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  1. Book: Nutritional management of inflammatory bowel diseases

    Ananthakrishnan, Ashwin N.

    a comprehensive guide

    2016  

    Keywords enteral nutrition ; Crohn’s disease ; microbiome ; parenteral nutrition ; ulcerative colitis ; short bowel syndrome
    Language English
    Size XV, 237 S. : Ill., graph. Darst., 28 schw.-w. Tab., 2 schw.-w. Ill., 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018920883
    ISBN 978-3-319-26888-0 ; 978-3-319-26890-3 ; 3-319-26888-0 ; 3-319-26890-2
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Inflammatory bowel diseases: are we ready to recommend a preventive diet for infants?

    Ananthakrishnan, Ashwin N

    Gut

    2024  Volume 73, Issue 4, Page(s) 559–560

    MeSH term(s) Infant ; Humans ; Inflammatory Bowel Diseases/prevention & control ; Colitis, Ulcerative ; Diet
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Precision medicine in inflammatory bowel diseases.

    Ananthakrishnan, Ashwin N

    Intestinal research

    2023  Volume 22, Issue 1, Page(s) 8–14

    Abstract: Inflammatory bowel diseases comprising Crohn's disease and ulcerative colitis have emerged as global diseases. Multiple distinct therapeutic mechanisms have allowed us to increase our rates of achieving remission and reducing permanent disease-related ... ...

    Abstract Inflammatory bowel diseases comprising Crohn's disease and ulcerative colitis have emerged as global diseases. Multiple distinct therapeutic mechanisms have allowed us to increase our rates of achieving remission and reducing permanent disease-related morbidity. However, there is limited data to inform relative positioning of different therapies. This review will summarize existing literature on use of clinical decision models to inform relative efficacy of one therapeutic mechanism compared to the other given individual patient characteristics. It will also demonstrate the value of serologic, transcriptomic (from biopsies), and microbiome-based biomarkers in identifying which therapy is most likely to work for a given patient. We will review the existing gaps in the literature in this field and suggest a path forward for future studies to better inform patient care, incorporating the principles of precision medicine in the management of inflammatory bowel disease.
    Language English
    Publishing date 2023-11-09
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3018469-1
    ISSN 2288-1956 ; 1598-9100
    ISSN (online) 2288-1956
    ISSN 1598-9100
    DOI 10.5217/ir.2023.00087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is it Time for the Alternative to Move to the Mainstream?

    Ananthakrishnan, Ashwin N

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 22, Issue 2, Page(s) 235–236

    MeSH term(s) Humans ; Curcumin ; Colitis, Ulcerative ; Patients
    Chemical Substances Curcumin (IT942ZTH98)
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upadacitinib for ulcerative colitis.

    Ananthakrishnan, Ashwin N

    Lancet (London, England)

    2022  Volume 399, Issue 10341, Page(s) 2077–2078

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Colitis, Ulcerative/drug therapy ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Janus Kinase Inhibitors/therapeutic use
    Chemical Substances Antirheumatic Agents ; Heterocyclic Compounds, 3-Ring ; Janus Kinase Inhibitors ; upadacitinib (4RA0KN46E0)
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00778-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial: immunosuppression and SARS-CoV-2 vaccination-where do we stand?

    Ananthakrishnan, Ashwin N

    Alimentary pharmacology & therapeutics

    2022  Volume 57, Issue 1, Page(s) 163–164

    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Immunosuppression Therapy ; Immune Tolerance
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: IBD risk prediction using multi-ethnic polygenic risk scores.

    Ananthakrishnan, Ashwin N

    Nature reviews. Gastroenterology & hepatology

    2021  Volume 18, Issue 4, Page(s) 217–218

    MeSH term(s) Biological Specimen Banks ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Inflammatory Bowel Diseases/genetics ; Penetrance ; Risk Factors
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-021-00425-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Frailty in Patients With Inflammatory Bowel Disease.

    Ananthakrishnan, Ashwin N

    Gastroenterology & hepatology

    2021  Volume 17, Issue 6, Page(s) 263–268

    Abstract: Older individuals comprise a growing proportion of patients with inflammatory bowel disease (IBD). Assessing older patients for frailty, defined as an age-related decline in multiple physiologic systems, is increasingly recognized as important for risk- ... ...

    Abstract Older individuals comprise a growing proportion of patients with inflammatory bowel disease (IBD). Assessing older patients for frailty, defined as an age-related decline in multiple physiologic systems, is increasingly recognized as important for risk-stratifying patients with IBD. Mechanistically, both persistent chronic inflammation and common microbial perturbations may predispose patients with IBD to the development of frailty. In those with IBD, frailty is associated with an increased risk for mortality that is independent of age and comorbidity. Among hospitalized patients, frailty is associated with a higher risk for readmission and postoperative complications. In patients starting on immunomodulator or tumor necrosis factor-alpha antagonist therapy, frailty is also associated with an increased risk for infectious complications, including serious infections. For a beneficial effect on patient outcomes, it is important that clinicians familiarize themselves with the tools for assessing frailty and implement interventions aimed at mitigating the individual components of the frailty phenotype. This article examines the proposed mechanisms for an association between frailty and IBD, tools for assessment of frailty, and data involving the impact of frailty on outcomes in patients with IBD.
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Geographic Inequities in Access to Phase 3 Clinical Trials for Inflammatory Bowel Disease in the United States.

    Boyd, Taylor / Ananthakrishnan, Ashwin N

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 22, Issue 3, Page(s) 659–661.e3

    Abstract: Randomized controlled trials (RCTs) are an important mode of access to treatments for patients with inflammatory bowel diseases (IBDs) (eg, Crohn's disease [CD], ulcerative colitis [UC]), and a critical step in the regulatory process toward the approval ... ...

    Abstract Randomized controlled trials (RCTs) are an important mode of access to treatments for patients with inflammatory bowel diseases (IBDs) (eg, Crohn's disease [CD], ulcerative colitis [UC]), and a critical step in the regulatory process toward the approval of new therapies. Prior studies examining disparities in RCT participation for patients with IBD have importantly focused on racial and age-related disparities.
    MeSH term(s) Humans ; United States ; Inflammatory Bowel Diseases/therapy ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.07.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative Effectiveness of Upadacitinib and Tofacitinib in Inducing Remission in Ulcerative Colitis: Real-World Data.

    Boneschansker, Leo / Ananthakrishnan, Ashwin N

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 21, Issue 9, Page(s) 2427–2429.e1

    MeSH term(s) Humans ; Colitis, Ulcerative/drug therapy ; Piperidines/therapeutic use ; Pyrimidines/therapeutic use ; Janus Kinase Inhibitors/therapeutic use
    Chemical Substances Piperidines ; Pyrimidines ; tofacitinib (87LA6FU830) ; upadacitinib (4RA0KN46E0) ; Janus Kinase Inhibitors
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.03.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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