49.98 µm in the study group; 346.15 ± 47.76, 330.15 ± 44.35, 298.95 ± 44.21 µm in the control group, respectively (P < 0.05).
    Conclusion: Patients with lipoid proteinosis have thicker choroid compared to control eyes. Hyalin deposition and ensuing potential inflammation in the disease process may explain this finding.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; Visual Acuity ; Choroid ; Refractive Errors ; Tomography, Optical Coherence/methods ; Refraction, Ocular
    Language English
    Publishing date 2022-07-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-022-02422-2
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  4. Article ; Online: Treatment of pediatric cutaneous leishmaniasis with liposomal amphotericin B.

    Erat, Tugba / An, Isa

    Dermatologic therapy

    2022  Volume 35, Issue 9, Page(s) e15706

    Abstract: The use of liposomal amphotericin B (L-AmB) in the treatment of cutaneous leishmaniasis (CL) is increasing. However, few data are available regarding the efficacy and safety of L-AmB in pediatric CL patients. Our aim in this study is to evaluate the ... ...

    Abstract The use of liposomal amphotericin B (L-AmB) in the treatment of cutaneous leishmaniasis (CL) is increasing. However, few data are available regarding the efficacy and safety of L-AmB in pediatric CL patients. Our aim in this study is to evaluate the efficacy and safety of L-AmB in pediatric CL patients. Pediatric patients admitted to a tertiary training and research hospital in a hyperendemic region for CL between January 2019 and May 2021 and receiving L-AmB therapy for CL were included in this retrospective study. L-AmB treatment was administered as 3 mg/kg for 5 consecutive days and on the 10th day, in a total of 6 doses (18 mg/kg total dose). A total of 52 pediatric patients who received L-AmB therapy for CL were included in the study. In the follow-up 3 months after L-AmB treatment, 16 (31%) patients showed complete clinical recovery, while treatment failure was detected in 36 (69%) patients. In conclusion, considering the low treatment success rate in our study, we think that the L-AmB dose used in our study is not an appropriate treatment option for the treatment of pediatric CL patients. However, we think that prospective studies with a large number of patients treated with higher doses of L-AmB and in whom the causative agents of CL were determined are needed.
    MeSH term(s) Amphotericin B/adverse effects ; Antifungal Agents ; Child ; Humans ; Leishmaniasis, Cutaneous/diagnosis ; Leishmaniasis, Cutaneous/drug therapy ; Prospective Studies ; Retrospective Studies
    Chemical Substances Antifungal Agents ; liposomal amphotericin B ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15706
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  5. Article ; Online: A rare complication of varicella: Acute peripheral facial paralysis.

    Erat, Tugba / An, Isa

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 10, Page(s) 5274–5275

    MeSH term(s) Humans ; Chickenpox/complications ; Facial Paralysis/etiology ; Herpesvirus 3, Human
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14937
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  6. Article: Measurement of epicardial fatty tissue thickness has a diagnostic value in lichen planus patients and is associated with fibrinogen to albumin ratio and neutrophil to lymphocyte ratio.

    Tosun, Veysel / Opan, Selcuk / An, Isa

    Bratislavske lekarske listy

    2023  Volume 124, Issue 7, Page(s) 540–544

    Abstract: Objective: Lichen planus (LP) is one of the chronic inflammatory diseases. Epicardial fatty tissue (EFT) is the adipose tissue in which pro-inflammatory and pro-atherogenic hormones and cytokines are secreted. We planned to investigate the predictive ... ...

    Abstract Objective: Lichen planus (LP) is one of the chronic inflammatory diseases. Epicardial fatty tissue (EFT) is the adipose tissue in which pro-inflammatory and pro-atherogenic hormones and cytokines are secreted. We planned to investigate the predictive value of EFT in LP patients by evaluating together with Fibrinogen to albumin ratio (FAR) other inflammation markers.
    Materials and methods: A total of 53 consecutive LP patients and 57 healthy controls were enrolled in this single-center, prospective, case-control study. Demographic data were recorded; blood tests were obtained from both groups. Then, EFT thickness was measured by echocardiography.
    Results: Fibrinogen, FAR, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, and EFT thickness were higher in LP patients (p < 0.05, for all). EFT was positively correlated with FAR (r = 0.306, p = 0.001), NLR (r = 0.240, p = 0.011), and PLR (r = 0.297, p = 0.002). ROC analysis indicated that FAR could predict LP with a sensitivity of 83 % and a specificity of 44 %; NLR could predict LP with a sensitivity of 80 % and a specificity of 46 %; EFT could predict LP with a sensitivity of 79 % and a specificity of 54 %. In the binary logistic regression analysis NLR, FAR, and EFT were found to be independent predictors of LP.
    Conclusion: We found a relationship between LP and FAR together with other inflammation parameters NLR, and PLR. We demonstrated for the first time that FAR, NLR and EFT were independent predictors of LP. Also, there was a significant relationship between these parameters and EFT (Tab. 4, Fig. 1, Ref. 30). Text in PDF www.elis.sk Keywords: lichen planus, epicardial fatty tissue, fibrinogen, albumin, neutrophil, lymphocyte.
    MeSH term(s) Humans ; Neutrophils ; Case-Control Studies ; Fibrinogen ; Prospective Studies ; Lymphocytes ; Inflammation ; Albumins ; Adipose Tissue/diagnostic imaging ; Lichen Planus ; Retrospective Studies
    Chemical Substances Fibrinogen (9001-32-5) ; Albumins
    Language English
    Publishing date 2023-05-22
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 127421-1
    ISSN 0006-9248
    ISSN 0006-9248
    DOI 10.4149/BLL_2023_083
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    Zs.B 355: Show issues Location:
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  7. Article ; Online: Do blood groups play a role in the aetiology of chronic urticaria?

    Ozturk, Murat / An, Isa

    International journal of clinical practice

    2021  Volume 75, Issue 6, Page(s) e13884

    MeSH term(s) Blood Group Antigens ; Causality ; Chronic Disease ; Chronic Urticaria ; Humans ; Urticaria/etiology
    Chemical Substances Blood Group Antigens
    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Letter
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.13884
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  8. Article ; Online: Evaluation of Clinical and Oral Findings in Patients with Epidermolysis bullosa.

    Yavuz, Yasemin / An, Isa / Yazmaci, Betul / Akkus, Zeki / Ortac, Hatice

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 7

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Humans ; Blister/complications ; Prospective Studies ; Dental Caries ; Epidermolysis Bullosa/complications ; Epidermolysis Bullosa/pathology ; Mouth
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59071185
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  9. Article ; Online: Evaluation of inflammatory parameters in lipoid proteinosis patients.

    Aksoy, Mustafa / An, Isa

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14495

    Abstract: Lipoid proteinosis (LP) is a rare metabolic storage disease characterized by the storage of hyaline-like substances in the skin, mucosa, and many other organs. The aim of this study was to compare the neutrophil/lymphocyte ratio (NLR), platelets/ ... ...

    Abstract Lipoid proteinosis (LP) is a rare metabolic storage disease characterized by the storage of hyaline-like substances in the skin, mucosa, and many other organs. The aim of this study was to compare the neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of LP patients with healthy control group and to determine the usefulness of these parameters in determining the inflammatory status in LP patients. This study included 14 patients who were admitted to our clinic between March 2013 and January 2017 and diagnosed as LP with clinical, radiological, and histopathological examinations with 14 individuals who had no systemic inflammatory disease or malignancy and has a hemogram result. There was no statistically significant difference between the two groups in comparison to the MPV and PLR values of the patients with LP and healthy controls (P values 0.666 and 0.654, respectively). When the NLR values of the patients with LP and healthy controls were compared, it was found that the LP-diagnosed NLR values were statistically higher. (P: 0.019). In conclusion, it can be said that NLR is an appropriate parameter in demonstrating inflammation in LP patients, but PLR and MPV are not a suitable parameter in demonstrating inflammation in LP patients. Prospective studies with more patients are needed.
    MeSH term(s) Biomarkers ; Humans ; Lymphocytes ; Mean Platelet Volume ; Neutrophils ; Prospective Studies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14495
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  10. Article ; Online: The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

    An, İsa / Aksoy, Mustafa / Ayhan, Erhan / Ozturk, Murat

    International journal of clinical practice

    2021  Volume 75, Issue 6, Page(s) e14114

    Abstract: Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) ... ...

    Abstract Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV).
    Materials and methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019.
    Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively).
    Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
    MeSH term(s) Antibodies, Monoclonal, Humanized ; Biomarkers ; Humans ; Lymphocytes ; Mean Platelet Volume ; Neutrophils ; Psoriasis/drug therapy ; Retrospective Studies
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2021-02-28
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14114
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