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  1. AU="Anagnostopoulos, Athanasios K"
  2. AU="Brody, Abraham A"
  3. AU="Hongyun Han"
  4. AU="Yoo Rha Hong"
  5. AU="Mokadam, Nahush A"
  6. AU="Khedis, Mehdi"
  7. AU="Radford, R L"
  8. AU="Kulkarni, Anand V"

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  1. Article ; Online: RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of

    Kattan, Fedon-Giasin / Koukouraki, Pelagia / Anagnostopoulos, Athanasios K / Tsangaris, George T / Doxakis, Epaminondas

    Open biology

    2023  Volume 13, Issue 11, Page(s) 230158

    Abstract: Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression. Currently, most of our ... ...

    Abstract Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression. Currently, most of our understanding of SNCA regulation is protein-based. Post-transcriptional mechanisms directly regulating
    MeSH term(s) Mice ; Animals ; 3' Untranslated Regions ; Active Transport, Cell Nucleus ; Heterogeneous Nuclear Ribonucleoprotein D0/genetics ; Heterogeneous Nuclear Ribonucleoprotein D0/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Protein Binding
    Chemical Substances 3' Untranslated Regions ; Heterogeneous Nuclear Ribonucleoprotein D0 ; RNA, Messenger ; RNA-Binding Proteins
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.230158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Feta cheese proteins: Manifesting the identity of Greece׳s National Treasure.

    Anagnostopoulos, Athanasios K / Tsangaris, George Th

    Data in brief

    2018  Volume 19, Page(s) 2037–2040

    Abstract: Over the last years, there has been tremendous debate regarding the identity of feta cheese and under which terms such food with historical ties to ancient Greece can be discriminated among others, based on its unique traits and characteristics. This ... ...

    Abstract Over the last years, there has been tremendous debate regarding the identity of feta cheese and under which terms such food with historical ties to ancient Greece can be discriminated among others, based on its unique traits and characteristics. This analysis sets the foundation towards a much anticipated control procedure, by deciphering for the first time the core elements of this food; its proteins. In this initial report, we amassed representative feta cheese samples/types from parts of Greece entitled to produce this "protected designation of origin" (p.d.o) cheese type and analyzed in full their protein content by employing exhaustive deep-proteome analyses. Several groups of proteins were identified, implicated in diverse functions as well as proteins under multiple abundances, while the final feta cheese protein list was set to include solely core-proteins identified in every analyzed sample. Through this data article we report, for the first time, the complete protein content of feta cheese, consisting of 489 proteins, thus setting the foundation towards developing a method for identification of the original Greek product.
    Language English
    Publishing date 2018-06-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2018.06.084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Proteomics of pediatric ependymomas: a review.

    Tsangaris, George Th / Anastasoviti, Maria C / Anagnostopoulos, Athanasios K

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2020  Volume 37, Issue 3, Page(s) 767–770

    Abstract: Ependymomas, affecting both children and adults, are neuroepithelial tumors occurring throughout all compartments of the central nervous system. Pediatric ependymomas arise almost exclusively intracranially and are associated with a poor 10-year overall ... ...

    Abstract Ependymomas, affecting both children and adults, are neuroepithelial tumors occurring throughout all compartments of the central nervous system. Pediatric ependymomas arise almost exclusively intracranially and are associated with a poor 10-year overall survival of around 60%. During the last years, the application of multi-omics technologies on the study and understanding of neuro-cancer diseases has become a standard; in this regard, application of these approaches on ependymomas has gained noticeable momentum. The objective of this review article was to summarize all knowledge generated by the application of modern omics approaches with regard to pediatric ependymal tumors, aiming at elucidating molecular mechanisms of oncogenesis as well as identification of pathway strategies that will help in therapeutic intervention.
    MeSH term(s) Adult ; Child ; Ependymoma/genetics ; Humans ; Proteomics
    Language English
    Publishing date 2020-05-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-020-04627-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2036: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Proteomic data of donkey's milk.

    Proikakis, Stavros C / Bouroutzika, Efterpi V / Anagnostopoulos, Athanasios K / Tsangaris, George Th

    Data in brief

    2021  Volume 39, Page(s) 107507

    Abstract: Donkey's milk has been recognized as milk of high biological value and it also has the closest composition to human milk. However, the total protein content of donkey's milk has not been adequately identified. The aim of this analysis is to investigate ... ...

    Abstract Donkey's milk has been recognized as milk of high biological value and it also has the closest composition to human milk. However, the total protein content of donkey's milk has not been adequately identified. The aim of this analysis is to investigate the proteomic content of that milk. Specific commercially available only milk was analyzed by ``shotgun'' proteomic methods to identify the proteins it contained in as much detail as possible. The application of the above approach resulted in the identification of a total of 633 different proteins, which were grouped based on their molecular function and their biological process. Furthermore, the proteins visualized graphically according to the GeneOntology (GO) system. The identified proteins confirm the high nutritional value of the donkey milk, governing future steps in optimizing its characteristic and uses.
    Language English
    Publishing date 2021-10-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2021.107507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Pediatric Ependymoma Protein Database (PEPD).

    Tsangaris, George Th / Anagnostopoulos, Athanasios K

    Data in brief

    2017  Volume 15, Page(s) 638–641

    Abstract: Proteomics, through application of modern high-end mass spectrometric (MS) approaches, offers the advantage of in-depth analysis of cancer tissues regarding their protein composition. Pediatric brain tumor malignancies are scarcely approached by modern ... ...

    Abstract Proteomics, through application of modern high-end mass spectrometric (MS) approaches, offers the advantage of in-depth analysis of cancer tissues regarding their protein composition. Pediatric brain tumor malignancies are scarcely approached by modern holistic technologies (e.g. genomics, proteomics) due to rarity of samples and most importantly difficulty in their collection. Ependymoma, is the third most common tumor in children and is thought to arise from ependymal cells in the wall of the cerebral ventricles or the spinal canal. Due to the heterogeneity of the disease its biological characteristics remain largely unknown and prognostic factors are basically based on clinical and histological criteria. Through application of a modified nanoLC-MS/MS analysis experimental approach we achieved, for the first time, the in-depth examination of the pediatric ependymoma tissue proteome. In the present article we report on the construction of a high-confidence database; the Pediatric Ependymoma Protein Database (PEPD), including 4,157 protein groups originating from the identification and analysis of more than 15,000 peptides. The PEPD offers a first step towards targeted protein validation of the protein content of this specific devastating disease affecting the young population.
    Language English
    Publishing date 2017-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2017.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Egg White and Yolk Protein Atlas: New Protein Insights of a Global Landmark Food.

    Sarantidi, Eleana / Ainatzoglou, Alexandra / Papadimitriou, Christine / Stamoula, Eleni / Maghiorou, Katerina / Miflidi, Argyro / Trichopoulou, Antonia / Mountzouris, Konstantinos C / Anagnostopoulos, Athanasios K

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: 1) Background: The chicken egg is an animal product of great agronomic interest. The egg white and yolk constitute high-quality protein sources for humans with high digestibility and well-balanced amino acid profiles. Despite the egg white and yolk ... ...

    Abstract (1) Background: The chicken egg is an animal product of great agronomic interest. The egg white and yolk constitute high-quality protein sources for humans with high digestibility and well-balanced amino acid profiles. Despite the egg white and yolk protein's undisputed value, research to unravel their full proteome content and its properties is still ongoing. We aimed to exhaustively analyze the proteome of egg white and yolk by applying intrinsic proteomics and bioinformatics approaches in order to unravel the full protein potential of this landmark food. (2) Methods: A total of 45 freshly laid, unfertilized, chicken eggs were subjected to nanoLC-MS/MS Orbitrap analysis following a peptide pre-fractionation step. A comprehensive bioinformatics processing step was undertaken towards elucidating potential activities and roles of identified molecules. In parallel, the literature was mined concerning all reported egg white and yolk protein identifications. (3) Results: Our analysis revealed 371 and 428 new proteins, reported for the first time to be present in the egg white and yolk, respectively. From the bioactivity standpoint, egg white and yolk proteins showed high enrichment for antioxidant and anti-inflammatory processes, while exerting high relevance for the apoptosis and focal adhesion pathways. (4) Conclusions: Egg white and yolk proteins exert diverse and multifaceted properties. A total of 799 proteins were reported for the first time as being part of the egg and yolk. Our novel protein data enriched those already published in the literature and the first ever chicken egg white and yolk Protein Atlas, comprising 1392 protein entries, was generated. This dataset will provide a cornerstone reference for future studies involving egg proteins.
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12183470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Proteomic data of donkey's milk

    Proikakis, Stavros C. / Bouroutzika, Efterpi V. / Anagnostopoulos, Athanasios K. / Tsangaris, George Th

    Data in Brief. 2021 Dec., v. 39

    2021  

    Abstract: Donkey's milk has been recognized as milk of high biological value and it also has the closest composition to human milk. However, the total protein content of donkey's milk has not been adequately identified. The aim of this analysis is to investigate ... ...

    Abstract Donkey's milk has been recognized as milk of high biological value and it also has the closest composition to human milk. However, the total protein content of donkey's milk has not been adequately identified. The aim of this analysis is to investigate the proteomic content of that milk. Specific commercially available only milk was analyzed by ``shotgun'' proteomic methods to identify the proteins it contained in as much detail as possible. The application of the above approach resulted in the identification of a total of 633 different proteins, which were grouped based on their molecular function and their biological process. Furthermore, the proteins visualized graphically according to the GeneOntology (GO) system. The identified proteins confirm the high nutritional value of the donkey milk, governing future steps in optimizing its characteristic and uses.
    Keywords ass milk ; breast milk ; milk ; nutritive value ; protein content ; proteomics
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2021.107507
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation.

    Vavilis, Theofanis / Petre, Maria Louiza / Vatsellas, Giannis / Ainatzoglou, Alexandra / Stamoula, Eleni / Sachinidis, Athanasios / Lamprinou, Malamatenia / Dardalas, Ioannis / Vamvakaris, Ioannis N / Gkiozos, Ioannis / Syrigos, Konstantinos N / Anagnostopoulos, Athanasios K

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background: Lung cancer is associated with a high incidence of mortality worldwide. Molecular mechanisms governing the disease have been explored by genomic studies; however, several aspects remain elusive. The integration of genomic profiling with in- ... ...

    Abstract Background: Lung cancer is associated with a high incidence of mortality worldwide. Molecular mechanisms governing the disease have been explored by genomic studies; however, several aspects remain elusive. The integration of genomic profiling with in-depth proteomic profiling has introduced a new dimension to lung cancer research, termed proteogenomics. The aim of this review article was to investigate proteogenomic approaches in lung cancer, focusing on how elucidation of proteogenomic features can evoke tangible clinical outcomes.
    Methods: A strict methodological approach was adopted for study selection and key article features included molecular attributes, tumor biomarkers, and major hallmarks involved in oncogenesis.
    Results: As a consensus, in all studies it becomes evident that proteogenomics is anticipated to fill significant knowledge gaps and assist in the discovery of novel treatment options. Genomic profiling unravels patient driver mutations, and exploration of downstream effects uncovers great variability in transcript and protein correlation. Also, emphasis is placed on defining proteogenomic traits of tumors of major histological classes, generating a diverse portrait of predictive markers and druggable targets.
    Conclusions: An up-to-date synthesis of landmark lung cancer proteogenomic studies is herein provided, underpinning the importance of proteogenomics in the landscape of personalized medicine for combating lung cancer.
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: On the Evidence Supporting That AN11127 Encodes an Aspergillus Nidulans Sec12 Orthologous Protein. Reply to Bravo-Plaza et al. Comment on "Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in

    Dimou, Sofia / Georgiou, Xenia / Sarantidi, Eleana / Diallinas, George / Anagnostopoulos, Athanasios K

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 12

    Abstract: Prof. Peñalva and co-workers provided evidence that AN11127 is related by sequence and function to Sec12 [ ... ]. ...

    Abstract Prof. Peñalva and co-workers provided evidence that AN11127 is related by sequence and function to Sec12 [...].
    Language English
    Publishing date 2021-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7121040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in

    Dimou, Sofia / Georgiou, Xenia / Sarantidi, Eleana / Diallinas, George / Anagnostopoulos, Athanasios K

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 7

    Abstract: Solute and ion transporters are proteins essential for cell nutrition, detoxification, signaling, homeostasis and drug resistance. Being polytopic transmembrane proteins, they are co-translationally inserted and folded into the endoplasmic reticulum (ER) ...

    Abstract Solute and ion transporters are proteins essential for cell nutrition, detoxification, signaling, homeostasis and drug resistance. Being polytopic transmembrane proteins, they are co-translationally inserted and folded into the endoplasmic reticulum (ER) of eukaryotic cells and subsequently sorted to their final membrane destination via vesicular secretion. During their trafficking and in response to physiological/stress signals or prolonged activity, transporters undergo multiple quality control processes and regulated turnover. Consequently, transporters interact dynamically and transiently with multiple proteins. To further dissect the trafficking and turnover mechanisms underlying transporter subcellular biology, we herein describe a novel mass spectrometry-based proteomic protocol adapted to conditions allowing for maximal identification of proteins related to N source uptake in
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7070560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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