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Article ; Online: Different responses of repetitive behaviours in juvenile and young adult mice to Δ

Gorberg, Victoria / McCaffery, Peter / Anavi-Goffer, Sharon

2020 Volume 178, Issue 3, Page(s) 614–625

Abstract: Background and purpose: Medicinal cannabis is in increasing use by patients with Tourette syndrome, a neuropsychiatric disorder that affects about 1% of the general population and has a childhood onset. However, the pharmacological effects of Δ: ... ...

Abstract	Background and purpose: Medicinal cannabis is in increasing use by patients with Tourette syndrome, a neuropsychiatric disorder that affects about 1% of the general population and has a childhood onset. However, the pharmacological effects of Δ Experimental approach: The administration of 2,5-dimethoxy-4-iodoamphetamine (DOI) increases head twitch response (HTR) and ear scratch response (ESR) and has been proposed as an animal model useful to respectively study motor tics and premonitory urges associated with tic disorders. Key results: Comparing the potency of Δ Conclusion and implications: Δ
MeSH term(s)	Animals ; Cannabidiol/pharmacology ; Child ; Decision Making ; Dronabinol/pharmacology ; Humans ; Medical Marijuana ; Mice ; Tourette Syndrome/drug therapy
Chemical Substances	Medical Marijuana ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2020-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.15302
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Article ; Online: Motor-like Tics are Mediated by CB

Gorberg, Victoria / Borisov, Veronika / Greig, Iain R / Pertwee, Roger G / McCaffery, Peter / Anavi-Goffer, Sharon

Molecular neurobiology

2022 Volume 59, Issue 8, Page(s) 5070–5083

Abstract: ... ...

Abstract	Δ
MeSH term(s)	Animals ; Dronabinol/pharmacology ; Endocannabinoids ; Female ; Humans ; Male ; Mice ; Monoacylglycerol Lipases ; Receptor, Cannabinoid, CB2/genetics ; Receptors, Cannabinoid ; Rimonabant/pharmacology ; Serotonin ; Tics ; Tourette Syndrome
Chemical Substances	Endocannabinoids ; GPR55 protein, mouse ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Serotonin (333DO1RDJY) ; Dronabinol (7J8897W37S) ; ABHD6 protein, human (EC 3.1.1.23) ; Monoacylglycerol Lipases (EC 3.1.1.23) ; Rimonabant (RML78EN3XE)
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-022-02884-6
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Article ; Online: Methylhonokiol attenuates neuroinflammation

Gertsch Jürg / Anavi-Goffer Sharon

Journal of Neuroinflammation, Vol 9, Iss 1, p

a role for cannabinoid receptors?

2012 Volume 135

Abstract: Abstract The cannabinoid type-2 G protein-coupled (CB 2 ) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer’s disease (AD) the orally administered natural product 4′-O- ... ...

Abstract	Abstract The cannabinoid type-2 G protein-coupled (CB 2 ) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer’s disease (AD) the orally administered natural product 4′-O-methylhonokiol (MH) has been shown to prevent amyloidogenesis and progression of AD by inhibiting neuroinflammation. In this commentary we discuss an intriguing link between the recently found CB 2 receptor-mediated molecular mechanisms of MH and its anti-inflammatory and protective effects in AD animal models. We argue that the novel cannabimimetic MH may exert its beneficial effects via modulation of CB 2 receptors expressed in microglial cells and astrocytes. The recent findings provide further evidence for a potential role of CB 2 receptors in the pathophysiology of AD, spurring target validation and drug discovery.
Keywords	Alzheimer’s disease ; Cannabinoids ; CB 2 receptors ; Endocannabinoid System ; Magnolia grandiflora ; Medicinal plant ; Methylhonokiol ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; DOAJ:Neurology
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modulation of l-α-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors.

Anavi-Goffer, Sharon / Irving, Andrew J / Ross, Ruth A

Journal of basic and clinical physiology and pharmacology

2016 Volume 27, Issue 3, Page(s) 303–310

Abstract: Background: GPR55 is a lipid-sensing G protein-coupled receptor that is activated by the endogenous lipid l-α-lysophosphatidylinositol (LPI) and can be modulated by certain cannabinoid ligands.: Methods: In this study we investigated the GPR55 ... ...

Abstract	Background: GPR55 is a lipid-sensing G protein-coupled receptor that is activated by the endogenous lipid l-α-lysophosphatidylinositol (LPI) and can be modulated by certain cannabinoid ligands. Methods: In this study we investigated the GPR55 activity of four synthetic CB2 receptor agonists using the AlphaScreen® SureFire® assay. Results: Here we show that the CB2 receptor-selective agonists HU-308, HU-433 and HU-910 do not promote GPR55-mediated ERK1/2 phosphorylation up to a concentration of 3 μM. However, LPI-induced ERK1/2 phosphorylation is inhibited by the (-)-enantiomer of HU-308, designated HU-433, whereas HU-308 has no effect on LPI activity. The carboxylic analogue of HU-910, designated HU-914, potently inhibits LPI-induced ERK1/2 phosphorylation; however, HU-914 was less effective, with potential biphasic effects. Conclusions: This structure-activity-relationship study has identified novel ligands which act both as CB2 receptor agonists and GPR55 modulators and related compounds that lack GPR55 activity.
MeSH term(s)	Bridged Bicyclo Compounds/pharmacology ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Antagonists/pharmacology ; Cannabinoids/pharmacology ; Cell Line ; HEK293 Cells ; Humans ; Ligands ; Lysophospholipids/metabolism ; MAP Kinase Signaling System/drug effects ; Phosphorylation/drug effects ; Receptor, Cannabinoid, CB2/agonists ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Signal Transduction/drug effects
Chemical Substances	Bridged Bicyclo Compounds ; Cannabinoid Receptor Agonists ; Cannabinoid Receptor Antagonists ; Cannabinoids ; GPR55 protein, human ; HU-910 ; Ligands ; Lysophospholipids ; Receptor, Cannabinoid, CB2 ; Receptors, G-Protein-Coupled ; lysophosphatidylinositol ; HU 308 (8I5L034D55)
Language	English
Publishing date	2016-05-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2015-0142
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Article ; Online: A Functional Assay for GPR55: Envision Protocol.

Anavi-Goffer, Sharon / Ross, Ruth A

Methods in molecular biology (Clifton, N.J.)

2016 Volume 1412, Page(s) 77–83

Abstract: AlphaScreen(®) SureFire(®) assay is a novel technology that combines luminescent oxygen channeling technology, nano-beads, and monocloncal antibodies to detect the level of a selected protein in a volume lower than 5 μl. This method is more sensitive ... ...

Abstract	AlphaScreen(®) SureFire(®) assay is a novel technology that combines luminescent oxygen channeling technology, nano-beads, and monocloncal antibodies to detect the level of a selected protein in a volume lower than 5 μl. This method is more sensitive compared with the traditional enzyme-linked immunosorbent assays (ELISA), and can detect an increasing number of new targets. Here, we described a method for AlphaScreen(®) SureFire(®) assay that targets ERK1/2 phosphorylation, a primary downstream signaling pathway that conveys activation of GPR55 by L-α-lysophosphatidylinositol (LPI) and certain cannabinoids.
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-3539-0_8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?

Gertsch, Jürg / Anavi-Goffer, Sharon

Journal of neuroinflammation

2012 Volume 9, Page(s) 135

Abstract: The cannabinoid type-2 G protein-coupled (CB₂) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer's disease (AD) the orally administered natural product 4'-O-methylhonokiol (MH) has ... ...

Abstract	The cannabinoid type-2 G protein-coupled (CB₂) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer's disease (AD) the orally administered natural product 4'-O-methylhonokiol (MH) has been shown to prevent amyloidogenesis and progression of AD by inhibiting neuroinflammation. In this commentary we discuss an intriguing link between the recently found CB₂ receptor-mediated molecular mechanisms of MH and its anti-inflammatory and protective effects in AD animal models. We argue that the novel cannabimimetic MH may exert its beneficial effects via modulation of CB₂ receptors expressed in microglial cells and astrocytes. The recent findings provide further evidence for a potential role of CB₂ receptors in the pathophysiology of AD, spurring target validation and drug discovery.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/physiopathology ; Animals ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/therapeutic use ; Humans ; Inflammation/prevention & control ; Lignans/pharmacology ; Lignans/therapeutic use ; Plants, Medicinal ; Receptor, Cannabinoid, CB2/physiology ; Receptors, Cannabinoid/physiology
Chemical Substances	Biphenyl Compounds ; Lignans ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; honokiol (11513CCO0N)
Language	English
Publishing date	2012-06-20
Publishing country	England
Document type	Editorial
ISSN	1742-2094
ISSN (online)	1742-2094
DOI	10.1186/1742-2094-9-135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Detection of Impending Aggressive Outbursts in Patients with Psychiatric Disorders: Violence Clues from Dogs.

Bakeman, Uriel / Eilam, Hodaya / Schild, Clara Moray / Grinstein, Dan / Eshed, Yuval / Laster, Morris / Fride, Ester / Anavi-Goffer, Sharon

Scientific reports

2019 Volume 9, Issue 1, Page(s) 17228

Abstract: Aggression in psychiatric wards is a continuing matter of concern for both patients and medical staff. Here we have tested the hypothesis that the frequency of such incidents can be reduced with a new strategy of using trained alert dogs that warn of ... ...

Abstract	Aggression in psychiatric wards is a continuing matter of concern for both patients and medical staff. Here we have tested the hypothesis that the frequency of such incidents can be reduced with a new strategy of using trained alert dogs that warn of impending violent outbursts. Dogs were positioned among patients in psychiatric wards. Analyses show that the dogs warned of impending aggressive outbursts, responding to signals from a specific patient out of a group of unfamiliar psychotic patients. Their alerts were not a response to stress as canine cortisol levels were not significantly changed. Visual glance was the preferred method used by young dogs to respond to patient. Until a similar electronic technology is developed, trained alert dogs can help caregivers to protect both the patient and those around them from injuries that may otherwise result from aggressive outbursts in psychiatric patients.
MeSH term(s)	Adolescent ; Aggression/psychology ; Animals ; Dogs ; Female ; Humans ; Male ; Mental Disorders/psychology ; Psychiatric Department, Hospital ; Violence/psychology
Language	English
Publishing date	2019-11-21
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-52940-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The polarised life of the endocannabinoid system in CNS development.

Anavi-Goffer, Sharon / Mulder, Jan

Chembiochem : a European journal of chemical biology

2009 Volume 10, Issue 10, Page(s) 1591–1598

Abstract: The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during brain development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and ... ...

Abstract	The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during brain development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis.Endocannabinoids (eCBs) play an important role in fine-tuning neurotransmission and have recently been shown to play an important role in brain development. The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis. Furthermore, pharmacological experiments and transgenic animal models have shown the impact of disrupted eCB signalling on normal brain development and revealed the danger of both cannabis abuse and exposure to cannabinoid drugs during embryonic development, childhood and adolescence. In this review, we focus on the dynamic expression of eCB components and the physiological role eCBs play during brain development.
MeSH term(s)	Animals ; Cannabinoid Receptor Agonists ; Cannabinoid Receptor Antagonists ; Cannabinoid Receptor Modulators/metabolism ; Central Nervous System/embryology ; Central Nervous System/growth & development ; Endocannabinoids ; Neurogenesis ; Receptors, Cannabinoid/metabolism ; Signal Transduction ; Synaptic Transmission
Chemical Substances	Cannabinoid Receptor Agonists ; Cannabinoid Receptor Antagonists ; Cannabinoid Receptor Modulators ; Endocannabinoids ; Receptors, Cannabinoid
Language	English
Publishing date	2009-07-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.200800827
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Article: The Polarised Life of the Endocannabinoid System in CNS Development

Anavi-Goffer, Sharon / Mulder, Jan

Chembiochem. 2009 July 06, v. 10, no. 10

2009

Abstract	The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during brain development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis.Endocannabinoids (eCBs) play an important role in fine-tuning neurotransmission and have recently been shown to play an important role in brain development. The spatiotemporal expression of cannabinoid receptors and endocannabinoid-metabolising enzymes during development guides major developmental processes including neurogenesis, cell differentiation, cell migration, neuronal specification and synaptogenesis. Furthermore, pharmacological experiments and transgenic animal models have shown the impact of disrupted eCB signalling on normal brain development and revealed the danger of both cannabis abuse and exposure to cannabinoid drugs during embryonic development, childhood and adolescence. In this review, we focus on the dynamic expression of eCB components and the physiological role eCBs play during brain development.
Language	English
Dates of publication	2009-0706
Size	p. 1591-1598.
Publishing place	Wiley-VCH Verlag
Document type	Article
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.200800827
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Revisiting stigma: Exposure to Tourette in an ordinary setting increases stigmatization.

Ben-Ezra, Menachem / Anavi-Goffer, Sharon / Arditi, Ella / Ron, Pazit / Atia, Rachel Paryenta / Rate, Yonat / Kaniasty, Krzysztof

Psychiatry research

2016 Volume 248, Page(s) 95–97

Abstract: Stigma toward people with mental disorders is frequently studied yet less is known about prejudice toward persons with tic disorders, especially sufferers of Gilles de la Tourette Syndrome (GTS). We examined stigmatizing attributions concerning a GTS ... ...

Abstract	Stigma toward people with mental disorders is frequently studied yet less is known about prejudice toward persons with tic disorders, especially sufferers of Gilles de la Tourette Syndrome (GTS). We examined stigmatizing attributions concerning a GTS patient in an online study with participants randomly assigned to one of two video clip conditions: the experimental group saw to a person with Tourette syndrome; the control group watched a nature scenic footage. Results revealed that participants in the experimental condition exhibited higher scores on a stigma questionnaire. Clinicians should be aware that GTS patients are prone to being stigmatized by general public.
MeSH term(s)	Adult ; Female ; Healthy Volunteers/psychology ; Humans ; Male ; Middle Aged ; Random Allocation ; Social Stigma ; Surveys and Questionnaires ; Tourette Syndrome/psychology
Language	English
Publishing date	2016-11-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2016.11.040
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