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  1. Article: [Effect of acidic oligosaccharides on P-selectin of pulmonary hypertensive rats induced by monocrotaline].

    Feng, Z / Hu, Y / An, N N / Feng, W J / Hu, T / Mao, Y J

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2018  Volume 41, Issue 2, Page(s) 90–94

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Animals ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/chemically induced ; Male ; Monocrotaline/pharmacology ; Oligosaccharides/pharmacology ; P-Selectin/blood ; P-Selectin/drug effects ; Pulmonary Artery ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Oligosaccharides ; P-Selectin ; Monocrotaline (73077K8HYV)
    Language Chinese
    Publishing date 2018-02-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    DOI 10.3760/cma.j.issn.1001-0939.2018.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Up-regulation of miR-190b promoted growth, invasion, migration and inhibited apoptosis of Wilms' tumor cells by repressing the PTEN expression.

    An, N-N / Shawn, J / Peng, J-P / Wu, M-D / Huang, L-G

    European review for medical and pharmacological sciences

    2018  Volume 22, Issue 4, Page(s) 961–969

    Abstract: Objective: Wilms' tumor (WT) is the most common malignant tumor in the children's urogenital system. MiR-190b was found to participate in the development and progression of several cancers. However, the molecular mechanism of miR-190b in WT is still ... ...

    Abstract Objective: Wilms' tumor (WT) is the most common malignant tumor in the children's urogenital system. MiR-190b was found to participate in the development and progression of several cancers. However, the molecular mechanism of miR-190b in WT is still unclear.
    Patients and methods: We detected the miR-190b in WT tissue samples compared to adjacent normal samples as well as in WT patients' blood sample compared to normal volunteers using qRT-PCR. With over-expression and knockdown of miR-190b in WT-derived cell line SK-NEP-1, we next studied cell proliferation, cell circle, apoptosis, invasion and migration abilities change caused by miR-190b ectopic expression. Dual-luciferase assay and Western-blot analysis were used to explain the mechanism of miR-190b in WT.
    Results: MiR-190b was over-expressed in WT tissue and blood samples compared to normal group, relatively. Up-regulation of miR-190b in SK-NEP-1 cells significantly increased the growth and decreased the apoptosis of cells, while its down-regulation reduced cell proliferation and promoted cell apoptosis of SK-NEP-1. Also, cell invasion and migration abilities were significantly improved after miR-190b over-expression. Moreover, PTEN was proved to be a direct target of miR-190b and its protein level was remarkably decreased after miR-190b up-regulation.
    Conclusions: miR-190b over-expressed in WT and promoted cell proliferation, invasion and migration while reduced cell apoptosis of WT cells by repressing PTEN repression, which might provide a potential target for WT diagnosis and therapy.
    MeSH term(s) Apoptosis/physiology ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Child, Preschool ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Infant ; Infant, Newborn ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Male ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Neoplasm Invasiveness/pathology ; PTEN Phosphohydrolase/antagonists & inhibitors ; PTEN Phosphohydrolase/biosynthesis ; PTEN Phosphohydrolase/genetics ; Up-Regulation/physiology ; Wilms Tumor/genetics ; Wilms Tumor/metabolism ; Wilms Tumor/pathology
    Chemical Substances MIRN190 microRNA, human ; MicroRNAs ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2018-03-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201802_14377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  3. Article: Relative stability of ploidy in a marine Synechococcus across various growth conditions

    Perez‐Sepulveda, Blanca / An N. N'Guyen / Andrew Millard / David J. Scanlan / Frances Pitt / Laurence Garczarek / Morgane Ratin

    Environmental microbiology reports. 2018 Aug., v. 10, no. 4

    2018  

    Abstract: Marine picocyanobacteria of the genus Synechococcus are ubiquitous phototrophs in oceanic systems. Consistent with these organisms occupying vast tracts of the nutrient impoverished ocean, most marine Synechococcus so far studied are monoploid, i.e., ... ...

    Abstract Marine picocyanobacteria of the genus Synechococcus are ubiquitous phototrophs in oceanic systems. Consistent with these organisms occupying vast tracts of the nutrient impoverished ocean, most marine Synechococcus so far studied are monoploid, i.e., contain a single chromosome copy. The exception is the oligoploid strain Synechococcus sp. WH7803, which on average possesses around 4 chromosome copies. Here, we set out to understand the role of resource availability (through nutrient deplete growth) and physical stressors (UV, exposure to low and high temperature) in regulating ploidy level in this strain. Using qPCR to assay ploidy status we demonstrate the relative stability of chromosome copy number in Synechococcus sp. WH7803. Such robustness in maintaining an oligoploid status even under nutrient and physical stress is indicative of a fundamental role, perhaps facilitating recombination of damaged DNA regions as a result of prolonged exposure to oxidative stress, or allowing added flexibility in gene expression via possessing multiple alleles.
    Keywords alleles ; autotrophs ; chromosomes ; DNA ; gene expression ; monoploidy ; oxidative stress ; quantitative polymerase chain reaction ; Synechococcus ; temperature
    Language English
    Dates of publication 2018-08
    Size p. 428-432.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 1758-2229
    DOI 10.1111/1758-2229.12614
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: PRIMENENIE ATROPINOVOGO TESTA DLIA DIAGNOSTIKI ALLERGICHESKIKH ZABOLEVANI I.

    ISHIMOVA, L M / AN, N N

    Sovetskaia meditsina

    1963  Volume 27, Page(s) 62–66

    Title translation USE OF THE ATROPINE TEST IN THE DIAGNOSIS OF ALLERGIC DISEASES.
    MeSH term(s) Asthma ; Atropine ; Coombs Test ; Eczema ; Histamine ; Humans ; Hypersensitivity ; Pruritus ; Rhinitis, Allergic, Seasonal ; Skin Tests ; Urticaria
    Chemical Substances Atropine (7C0697DR9I) ; Histamine (820484N8I3)
    Language Russian
    Publishing date 1963-10
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128565-8
    ISSN 0038-5077
    ISSN 0038-5077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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