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  1. Article ; Online: Heat FLiPs a Hormonal Switch for Longevity.

    Artan, Murat / An, Seon Woo A / Lee, Seung-Jae V

    Developmental cell

    2016  Volume 39, Issue 2, Page(s) 133–134

    Abstract: Temperature-sensing neurons in C. elegans reduce the life-shortening effects of high temperatures via steroid signaling. In this issue of Developmental Cell, Chen et al. (2016) elucidate the underlying mechanisms by which the transcription factor CREB ... ...

    Abstract Temperature-sensing neurons in C. elegans reduce the life-shortening effects of high temperatures via steroid signaling. In this issue of Developmental Cell, Chen et al. (2016) elucidate the underlying mechanisms by which the transcription factor CREB induces the neuropeptide FLP-6 in the temperature-sensing neurons to counteract the life-shortening effects of high temperature.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Hot Temperature ; Longevity ; Transcription Factors
    Chemical Substances Caenorhabditis elegans Proteins ; Transcription Factors
    Language English
    Publishing date 2016--24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2016.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5742: Show issues Location:
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  2. Article ; Online: eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.

    Kim, Eunah / Kim, Joon Hyun / Seo, Keunhee / Hong, Ka Young / An, Seon Woo A / Kwon, Junyoung / Lee, Seung-Jae V / Jang, Sung Key

    Cellular and molecular life sciences : CMLS

    2018  Volume 75, Issue 23, Page(s) 4287–4300

    Abstract: The initiator tRNA (Met- ... ...

    Abstract The initiator tRNA (Met-tRNA
    MeSH term(s) Amino Acid Sequence ; Animals ; Blotting, Western ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factors/genetics ; Eukaryotic Initiation Factors/metabolism ; HEK293 Cells ; Humans ; Mutation ; Protein Binding ; RNA Interference ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism ; Sequence Homology, Amino Acid ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; Eukaryotic Initiation Factor-2 ; Eukaryotic Initiation Factors ; RNA, Transfer, Met ; eukaryotic initiation factor-5B ; eIF-2 Kinase (EC 2.7.11.1)
    Language English
    Publishing date 2018-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-018-2870-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B

    Kim, Eunah / Kim, Joon Hyun / Seo, Keunhee / Hong, Ka Young / An, Seon Woo A / Kwon, Junyoung / Lee, Seung-Jae V / Jang, Sung Key

    Cellular and molecular life sciences. 2018 Dec., v. 75, no. 23

    2018  

    Abstract: The initiator tRNA (Met-tRNA iMet) at the P site of the small ribosomal subunit plays an important role in the recognition of an mRNA start codon. In bacteria, the initiator tRNA carrier, IF2, facilitates the positioning of Met-tRNA iMet on the small ... ...

    Abstract The initiator tRNA (Met-tRNA iMet) at the P site of the small ribosomal subunit plays an important role in the recognition of an mRNA start codon. In bacteria, the initiator tRNA carrier, IF2, facilitates the positioning of Met-tRNA iMet on the small ribosomal subunit. Eukarya contain the Met-tRNA iMet carrier, eIF2 (unrelated to IF2), whose carrier activity is inhibited under stress conditions by the phosphorylation of its α-subunit by stress-activated eIF2α kinases. The stress-resistant initiator tRNA carrier, eIF2A, was recently uncovered and shown to load Met-tRNA iMet on the 40S ribosomal subunit associated with a stress-resistant mRNA under stress conditions. Here, we report that eIF2A interacts and functionally cooperates with eIF5B (a homolog of IF2), and we describe the functional domains of eIF2A that are required for its binding of Met-tRNA iMet , eIF5B, and a stress-resistant mRNA. The results indicate that the eukaryotic eIF5B–eIF2A complex functionally mimics the bacterial IF2 containing ribosome-, GTP-, and initiator tRNA-binding domains in a single polypeptide.
    Keywords bacteria ; guanosine triphosphate ; messenger RNA ; phosphorylation ; phosphotransferases (kinases) ; polypeptides ; protein subunits ; ribosomal proteins ; start codon ; transfer RNA
    Language English
    Dates of publication 2018-12
    Size p. 4287-4300.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-018-2870-4
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  4. Article ; Online: Caenorhabditis elegans Lipin 1 moderates the lifespan-shortening effects of dietary glucose by maintaining ω-6 polyunsaturated fatty acids.

    Jung, Yoonji / Kwon, Sujeong / Ham, Seokjin / Lee, Dongyeop / Park, Hae-Eun H / Yamaoka, Yasuyo / Jeong, Dae-Eun / Artan, Murat / Altintas, Ozlem / Park, Sangsoon / Hwang, Wooseon / Lee, Yujin / Son, Heehwa G / An, Seon Woo A / Kim, Eun Ji E / Seo, Mihwa / Lee, Seung-Jae V

    Aging cell

    2020  Volume 19, Issue 6, Page(s) e13150

    Abstract: Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN-1, a phosphatidic acid phosphatase and a putative transcriptional ... ...

    Abstract Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN-1, a phosphatidic acid phosphatase and a putative transcriptional coregulator, prevents life-shortening effects of dietary glucose on Caenorhabditis elegans. We found that depletion of lpin-1 decreased overall lipid levels, despite increasing the expression of genes that promote fat synthesis and desaturation, and downregulation of lipolysis. We then showed that knockdown of lpin-1 altered the composition of various fatty acids in the opposite direction of dietary glucose. In particular, the levels of two ω-6 polyunsaturated fatty acids (PUFAs), linoleic acid and arachidonic acid, were increased by knockdown of lpin-1 but decreased by glucose feeding. Importantly, these ω-6 PUFAs attenuated the short lifespan of glucose-fed lpin-1-inhibited animals. Thus, the production of ω-6 PUFAs is crucial for protecting animals from living very short under glucose-rich conditions.
    MeSH term(s) Animals ; Caenorhabditis elegans/enzymology ; Caenorhabditis elegans/metabolism ; Diet ; Fatty Acids, Unsaturated/metabolism ; Glucose/metabolism ; Humans ; Phosphatidate Phosphatase/metabolism
    Chemical Substances Fatty Acids, Unsaturated ; LPIN1 protein, human (EC 3.1.3.4) ; Phosphatidate Phosphatase (EC 3.1.3.4) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13150
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    Zs.A 6581: Show issues Location:
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  5. Article ; Online: MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis.

    Lee, Dongyeop / An, Seon Woo A / Jung, Yoonji / Yamaoka, Yasuyo / Ryu, Youngjae / Goh, Grace Ying Shyen / Beigi, Arshia / Yang, Jae-Seong / Jung, Gyoo Yeol / Ma, Dengke K / Ha, Chang Man / Taubert, Stefan / Lee, Youngsook / Lee, Seung-Jae V

    PLoS biology

    2019  Volume 17, Issue 8, Page(s) e3000415

    Abstract: Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans ... ...

    Abstract Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures. We then demonstrate that maintaining a high UFA/SFA ratio is essential for proteostasis at low temperatures. We show that dietary supplementation with a monounsaturated fatty acid, oleic acid (OA), substantially mitigates the short life span and proteotoxicity in mdt-15(-) animals at low temperatures. Thus, lipidostasis regulated by MDT-15 appears to be a limiting factor for proteostasis and longevity at low temperatures. Our findings highlight the crucial roles of lipid regulation in maintaining normal organismal physiology under different environmental conditions.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/metabolism ; Cold Temperature ; Dietary Supplements ; Fatty Acid Desaturases/metabolism ; Homeostasis ; Lipid Metabolism ; Longevity/physiology ; Oleic Acid/administration & dosage ; Proteostasis ; Transcription Factors/metabolism ; Transcriptional Activation
    Chemical Substances ARC105 protein, C elegans ; Caenorhabditis elegans Proteins ; MDT-15 protein, C elegans ; Transcription Factors ; Oleic Acid (2UMI9U37CP) ; Fatty Acid Desaturases (EC 1.14.19.-)
    Language English
    Publishing date 2019-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3000415
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    Zs.A 6193: Show issues Location:
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  6. Article: RNAi targeting

    Park, Sangsoon / Jung, Yoonji / An, Seon Woo A / Son, Heehwa G / Hwang, Wooseon / Lee, Dongyeop / Artan, Murat / Park, Hae-Eun H / Jeong, Dae-Eun / Lee, Yujin / Lee, Seung-Jae V

    F1000Research

    2017  Volume 6, Page(s) 1515

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2017-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.12337.4
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  7. Article ; Online: Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in

    Son, Heehwa G / Seo, Keunhee / Seo, Mihwa / Park, Sangsoon / Ham, Seokjin / An, Seon Woo A / Choi, Eun-Seok / Lee, Yujin / Baek, Haeshim / Kim, Eunju / Ryu, Youngjae / Ha, Chang Man / Hsu, Ao-Lin / Roh, Tae-Young / Jang, Sung Key / Lee, Seung-Jae V

    Genes & development

    2018  Volume 32, Issue 23-24, Page(s) 1562–1575

    Abstract: Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. ... ...

    Abstract Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Forkhead Transcription Factors/metabolism ; Insulin/metabolism ; Insulin-Like Growth Factor I/metabolism ; Intestines/physiology ; Longevity/genetics ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Protein Binding ; Signal Transduction/genetics ; Subcutaneous Tissue/physiology ; Transcription Factors/metabolism ; Transcriptional Activation/genetics
    Chemical Substances Caenorhabditis elegans Proteins ; Forkhead Transcription Factors ; Insulin ; Molecular Chaperones ; Transcription Factors ; daf-16 protein, C elegans ; heat shock factor-1, C elegans ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2018-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.317362.118
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  8. Article ; Online: KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.

    An, Seon Woo A / Choi, Eun-Seok / Hwang, Wooseon / Son, Heehwa G / Yang, Jae-Seong / Seo, Keunhee / Nam, Hyun-Jun / Nguyen, Nhung T H / Kim, Eun Ji E / Suh, Bo Kyoung / Kim, Youngran / Nakano, Shunji / Ryu, Youngjae / Man Ha, Chang / Mori, Ikue / Park, Sang Ki / Yoo, Joo-Yeon / Kim, Sanguk / Lee, Seung-Jae V

    Aging cell

    2019  Volume 18, Issue 3, Page(s) e12906

    Abstract: PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly understood. ... ...

    Abstract PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly understood. Here, we demonstrate that KIN-4, a PDZ domain-containing microtubule-associated serine-threonine (MAST) protein kinase, is a key longevity factor acting through binding PTEN phosphatase in Caenorhabditis elegans. Through a targeted genetic screen for PDZ proteins, we find that kin-4 is required for the long lifespan of daf-2/insulin/IGF-1 receptor mutants. We then show that neurons are crucial tissues for the longevity-promoting role of kin-4. We find that the PDZ domain of KIN-4 binds PTEN, a key factor for the longevity of daf-2 mutants. Moreover, the interaction between KIN-4 and PTEN is essential for the extended lifespan of daf-2 mutants. As many aspects of lifespan regulation in C. elegans are evolutionarily conserved, MAST family kinases may regulate aging and/or age-related diseases in mammals through their interaction with PTEN.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Longevity/genetics ; PDZ Domains/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; PTEN Phosphohydrolase (EC 3.1.3.67)
    Language English
    Publishing date 2019-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12906
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  9. Article ; Online: RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans.

    Son, Heehwa G / Seo, Mihwa / Ham, Seokjin / Hwang, Wooseon / Lee, Dongyeop / An, Seon Woo A / Artan, Murat / Seo, Keunhee / Kaletsky, Rachel / Arey, Rachel N / Ryu, Youngjae / Ha, Chang Man / Kim, Yoon Ki / Murphy, Coleen T / Roh, Tae-Young / Nam, Hong Gil / Lee, Seung-Jae V

    Nature communications

    2017  Volume 8, Page(s) 14749

    Abstract: Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role ... ...

    Abstract Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Gene Expression Profiling ; Insulin/genetics ; Insulin-Like Growth Factor I/genetics ; Longevity/genetics ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mutation ; Nonsense Mediated mRNA Decay ; RNA/genetics ; RNA/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Insulin/genetics
    Chemical Substances Caenorhabditis elegans Proteins ; Insulin ; Luminescent Proteins ; RNA, Messenger ; RNA (63231-63-0) ; Insulin-Like Growth Factor I (67763-96-6) ; DAF-2 protein, C elegans (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
    Language English
    Publishing date 2017-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/ncomms14749
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