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  1. Article: Leptin levels in childhood tuberculosis and its correlation with body mass index, IFN-γ, and TNF-α in an Indonesian population.

    Anam, Moh Syarofil / Mexitalia, Maria / Panunggal, Binar / Sidhartani, Magdalena / Rachmawati, Banundari / Subagio, Hertanto Wahyu

    The Indian journal of tuberculosis

    2023  Volume 71, Issue 1, Page(s) 35–40

    Abstract: Background: Leptin plays a key role in the regulation of energy and inflammation in tuberculosis (TB). However, its correlation in children with TB remains unclear. Therefore, this study aimed to evaluate the correlations between body mass index, IFN-γ, ...

    Abstract Background: Leptin plays a key role in the regulation of energy and inflammation in tuberculosis (TB). However, its correlation in children with TB remains unclear. Therefore, this study aimed to evaluate the correlations between body mass index, IFN-γ, TNF-α, and leptin levels in children with TB.
    Methods: This was a cross-sectional study of children aged 2-14 years with TB. Sputum examination, chest radiography, and tuberculin skin test findings and clinical symptoms were considered for TB diagnosis. Data on body weight; height; mid-upper arm circumference (MUAC); body mass index (BMI); food intake; and IFN-γ, TNF-α, and leptin levels were collected and analyzed.
    Results: Of the 64 diagnosed TB subjects, 2 subjects had positive bacteriological results. The median age was 6 (2-14) years, body weight was 17.7 (9.45-55) kg, height was 114 ± 21.46 cm, and Z score BMI was -0.85 ± 1.14 kg/m
    Conclusion: There were positive correlations between BMI and leptin levels, whereas IFN-γ and MUAC showed weak correlations.
    MeSH term(s) Child ; Humans ; Adolescent ; Body Mass Index ; Tumor Necrosis Factor-alpha ; Leptin ; Cross-Sectional Studies ; Indonesia/epidemiology ; Tuberculosis/diagnosis ; Body Weight
    Chemical Substances Tumor Necrosis Factor-alpha ; Leptin
    Language English
    Publishing date 2023-03-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2023.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Karakteristik Bayi Baru Lahir dari Ibu Terkait COVID-19 di RSUP Dr. Kariadi Semarang

    Radityo, Adhie Nur / Rini, Arsita Eka / Anam, Moh Syarofil / Sarosa, Gatot Irawan

    JOURNAL OF CLINICAL MEDICINE; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 166-170 ; Medica Hospitalia : Journal of Clinical Medicine; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 166-170 ; 2685-7898 ; 2301-4369 ; 10.36408/mhjcm.v7i1A

    2020  

    Abstract: Latar belakang Kejadian kasus COVID-19 pada bayi belum banyak dilaporkan dan mekanisme penularan terhadap bayi baru lahir masih belum jelas. Tujuan Melaporkan perbedaan karakteristik bayi baru lahir dari ibu terkait COVID-19 di RSUP Dr. Kariadi Semarang ... ...

    Abstract Latar belakang Kejadian kasus COVID-19 pada bayi belum banyak dilaporkan dan mekanisme penularan terhadap bayi baru lahir masih belum jelas. Tujuan Melaporkan perbedaan karakteristik bayi baru lahir dari ibu terkait COVID-19 di RSUP Dr. Kariadi Semarang Metode Penelitian retrospektif dengan data sekunder catatan medik bayi baru lahir dari ibu terkait COVID-19 di RSUP dr Kariadi Semarang pada periode April-Mei 2020 dengan kelompok pembanding bayi baru lahir dari ibu tidak terkait COVID-19. Kriteria inklusi semua bayi lahir dari ibu terkait COVID-19 dirawat di rumah sakit dan dilakukan pemeriksaan PCR dengan spesimen swab nasofaring. Data yang dikumpulkan adalah usia kehamilan, jenis kelamin, berat lahir, cara persalinan, usia ibu dan jenis minum yang diberikan pada bayi. Dilakukan uji beda menggunakan uji chi square dan shapiro wilk. Analisis data menggunakan program komputer SPSS. Hasil Dari 46 sampel penelitian terdiri dari 23 bayi lahir dari ibu terkait COVID-19 dan 23 bayi lahir dari ibu tidak terkait COVID-19 dilakukan analisis dengan hasil tidak terdapat perbedaan bermakna dari usia kehamilan, berat lahir, cara persalinan dan usia ibu. Pada kelompok bayi lahir terkait COVID-19 mayoritas lahir dengan jenis kelamin perempuan (74%) dan jenis minum yang diberikan sekitar 86% dengan susu formula. Tidak ada bayi yang mendapat ASI eksklusif pada bayi yang lahir dari ibu terkait COVID-19. Semua bayi yang lahir dari ibu terkait COVID-19 didapatkan hasil swab nasofaring negatif dan tidak menunjukkan gejala apapun sampai dengan pulang. Simpulan Tidak didapatkan perbedaan karakteristik usia kehamilan, berat lahir, cara persalinan dan usia ibu. Terdapat perbedaan karakteristik jenis kelamin dan jenis minum yang diberikan pada kedua kelompok penelitian. Keyword: bayi baru lahir, COVID-19 Background The incidence of COVID-19 cases in newborn has not been widely reported and the mechanism of transmission to the newborn is unclear. Objective To report the characteristics of newborns from mothers related to COVID-19 at Kariadi Hospital Semarang. Method Retrospective study with secondary data on medical records of newborns from mothers related to COVID-19 at Kariadi Hospital in the April-May 2020 period with a comparison group of newborns from mothers not related to COVID-19. Criteria for inclusion of all infants born to mothers associated with COVID-19 were hospitalized and PCR examination carried out with nasopharyngeal swab specimens. Data collected were gestational age, sex, birth weight, mode of delivery, maternal age and type of dietary given to the baby. Analysis tests were performed using chi square test and Shapiro Wilk. Data analysis using SPSS computer programs Result Of the 46 study samples consisting of 23 babies born to mothers related to COVID-19 and 23 babies born to mothers not related to COVID-19 were analyzed with the results that there were no significant differences in gestational age, birth weight, mode of delivery and maternal age. In the group of babies born with COVID-19 the majority were born with a female sex (74%) and the type of dietary given was around 86% with formula milk. No baby gets exclusive breastfeeding for babies born to mothers related to COVID-19. All babies born to mothers related to COVID-19 obtained negative nasopharyngeal swab results and did not show any symptoms until discharge. Conclusion There were no differences in the characteristics of gestational age, birth weight, mode of delivery and maternal age. There were differences in the characteristics of the sexes and types of dietary given in the two study groups. Keyword: newborn, COVID-19
    Keywords covid19
    Language Indonesian
    Publishing date 2020-08-28
    Publisher RSUP Dr. Kariadi
    Publishing country id
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Profil Klinis, Laboratorium, Radiologis dan Luaran Pasien COVID-19 Pada Anak di RSUP Dr. Kariadi Semarang

    Anam, Moh Syarofil / Wistiani, Wistiani / Sahyuni, Riza / Hapsari, Maria Magdalena Diah Endang Apriani Harry

    JOURNAL OF CLINICAL MEDICINE; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 130-136 ; Medica Hospitalia : Journal of Clinical Medicine; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 130-136 ; 2685-7898 ; 2301-4369 ; 10.36408/mhjcm.v7i1A

    2020  

    Abstract: Latar belakang Kasus COVID-19 pada anak menunjukkan karakteristik klinis yang bervariasi, meskipun umumnya ringan dapat menjadi sumber penularan dan memunyai dampak terhadap kesehatan secara umum. Tujuan Melaporkan karakteristik klinis, laboratorium, ... ...

    Abstract Latar belakang Kasus COVID-19 pada anak menunjukkan karakteristik klinis yang bervariasi, meskipun umumnya ringan dapat menjadi sumber penularan dan memunyai dampak terhadap kesehatan secara umum. Tujuan Melaporkan karakteristik klinis, laboratorium, gambaran radiologis dan luaran pasien COVID-19 pada anak di RSUP Dr. Kariadi Semarang Metode Penelitian retrospektif, dengan data dari rekam medis pasien terduga COVID-19 di RSUP dr Kariadi Semarang pada periode Maret – April 2020. Kriteria inklusi pasien usia 0-18 tahun terduga COVID dirawat di rumah sakit, dan dilakukan pemeriksaan PCR dengan spesimen swab. Data yang dikumpulkan adalah demografi, manifestasi klinis, laboratorium, gambaran radiologis, penyakit komorbid, dan luaran. Analisis data menggunakan SPPS for window 12.0 version. Hasil Enam puluh satu pasien yang terduga COVID, 41 kasus dilakukan analisis dengan temuan hasil positif pada 5 (12%) kasus, laki-laki 22 (53,7%) dan perempuan 19( 46,3%) dengan median usia 36 bulan (rentang 3-214 bulan), gejala utama batuk 38 (92,7%), demam 37 (90,2%), dan ronkhi 25 (61%). Pada kelompok kasus COVID positif batuk dijumpai pada 5/5 pasien, demam 3/5 pasien, ronkhi 2/5 pasien. Seluruh pasien dari kelompok COVID positif pulang perbaikan, dan 4 kasus dari kelompok COVID negatif meninggal. Kadar lekosit dan limfosit kelompok COVID positif dan negatif berturut-turut dengan nilai signifikansi p 0,62 dan p 0.72, gambaran radiologis antar kelompok p 0,56 Simpulan Tidak didapatkan perbedaan karakteristik riwayat epidemiologis, gejala dan tanda klinis, laboratorium, foto rontgen toraks serta luaran antar kelompok pasien COVID-19 positif dan negatif.
    Keywords covid19
    Language Indonesian
    Publishing date 2020-08-28
    Publisher RSUP Dr. Kariadi
    Publishing country id
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia.

    Farida, Helmia / Triasih, Rina / Lokida, Dewi / Mardian, Yan / Salim, Gustiani / Wulan, Wahyu Nawang / Butar-Butar, Deni P / Sari, Rizki Amalia / Budiman, Arif / Hayuningsih, Chakrawati / Anam, Moh Syarofil / Dipayana, Setya / Mujahidah, Mujahidah / Setyati, Amalia / Aman, Abu Tholib / Naysilla, Adhella Menur / Lukman, Nurhayati / Diana, Aly / Karyana, Muhammad /
    Kline, Ahnika / Neal, Aaron / Lane, H Clifford / Kosasih, Herman / Lau, Chuen-Yen

    Frontiers in medicine

    2023  Volume 10, Page(s) 1140100

    Abstract: Background: Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistance. This ... ...

    Abstract Background: Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistance. This study aimed to develop a prediction model using epidemiological, clinical and laboratory data to differentiate between bacterial and viral CAP.
    Methods: Data from 155 children with confirmed bacterial or mixed bacterial and viral infection (
    Results: Diarrhea was more frequently reported in bacterial and mixed CAP, while viral infections more frequently occurred during Indonesia's rainy season. White blood cell counts (WBC), absolute neutrophil counts (ANC), neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) were significantly higher in bacterial and mixed cases. After adjusting for covariates, the following were the most important predictors of bacterial or mixed CAP: rainy season (aOR 0.26; 95% CI 0.08-0.90;
    Conclusion: Combining clinical and laboratory profiles is potentially valuable for discriminating bacterial and mixed from viral pediatric CAP and may guide antibiotic use. Further studies with a larger sample size should be performed to validate this model.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1140100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seorang Anak Perempuan Probable Covid-19 dengan Keterlibatan Ginjal (Laporan kasus)

    Mellyana, Omega / Latifah, Nur / Trixie, Marcella / Mardiana, Frederika / Anam, Moh Syarofil / Sahyuni, Riza / Wistiani, Wistiani

    JOURNAL OF CLINICAL MEDICINE; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 207-213 ; Medica Hospitalia : Journal of Clinical Medicine; Vol 7 No 1A (2020): Med Hosp; Agustus 2020, Edisi Khusus Covid-19; 207-213 ; 2685-7898 ; 2301-4369 ; 10.36408/mhjcm.v7i1A

    2020  

    Abstract: Latar belakang: Kasus Probable Covid-19 adalah kasus penderita dengan gambaran klinis dan pemeriksaan penunjang yang meyakinkan Covid-19 namun tidak terkonfirmasi dengan pemeriksaan real-time polymerase chain reaction (RT-PCR). Kasus probable banyak ... ...

    Abstract Latar belakang: Kasus Probable Covid-19 adalah kasus penderita dengan gambaran klinis dan pemeriksaan penunjang yang meyakinkan Covid-19 namun tidak terkonfirmasi dengan pemeriksaan real-time polymerase chain reaction (RT-PCR). Kasus probable banyak menimbulkan kekhawatiran karena risiko penularan dan keraguan dalam tata laksana baik bagi dokter, perawat, dan penanggung jawab pasien. Tujuan penulisan artikel ini adalah untuk melaporkan kasus seorang anak dengan probable Covid-19 dan mendiskusikan kemungkinan diagnosis banding lain sebagai pemikiran di tengah pandemi Covid-19 guna pengelolaan pasien yang lebih optimal. Kasus: Anak perempuan 14 tahun 5 bulan dengan keluhan utama batuk selama dua minggu sebelum masuk rumah sakit, disertai demam, diare dan sesak. Selama perawatan, sesak makin bertambah. Tiga hari perawatan ditemukan oliguria, proteinuria, anemia, leukositosis, trombositopenia, hipersegmentasi neutrofil, limfopenia, peningkatan prokalsitonin, hipoalbuminemia dan penurunan fungsi ginjal (51 ml/menit/1,73 m2). Gambaran rontgen dada menunjukkan bronkopneumonia dan kardiomegali. MSCT dada terdapat gambaran konsolidasi dan ground glass appearance (GGO) di kedua paru mendukung ke arah Covid-19. Pada hari perawatan ke 16 anak mengalami gagal nafas, hemoptoe, penurunan kesadaran hingga meninggal. Swab RT-PCR 3 kali negatif (selama perawatan dan post mortem). Ringkasan : Infeksi Covid-19 adalah penyebab infeksi saluran nafas yang serius dan berat. Telah dilaporkan seorang anak perempuan 14 tahun 5 bulan yang meninggal karena Probable Covid-19. Di tengah pandemi Covid-19 ini seorang dokter perlu meningkatkan kewaspadaan yang tinggi terhadap infeksi virus atau bakteri lain untuk memperbaiki tata laksana dan luaran pada penderita. Kata kunci: Covid-19, probable, ground glass opacity, RT-PCR Background: Probable Covid-19 cases are patients with clinical features and convincing investigations for covid-19 but there is not confirmed by real time polymerase chain reaction (RT-PCR). Probable cases raise many concerns because of the risk of transmission and doubt in good management for the doctor / nurse in charge of the patient. The purpose of writing was to report the child with probable Covid-19 and provide a discussion of possible other differential diagnoses as thoughts in the midst of the Covid-19 pandemic for optimal management of sufferers. Case: A girl 14 years 5 months old had a cough for two weeks before admission, accompanied by fever, diarrhea and breathlessness. During treatment, the shortness of breath increased, three days of treatment found oliguria, proteinuria, hematuria, anemia, leukocytosis, thrombocytopenia, neutrophil hypersegmentation, lymphopenia, increased procalcitonin, hypoalbuminemia and decreased renal function (51 ml / min / 1.73 m2). Chest x-ray of bronchopneumonia and cardiomegaly. In the finding of chest computed tomography scan showed consolidation and ground glass appearance (GGO) in both lungs supporting the diagnose of Covid-19. On the 16th day of treatment, the child suffered respiratory failure, hemoptoes, decreased consciousness until death. RT-PCR swabs were 3 times negative (during treatment and post mortem). Summary: Covid-19 is a serious and severe cause of respiratory tract infection. It has been reported that a girl of 14 years and 5 months who died of Probable Covid-19 has been reported. During the Covid-19 pandemic, a doctor may need to increase high awareness of other viral or bacterial infections to improve management and outcome of patients in the future. Key word: Covid-19, Children, Ground Glass Opacity, RT_PCR
    Keywords covid19
    Language Indonesian
    Publishing date 2020-08-28
    Publisher RSUP Dr. Kariadi
    Publishing country id
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.

    Lokida, Dewi / Farida, Helmia / Triasih, Rina / Mardian, Yan / Kosasih, Herman / Naysilla, Adhella Menur / Budiman, Arif / Hayuningsih, Chakrawati / Anam, Moh Syarofil / Wastoro, Dwi / Mujahidah, Mujahidah / Dipayana, Setya / Setyati, Amalia / Aman, Abu Tholib / Lukman, Nurhayati / Karyana, Muhammad / Kline, Ahnika / Neal, Aaron / Lau, Chuen-Yen /
    Lane, Clifford

    BMJ open

    2022  Volume 12, Issue 6, Page(s) e057957

    Abstract: Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.: Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an ... ...

    Abstract Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.
    Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.
    Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang.
    Participants: Hospitalised children aged 2-59 months who met the criteria for pneumonia were eligible. Children were excluded if they had been hospitalised for >24 hours; had malignancy or history of malignancy; a history of long-term (>2 months) steroid therapy, or conditions that might interfere with compliance with study procedures.
    Main outcomes measures: Causative bacterial, viral or mixed pathogen(s) for pneumonia were determined using microbiological, molecular and serological tests from routinely collected specimens (blood, sputum and nasopharyngeal swabs). We applied a previously published algorithm (PEER-PePPeS rules) to determine the causative pathogen(s).
    Results: 188 subjects were enrolled. Based on our algorithm, 48 (25.5%) had a bacterial infection, 31 (16.5%) had a viral infection, 76 (40.4%) had mixed bacterial and viral infections, and 33 (17.6%) were unable to be classified. The five most common causative pathogens identified were
    Conclusions: Our study found that
    Trail registration number: NCT03366454.
    MeSH term(s) Child ; Child, Hospitalized ; Child, Preschool ; Community-Acquired Infections/microbiology ; Haemophilus influenzae type b ; Humans ; Indonesia/epidemiology ; Infant ; Pneumonia/etiology ; Prospective Studies ; Respiratory Syncytial Virus, Human ; Virus Diseases/complications
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-057957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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