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  1. Article ; Online: Complete Genome Assembly and Annotation of Escherichia coli Bacteriophage 55 from Rivière la Quint in Gonaïves, Haiti.

    Schwarz, Joshua C / An, William / Theroux, Austen / Vargas, Luz D / Chan, Benjamin K / Turner, Paul E / Burmeister, Alita R

    Microbiology resource announcements

    2023  Volume 12, Issue 7, Page(s) e0010723

    Abstract: We present the structural and functional annotation of Escherichia coli bacteriophage 55, which has a genome length of 170,393 bp, with 219 predicted genes. ...

    Abstract We present the structural and functional annotation of Escherichia coli bacteriophage 55, which has a genome length of 170,393 bp, with 219 predicted genes.
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00107-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University.

    Würstle, Silvia / Lee, Alina / Kortright, Kaitlyn E / Winzig, Franziska / An, William / Stanley, Gail L / Rajagopalan, Govindarajan / Harris, Zach / Sun, Ying / Hu, Buqu / Blazanin, Michael / Hajfathalian, Maryam / Bollyky, Paul L / Turner, Paul E / Koff, Jonathan L / Chan, Benjamin K

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2657

    Abstract: Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first publication on the clinical applications of phages. At the Center for ... ...

    Abstract Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first publication on the clinical applications of phages. At the Center for Phage Biology & Therapy at Yale University, a preparatory modular approach has been established to offer safe and potent phages for single-patient investigational new drug applications while recognizing the time constraints imposed by infection(s). This study provides a practical walkthrough of the pipeline with an Autographiviridae phage targeting Pseudomonas aeruginosa (phage vB_PaeA_SB, abbreviated to ΦSB). Notably, a thorough phage characterization and the evolutionary selection pressure exerted on bacteria by phages, analogous to antibiotics, are incorporated into the pipeline.
    MeSH term(s) Humans ; Bacteriophages ; Phage Therapy ; Pseudomonas aeruginosa ; Universities ; Pseudomonas Phages/genetics ; Pseudomonas Infections/therapy ; Pseudomonas Infections/microbiology
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52192-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genotype and clinical characteristics of patients with Wolfram syndrome and WFS1-related disorders.

    Lee, Evan M / Verma, Megha / Palaniappan, Nila / Pope, Emiko M / Lee, Sammie / Blacher, Lindsey / Neerumalla, Pooja / An, William / Campbell, Toko / Brown, Cris / Hurst, Stacy / Marshall, Bess / Hershey, Tamara / Nunes, Virginia / López de Heredia, Miguel / Urano, Fumihiko

    Frontiers in genetics

    2023  Volume 14, Page(s) 1198171

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1198171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Genotype and Clinical Characteristics of Patients with Wolfram Syndrome and WFS1-related Disorders.

    Lee, Evan M / Verma, Megha / Palaniappan, Nila / Pope, Emiko M / Lee, Sammie / Blacher, Lindsey / Neerumalla, Pooja / An, William / Campbell, Toko / Brown, Cris / Hurst, Stacy / Marshall, Bess / Hershey, Tamara / Nunes, Virginia / de Heredia, Miguel López / Urano, Fumihiko

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Objective: Wolfram syndrome (WFS) is an autosomal recessive disorder associated with juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. We sought to elucidate the relationship between genotypic and ... ...

    Abstract Objective: Wolfram syndrome (WFS) is an autosomal recessive disorder associated with juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and sensorineural hearing loss. We sought to elucidate the relationship between genotypic and phenotypic presentations of Wolfram syndrome which would assist clinicians in classifying the severity and prognosis of Wolfram syndrome more accurately.
    Approach: Patient data from the Washington University International Registry and Clinical Study for Wolfram Syndrome and patient case reports were analyzed to select for patients with two recessive mutations in the WFS1 gene. Mutations were classified as being either nonsense/frameshift variants or missense/in-frame insertion/deletion variants and statistical analysis was performed using unpaired and paired t-tests and one- and two-way ANOVA with Tukey's or Dunnett's tests.
    Results: A greater number of genotype variants correlated with earlier onset and a more severe presentation of Wolfram syndrome. Secondly, non-sense and frameshift variants had more severe phenotypic presentations than missense variants, as evidenced by optic atrophy emerging significantly earlier in patients with 2 nonsense/frameshift alleles compared with 0 missense transmembrane variants. In addition, the number of transmembrane in-frame variants demonstrated a statistically significant dose-effect on age of onset of diabetes mellitus and optic atrophy.
    Summary / conclusions: The results contribute to our current understanding of the genotype-phenotype relationship of Wolfram syndrome, suggesting that alterations in coding sequences result in significant changes in the presentation and severity of Wolfram. The impact of these findings is significant, as the results will aid clinicians in predicting more accurate prognoses and pave the way for personalized treatments for Wolfram syndrome.
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.15.23284904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assembly and Annotation of Escherichia coli Bacteriophage U115.

    An, William / Emsbo, Camilla / Frey, Emma / Hu, Vicky / Jones, Ashley / Latif, Nipa / Perrilli, Makayla / Reillo, Krystalia / Schwarz, Joshua C / Strasner, Sydney / Theroux, Austin / Vargas, Luz D / Turner, Paul E / Burmeister, Alita R

    Microbiology resource announcements

    2022  Volume 11, Issue 2, Page(s) e0094921

    Abstract: We present the annotated genome sequence of Escherichia coli bacteriophage U115, a T4-like bacteriophage. Phage U115 has a genome length of 166,986 bp and has 286 predicted genes. ...

    Abstract We present the annotated genome sequence of Escherichia coli bacteriophage U115, a T4-like bacteriophage. Phage U115 has a genome length of 166,986 bp and has 286 predicted genes.
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00949-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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