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  1. Article: Squamous Cell Carcinoma of the Thumb: A Case Report.

    Georgiev, Georgi P / Ananiev, Julian M / Groudeva, Violeta

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54046

    Abstract: Squamous cell carcinoma (SCC) is the most common tumor of the hand with a high tendency for local recurrence and a low rate of metastasis. Herein, we present an interesting case of SCC of the thumb of the right hand in a 68-year-old patient with one ... ...

    Abstract Squamous cell carcinoma (SCC) is the most common tumor of the hand with a high tendency for local recurrence and a low rate of metastasis. Herein, we present an interesting case of SCC of the thumb of the right hand in a 68-year-old patient with one recurrence, treated with surgical excision and following radiotherapy. Five years postoperative, there are no clinical and imaging data for local recurrence, as well as the presence of metastases. We also make a brief review of the current literature on this neoplasia.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Case Report: Spontaneous Left Inferior Epigastric Artery Injury in a COVID-19 Female Patient Undergoing Anticoagulation Therapy.

    Abrashev, Hristo / Ananiev, Julian / Georgieva, Ekaterina

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Since the beginning of the pandemic, a recommendation was made for the use of anticoagulants in high-risk hospitalized patients. This therapeutic approach has positive and negative effects regarding the outcome of the disease. Anticoagulant therapy ... ...

    Abstract Since the beginning of the pandemic, a recommendation was made for the use of anticoagulants in high-risk hospitalized patients. This therapeutic approach has positive and negative effects regarding the outcome of the disease. Anticoagulant therapy prevents thromboembolic events, but it can also lead to spontaneous hematoma formation, or be accompanied by massive active bleeding. We present a 63-year-old COVID-19-positive female patient with a massive retroperitoneal hematoma and spontaneous left inferior epigastric artery injury.
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12051842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protective Role of

    Aleksandrova, Elina / Vlaykova, Tatyana / Ananiev, Julian / Gulubova, Maya

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 11

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Bulgaria/epidemiology ; Case-Control Studies ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Interleukin-17/genetics
    Chemical Substances IL17A protein, human ; Interleukin-17
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58111632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Paroxysmal Finger Hematoma-A Probable Vascular Disorder in Post-COVID-19 Condition: Two Clinical Case Presentations.

    Abrashev, Hristo / Ananiev, Julian / Georgieva, Ekaterina

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 7

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) COVID-19/complications ; Female ; Fingers ; Hematoma/complications ; Humans ; Rare Diseases/pathology ; SARS-CoV-2 ; Syndrome ; Vascular Diseases
    Language English
    Publishing date 2022-07-10
    Publishing country Switzerland
    Document type Case Reports ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58070915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Role of Elevated Serum TGF-β1 and the Common Promoter

    Aleksandrova, Elina / Mindov, Ivan / Petrov, Bozhidar / Dimitrova, Ivelina / Petrov, Nikolay / Ananiev, Julian / Vlaykova, Tatyana / Valkanov, Stefan

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Transforming Growth Factor beta1/genetics ; Glioma ; Brain Neoplasms/genetics ; Polymorphism, Genetic ; Cytokines
    Chemical Substances Transforming Growth Factor beta1 ; Cytokines ; TGFB1 protein, human
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Azadirachta indica (Neem) Seed Oil Reduced Chronic Redox-Homeostasis Imbalance in a Mice Experimental Model on Ochratoxine A-Induced Hepatotoxicity

    Nikolova, Galina / Ananiev, Julian / Ivanov, Veselin / Petkova-Parlapanska, Kamelia / Georgieva, Ekaterina / Karamalakova, Yanka

    Antioxidants. 2022 Aug. 28, v. 11, no. 9

    2022  

    Abstract: Liver damage severity depends on both the dose and the exposure duration. Oxidative stress may increase the Ochratoxine-A (OTA) hepatotoxicity and many antioxidants may counteract toxic liver function. The present study aims to investigate the ... ...

    Abstract Liver damage severity depends on both the dose and the exposure duration. Oxidative stress may increase the Ochratoxine-A (OTA) hepatotoxicity and many antioxidants may counteract toxic liver function. The present study aims to investigate the hepatoprotective potential of Azadirachta indicaA (A. indica; neem oil) seed oil to reduce acute oxidative disorders and residual OTA toxicity in a 28-day experimental model. The activity of antioxidant and hepatic enzymes, cytokines and the levels of oxidative stress biomarkers –MDA, GSPx, Hydroxiproline, GST, PCC, AGEs, PGC-1, and STIR-1 were analyzed by ELISA. The free radicals ROS and RNS levels were measured by EPR. The protective effects were studied in BALB/C mice treated with A. indica seed oil (170 mg/kg), alone and in combination with OTA (1.25 mg/kg), by gavage daily for 28 days. At the end of the experiment, mice treated with OTA showed changes in liver and antioxidant enzymes, and oxidative stress parameters in the liver and blood. A. indica oil significantly reduced oxidative stress and lipid peroxidation compared to the OTA group. In addition, the hepatic histological evaluation showed significant adipose tissue accumulation in OTA-treated tissues, while treatment with 170 mg/kg A. indica oil showed moderate adipose tissue accumulation.
    Keywords Azadirachta indica ; adipose tissue ; antioxidants ; biomarkers ; blood ; cytokines ; exposure duration ; hepatotoxicity ; histology ; lipid peroxidation ; liver ; liver function ; models ; neem oil ; oxidative stress
    Language English
    Dates of publication 2022-0828
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11091678
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: The

    Nikolova, Galina / Ananiev, Julian / Ivanov, Veselin / Petkova-Parlapanska, Kamelia / Georgieva, Ekaterina / Karamalakova, Yanka

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 9

    Abstract: Liver damage severity depends on both the dose and the exposure duration. Oxidative stress may increase the Ochratoxine-A (OTA) hepatotoxicity and many antioxidants may counteract toxic liver function. The present study aims to investigate the ... ...

    Abstract Liver damage severity depends on both the dose and the exposure duration. Oxidative stress may increase the Ochratoxine-A (OTA) hepatotoxicity and many antioxidants may counteract toxic liver function. The present study aims to investigate the hepatoprotective potential of
    Language English
    Publishing date 2022-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11091678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Vitamin E and Silymarin Reduce Oxidative Tissue Damage during Gentamycin-Induced Nephrotoxicity.

    Georgiev, Tsvetelin / Nikolova, Galina / Dyakova, Viktoriya / Karamalakova, Yanka / Georgieva, Ekaterina / Ananiev, Julian / Ivanov, Veselin / Hadzhibozheva, Petya

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: Aminoglycoside antibiotics and gentamicin (GN), in particular, are still widely used in clinical practice. It is a well-known fact that GN causes nephrotoxicity, and redox disturbances are discussed as a factor in its side effects. Recently, a new type ... ...

    Abstract Aminoglycoside antibiotics and gentamicin (GN), in particular, are still widely used in clinical practice. It is a well-known fact that GN causes nephrotoxicity, and redox disturbances are discussed as a factor in its side effects. Recently, a new type of cell oxidative death, named ferroptosis, was discovered; it is associated with iron accumulation in the cell, glutathione (GSH) depletion and inactivation of glutathione peroxidase-4 (GPX4), reactive oxygen species (ROS) increment with concomitant lipid peroxidation. In this regard, a possible connection between GN-induced renal damage, ferroptosis and the overall antioxidant status of the organism could be investigated. Moreover, due to its beneficial effects, GN is still one of the main choices as a therapeutic agent for several diseases, and the possible reduction of its side effects with the application of certain antioxidants will be of important clinical significance. The study was conducted with adult male white mice divided into several groups (n = 6). GN nephrotoxicity was induced by the administration of GN 100-200 mg/kg i.p. for 10 days. The control group received only saline. The other groups received either Vitamin E (400 mg/kg p.o.) or Silymarin (200 mg/kg p.o.) applied alone or together with GN for the same period. After the end of the study, the animals were sacrificed, and blood and tissue samples were taken for the assessment of biochemical parameters and antioxidant status, as well as routine and specific for GPX4 histochemistry examination. The experimental results indicate that GN-induced nephrotoxicity negatively modulates GPX4 activity and is associated with increased production of ROS and lipid peroxidation. The groups treated with antioxidants demonstrated preserved antioxidant status and better GPX4 activity. In conclusion, the inhibition of ROS production and especially the suppression of ferroptosis, could be of clinical potential and can be applied as a means of reducing the toxic effects of GN application.
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16101365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Do the Differences in the Epiligament of the Proximal and Distal Parts of the Anterior Cruciate Ligament Explain Their Different Healing Capacities? Quantitative and Immunohistochemical Analysis of CD34 and α-SMA Expression in Relation to the Epiligament Theory.

    Georgiev, Georgi P / Yordanov, Yordan / Olewnik, Łukasz / Tubbs, Richard Shane / LaPrade, Robert F / Ananiev, Julian / Slavchev, Svetoslav A / Dimitrova, Iva N / Gaydarski, Lyubomir / Landzhov, Boycho

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: The aim of this study was to assess the epiligament theory by determining the normal epiligament morphology of the proximal and distal parts of the anterior cruciate ligament in humans and analyzing the differences between them and the midportion of the ... ...

    Abstract The aim of this study was to assess the epiligament theory by determining the normal epiligament morphology of the proximal and distal parts of the anterior cruciate ligament in humans and analyzing the differences between them and the midportion of the ligament in terms of cell numbers and expression of CD34 and α-SMA. Samples were obtained from the anterior cruciate ligaments of 12 fresh knee joints. Monoclonal antibodies against CD34 and α-SMA were used for immunohistochemistry. Photomicrographs were analyzed using ImageJ software, version 1.53f. The cell density was higher in the epiligament than in the ligament connective tissue. Cell counts were higher in the proximal and distal thirds than in the midsubstance of the epiligament. CD34 was expressed similarly in the proximal and distal thirds, although it seemed slightly more pronounced in the distal third. α-SMA expression was more robust in the proximal than the distal part. The results revealed that CD34 and α-SMA are expressed in the human epiligament. The differences between the numbers of cells in the proximal and distal parts of the epiligament and the expression of CD34 and α-SMA enhance epiligament theory. Future investigations into improving the quality of ligament healing should not overlook the epiligament theory.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Are There Any Differences in the Healing Capacity between the Medial Collateral Ligament's (MCL) Proximal and Distal Parts in the Human Knee? Quantitative and Immunohistochemical Analysis of CD34, α-Smooth Muscle Actin (α-SMA), and Vascular Endothelial Growth Factor (VEGF) Expression Regarding the Epiligament (EL) Theory.

    Georgiev, Georgi P / Yordanov, Yordan / Gaydarski, Lyubomir / Tubbs, Richard Shane / Olewnik, Łukasz / Zielinska, Nicol / Piagkou, Maria / Ananiev, Julian / Dimitrova, Iva N / Slavchev, Svetoslav A / Terziev, Ivan / Suwannakhan, Athikhun / Landzhov, Boycho

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: The human knee is a complex joint that comprises several ligaments, including the medial collateral ligament (MCL). The MCL provides stability to the knee and helps prevent its excessive inward movement. The MCL also has a thin layer of connective tissue ...

    Abstract The human knee is a complex joint that comprises several ligaments, including the medial collateral ligament (MCL). The MCL provides stability to the knee and helps prevent its excessive inward movement. The MCL also has a thin layer of connective tissue known as the epiligament (EL), which adheres to the ligament. This unique feature has drawn attention in the field of ligament healing research, as it may have implications for the recovery process of MCL injuries. According to the EL theory, ligament regeneration relies heavily on the provision of cells, blood vessels, and molecules. The present study sought to compare the expression of vascular endothelial growth factor (VEGF), CD34, and α-smooth muscle actin (α-SMA) in healthy knees' proximal and distal MCL segments to better understand how these proteins affect ligament healing. By improving the EL theory, the current results could lead to more effective treatments for ligament injury. To conduct the present analysis, monoclonal antibodies were used against CD34, α-SMA, and VEGF to examine samples from 12 fresh knee joints' midsubstance MCLs. We identified a higher cell density in the EL than in the ligament connective tissue, with higher cell counts in the distal than in the proximal EL part. CD34 immunostaining was weak or absent in blood vessels and the EL, while α-SMA immunostaining was strongest in smooth muscle cells and the EL superficial layer. VEGF expression was mainly in the blood vessels' tunica media. The distal part showed more SMA-positive microscopy fields and higher cell density than the proximal part (4735 vs. 2680 cells/mm
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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