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  1. Article ; Online: NOTCH signalling – a core regulator of bile duct disease?

    Anabel Martinez Lyons / Luke Boulter

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 9

    Keywords bile duct ; cancer ; liver ; notch ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The developmental origins of Notch-driven intrahepatic bile duct disorders

    Anabel Martinez Lyons / Luke Boulter

    Disease Models & Mechanisms, Vol 14, Iss

    2021  Volume 9

    Abstract: The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of ...

    Abstract The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of Notch signaling results in failure to form bile ducts, a complex tubular network that radiates throughout the liver, which, in healthy individuals, transports bile from the liver into the bowel. Loss of a functional biliary network through congenital malformations during development results in cholestasis and necessitates liver transplantation. Here, we examine to what extent Notch signaling is necessary throughout embryonic life to initiate the proliferation and specification of biliary cells and concentrate on the animal and human models that have been used to define how perturbations in this signaling pathway result in developmental liver disorders.
    Keywords bile duct ; cholangiocyte ; liver ; notch ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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