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Article ; Online: Extensive red papules and plaques on the left arm of a middle-aged female.

Gu, An Kang / Zhang, Yu / Wang, Hong Mei

2024

Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llae011
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Zs.A 1278: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Review: Mechanism of herbivores synergistically metabolizing toxic plants through liver and intestinal microbiota.

Tan, Yuchen / An, Kang / Su, Junhu

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2024 Volume 281, Page(s) 109925

Abstract: Interspecific interactions are central to ecological research. Plants produce toxic plant secondary metabolites (PSMs) as a defense mechanism against herbivore overgrazing, prompting their gradual adaptation to toxic substances for tolerance or ... ...

Abstract	Interspecific interactions are central to ecological research. Plants produce toxic plant secondary metabolites (PSMs) as a defense mechanism against herbivore overgrazing, prompting their gradual adaptation to toxic substances for tolerance or detoxification. P450 enzymes in herbivore livers bind to PSMs, whereas UDP-glucuronosyltransferase and glutathione S-transferase increase the hydrophobicity of the bound PSMs for detoxification. Intestinal microorganisms such as Bacteroidetes metabolize cellulase and other macromolecules to break down toxic components. However, detoxification is an overall response of the animal body, necessitating coordination among various organs to detoxify ingested PSMs. PSMs undergo detoxification metabolism through the liver and gut microbiota, evidenced by increased signaling processes of bile acids, inflammatory signaling molecules, and aromatic hydrocarbon receptors. In this context, we offer a succinct overview of how metabolites from the liver and gut microbiota of herbivores contribute to enhancing metabolic PSMs. We focused mainly on elucidating the molecular communication between the liver and gut microbiota involving endocrine, immune, and metabolic processes in detoxification. We have also discussed the potential for future alterations in the gut of herbivores to enhance the metabolic effects of the liver and boost the detoxification and metabolic abilities of PSMs.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2024.109925
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Zs.A 44/C: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Enhanced transverse magneto-optical Kerr effect using ferromagnetic metal perforated with nanopore arrays.

Zhang, Weiwei / Du, Guoqiang / Chen, Hongming / An, Kang

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 14, Page(s) 9796–9799

Abstract: Enhancement of transverse magneto-optical Kerr effects (T-MOKEs) based on surface plasmon resonance has attracted wide attention because of their high sensing performance. Most studies, however, mainly focus on prism-based magnetoplasmonic structures or ... ...

Abstract	Enhancement of transverse magneto-optical Kerr effects (T-MOKEs) based on surface plasmon resonance has attracted wide attention because of their high sensing performance. Most studies, however, mainly focus on prism-based magnetoplasmonic structures or architectures that incorporate a noble metal lattice and ferromagnetic layer, hindering device fabrication, miniaturization, and integration into a microfluidic sensing configuration. Herein, we propose a single Co
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp00460k
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Article: Transcatheter aortic valve replacement in patients with preoperative ascending aortic diameter ≥45 mm.

An, Kang / Zhang, Fengwen / Ouyang, Wenbin / Pan, Xiangbin

Cardiovascular diagnosis and therapy

2023 Volume 13, Issue 6, Page(s) 939–947

Abstract: Background: Current indication for concomitant replacement of ascending aorta (AA) in patients undergoing surgical aortic valve replacement is that AA diameter exceeds 45 mm. However, the impact of AA dilation (≥45 mm) in patients undergoing ... ...

Abstract	Background: Current indication for concomitant replacement of ascending aorta (AA) in patients undergoing surgical aortic valve replacement is that AA diameter exceeds 45 mm. However, the impact of AA dilation (≥45 mm) in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. Methods: We retrospectively evaluated 467 consecutive patients who underwent transfemoral TAVR from January 2016 to April 2021. Cox proportional hazards regression was performed to identify risk factors for all-cause mortality. The primary endpoint was the all-cause mortality, and the secondary endpoints were the occurrence of the aortic dissection and/or rupture. Results: One hundred patients (21.4%) presented preoperative AA ≥45 mm. The median age was 73 years for patients with AA ≥45 mm and 75 years for patients with AA <45 mm (P=0.021). The in-hospital mortality rate was 1.1%. There was no iatrogenic injury to the AA. Only one patient (0.2%) in AA <45 mm group experienced retrograde type B aortic dissection in the descending aorta. The median follow-up was 19 [16-34] months in patients with AA ≥45 mm and 27 [15-37] months in patients with AA <45 mm (P=0.152). No statistical difference was found between the two groups regarding the overall survival (92.5%±3.5% Conclusions: Transfemoral TAVR can be performed safely in patients with preoperative AA ≥45 mm with a low intraprocedural risk. The mid-term survival appears not to be affected by the presence of AA ≥45 mm, and adverse aortic events are rare.
Language	English
Publishing date	2023-12-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-23-324
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Article: Case report: Uncommon presentation of

An, Kang / Wu, Zengxiang / Zhong, Cejun / Li, Shuangqing

Frontiers in medicine

2023 Volume 10, Page(s) 1276360

Abstract: Background: Salmonella: Case presentation: The patient had a history of spinal tuberculosis and poorly controlled diabetes. The abscess was successfully managed by drainage, and a 12-week course of moxifloxacin resulted in complete recovery. : ... ...

Abstract	Background: Salmonella Case presentation: The patient had a history of spinal tuberculosis and poorly controlled diabetes. The abscess was successfully managed by drainage, and a 12-week course of moxifloxacin resulted in complete recovery. Discussion: Increasing the awareness of
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1276360
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Article: Comparison of self- and balloon-expandable valves in patients with dilatated ascending aorta undergoing transcatheter aortic valve replacement.

An, Kang / Zhang, Fengwen / Ouyang, Wenbin / Pan, Xiangbin

Journal of thoracic disease

2023 Volume 15, Issue 9, Page(s) 4826–4835

Abstract: Background: Limited studies have focused on the performance of self-expandable valves (SEVs) and balloon-expandable valves (BEVs) in patients with dilatated ascending aorta (AA) undergoing transcatheter aortic valve replacement (TAVR). The present study ...

Abstract	Background: Limited studies have focused on the performance of self-expandable valves (SEVs) and balloon-expandable valves (BEVs) in patients with dilatated ascending aorta (AA) undergoing transcatheter aortic valve replacement (TAVR). The present study compared the performance of widely used Edwards BEVs and domestic SEVs in patients with dilatated AA among Chinese population. Methods: We identified and reviewed 207 patients who had baseline AA diameter ≥40 mm and underwent transfemoral TAVR. Patients were divided into two groups: SEV and BEV. The SEVs were locally manufactured valves that have received Chinese regulatory approval (Venus-A, Taurus One, and VitaFlow), while the BEVs were Edwards Sapien XT and Sapien3. Procedural device success and post-procedural changes of AA diameters were compared. Results: The sample size of SEV group was larger than that of BEV group because BEVs were not available in China in the early clinical practice. The overall device success was slightly lower in SEV group compared with BEV group (84.2% Conclusions: In patients with dilatated AA who underwent TAVR, the type of THVs did not affect the procedural device success. BAV appeared to be a risk factor for both device failure and higher aortic expansion rate in these patients.
Language	English
Publishing date	2023-08-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-364
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Article: Two plants improve stress response of a subterranean herbivore by downregulating amphetamine addiction pathways.

Zhang, Feiyu / Tan, Yuchen / Cai, Zhiyuan / An, Kang / Liu, Yongjie / Su, Junhu

Frontiers in veterinary science

2024 Volume 10, Page(s) 1342630

Abstract: Introduction: Captivity serves as the primary method for enhancing animal survival and productivity. However, the stress induced by confinement can hinder animal growth and reproduction. The administration of drugs to captive animals can effectively ... ...

Abstract	Introduction: Captivity serves as the primary method for enhancing animal survival and productivity. However, the stress induced by confinement can hinder animal growth and reproduction. The administration of drugs to captive animals can effectively regulate their stress response and can also be used inartificial breeding, reproduction, and experimental animalization of wild species. The plateau zokor ( Methods: In our study, we utilized Results: Our findings demonstrated that RA and AS treatment considerably improved food intake and reduced weight loss, stress-related behavior, and stress hormone levels in plateau zokors. Furthermore, the excitatory pathway of amphetamine addition in the hypothalamus was suppressed by RA and AS treatment, acting through the Discussion: In conclusion, our research demonstrates that RA and AS treatment can effectively alleviate the stress response of plateau zokors in captive environments. The downregulation of the excitation pathway and upregulation of the immune pathway offer valuable insights into the response and potential mechanisms of plant-based drugs in mitigating animal stress.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1342630
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Article ; Online: Histiocytic sarcoma following CAR T-cell therapy: a case report.

An, Kang / He, Yan / Tang, Yanjing / Gu, Xiaoyan / Qian, Juan / Li, Benshang

International journal of hematology

2024 Volume 119, Issue 3, Page(s) 338–341

Abstract: Background: Development of secondary tumor after CART treatment is not well investigated. We report a pediatric B-cell acute lymphoblastic leukemia (B-ALL) patient who developed histiocytic sarcoma shortly after CART therapy.: Case report: A 9-year- ... ...

Abstract	Background: Development of secondary tumor after CART treatment is not well investigated. We report a pediatric B-cell acute lymphoblastic leukemia (B-ALL) patient who developed histiocytic sarcoma shortly after CART therapy. Case report: A 9-year-old boy diagnosed with relapsed B-ALL presenting the KRAS A146T mutation received autologous mouse-derived CD19 and CD22 chimeric antigen receptor T-cell therapy at our center (Chinese Clinical Trial Registry: ChiCTR2000032211). Thirty days post-CART therapy, the bone marrow showed complete remission. At 85 days post-CART therapy, the boy presented with fever and chills. An abdominal CT scan showed massive hepatomegaly with multiple low-density lesions in the liver. At 130 days post-CART therapy, a bone marrow smear showed abnormal proliferation of macrophages, some of which exhibited phagocytosis. On day 136 post-CART therapy, laparoscopic liver biopsy was performed, revealing multiple yellow-white lesions on the surface of the liver. Microscopically, multifocal lesions were observed, predominantly composed of cells with abundant cytoplasm. Immunohistochemical staining indicated histiocytic origin. Based on the immunohistochemical results, histiocytic sarcoma was diagnosed. The same cytogenetic markers were identified in histiocytic sarcoma. Conclusion: Our case illustrates a rare complication after CART therapy. The diagnosis and treatment of histiocytic sarcoma pose many challenges.
MeSH term(s)	Male ; Humans ; Child ; Animals ; Mice ; Immunotherapy, Adoptive/methods ; Histiocytic Sarcoma/etiology ; Histiocytic Sarcoma/therapy ; Antigens, CD19 ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Bone Marrow/pathology
Chemical Substances	Antigens, CD19
Language	English
Publishing date	2024-01-31
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03695-8
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Zs.A 269: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Table Tennis Track Detection Based on Temporal Feature Multiplexing Network.

Li, Wenjie / Liu, Xiangpeng / An, Kang / Qin, Chengjin / Cheng, Yuhua

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: Recording the trajectory of table tennis balls in real-time enables the analysis of the opponent's attacking characteristics and weaknesses. The current analysis of the ball paths mainly relied on human viewing, which lacked certain theoretical data ... ...

Abstract	Recording the trajectory of table tennis balls in real-time enables the analysis of the opponent's attacking characteristics and weaknesses. The current analysis of the ball paths mainly relied on human viewing, which lacked certain theoretical data support. In order to solve the problem of the lack of objective data analysis in the research of table tennis competition, a target detection algorithm-based table tennis trajectory extraction network was proposed to record the trajectory of the table tennis movement in video. The network improved the feature reuse rate in order to achieve a lightweight network and enhance the detection accuracy. The core of the network was the "feature store & return" module, which could store the output of the current network layer and pass the features to the input of the network layer at the next moment to achieve efficient reuse of the features. In this module, the Transformer model was used to secondarily process the features, build the global association information, and enhance the feature richness of the feature map. According to the designed experiments, the detection accuracy of the network was 96.8% for table tennis and 89.1% for target localization. Moreover, the parameter size of the model was only 7.68 MB, and the detection frame rate could reach 634.19 FPS using the hardware for the tests. In summary, the network designed in this paper has the characteristics of both lightweight and high precision in table tennis detection, and the performance of the proposed model significantly outperforms that of the existing models.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031726
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Article ; Online: User Pairing for Delay-Limited NOMA-Based Satellite Networks with Deep Reinforcement Learning.

Zhang, Qianfeng / An, Kang / Yan, Xiaojuan / Xi, Hongxia / Wang, Yuli

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 16

Abstract: In this paper, we investigate a user pairing problem in power domain non-orthogonal multiple access (NOMA) scheme-aided satellite networks. In the considered scenario, different satellite applications are assumed with various delay quality-of-service ( ... ...

Abstract	In this paper, we investigate a user pairing problem in power domain non-orthogonal multiple access (NOMA) scheme-aided satellite networks. In the considered scenario, different satellite applications are assumed with various delay quality-of-service (QoS) requirements, and the concept of effective capacity is employed to characterize the effect of delay QoS limitations on achieved performance. Based on this, our objective was to select users to form a NOMA user pair and utilize resource efficiently. To this end, a power allocation coefficient was firstly obtained by ensuring that the achieved capacity of users with sensitive delay QoS requirements was not less than that achieved with an orthogonal multiple access (OMA) scheme. Then, considering that user selection in a delay-limited NOMA-based satellite network is intractable and non-convex, a deep reinforcement learning (DRL) algorithm was employed for dynamic user selection. Specifically, channel conditions and delay QoS requirements of users were carefully selected as state, and a DRL algorithm was used to search for the optimal user who could achieve the maximum performance with the power allocation factor, to pair with the delay QoS-sensitive user to form a NOMA user pair for each state. Simulation results are provided to demonstrate that the proposed DRL-based user selection scheme can output the optimal action in each time slot and, thus, provide superior performance than that achieved with a random selection strategy and OMA scheme.
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23167062
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