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  1. Article ; Online: Are the invasive grasses Cynodon dactylon and Eragrostis plana more phytotoxic than a co-occurring native?

    Anaclara Guido / Amparo Quiñones / Ana L. Pereira / Eliane R. Da Silva

    Ecología Austral, Vol 30, Iss

    2020  Volume 2

    Abstract: Allelopathy, the release of phytotoxins by plants, may be a key mechanism by which an invasive species displaces residents. However, methodological procedures are still questioned in the literature. We evaluated the phytotoxic effects of Cynodon dactylon ...

    Abstract Allelopathy, the release of phytotoxins by plants, may be a key mechanism by which an invasive species displaces residents. However, methodological procedures are still questioned in the literature. We evaluated the phytotoxic effects of Cynodon dactylon and Eragrostis plana, the most invasive grasses of the Río de la Plata grasslands. Although allelopathy has been claimed as one of the possible mechanisms involved in the establishment and impact of these species, no empirical evidence has convincingly supported it. We performed a germination experiment to assess the effect of both invasive species on Eragrostis bahiensis, a native grass from the region. We used aqueous extracts from fresh and dry leaves of three donor species: two invasive (C. dactylon and E. plana) and one co-occurring native from the introduced range (Coelorachis selloana). This approach allows to relativize the invasive species effect from resident species, according to the novel weapon hypothesis. As a result, only aqueous extracts from dried leaves inhibited the germination and early growth of E. bahiensis. The magnitude of these effects varied between donor species, but there was no consensus to conclude both invasive species had greater effects. Cynodon dactylon caused the strongest inhibitory effect on E. bahiensis. However, the native C. selloana also presented a potent inhibitory effect, stronger than the well-known invasive E. plana. Thus, the role of allelopathy on E. plana invasion in the Río de la Plata grasslands should be questioned. Finally, we addressed some suggestions for improving experimental design for testing the novelty of phytotoxic effects in the introduced range.
    Keywords bermudagrass ; capim Annoni ; invasion ; lovegrass ; phytotoxins ; Río de la Plata grasslands ; Environmental sciences ; GE1-350 ; Ecology ; QH540-549.5
    Subject code 580
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Asociación Argentina de Ecología
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma

    Lesly J. Bueno-Urquiza / Marcela G. Martínez-Barajas / Carlos E. Villegas-Mercado / Jonathan R. García-Bernal / Ana L. Pereira-Suárez / Maribel Aguilar-Medina / Mercedes Bermúdez

    Cells, Vol 12, Iss 727, p

    2023  Volume 727

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of HNSCC patients. Long non-coding RNAs (lncRNAs) are molecular regulators composed of 200 to 100,000 nucleotides that act on the modulation of genes that activate signaling pathways associated with oncogenic processes such as proliferation, migration, invasion, and metastasis in tumor cells. However, up until now, few studies have discussed the participation of lncRNAs in modeling the tumor microenvironment (TME) to generate a protumor or antitumor environment. Nevertheless, some immune-related lncRNAs have clinical relevance, since AL139158.2, AL031985.3, AC104794.2, AC099343.3, AL357519.1, SBDSP1, AS1AC108010.1, and TM4SF19-AS1 have been associated with overall survival (OS). MANCR is also related to poor OS and disease-specific survival. MiR31HG, TM4SF19-AS1, and LINC01123 are associated with poor prognosis. Meanwhile, LINC02195 and TRG-AS1 overexpression is associated with favorable prognosis. Moreover, ANRIL lncRNA induces resistance to cisplatin by inhibiting apoptosis. A superior understanding of the molecular mechanisms of lncRNAs that modify the characteristics of TME could contribute to increasing the efficacy of immunotherapy.
    Keywords HNSCC ; tumor microenvironment ; LncRNAs ; cancer-associated fibroblasts ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Genomic and Phenotypic Characterization of Campylobacter fetus subsp. venerealis Strains

    Marta F. Silva / Ana L. Pereira / Maria J. Fraqueza / Gonçalo Pereira / Luísa Mateus / Luís Lopes-da-Costa / Elisabete Silva

    Microorganisms, Vol 9, Iss 2, p

    2021  Volume 340

    Abstract: The pathogenesis mechanisms of Campylobacter fetus subsp. venerealis ( Cfv ), the etiologic agent of Bovine Genital Campylobacteriosis remain elusive. This study evaluated the virulence potential and biovar characteristics of Cfv isolates ( n = 13) by ... ...

    Abstract The pathogenesis mechanisms of Campylobacter fetus subsp. venerealis ( Cfv ), the etiologic agent of Bovine Genital Campylobacteriosis remain elusive. This study evaluated the virulence potential and biovar characteristics of Cfv isolates ( n = 13) by PCR screening of putative virulence-factor (VF) genes, Multilocus Sequence Typing (MLST) analysis, antimicrobial susceptibility to tetracycline, penicillin, enrofloxacin and streptomycin testing and whole-genome sequencing (WGS; n = 5), also comparing the latter with 26 other whole-genome sequences of Cfv strains. The putative VF genes encoding type IV secretion system of Cfv ( virB2 - virB11 / virD4 ) were absent in 92% of isolates, including isolates from aborted foetuses, evidencing that these VF genes are not essential for Cfv pathogenicity. The parA gene, used as a Cfv diagnostic molecular target, was detected in only 3 of 13 isolates, invalidating its use for diagnosis purposes. Three novel sequence types were identified by MLST. Although no in vitro antimicrobial resistance was detected, WGS identified antimicrobial resistance-related genes, including those encoding the multidrug efflux pumps CmeABC and YkkCD, indicating that their presence is not enough to provide antimicrobial resistance. The SNP and accessory protein families analysis segregated the Cfv and Cfv biovar intermedius ( Cfvi ) strains into different clusters. In conclusion, this study evidenced virulence potential and biovar characteristics of Cfv and Cfvi , which are of relevance for the control of Bovine Genital Campylobacteriosis.
    Keywords Campylobacter fetus subsp. venerealis ; biovar intermedius ; multilocus sequencing typing ; virulence potential ; antimicrobial susceptibility ; genomic characterization ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Liver fibrosis in bile duct-ligated rats correlates with increased hepatic IL-17 and TGF-β2 expression

    Adelaida Sara M. Zepeda-Morales / Susana Del Toro-Arreola / Leonel García-Benavides / Blanca E. Bastidas-Ramírez / Mary Fafutis-Morris / Ana L. Pereira-Suárez / Miriam R. Bueno-Topete

    Annals of Hepatology, Vol 15, Iss 3, Pp 418-

    2016  Volume 426

    Abstract: Background and rationale for the study. IL-17, TGF-β1/2 are cytokines involved in the development of kidney, pulmonary and liver fibrosis. However, their expression kinetics in the pathogenesis of cholestatic liver fibrosis have not yet been fully ... ...

    Abstract Background and rationale for the study. IL-17, TGF-β1/2 are cytokines involved in the development of kidney, pulmonary and liver fibrosis. However, their expression kinetics in the pathogenesis of cholestatic liver fibrosis have not yet been fully explored. The aim of the study was to analyze the expression of IL-17, RORγt, NKp46, TGF-β1, and TGF-β2 in the liver of rats with bile duct ligation (BDL).Results. Hepatic IL-17A gene expression analyzed by qRT-PCR showed a dramatic increase of 350 and 10 fold, at 8 and 30 days post BDL, respectively. TGFβ1 and TGFβ2 gene expression significantly increased throughout the whole fibrotic process. At the protein level in liver homogenates, IL-17, TGF-β1, and RORγt significantly increased at 8 and 30 days after BDL. Interestingly, a significant increase in the protein levels of TGF-β2 and decrease of NKp46 was observed only 30 days after BDL. Unexpectedly, TGF-β2 exhibited stronger signals than TGF-β1 at the gene expression and protein levels. Histological analysis showed bile duct proliferation and collagen deposition.Conclusions. Our results suggest that pro-fibrogenic cytokines IL-17, TGF-β1 and, strikingly, TGF-β2 might be important players of liver damage in the pathogenesis of early and advanced experimental cholestatic fibrosis. Th17 cells might represent an important source of IL-17, while NK cell depletion may account for the perpetuation of liver damage in the BDL model.
    Keywords ROR γ ; TGF-β ; NK cells bile duct ligation ; Specialties of internal medicine ; RC581-951
    Subject code 500
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Association of extrapituitary prolactin promoter polymorphism with disease susceptibility and anti-RNP antibodies in Mexican patients with systemic lupus erythematosus

    Jorge Hernández-Bello / Claudia A. Palafox-Sanchez / Samuel García-Arellano / Zyanya Reyes-Castillo / Ana L. Pereira-Suárez / Isela Parra-Rojas / José E. Navarro-Zarza / Ulises De la cruz-Mosso / Nora M. Torres-Carrillo / José Francisco Muñoz-Valle

    Archives of Medical Science, Vol 14, Iss 5, Pp 1025-

    2016  Volume 1032

    Abstract: Introduction : Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary and extrapituitary tissues such as immune cells due to its expression being regulated by two independent promoter regions. The promoter which is ... ...

    Abstract Introduction : Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary and extrapituitary tissues such as immune cells due to its expression being regulated by two independent promoter regions. The promoter which is responsible for extrapituitary expression contains the single nucleotide polymorphism (SNP) –1149 G/T previously associated with autoimmune diseases in various populations. This study evaluates the relationship of PRL –1149 G/T polymorphism with PRL serum levels and clinical characteristics in systemic lupus erythematosus (SLE) patients from western Mexico. Material and methods: One hundred and sixty-three SLE patients classified according to the 1982 American College of Rheumatology (ACR) SLE classification criteria and 326 unrelated control subjects (CS), both from western Mexico, were included. The PRL –1149 G/T polymorphism was genotyped using the polymorphism was performed by the polymerase chain reaction restriction fragment length polymorphism technique, and both PRL serum levels and autoantibodies were measured by enzyme-linked immunosorbent assay (ELISA). Results : We found an association between the PRL –1149 TT genotype and SLE according to the recessive genetic model (OR = 2.26, 95% CI: 1.01–5.08, p = 0.04). The TT genotype was associated with anti-RNP antibodies (p = 0.04) and with higher scores of the Mex-SLEDAI (p = 0.02). Moreover, SLE patients showed elevated PRL serum levels (12.4 ng/ml; p < 0.01), and this condition was associated with renal activity and the presence of anti-RNP antibodies. Conclusions : PRL –1149 TT genotype is associated with susceptibility to SLE in a Mexican-Mestizo population, and high PRL serum levels are associated with anti-RNP antibodies and renal activity.
    Keywords systemic lupus erythematosus ; prolactin ; genetic polymorphism ; autoimmunity ; anti-RNP antibodies ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

    Ksenija Drabek / Laura Gutiérrez / Marcel Vermeij / Thomas Clapes / Sunita R. Patel / Jean-Charles Boisset / Jeffrey van Haren / Ana L. Pereira / Zhe Liu / Umut Akinci / Tatjana Nikolic / Wilfred van IJcken / Mirjam van den Hout / Marjolein Meinders / Clara Melo / Clara Sambade / Dubravka Drabek / Rudi W. Hendriks / Sjaak Philipsen /
    Mieke Mommaas / Frank Grosveld / Helder Maiato / Joseph E. Italiano, Jr. / Catherine Robin / Niels Galjart

    Cell Reports, Vol 2, Iss 4, Pp 781-

    2012  Volume 788

    Abstract: Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells. We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, ... ...

    Abstract Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells. We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, progressive anemia, and pancytopenia, due to defects in megakaryopoiesis, in erythropoiesis, and in the maintenance of hematopoietic stem cell activity. Furthermore, microtubule stability and organization are affected upon attachment of Clasp2 knockout hematopoietic stem-cell-enriched populations, and these cells do not home efficiently toward their bone marrow niche. Strikingly, CLASP2-deficient hematopoietic stem cells contain severely reduced mRNA levels of c-Mpl, which encodes the thrombopoietin receptor, an essential factor for megakaryopoiesis and hematopoietic stem cell maintenance. Our data suggest that thrombopoietin signaling is impaired in Clasp2 knockout mice. We propose that the CLASP2-mediated stabilization of microtubules is required for proper attachment, homing, and maintenance of hematopoietic stem cells and that this is necessary to sustain c-Mpl transcription.
    Keywords Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2012-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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